Category: 583-02-8

Reference of 583-02-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-02-8, name is Ethyl 4-(trifluoromethyl)benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 2,2,6,6-tetramethylpiperidine (TMPH, 1.5equiv) in THF (2mL/mmol of ester), a solution of n-butyllithium (1.45M in hexane, 1.5equiv) was added at -30C over 30min. After cooling at -78C, tris(isopropyl)borate (2.0equiv) was added over 20min. Ethyl benzoate or 4-(trifluoromethyl)benzoate or ethyl isonicotinate (1.0equiv) was added via syringe to the reaction mixture over 10min and the mixture was stirred at -78C for 3.5h. After warming to -30C, glacial acetic acid (1.5equiv) was added causing the internal temperature rising to -10C. Neopentyl glycol (1.5equiv) was added and the mixture was stirred at room temperature for 2h. Dichloromethane (20mL/mmol of ester) was then added. The organic phase was successively washed three times with satd aqueous NH4Cl, with satd aqueous NaHCO3 and with water, dried over MgSO4 and evaporated to give the desired compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(trifluoromethyl)benzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fresneau, Nathalie; Cailly, Thomas; Fabis, Frederic; Bouillon, Jean-Philippe; Tetrahedron; vol. 69; 26; (2013); p. 5393 – 5400;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-02-8, name is Ethyl 4-(trifluoromethyl)benzoate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H9F3O2

First access to the microchannel reactor15 minutes of nitrogen replacement system air,Under full nitrogen protection conditions,Cool down between -40 and -30 C and start adding110 g (0.5 mol, 99%)Ethyl p-trifluoromethylbenzoate and 500a mixture of milliliters of methyl tert-butyl ether,At the same time, 0.183 liters (0.55 mol, 3 mol/L) were added dropwise.Butyl lithium solution,The reaction solution all enters the low temperature collector to obtain the compound (III);Re-use the metering pump to compound (III) and 66.1 g(0.6 mol, 99%) methyl methanesulfonate remained inBetween -40 and -30 C,Drip through the microchannel reactor for 2 hours,Sampling analysis did not detect ethyl trifluoromethylbenzoate, and the reaction solution was slowly added dropwise in ice water between 0-5 C under nitrogen protection conditions.The solvent was removed by distillation under reduced pressure to give a yellow solid;Confirmed by nuclear magnetic resonance,Target productEthyl 2-methylsulfonyl-4-trifluoromethylbenzoateThe amount of 146.5 grams,97% content,The yield was 96%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 583-02-8.

Reference:
Patent; Papanna (Beijing) Technology Co., Ltd.; Xing Wenlong; Fu Renji; (7 pag.)CN109705005; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-02-8, name is Ethyl 4-(trifluoromethyl)benzoate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 4-(trifluoromethyl)benzoate

General procedure: A mixture of substituted ethyl benzoate 2 (10 mmol) and hydrazinehydrate (20 mmol) in ethanol was stirred at room temperaturefor 3 h and then filtered. The crude product recrystallizedfrom absolute alcohol to give 3a-l, which were used directly forthe next step. Under this same condition, the intermediate compounds 8a-d were also prepared.

The synthetic route of 583-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; He, Haifeng; Wang, Wei; Zhou, Yuan; Xia, Qin; Ren, Yanliang; Feng, Jiangtao; Peng, Hao; He, Hongwu; Feng, Lingling; Bioorganic and Medicinal Chemistry; vol. 24; 8; (2016); p. 1879 – 1888;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

583-02-8, name is Ethyl 4-(trifluoromethyl)benzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: esters-buliding-blocks

General procedure: To a solution of 1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexyl iodide (0.22 mL, 1.0 mmol), ethyl benzoate (0.16 mL, 1.1 mmol) in Et2O (3 mL) was added at -80C methyllithium (1.5 M in Et2O with lithium bromide; 0.73 mL, 1.1 mmol) and stirring was continued for 30 min at the same temperature where diethyl-aluminium chloride (1 M in n-hexane; 1.1 mL, 1.1 mmol) was gradually added and further stirring for 15 min at -80 C. In a separate flask, lithium bromide (0.12 g, 1.4 mmol), triethyl phosphonoacetate (0.26 mL, 1.3 mmol), and THF (1 mL) was mixed at 0 C where triethylamine (0.19 mL, 1.4 mmol) was added and the solution was stirred for 10 min at room temperature. This mixture was slowly introduced to an aluminium acetal solution prepared above with the aid of cannula and the whole mixture was further stirred for 1 h at room temperature. To this solution were successively added Et2O (3 mL), NaF (0.185 g, 4.4 mmol) and H2O (59 mg, 3.3 mmol), which was stirred for 0.5 h at room temperature. Filtration with a pad of silica gel and concentration furnished a crude mixture which was purified by silica gel column chromatography (n-hexane:CH2Cl2=6:1) to afford 0.484 g (0.979 mmol, 98% yield, E_Z=>99:1) of the title compound 5ca as a colourless oil.

The synthetic route of 583-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yamazaki, Takashi; Mano, Noriko; Hikage, Reo; Kaneko, Tsutomu; Kawasaki-Takasuka, Tomoko; Yamada, Shigeyuki; Tetrahedron; vol. 71; 42; (2015); p. 8059 – 8066;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics