Category: 57625-74-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57625-74-8, name is Methyl 2-methyl-2-phenylpropanoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C11H14O2

Example-l: Preparation of 2-methyl-2-phenylpropanoic acid (FormuIa-3) Methyl 2-methyl-2-phenylpropanoate compound of formula-2 (100 gm) and methanol (500 ml) were added to a pre-cooled mixture of sodium hydroxide (45 gm) and water (500 ml) at 10-15C. Heated the reaction mixture to reflux temperature and stirred for 3 hrs at the same temperature. Distilled off the solvent completely from the reaction mixture under reduced pressure and cooled the reaction mixture to 25-30C. Water was added to the reaction mixture and cooled to 5-10C. Acidified the reaction mixture using dil.HCl solution at 5-10C. Raised the temperature of the reaction mixture to 25-30C and stirred for 30 rhin at the same temperature. Filtered the solid, washed with water and dried the material to get the title compound. Yield: 89.0 gm.

According to the analysis of related databases, 57625-74-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MSN LABORATORIES PRIVATE LIMITED; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; WO2014/188453; (2014); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57625-74-8, name is Methyl 2-methyl-2-phenylpropanoate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Methyl 2-methyl-2-phenylpropanoate

General procedure: The ester II was added to a mixture of NaOH (2.0 M, 8 mL) and methanol (10 mL)and stirred overnight at 65 C. After removal of methanol in vacuo, the residue wasdiluted with water and extracted with EtOAc (10 mL × 3). Then the pH value of thewater layer was adjusted to 2.0 with HCl (2.0 M) and extracted with EtOAc (30 mL ×3). The combined organic phases were evaporated in vacuo to give the crudecarboxylic acid III, which was used directly for the next step without furtherpurification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57625-74-8.

Reference:
Article; Zhou, Danni; Wang, Chunxia; Li, Mingliang; Long, Zheng; Lan, Jingbo; Chinese Chemical Letters; vol. 29; 1; (2018); p. 191 – 193;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 57625-74-8,Some common heterocyclic compound, 57625-74-8, name is Methyl 2-methyl-2-phenylpropanoate, molecular formula is C11H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step C. To a suspension ofAlCl3 (500.0 mg, 3.75 mmol) inCH2Cl2 at-10 C was added dropwise oxalyl chloride (476.0 mg, 3.75 mmol) inCH2C12. The mixture was stirred at this temperature for 30 min. Then a solution of 2-methyl-2- phenyl-propionic acid methyl ester (178.0 mg, 1.0 mmol) inCH2C12 was added. The resulted mixture was stirred at-10 C for 1 hr and rt overnight. The mixture was filtered through a pad of celite, the solvent and excess oxalyl chloride was removed under reduced pressure. The residue was dissolved in chlorobenzene and refluxed for 4 hr. Solvent was removed and the residue was dried to give2- (4- chlorocarbonyl-phenyl) -2-methyl-propionic acid methyl ester.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-methyl-2-phenylpropanoate, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99276; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 57625-74-8, name is Methyl 2-methyl-2-phenylpropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 2-methyl-2-phenylpropanoate

(b) Reaction of Methyl-alpha,alpha-dimethylphenyl acetic acid with 4-Chlorobutyryl chlorideMethyl-alpha,alpha-dimethylphenylacetic acid on Fridel-Craft’s acylation with 4-chlorobutyryl chloride in presence of anhydrous aluminum chloride in ethylene dichloride produced acylated Methyl-alpha,alpha-dimethylphenyl acetic acid, i.e., ketone intermediate as meta and para- isomers.More particularly, aluminum chloride was taken in dichloroethane and cooled in between about 0 to 2O0C. To the above pre cooled solution, Methyl-alpha,alpha-dimethylphenyl acetic acid was added at low temperature. To the reaction mixture, 4-chlorobutyryl chloride was added between about 0 to 20C. After addition of acid chloride the reaction mixture was stirred for about 8 to 10 hours at the same temperature. After completion of the reaction, mixture was quenched over chilled mixture of potable water and cone, hydrochloric acid followed by stirring the reaction mixture for another 4 hours. The reaction mixture was washed with aqueous solution of sodium bicarbonate and finally with water. Removal of dichloromethane provided Methyl-4-(4-chloro-l-oxobutyryl)-alpha,alpha-dimethylphenyl acetate (Ketone) in about 95 % HPLC purity.EXAMPLE 2Methyl-4-(4-chloro-l-oxobutyryl)- a, a-dimethyl phenyl acetate (Ketone)95 Kg (0.7124 Kmole) of aluminium chloride was taken in 120 Ltr dichloroethane and reaction mixture was cooled to 0 to 2O0C. To it was added ester of example 1, 46 Kg (0.2584 Kmole) through addition flask, maintaining the temperature 0 to 200C. Finally, to the reaction mixture was added 80 Kg (0.5673 Kmoles) of 4-chlorobutyryl chloride through addition flask maintaining the temperature 0 to 200C. After addition of acid chloride stirred the reaction mixture at 0 to 200C for 8 to 10 hours. After completion it was quenched over chilled mixture of potable water and concentrated hydrochloric acid. Then stirred the reaction mixture at 0 to 200C for 4 hours and finally extracted in dichloroethane. It was washed with 10% w/v aqueous solution of sodium bicarbonate and finally with water. Removal of the solvent under vacuum provides thick oily mass of Methyl-4-(4-chloro-l-oxobutyryl)-alpha-alpha-dimethyl phenyl acetate (Ketone). HPLC purity = 95%. Yield = 65 to 70 Kg.

The synthetic route of Methyl 2-methyl-2-phenylpropanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; MERWADE, Aravind, Yekanathsa; KHAN, Anjum, Reyaz; SOLANKI, Pawan, Vrajlal; WO2007/7347; (2007); A1;,
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Ester – an overview | ScienceDirect Topics

Reference of 57625-74-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57625-74-8, name is Methyl 2-methyl-2-phenylpropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Into a 250-ML THREE-NECKED FLASK there were placed 2.5 g of 2-PHENYL-2-METHYL propionic acid methyl ester and 2.4 g of zinc cyanide and 100 ml of tetrachloroethane. A strong flow of hydrogen chloride was introduced into the flask with intense stirring during 4 hours. The flask was cooled down with an ice bath and 4.8 g of finely divided aluminium chloride were added in one dose with continued intense stirring. The stirring continued for another thirty minutes and the flask was placed onto an oil bath where it was gradually heated up to the temperature of 70 C. Further on, the mixture was kept at the given temperature for three hours. After cooling with running water, the contents of the flask were poured onto crushed ICE/15M1 conc. HCI. The reaction mixture was left to stand overnight. Then it was transferred to the flask where it was REFLUXED for three hours and after cooling, it was divided in a separatory funnel. The organic layer was separated; the aqueous layer was extracted with 15 mi of TETRACHLOROETHANE. The combined organic extracts were washed with water, with 10% sodium carbonate and dried over sodium sulphate. The solvent was distilled off until 1/3 of the volume and the product was filtered through a short column of silica gel. 2. 1 G of the product were obtained having 92.6% GC purity.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-methyl-2-phenylpropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ZENTIVA, A.S.; WO2004/43922; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics