Dumond, Clement published the artcileEpidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS-SPORE registry, SDS of cas: 55981-09-4, the main research area is microsporidiosis kidney transplant recipients Enterocytozoon bieneusi fumagillin; fumagillin; immunosuppressive regimen; kidney transplantation; microsporidiosis.
Introduction : Microsporidiosis is an emerging opportunistic infection in renal transplantation (RT) recipients. We aimed to describe its clin. presentation and treatment. Materials and methods : We collected microsporidiosis cases identified in RT recipients between 2005 and 2019 in six French centers from the Crystal, Divat and Astre prospective databases. Results : We report 68 RT recipients with intestinal microsporidiosis; the patients were predominantly male (61.8%), with a median age of 58 (46-69) years. Infection occurred at a median time of 3 (0.8-6.8) years posttransplant. Only Enterocytozoon bieneusi was found. Microsporidiosis manifested as diarrhea (98.5% of patients) with weight loss (72.1%) and acute renal injury (57.4%) without inflammatory biol. parameters. The therapeutic approaches were no treatment (N = 9), reduction of the immunosuppressive regimen (ΔIS) (N = 22), fumagillin alone (N = 9), fumagillin and ΔIS (N = 19), and albendazole or nitazoxanide and ΔIS (N = 9). Overall clin. remission was observed in 60 patients (88.2%). We observed no acute kidney rejection, renal transplant failure, or death within 6 mo after microsporidiosis. Conclusion : E. bieneusi is an underestimated opportunistic pathogen in RT recipients, and infection with E. bieneusi leads to diarrhea with important dehydration and acute renal injury. The treatment is based on the reduction of the immunosuppressive regimen and the administration of fumagillin if available.
Transplant Infectious Disease published new progress about Acute kidney injury. 55981-09-4 belongs to class esters-buliding-blocks, name is 2-((5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate, and the molecular formula is C12H9N3O5S, SDS of cas: 55981-09-4.
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