Category: 539-88-8

Gundekari, Sreedhar published the artcileSelective preparation of renewable ketals from biomass-based carbonyl compounds with polyols using β-zeolite catalyst, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is zeolite preparation surface area catalyst ketal preparation; levulinic acid ester polyol zeolite catalyst ketalization; ketal selective preparation zeolite catalyst.

The preparation of ketals from biomass-based carbonyl compounds and polyols was demonstrated. The emphasis is on levulinate-based ketals using Et levulinate (EL) with ethylene glycol (EG) or glycerol (Gly) as polyols. Among the catalysts screened, Na-β zeolite resulted in 99% conversion of EL with 100% selectivity for the corresponding ketal within 1 h, when used in conjunction with azeotropic distillation in cyclohexane medium. Using Gly as the polyol, a similar yield and selectivity was obtained, albeit after a longer reaction time (4 h). The authors explored the reaction scope by using a multitude of biomass-based ketones and polyols as reactants, which showed excellent selectivity for the ketals. Slight deactivation of the catalyst was observed after reaction, owing to the deposition of organic carbon on the catalyst, which was identified using anal. tools. The deactivated catalyst was regenerated on calcination. This strategy was successfully demonstrated for ketal preparation using crude glycerol with EL.

Molecular Catalysis published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xin published the artcileCopper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications, COA of Formula: C7H12O3, the main research area is copper bioorthogonal cleavage reaction protein cell surface.

Temporal and reversible control over protein and cell conjugations holds great potential for traceless release of antibody-drug conjugates (ADCs) on tumor sites as well as on-demand altering or removal of targeting elements on cell surface. We herein developed a bioorthogonal and traceless releasable reaction on proteins and intact cells to fulfill such purposes. A systematic survey of transition metals in catalyzing the bioorthogonal cleavage reactions revealed that copper complexes such as Cu(I)-BTTAA and dual-substituted propargyl (dsPra) or propargyloxycarbonyl (dsProc) moieties offered a bioorthogonal releasable pair for reversible blockage and rescue of primary amines and phenol alcs. on small mol. drugs, protein side chains, as well as intact cell surface. For proof-of-concept, we employed such Cu(I)-BTTAA/dsProc and Cu(I)-BTTAA/dsPra pairs as a “”traceless linker”” strategy to construct cleavable ADCs to unleash cytotoxic compounds on cancer cells in situ and as a “”reversible modification”” strategy for cell surface engineering. Furthermore, by coupling with the genetic code expansion strategy, we site-specifically modulated ligand-receptor interactions on live cell membranes. Together, our work expanded the transition-metal-mediated bioorthogonal cleavage tool kit from terminal decaging to internal-linker breakage, which offered a temporal and reversible conjugation strategy on therapeutic proteins and cells.

Journal of the American Chemical Society published new progress about Bioorthogonal reaction. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, COA of Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia, Ainhoa published the artcileSynthesis of 2-Prenylated Alkoxylated Benzopyrans by Horner-Wadsworth-Emmons Olefination with PPARα/γ Agonist Activity, Synthetic Route of 539-88-8, the main research area is prenyl alkoxy benzopyran preparation PPAR agonist activity; alkylphosphonate aldehyde Horner Wadsworth Emmons reaction.

2-Prenylated benzopyrans such as I were prepared as analogs of polycerasoidol, a natural product dual PPARα/γ agonist with anti-inflammatory effects. The prenylated side chain consists of five or nine carbons with an α-alkoxy-α,β-unsaturated ester moiety. Prenylation was introduced via the Grignard reaction, followed by Johnson-Claisen rearrangement, and the α-alkoxy-α,β-unsaturated ester moiety was introduced by the Horner-Wadsworth-Emmons reaction. Synthetic derivatives showed high efficacy to activate both hPPARβ and hPPARγ as dual PPARα/γ agonists. These prenylated benzopyrans emerge as lead compounds potentially useful for preventing cardiometabolic diseases.

ACS Medicinal Chemistry Letters published new progress about Grignard reaction. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Synthetic Route of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Imyen, Thidarat published the artcileInvestigation of ZSM-12 nanocrystals evolution derived from aluminosilicate nanobeads for sustainable production of ethyl levulinate from levulinic acid esterification with ethanol, Quality Control of 539-88-8, the main research area is aluminosilicate nanobead zeolite nanocrystal ethanol levulinic acid esterification.

The evolution of hierarchical ZSM-12 nanosized crystals as a function of crystallization time has been demonstrated using amorphous aluminosilicate (AS) nanobeads as simultaneous silica and alumina sources and cyclic diquaternary ammonium as a structure-directing agent (SDA) in a one-pot hydrothermal synthesis. The physicochem. properties of the derived ZSM-12 products were characterized by means of x-ray diffraction (x-ray diffraction), x-ray fluorescence spectroscopy (XRF), Fourier transform IR (FTIR) spectroscopy, SEM, TEM, energy dispersive x-ray spectroscopy (EDS) elemental anal., N2 physisorption, temperature-programmed desorption of ammonia (NH3-TPD), and pyridine adsorption. It is clearly demonstrated that crystallinity, textural properties, and acidity of the zeolite products are enhanced as a function of crystallization time. The structure of nanocrystalline ZSM-12 is well-developed after 120 h of crystallization and the corresponding zeolite product exhibits the promising catalytic performance for sustainable production of Et levulinate (EL) from levulinic acid (LA) esterification with ethanol. This contribution illustrates an alternative way to synthesize hierarchical zeolite nanocrystals with MTW framework via the use of homogeneously dispersed aluminosilicate nanobeads as the starting materials and opens up the perspectives for the sustainable application of zeolites nanosized crystals in a bulky-mol. reaction of bio-based chem. synthesis.

Microporous and Mesoporous Materials published new progress about Bronsted acidity. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Quality Control of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics