Category: 57267-03-5

These common heterocyclic compound, 57267-03-5, name is Ethyl 2,2,2-triethoxyacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Ethyl 2,2,2-triethoxyacetate

To a solution of 2M LDA in THF/hexane/ethylbenzene (4.3 ml, 8.60 mmol) in dry THF (5 ml) cooled to -78C under inert atmosphere was added methylpyrazine (0.40 g, 4.25 mmol). The RM was stirred for 15 min then ethyl 2,2,2-triethoxyacetate (1.03 ml, 4.68 mmol) was added. The solution was allowed to warm to RT and stirred for 16 h. The RM was poured into 1M HC1 and stirred for 1 h. The mixture was neutralized with NaHC03 solution and extracted three times with DCM. The combined organics were washed with brine, dried over Na2S04, filtered and evaporated. The crude was purified by FCC (0 – 90 % EtOAc in DCM) to give the title compound as an orange solid. Y = 87 %. NMR (300 MHz, chloroform-) delta 13.01 (s, 1H), 8.60 (d, J= 2 Hz, 1H), 8.49 (d, J= 3 Hz, 1H), 8.45 – 8.41 (m, 1H), 6.66 (s, 1H), 4.40 (q, J= 7 Hz, 2H), 1.42 (t, J= 7 Hz, 3H)

The synthetic route of Ethyl 2,2,2-triethoxyacetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019/25467; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 57267-03-5, A common heterocyclic compound, 57267-03-5, name is Ethyl 2,2,2-triethoxyacetate, molecular formula is C10H20O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,5-Diamino-benzene-1 ,4-dithiol hydrochloride (5.00 g; 20.39 mmol; 1.00 eq.) is suspended in anhydrous N,N-dimethylformamide (37 cm3) at 50 C. Anhydrous pyridine (3.39 g; 3.49 cm3 42.82 mmol; 2.10 eq.) is slowly added and the mixture stirred at 50 00 for 1 hour under a flow of nitrogen. The clear yellow solution obtained is transferred to a flask containing triethoxy-acetic acid ethyl ester (16.62 g; 75.45 mmol; 3.70 eq.) andyttrium(III) triflate (0.57 g; 1 .02 mmol; 0.05 eq.). Slow precipitation is observed. The mixture is stirred at 60 00 for 72 hours under nitrogen. Subsequently, the mixture is cooled to room temperature. The precipitate is isolated by filtration and washed copiously with methanol, yielding the product as a yellow powder (4.07 g, 59.3%).1H NMR (300 MHz, Chloroform-d) 6: 8.84 (5, 2H), 4.60 (q, 4h), 1.52 (t,6H).

The synthetic route of 57267-03-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; NANSON, Lana; PRON, Agnieszka; KROMPIEC, Michal; (147 pag.)WO2017/157782; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 57267-03-5,Some common heterocyclic compound, 57267-03-5, name is Ethyl 2,2,2-triethoxyacetate, molecular formula is C10H20O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 2,2,2-triethoxyacetate (221.9 mg, 1.02 mmol) was added dropwise to a solution of (s)-tert-butyl (1 -((2?,3 ?-diamino-3 -(N,N-bis(4-methoxybenzyl)sulfamoyl)-2-(2-(4- methoxybenzyl)-2H-tetrazol-5 -yl)-[ 1,1 ?-biphenyl] -4-yl)sulfonyl)propan-2-yl)carbamate (300 mg, 0.328 mmol) in EtOH (5 ml) at 0C. The mixture was evacuated and backfilled with nitrogen 3 timesand stirred at 80C for l6hr. The reaction progress was monitored by LCMS. When the reaction was completed, it was concentrated under vacuum. The residue was applied on a silica gel column with EA/PE(1/1) to give the title compound as a solid.: LCMS (ESI) calc?d for C49H54N801152 [M + H]: 995, found 995.

The synthetic route of 57267-03-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BENNETT, Frank; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; SCOTT, Jack D.; TANG, Haiqun; ZHAO, Zhiqiang; HUANG, Yuhua; HUNTER, David; YANG, Dexi; ZHANG, Zhibo; FU, Jianmin; BAI, Yunfeng; ZHENG, Zhixiang; ZHANG, Xu; YOUNG, Katherine; XIAO, Li; (580 pag.)WO2016/206101; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 57267-03-5, name is Ethyl 2,2,2-triethoxyacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 57267-03-5

To a solution of 2M LDA in THF/hexane/ethylbenzene (6.4 ml, 12.8 mmol) in dry THF (15 ml) cooled to -78C under inert atmosphere was added 2-methylpyrimidine (0.60 g, 6.4 mmol). The RM was stirred for 1 h then ethyl 2,2,2-triethoxyacetate (1.31 ml, 7.0 mmol) was added. The solution was allowed to warm to RT and stirred for 3 days. The RM was poured into 1M HC1 and stirred for 1 h. The mixture was neutralised with NaHC03 solution and extracted three times with EtOAc. The combined organics were washed with brine, dried over Na2S04, filtered and evaporated. The crude was purified by FCC (0 – 50 % EtOAc in hexane) to give the title compound as a yellow solid. Y = 35 %. NMR (300 MHz, DMSO-) delta 13.63 (s, 1H), 8.89 (d, J= 5 Hz, 2H), 7.43 (t, J= 5 Hz, 1H), 6.52 (s, 1H), 4.29 (q, J= 7 Hz, 2H), 1.30 (t, J= 7 Hz, 3H).

The synthetic route of Ethyl 2,2,2-triethoxyacetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019/25467; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics