Category: 55954-23-9

Reference of 55954-23-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55954-23-9, name is Methyl 2,4-dichlorophenylacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[0198] To the mixture of methyl 2-(2,4-dichlorophenyl)acetate (0.5 g, 2.29 mmol) in THF (10 mL) was added NaH(0.12 g, 2.98 mmol) at oo C. portionwise, then the mixturewas stirred at 25 C. for 0.5 hr, then to the mixture was addedMel (0.42 g, 2.98 mmol) dropwise, the mixture was stirred at25 C. for 2 hrs. After the starting material was consumedcompletely detected by TLC, the mixture was quenched byH20 (lOmL), extracted withEtOAc (10mL*3). The organicswere dried over Na2S04 and concentrated in vacuum to getthe title compound (0.3 g, yield: 50.8%) as yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,4-dichlorophenylacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Hodous, Brian L.; (150 pag.)US2016/31892; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55954-23-9, name is Methyl 2,4-dichlorophenylacetate, A new synthetic method of this compound is introduced below., COA of Formula: C9H8Cl2O2

To a suspension of 2,4-dichlorophenylacetic acid methyl ester (1 .38 mmol) and paraformaldehyde (1 .45 mmol) in 2.7 mL DMSO was added NaHC03 (0.07 mmol). The reaction mixture was stirred at RT for 2 h and then quenched with water. The mixture was neutralized with 1 M HCI solution and extracted with EtOAc (2x). The combined organic layers were dried over MgS04 and concentrated in vacuo. Purification by CC (KP-SIL from Biotage) using Hept to Hept/EtOAc (1/1 ) gives the desired compound as colorless oil; LC-MS (B): tR = 0.77 min; 1 H NMR ((CD3)2SO) delta: 7.64 (d, 1 H), 7.46 (m, 2H), 5.14 (t, 1 H), 4.18 (m, 1 H), 3.92 (m, 1 H), 3.72 (m, 1 H), 3.62 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; WO2013/14587; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

55954-23-9, name is Methyl 2,4-dichlorophenylacetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 2,4-dichlorophenylacetate

Methyl 2-(2,4-dichlorophenyl) acetate (10.6 g, 48.4 mmol) was dissolved in THF (100 mL), and sodium hydride (55% w/w, 2.53 g, 58.1 mmol) was added little by little thereto under ice-cooling, followed by stirring for 10 minutes. tert-Butyl dicarbonate (11.1 g, 50.8 mmol) was added to the reaction solution at the same temperature, and the temperature was slowly raised to room temperature, followed by stirring for 23 hours. Thereafter, tetrabutyl ammonium chloride (4.03 g, 14.5 mmol) was added to the reaction solution, followed by stirring for 20 hours. Sodium hydride (55% w/w, 2.53 g, 58.1 mmol) was added little by little to the reaction solution under ice-cooling, followed by refluxing for 23 hours. After the reaction was completed, the reaction solution was added little by little to saturated ammonium chloride aqueous solution (150 mL) under ice-cooling, and the resultant product was extracted with ethyl acetate (100 mL*2, 50 mL*1). The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure, whereby a brown oily crude product (13.4 g) was obtained. This was purified by silica gel column chromatography (hexane:ethyl acetate=10:1), whereby tert-butyl 2-(2,4-dichlorophenyl) malonate (5.41 g, yield: 35%) was obtained as a yellow oily material. 1H-NMR (400 MHz, CDCl3): delta1.46 (s, 9H), 3.67 (s, 3H), 5.09 (s, 1H), 7.27-7.44 (m, 3H).

The synthetic route of 55954-23-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KAKEN PHARMACEUTICAL CO., LTD.; SAGAMI CHEMICAL RESEARCH INSTITUTE; KOBAYASHI, Osamu; NIIKURA, Naoko; INOUE, Tomoko; MIZUTA, Satoshi; TAKATSUNA, Reiko; HIRAI, Kenji; SHIROUZU, Kentaro; OBATA, Miyoo; (183 pag.)US2016/24110; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics