Category: 54810-63-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54810-63-8, name is Methyl 2-chloro-5-methoxybenzoate, A new synthetic method of this compound is introduced below., Computed Properties of C9H9ClO3

At -10C to -5C in anhydrous THF (200 mL)Methyl 2-chloro-5-methoxybenzoate EEE-1 (4.55 g, 22.7 mmol)LiAlH4 (1.72 g, 45.4 mmol) was added portionwise to the solution.Increase the temperature to 0 C. After addition, the reaction was stirred at 0 C for 2 hours.The reaction mixture was quenched with 5% NaOH.The reaction mixture was filtered through a pad of Celite. Add THF to the diatomaceous earth block(100 mL) and EtOAc (100 mL) and stir at 25 C for 0.5 h.The mixture was filtered and the combined organic layers were dried over Na2SO4 and concentrated to provide crude EEE-2 (4.5 g) as a colorless oil and used directly in the next step.

The synthetic route of 54810-63-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; KUMPF, ROBERT ARNOLD; MCALPINE, INDRAWAN JAMES; MCTIGUE, MICHELE ANN; PATMAN, RYAN; RUI, EUGENE YUANJIN; TATLOCK, JOHN HOWARD; TRAN-DUBE, MICHELLE BICH; WYTHES, MARTIN JAMES; (445 pag.)TW2018/2074; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 54810-63-8, name is Methyl 2-chloro-5-methoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54810-63-8, Recommanded Product: Methyl 2-chloro-5-methoxybenzoate

Methyl (2-chloro-5-methoxy)benzoate (18) (1.19 g, 6.47 mmol) was stirred vigorously in neat aqueous ammonia (28%, 7.8 mL) at room temperature. After 24 h, the resulting mixture was treated with chloroform and the separated organic phase washed with aqueous hydrochloric acid (5 M, 55 mL), water (40 mL), brine (40 mL) then dried (MgSO4), filtered and concentrated under reduced pressure to give 19 as a white powder (0.93 g, 78% yield). m.p. 125.3-126.9 C; IR (ZnSe): 3372, 3178, 1650, 1480, 1461, 1446, 1239, 1028, 821 cm-1; 1H NMR (300 MHz, MeOD): delta 7.34 (1H, d, J = 8.8 Hz), 7.05 (1H, d, J = 2.9 Hz), 7.00 (1H, dd, J = 2.9 and 8.8 Hz), 3.81 (3H, s) ppm; 13C NMR (75 MHz, MeOD): delta 172.1, 159.8, 137.9, 132.0, 122.8, 117.9, 115.2, 56.2 ppm; LRMS (GC-MS): 185 ([M], 60%), 169 ([M-NH2], 100%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-chloro-5-methoxybenzoate, and friends who are interested can also refer to it.

Reference:
Article; Callis, Timothy B.; Reekie, Tristan A.; O’Brien-Brown, James; Wong, Erick C.N.; Werry, Eryn L.; Elias, Nabiha; Jorgensen, William T.; Tsanaktsidis, John; Rendina, Louis M.; Kassiou, Michael; Tetrahedron; vol. 74; 12; (2018); p. 1207 – 1219;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics