Category: 58101-60-3

Related Products of 58101-60-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58101-60-3 name is Methyl 3-cyclopentenecarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of N-methylmorpholine-N-oxide (2786 mg) in H20 (7 mL) and THF (19 mL) were added potassium osmate (VI) dihydrate (43.8 mg) in tBuOH (8 mL) and methyl 3- cyclopentenecarboxylate (1500 mg) under N2. The resulting mixture was stirred at rt overnight. The reaction mixture was treated with sodium bisulphite and extracted with DCM. The org. layer was washed with brine, dried over MgS04, filtered and concentrated under reduced pressure, affording a crude orange oil (1.39 g; 73% yield) which was used directly in the next step. 1H MR (CDC13) delta: 4.15-4.27 (m, 1H); 3.95-4.11 (m, 1H); 3.67 (s, 3H); 3.07-3.25 (m, 1H); 1.87-2.32 (m, 4H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-cyclopentenecarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; CREN, Sylvaine; FRIEDLI, Astrid; HUBSCHWERLEN, Christian; RUEEDI, Georg; ZUMBRUNN, Cornelia; WO2014/170821; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

58101-60-3, The chemical industry reduces the impact on the environment during synthesis 58101-60-3, name is Methyl 3-cyclopentenecarboxylate, I believe this compound will play a more active role in future production and life.

EXAMPLE 39 (+-) Methyl 3-Butyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-5-carboxylate (45, Scheme 9, Ester Group and Isooxazoline Ring are cis to Each Other), and (+-) Methyl 3-Butyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-5-carboxylate. (46, Scheme 9, Ester Group and Isooxazoline Ring are trans to Each Other) To a refluxing solution of methyl 3-cyclopenten-1-carboxylate 43 (10.21 g, 80.9 mmol) and phenyl isocyanate (17.5 mL, 161 mmol) in dry benzene (50 mL) was added dropwise, a mixture of 1-nitropentane (10.8 mL, 87.8 mmol) and Et3N (20 drops) in dry benzene (30 mL) over a period of 1 h. The mixture was heated at reflux for an additional hour. The solids were removed by filtration, and washed with Et2O. The combined filtrate was concentrated to yield orange oil, which was purified by flash chromatography (silica gel, 0 to 50% ethyl acetate in hexanes).

The chemical industry reduces the impact on the environment during synthesis Methyl 3-cyclopentenecarboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BioCryst Pharmaceuticals, Inc.; US6562861; (2003); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics