Related Products of 54335-33-0, These common heterocyclic compound, 54335-33-0, name is Methyl 2,4-dibromobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of benzoic acid methyl ester (3, 4a,b) (500 mg), the respective arylamine compounds (2.4 equiv for 3, 1.2 equiv for 4a,b), Cs2CO3 (2.8 equiv for 3, 1.4 equiv for 4a,b), BINAP (0.08 equiv) in 1,4-dioxane (5 mL) was added Pd(OAc)2 (5 mol percent) under nitrogen. And the reaction mixture was stirred at 100 °C for 10?24 h. The reaction mixture was cooled to room temperature, and then H2O was added. The mixture was extracted with ethyl acetate, and then the organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatography.
The synthetic route of 54335-33-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yang, Chao; Lin, Kai; Huang, Lan; Pan, Wei-Dong; Liu, Sheng; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2490 – 2494;,
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