57486-68-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57486-68-7, name is Methyl 2-chlorophenylacetate, A new synthetic method of this compound is introduced below.
General procedure: To a solution of dry diisopropylamine (0.3 mL, 2.17 mmol) in dry THF (3 mL) in two-necked flask was added n-butyllithium (2.5M solution in hexane, 0.87 mL, 2.17 mmol) at -78 to 0 for 1 h, and recooled to -78 , the acetic ester (6a-f, 200 mg, 1.083 mmol) dissolved in dry THF (6.4 mL) was added by a syringe within 30 min. The mixture was stirred at -78 for 30 min, and subsequently the 4a-d (260 mg, 1.192 mmol) dissolved in dry THF (2.6 mL) was added by syringe. The mixture was vigorously stirred for 3 h. The reaction mixture was quenched by ammonium chloride aqueous solution and the mixture was extracted with ethyl acetate, the organic layer was dried over sodium sulfate, filtered and concentrated reduced pressure. The residue was purified by flash column chromatography (SiO2, EA/Hex=1/10) to give 7a-v.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Park, Jung-Eun; Song, Chiman; Choi, Keehyun; Sim, Taebo; Moon, Bongjin; Roh, Eun Joo; Bioorganic and Medicinal Chemistry Letters; vol. 23; 20; (2013); p. 5515 – 5518;,
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