5788-17-0, A common heterocyclic compound, 5788-17-0, name is Methyl trans-3-methoxyacrylate, molecular formula is C5H8O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Amino-5-[1-methoxy-2-(methoxycarbonyl)ethenyl]-7-(2-C- methyl-ss-D-ribofurnaosyl)-7H-pyrrolo [2,3-d]pyrimidine (13.1) [0191] To a solution of compound 11.2 (200 mg, 0.492 mmol) in 5 mL of anhydrous DMF were added Cul (19 mg, 0.2 eq. ), E-3-methoxymethacrylate (1. 06 mL, 20 eq.), triethylamine (137 7 LL, 2 eq. ) and Pd (PPh3) 4 (57 mg, 0.1 eq. ) at room temperature under an argon atmosphere. The reaction mixture was heated at 70C for 24 hr. then cooled to room temperature and 100 mL of 1/1 MeOH/CH2Cl2 was added. 400 mg Dowex 1×2-100 Bicarb form was then added and the suspension stirred at room temperature for 45 min. , then filtered. The resin was washed with 3X10 ML MEOH/CH2CL2 : 111. DMF was finally evaporated by azeotropic co-evaporation with toluene (2×5 mL). Chromatographic purification of the residue on silica gel (eluent: CH2CL2/MEOH : 95/5) gave 87 mg of product 13.1 (yield: 45%).
The synthetic route of 5788-17-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOTA, INC.; WO2005/21568; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics