Category: 5445-17-0

Adding a certain compound to certain chemical reactions, such as: 5445-17-0, name is Methyl 2-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5445-17-0, Recommanded Product: Methyl 2-bromopropanoate

A solution of 1-(5-trifluoromethyl-pyridin-2-yl)-piperazine (0.9 g, 3.9 mmoles) in MeOH (13 mL) and DIPEA (1.5 mL) was treated with 2-bromo-propionic acid methyl ester (0.48 mL, 4.3 mmoles) and stirred overnight at 70 C. MeOH was removed under reduced pressure and the residue was purified (silica gel, 10-40% acetone in hexane) to provide the title compound as a yellowish solid (1.23 g, 99%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-bromopropanoate, and friends who are interested can also refer to it.

Reference:
Patent; Hoff, Ethan D.; Link, James T.; Pliushchev, Marina A.; Rohde, Jeffrey J.; Winn, Martin; US2005/245532; (2005); A1;,
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Adding a certain compound to certain chemical reactions, such as: 5445-17-0, name is Methyl 2-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5445-17-0, Safety of Methyl 2-bromopropanoate

tert-Butyl 5<;hloro-3-(1 -methoxycarbonylethyl)-2<>xo-2,3Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
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Reference of 5445-17-0, These common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a dry 10 mL schlenk flask was added 72.0 mg (0.4 mmol) of 1,1-diphenylethylene,Methyl-2-bromopropionate (99.6 mg, 0.6 mmol)Silver oxide (9.3 mg, 0.04 mmol)Tert-butyl peroxide 72.0 mg (0.8 mmol)Triethylamine 80.8 mg (0.8 mmol)N, N-dimethylacetamide (2 mL),The reaction flask was stirred at 80 C for 24 h under argon atmosphere.After the reaction is complete,The reaction solution was washed with saturated brine,Ethyl acetate extraction (3 x 10 mL),Collecting organic phase,And dried over anhydrous magnesium sulfate.The organic solvent was removed by rotary evaporation,The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate)To give the title product (2-methyl-4,4-diphenylbut-3-enoic acid methyl ester)Yellow oily liquid,Yield 92%.

Statistics shows that Methyl 2-bromopropanoate is playing an increasingly important role. we look forward to future research findings about 5445-17-0.

Reference:
Patent; Ningbo University; Huang Huiyan; Wei Wenting; Zhu Wenming; Ying Weiwei; Zhao Chuanli; Yang Chenguang; Chen Weidong; (6 pag.)CN106892818; (2017); A;,
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Synthetic Route of 5445-17-0, The chemical industry reduces the impact on the environment during synthesis 5445-17-0, name is Methyl 2-bromopropanoate, I believe this compound will play a more active role in future production and life.

General procedure: In a round-bottomed flask, activated iron dust (168 mg,3 mmol) was added to a solution of alpha-bromo carbonyl compounds (1.0 mmol) and diaryl disulfides (0.5 mmol) in DMF (3.0mL). The reaction mixture was stirred at 90C under N2 atmosphere for 15 h. Then ethyl acetate (20 mL) was added, stirred, and filtered. To filter liquor, the water (15 mL) was added and the mixture was extracted with ethyl acetate (15 mL × 3). The combined organic phase was washed with water (20 mL × 2), dried over anhydrous Na2SO4 , and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (petroleum ether /ethyl acetate = 30:1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; He, Yun-Hua; Li, Ning-Bo; Chen, Jin-Yang; Qiu, Ren-Hua; Wang, Xie; Xu, Xin-Hua; Synthetic Communications; vol. 45; 15; (2015); p. 1817 – 1822;,
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Related Products of 5445-17-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5445-17-0, name is Methyl 2-bromopropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Under N2 atmosphere, a solution of complex 1 (68.7 mg, 5 mol%) in THF (3.0 mL), zinc dust (80 mg, 1.2 mmol), diphenyl disulfide (109 mg, 0.5 mmol), and ethyl 2-bromoacetate (184 mg, 1.1 mmol) were added. Then the mixture was stirred for 2 h at room temperature, monitored by thin-layer chromatography (TLC). The resulting reaction mixture was diluted with diethyl ether (10 mL x 3), filtered, and evaporated, and then the residue was subjected to column chromatography using petroleum ether:ethyl acetate as eluent (30:1) to afford the pure product 6a.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Lingxiao; Qiao, Jie; Wei, Jiancong; Liang, Zhiwu; Xu, Xinhua; Li, Ningbo; Tetrahedron; vol. 76; 4; (2020);,
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Application of 5445-17-0,Some common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, molecular formula is C4H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-bromo-propanoic acid, methyl ester (0.03 mol) was added to a solution of potassium fluoride (0.075 mol) in DMF (25ml). The mixture was stirred at room temperature for 15 minutes. 2-amino-5-nitro- phenol (0.03 mol) was added. The mixture was stirred at 600C for 6 hours, poured out into ice water (150ml), filtered, washed with water and dried, yielding 7g of intermediate 16.

The synthetic route of 5445-17-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/37343; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, molecular formula is C4H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 2-bromopropanoate

General procedure: To a solution of appropriate amount of 3-(arylimino)-2,3-dihydro-1H-isoindol-1-one 15 (0.75 mmol) in 10 cm3 dryacetone methyl 2-bromoalkanoate (1.12 mmol), 0.186 gpotassium iodide (1.12 mmol), and 0.207 g anhydrouspotassium carbonate (1.5 mmol) were added. The obtainedmixture was stirred at room temperature until the TLCshowed the absence of starting isoindolone 15(* 2-3 days). After that inorganic salts were filtered offand washed with 5 cm3 acetone. The filtrate was concentratedunder reduced pressure and the crude product waspurified by column chromatography (EtOAc/petroleumether 1:1) to afford the desired compound 16.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5445-17-0, its application will become more common.

Reference:
Article; Tkachuk, Volodymyr A.; Hordiyenko, Olga V.; Omelchenko, Irina V.; Medviediev, Volodomir V.; Arrault, Axelle; Monatshefte fur Chemie; vol. 149; 12; (2018); p. 2293 – 2309;,
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Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5445-17-0, name is Methyl 2-bromopropanoate, A new synthetic method of this compound is introduced below., Computed Properties of C4H7BrO2

To a suspension of K2CO3 (3.6 g, 26.5 mmol) and tert- butyl piperazine-1-carboxylate (1.0 g, 5.3 mmol) in CH3CN (15 mL) was added methyl 2- bromopropanoate (2.2 g, 13.4 mmol). The reaction was stirred at 80 C for 10 hours. TLC showed that the reaction was complete. The reaction mixture was allowed to cool to room temperature, then the solid filtered off and solvent removed under vacuum. The residue was purified by silica gel column chromatography (CH2Cl2/MeOH = 50:1) to give tert-butyl 4-(1-methoxy-1-oxopropan-2-yl)piperazine-1- carboxylate (2-2) as a brown oil (1.4 g, yield: 99%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KURA ONCOLOGY, INC.; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WU, Tao; LI, Liansheng; WANG, Yi; REN, Pingda; GREMBECKA, Jolanta; CIERPICKI, Tomasz; KLOSSOWSKI, Szymon; POLLOCK, Jonathan; BORKIN, Dmitry; (198 pag.)WO2017/161028; (2017); A1;,
Ester – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5445-17-0 as follows. Computed Properties of C4H7BrO2

Example 13 Preparation of (Z)-3-(2-cyclopropylphenyl)-5-methyl-2-((E)-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzylidene)hydrazono)thiazolidin-4-one (Compound 127C) (Synthesis Method F) To (E)-N-(2-cyclopropylphenyl)-2-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzylidene)hydrazinecarbothioamide (100 mg, 0.191 mmol) and sodium acetate (63.0 mg, 0.765 mmol) in EtOH (4 mL) was added methyl 2-bromopropanoate (0.026 mL, 0.230 mmol). The reaction was heated to 60 C. overnight. The reaction was then heated to 85 C. for 72 hours. The reaction mixture was diluted with DCM and washed with water. The aqueous layer was extracted with DCM. The organic layers were poured through a phase separator and concentrated. Purification by flash column chromatography provided the title compound as a white solid (32.5 mg, 0.056 mmol, 30%): mp 112-115 C.; 1H NMR (400 MHz, CDCl3) delta 8.58 (s, 1H), 8.32 (s, 1H), 8.22 (d, J=8.3 Hz, 2H), 7.87-7.75 (m, 4H), 7.43-7.32 (m, 4H), 7.26-7.24 (m, 2H), 4.23 (q, J=7.3 Hz, 1H), 1.85-1.78 (m, 4H), 0.90-0.78 (m, 2H), 0.78-0.69 (m, 1H), 0.65-0.55 (m, 1H); ESIMS m/z 578 (M+H).

According to the analysis of related databases, 5445-17-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Crouse, Gary D.; Sparks, Thomas C.; Dent, III, William H.; McLeod, CaSandra L.; Creemer, Lawrence C.; Demeter, David A.; Fritz, Amanda E.; Fischer, Lindsey G.; Baum, Erich W.; US2012/202687; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5445-17-0, name is Methyl 2-bromopropanoate, A new synthetic method of this compound is introduced below., Recommanded Product: 5445-17-0

To a solution of E/Z mixture (5:1) of 2-propenylphenol (2.0 g, 14.9 mmol) in anhydrous DMF (30 mL) was added K2CO3 (2.68 g, 19.37 mmol) at 0 C. After stirring for 30 min at room temperature, methyl 2-bromopropionate (2.5 mL, 22.36 mmol) was added drop-wisely to the reaction mixture with a syringe. The reaction mixture was stirred for 10 h at room temperature, and poured into water (100 mL). The organic compounds were extracted with EtOAc (3 x 50 mL). The combined organic layer was washed with brine, dried (MgSO4), and concentrated under vacuum. Purification by silica gel chromatography (EtOAc/hexane=1/9, v/v) afforded the desired product as a colorless oil (3.34 g, 96%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Lee, Sujin; Shin, Ju Yeon; Lee, Sang-Gi; Tetrahedron Letters; vol. 54; 7; (2013); p. 684 – 687;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics