Category: 539-88-8

Kumaravel, Sakthivel published the artcileRu/TiO2 nanostructured catalysts: synthesis, characterization and catalytic activity towards hydrogenation of ethyl levulinate, Product Details of C7H12O3, the main research area is ruthenium titania ethyl levulinate catalyst hydrogenation nanostructure.

Pristine TiO2 and x% Ru/TiO2 catalysts with different weight% of Ru (x%= 1.5%, 2%, 2.5% and 3%) were synthesized using sol-gel and simple impregnation methods. Different characterization techniques such as X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), SEM (SEM), High-resolution transmission electron microscope (HR-TEM), Inductively coupled plasma-optical emission spectrometry (ICP-OES) and Thermogravimetry/DTA (TG/DTA) were used to study the physicochem. and morphol. properties. The XRD patterns of the as-prepared pristine TiO2 catalyst showed high crystalline nature. The HR-TEM images revealed that the Ru nanoparticles (NPs) were evenly dispersed on the TiO2 surface. The prepared catalysts were evaluated for their catalytic activity towards the liquid phase hydrogenation of Et levulinate under mild reaction conditions (ambient H2 pressure). Among the various catalysts, 2.5% Ru/TiO2 catalyst showed the maximum catalytic activity of 79% Et levulinate (EL) conversion with 82% selectivity of γ-valerolactone (GVL). The recyclability test revealed that the most active 2.5% Ru/TiO2 also showed the highest stability of the catalyst under optimized exptl. conditions.

Journal of Nanoscience and Nanotechnology published new progress about Attenuated-total-reflectance Fourier-transform IR spectroscopy. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yuxin published the artcileA novel and efficient N-doping carbon supported cobalt catalyst derived from the fermentation broth solid waste for the hydrogenation of ketones via Meerwein-Ponndorf-Verley reaction, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is ketone hydrogenation oxytetracycline fermentation residue carbon nitrogen cobalt catalyst.

Most of the non-noble metal catalysts used for the Meerwein-Ponndorf-Verley (MPV) reaction of carbonyl compounds rely on the addnl. alk. additives during preparation to achieve high efficiency. To solve this problem, in this work, we prepared a novel N-doped carbon supported cobalt catalyst (Co@CN), in which the carriers were derived from the nitrogen-rich organic waste, i.e., oxytetracycline fermentation residue (OFR, obtained from oxytetracycline refining workshop). No addnl. nitrogen sources were used during preparation The results showed that inherent nitrogen in OFR could provide N-containing basic sites, and formed Co-N structures via coordinating with cobalt. The Co-N sites together with the coexisting Co(0) cooperated to catalyze the conversion of Et levulinate (EL) to γ-valerolactone (GVL) by MPV reaction. Co(0) dominated the activation of H in isopropanol, while Co-N dominated the formation of the six-membered ring transition state.

Applied Catalysis, A: General published new progress about Alcohols Role: IMF (Industrial Manufacture), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Wenfeng published the artcileAmmonia borane enabled upgrading of biomass derivatives at room temperature, Formula: C7H12O3, the main research area is ammonia borane enabled upgrading biomass derivative room temperature.

Simplifying biomass conversion to valuable products with high efficiency is pivotal for the sustainable development of society. Herein, an efficient catalyst-free system using ammonia borane (AB) as the hydrogen donor is described, which enables controllable reaction selectivity towards four value-added products in excellent yield (82-100%) under very mild conditions. In particular, the system is uniquely efficient to produce γ-valerolactone (GVL) at room temperature Combined in situ NMR and computational studies elucidate the hydrogen transfer mechanism of AB in methanol, the novel pathway of GVL formation from levulinate in water, and a competitive mechanism between reduction and reductive amination in the same system. Moreover, carbohydrates are converted directly into GVL in good yield, using a one-pot, two-step strategy. Products of a rather broad scope are prepared within a short reaction time of 30 min by using this catalyst-free strategy in methanol at room temperature

Green Chemistry published new progress about Beta zeolites Role: CAT (Catalyst Use), USES (Uses) (Sn-containing). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Wen-Yan published the artcileTransition-Metal-Free Valorization of Biomass-derived Levulinic Acid Derivatives: Synthesis of Curcumene and Xanthorrhizol, Computed Properties of 539-88-8, the main research area is valorization biomass levulinic acid curcumene xanthorrhizol methyltetralone synthesis; biomass conversion; levulinic acid derivatives; rac-curcumene; rac-xanthorrhizol; tosylhydrazone.

Levulinic acid (LA) is acknowledged one of the most promising biomass-derived platform mols. and can be transformed into various value-added chems. Here, we report a new reaction process for the valorization of LA derivatives under transition-metal-free condition. The protocol combined with the conversion of the levulinate to tosylhydrazone and base promoted arylation, acylation, and etherification cross-coupling. Moreover, our method was applied to synthesize three biol. active mols., rac-curcumene (I), rac-xanthorrhizol synthetic precursor (II), and rac-4,7-dimethyl-α-tetralone (III). This reaction discloses a new avenue for the high-value utilization of platform mols.

ChemSusChem published new progress about Acylation (acylation of tosylhydrazones with furancarboxaldehydes). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bermejo, Almudena published the artcileSynthesis of benzopyran derivatives as PPARα and/or PPARγ activators, Product Details of C7H12O3, the main research area is peroxisome proliferator receptor alpha gamma structure activity benzopyran; alkyl hydroxy benzopyran preparation PPARalpha PPARgamma activator lipophilicity; Benzopyrans; PPARα agonism; PPARγ agonism; Polycerasoidol.

The authors describe the synthesis of benzopyran derivatives I [R = n-pentyl, 3-hydroxy-1-Bu, 3-ethoxy-3-oxo-Pr, etc.; R1 = hydroxy, acetoxy; R2 = H, chloro] and II [R3 = hydroxy, n-propyloxy; R4 = H, hydroxy; R5 = 2-carboxyethyl, 4-methylpent-3-enyl, 3-methoxy-3-oxo-Pr, etc.], small polycerasoidol analogs, that are Lipinski’s rule-of-five compliant. In order to confirm key structural features to activate PPARα and/or PPARγ, the authors have adopted structural modifications in the following parts: (i) the benzopyran core (hydrophobic nucleus) by benzopyran-4-one, dihydrobenzopyran or benzopyran-4-ol; (ii) the side chain at the 2-position by shortening to C3, C4 and C5-carbons vs. C-9-carbons of polycerasoidol; and (iii) the carboxylic group (polar head) by oxygenated groups (hydroxyl, acetoxy, epoxide, ester, aldehyde) or non-oxygenated motifs (allyl and alkyl). Benzopyran-4-ones I [R = 3-ethoxy-3-oxo-Pr, 3-hydroxybutyl, 3-hydroxy-3-methylbutyl, R1 = hydroxy, R2 = H; R = 3-acetoxybutyl, R1 = acetoxy, R2 = H] as well as dihydrobenzopyrans II [R3 = hydroxy, R4 = H, R5 = 3-methylbut-3-enyl, 2-carboxyethyl, 3-methoxy-3-oxopropyl] were able to activate hPPARα, whereas benzopyran-4-one I [R = n-pentyl, R1 = hydroxy, R2 = chloro] with C5-carbons in the side chain exhibited hPPARγ agonism. According to our previous docking studies, structure-activity studies confirmed that the hydrophobic nucleus (benzopyran-4-one or dihydrobenzopyran) was essential to activated PPARα and/or PPARγ and the flexible linker (side alkyl chain) should contain at least C5-carbon atoms to activate PPARγ. By contrast, the polar head (“”carboxylic group””) tolerated several oxygenated groups but also non-oxygenated motifs. Taking into account these key structural features, small polycerasoidol analogs might provide potential active mols. useful in the treatment of dyslipidemia and/or type 2 diabetes.

Bioorganic & Medicinal Chemistry published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Zhen published the artcileOrganocatalytic, Enantioselective Reductive Bis-functionalization of Secondary Amides: One-Pot Construction of Chiral 2,2-Disubstituted 3-Iminoindoline, Computed Properties of 539-88-8, the main research area is organocatalytic enantioselective reductive functionalization secondary amide; one pot stereoselective preparation chiral iminoindoline mol modeling.

We report the first catalytic, enantioselective reductive bis-functionalization of common amides, which provides a facile access to a variety of 2,2-disubstituted 3-iminoindolines in good yields and with excellent enantioselectivities. The reaction conditions are quite mild and can be run on a gram scale. In this one-pot reaction, three C-C bonds, one ring, and one nitrogen-containing tetrasubstituted carbon stereocenter are created in a catalytic enantioselective manner.

Organic Letters published new progress about Amides, secondary Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Misal Castro, Luis C. published the artcileDirect Synthesis of Indoles from Azoarenes and Ketones with Bis(neopentylglycolato)diboron Using 4,4′-Bipyridyl as an Organocatalyst, SDS of cas: 539-88-8, the main research area is azoarene ketone bipyridyl catalyst Fischer indole cyclization; indole preparation.

Multifunctionalized indole derivatives were prepared by reducing azoarenes in the presence of ketones and bis(neopentylglycolato)diboron (B2nep2) with a catalytic amount of 4,4′-bipyridyl under neutral reaction conditions, where 4,4′-bipyridyl acted as an organocatalyst to activate the B-B bond of B2nep2 and form N,N’-diboryl-1,2-diarylhydrazines as a key intermediate. Further reaction of N,N’-diboryl-1,2-diarylhydrazines with ketones afforded N-vinyl-1,2-diarylhydrazines, which rearranged to the corresponding indoles via the Fischer indole mechanism. This organocatalytic system was applied to diverse alkyl cyclic ketones, dialkyl, and alkyl/aryl ketones, including heteroatoms. Me alkyl ketones gave the corresponding 2-methyl-3-substituted indoles in a regioselective manner. This protocol allowed us to expand the preparation of indoles having high compatibility with not only electron-donating and electron-withdrawing groups but also N- and O-protecting functional groups.

Journal of Organic Chemistry published new progress about Diazo compounds, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, SDS of cas: 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Munoz-Olasagasti, M. published the artcileElucidating the roles of acid site nature and strength in the direct conversion of levulinic acid into ethyl valerate: the case of Zr-modified beta zeolite-supported Pd catalysts, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is zirconium zeolite palladium catalyst levulinic acid one pot conversion; surface acidity.

The effects of the nature and strength of surface acid sites on the properties of the catalyst used for the one-pot conversion of levulinic acid to valeric biofuels have been investigated. The acid supports were prepared from a com. beta zeolite (HBEA) modified by partial substitution of Al by Zr atoms. This procedure enables changes in the nature and strength of the acidic sites of the starting zeolite. A constant amount of Pd (2 wt%) was incorporated on these acid supports by the incipient wetness impregnation method. These catalysts were tested in liquid phase reactions and the Pd/HBEA catalyst showed the best catalytic performance, achieving an 80% yield of valeric biofuel after 2 h of the reaction. The fresh catalysts were characterized by DRIFT spectroscopy using pyridine, CD3CN, and CO as probe mols. and by XRD to explain the differences in catalytic performance. The presence of strong Bronsted acid sites (BAS) was shown to be critical for reaching high Et valerate yields since the differences in catalytic behavior and the concentration of these acid sites parallel each other. Up to three types of Lewis acid sites (LAS) of different strengths were also identified. The spent catalyst underwent a simple calcination treatment at 773 K and this was adequate for the recovery of the surface acidity, but the reducibility of the Pd species was affected. This prevented complete recovery of catalytic activity.

Sustainable Energy & Fuels published new progress about Beta zeolites Role: CAT (Catalyst Use), PRP (Properties), USES (Uses). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lombardi, Lorenzo published the artcileAllylic and Allenylic Dearomatization of Indoles Promoted by Graphene Oxide by Covalent Grafting Activation Mode, Formula: C7H12O3, the main research area is indole arylpropenol graphene oxide regioselective diastereoselective allylation dearomatization; arylpropenyl indole preparation green chem; arylpropynol indole graphene oxide regioselective diastereoselective allenylation dearomatization; arylallenyl indole preparation green chem; alcohols; carbocatalysis; dearomatization; graphene oxide; indole.

The site-selective allylative and allenylative dearomatization of indoles with alcs. was performed under carbocatalytic regime in the presence of graphene oxide (GO, 10 wt % loading) as the promoter. Metal-free conditions, absence of stoichiometric additive, environmentally friendly conditions (H2O/CH3CN, 55 C, 6 h), broad substrate scope (33 examples, yield up to 92%) and excellent site- and stereoselectivity characterize the present methodol. Moreover, a covalent activation model exerted by GO functionalities was corroborated by spectroscopic, exptl. and computational evidences. Recovering and regeneration of the GO catalyst through simple acidic treatment was also documented.

Chemistry – A European Journal published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seo, Hyowon published the artcileCatalytic Generation and Use of Ketyl Radical from Unactivated Aliphatic Carbonyl Compounds, Quality Control of 539-88-8, the main research area is alc preparation continuous flow batch process; aliphatic ketone aldehyde styrene ketyl radical reductive coupling.

Generation of a ketyl radical from unactivated aliphatic carbonyl compounds is an important strategy in organic synthesis. Herein, catalytic generation and use of a ketyl radical for the reductive coupling of aliphatic carbonyl compounds and styrenes by organic photoredox catalysis is described. This method is applicable to both aliphatic ketones and aldehydes to afford the corresponding tertiary and secondary alcs. in continuous flow and batch. A preliminary mechanistic investigation suggests the catalytic formation of a ketyl radical intermediate.

Organic Letters published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Quality Control of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics