Category: 584-74-7

Laurent, Eliane et al. published their research in Journal of Fluorine Chemistry in 1990 | CAS: 584-74-7

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Ethyl 2-fluorophenylacetate

Electrochemical fluorination of a benzylic position in sulfolane solvent was written by Laurent, Eliane;Marquet, Bernard;Tardivel, Robert. And the article was included in Journal of Fluorine Chemistry in 1990.Safety of Ethyl 2-fluorophenylacetate This article mentions the following:

The use of sulfolane as a solvent instead of MeCN in the electrofluorination of benzylic derivatives, e.g. RC6H4CH2E [R = H, Cl; E = COMe, CO(OEt), CN)], gives greater yields of benzylic fluorides (e.g. RC6H4CFHE) because the formation of acetamido byproducts is prevented. However, the parallel fluorination of the aromatic nucleus is not avoided under these conditions. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Safety of Ethyl 2-fluorophenylacetate).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Ethyl 2-fluorophenylacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Blaschke, Gottfried et al. published their research in Pharmazeutische Zeitung in 1985 | CAS: 584-74-7

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C10H11FO2

Identification of an impurity in diuretic paraflutizide and its detection in the dosage form was written by Blaschke, Gottfried;Maibaum, Juergen. And the article was included in Pharmazeutische Zeitung in 1985.Electric Literature of C10H11FO2 This article mentions the following:

During experiments in the chromatog. separation of enantiomers, a considerable amount of an impurity was detected in paraflutizide (I) [1580-83-2]. This impurity, also detectable by TLC, was identified by spectroscopic methods as 6-chloro-3-(2-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide (II) [96782-83-1]. An unambiguous synthesis confirmed this structure. 19F-NMR spectroscopy enabled the fast and reliable identification of II in a I-containing dosage form besides a large excess of other ingredients. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Electric Literature of C10H11FO2).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C10H11FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bunton, C. A. et al. published their research in Journal of the Chemical Society in 1963 | CAS: 584-74-7

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 584-74-7

The hydrolysis of carboxylic anhydrides. IV. Succinic and tetramethylsuccinic anhydrides was written by Bunton, C. A.;Fendler, J. H.;Fuller, N. A.;Perry, S.;Rocek, J.. And the article was included in Journal of the Chemical Society in 1963.Related Products of 584-74-7 This article mentions the following:

Hydrolysis of succinic and tetramethylsuccinic anhydride is retarded by aqueous mineral acids (except for dilute H2SO4 and HCl). It is acid-catalyzed in aqueous dioxane. Hydrolysis of succinic anhydride in water is accelerated by bivalent electrolytes, but retarded by univalent electrolytes (except for NaHSO4). In water the feeble catalysis by protons is opposed by a sp. neg. salt effect, but the rate in aqueous acid is always greater than that in solutions of the alkali-metal salts. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Related Products of 584-74-7).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 584-74-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bunton, C. A. et al. published their research in Journal of the Chemical Society in 1963 | CAS: 584-74-7

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 584-74-7

The hydrolysis of carboxylic anhydrides. IV. Succinic and tetramethylsuccinic anhydrides was written by Bunton, C. A.;Fendler, J. H.;Fuller, N. A.;Perry, S.;Rocek, J.. And the article was included in Journal of the Chemical Society in 1963.Related Products of 584-74-7 This article mentions the following:

Hydrolysis of succinic and tetramethylsuccinic anhydride is retarded by aqueous mineral acids (except for dilute H2SO4 and HCl). It is acid-catalyzed in aqueous dioxane. Hydrolysis of succinic anhydride in water is accelerated by bivalent electrolytes, but retarded by univalent electrolytes (except for NaHSO4). In water the feeble catalysis by protons is opposed by a sp. neg. salt effect, but the rate in aqueous acid is always greater than that in solutions of the alkali-metal salts. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Related Products of 584-74-7).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 584-74-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simple exploration of 584-74-7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 584-74-7, name is Ethyl 2-fluorophenylacetate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

Ethyl (2-fluorophenyl)acetate (900 mg, 5 mmol) and 60 % NaH (240 mg, 6 mmol) were dissolved in DMF (25 mL) and cooled to 0C. Cyclopentyl bromide (745 mg, 5 mmol) was added and the reaction was gradually warmed to rt. Reaction was stirred at rt for 16 h and then partitioned between EtOAc (100 mL) and NaHC03 (150 mL). The reaction was washed with brine (150 mL), dried over MgS04 and solvent was removed under reduced pressure. Saponification was conducted by addition of 2 M NaOH (20 mL) and heating at 60C for 16 h. The mixture was then acidified with 2 M aq HC1 and then extracted with EtOAc. The solution was dried over MgS04 and concentrated to give the title compound (yellow solid, 800 mg, 72 %). ? NMR (400 MHz, CDCl3) delta ppm 7.46 (t, .7=6.6 Hz, 1 H), 7.20 – 7.26 (m, 1 H), 7.12 (t, .7=7.5 Hz, 1 H), 7.05 (t, .7=9.2 Hz, 1 H), 3.78 (d, .7=11.0 Hz, 1 H), 2.47 – 2.60 (m, 1 H), 1.93-2.04 (m, 1 H), 1.54-1.75 (m, 3 H), 1.41-1.54 (m, 2 H), 1.29-1.41 (m, 1 H), 0.98-1.12 (m, 1 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UNIVERSITY HEALTH NETWORK; PAULS, Heinz W.; LAUFER, Radoslaw; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; LANG, Yunhui; PATEL, Narendra Kumar B.; EDWARDS, Louise G.; NG, Grace; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.; WO2013/53051; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New learning discoveries about C10H11FO2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 584-74-7, name is Ethyl 2-fluorophenylacetate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 584-74-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 584-74-7, name is Ethyl 2-fluorophenylacetate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 584-74-7

Add 16.82 g of ethyl 2-fluorophenylacetate to the three-necked flask and add 100 ml of N,N-dimethylformamide.Stir and dissolve at room temperature, add 0.14 mol of pyridine, and slowly add 9.65 g of cyclopropanecarbonyl chloride at room temperature.After the drop is warmed to 30C, the reaction is stirred for 8 hours, and it is reduced to room temperature and filtered.Slowly add 1ml/L of a mixture of sulfuric acid and acetic acid to the filtrate and add 280ml.After the reaction was completed, the extraction procedure was the same as in Example 1 to obtain 16.30 g of compound (III) in a yield of 91.4%.

According to the analysis of related databases, 584-74-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shandong New Age Pharmaceutical Co., Ltd.; Zhao Zhiquan; Bai Wenqin; Sun Dexin; (6 pag.)CN104418718; (2018); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The important role of Ethyl 2-fluorophenylacetate

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-fluorophenylacetate, and friends who are interested can also refer to it.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 584-74-7 name is Ethyl 2-fluorophenylacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 584-74-7

At -78 C., DIBAL-H (1 M in toluene, 125 ml, 0.125 mol) was added dropwise to a solution of ethyl 2-fluorophenylacetate (22.7 g) in toluene (90 ml). After the addition, the mixture was stirred at this temperature for another 3 hours, and MeOH (90 ml) was then added dropwise. The suspension was poured into hydrochloric acid (2 M, 400 ml) and extracted with MTBE (3¡Á300 ml). The combined organic phases were dried over sodium sulfate and concentrated. This gave 16.2 g of the desired product as a colorless oil (94%). 1H NMR (300 MHz, CDCl3) delta 9.76 (s, 1H), 7.34-7.07 (m, 4H), 3.73 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-fluorophenylacetate, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; US2011/172097; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics