Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55150-07-7, name is Methyl 5-chloro-2-(methylamino)benzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 55150-07-7
EXAMPLE 3 Under nitrogen, 3 g of a 55% strength dispersion of sodium hydride, which has been washed with pentane, are suspended in 30 ml of dimethylsulphoxide. After adding 9.3 g of methylphenylsulphone, the mixture is warmed to 60. After the evolution of hydrogen has ceased, the mixture is cooled to 0, diluted with 50 ml of tetrahydrofurane and, at this temperature, a solution of 4 g of methyl N-methyl-5-chloro-anthranilate in 20 ml of tetrahydrofurane is added dropwise in the course of about 20 minutes. The mixture is stirred overnight at room temperature and then poured into about 200 ml of ice-water. The resulting mixture is acidified with 2 N hydrochloric acid and stirred for a further 1 hour. The oily precipitate crystallises slowly. It is filtered off with suction and recrystallized from chloroform/ethanol. 2′-N-Methylamino-5′-chloro-2-(phenylsulphonyl)-acetophenone with a melting point of 160-162 is obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Ciba-Geigy Corporation; US4192873; (1980); A;,
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