Category: 53838-27-0

On March 26, 2019, Wang, Huijia; Li, Mou; Zhang, Zhongqi; Wang, Hui; Zhao, Jinli; Yang, Xiaolin published a patent.Product Details of 53838-27-0 The title of the patent was Method for preparation of glutamic acid 1-methyl 5-tert-butyl ester. And the patent contained the following:

The title method comprises the steps of: performing a reaction on glutamic acid and methanol under the action of thionyl chloride to generate di-Me glutamate, reacting with tri-Ph chloromethane to protect the amino group of di-Me glutamate with triphenylmethyl, treating with NaOH to remove 5-position Me ester and obtain triphenylmethyl-glutamic acid-1-Me ester, reacting with trichloroacetyl imine t-Bu ester to obtain triphenylmethyl-glutamic acid-1-Me ester-5-t-Bu ester, adding in low-concentration trifluoroacetic acid dichloromethane solution, adding a small amount of triisopropyl silane, and reacting to remove triphenylmethyl and obtain glutamic acid-1-Me ester-5-t-Bu ester. The method has the advantages of easy operation, little byproduct, very easy treatment of product, and high yield. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0

The Article related to preparation glutamic acid methyl tertbutyl ester, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 20, 2008, Koppel, Gary A.; Chaney, Michael O. published a patent.Product Details of 53838-27-0 The title of the patent was Preparation of β-lactamylalkanoic acids as cannabinoid receptor modulators. And the patent contained the following:

Substituted 2-(azetidin-2-on-1-yl)alkanoic acids, alkanedioic acids, 2-hydroxyalkyl and 2-acyl alkanoic acids, e.g., I [R4 = substituted phenylethenyl; X = (CH2)n; n = 1-2; A = OH, NH2 and derivatives; or A is taken together with the attached CO group to form an ester; A’ = OH, NH2 and derivatives; or A’ is taken together with the attached CO group to form an ester], were prepared as cannabinoid-1 (CB1) and/or cannabinoid-2 (CB2) receptor modulators for treating disease states associated with and responsive to modulation of the CB1 and/or CB2 receptor activity. modulators. Pharmaceutical compositions containing I are described. Thus, II was prepared, and had IC50 value of < 10 μM and about 1 μM in CB1 and CB2 binding assays on cells. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0

The Article related to lactamylalkanoic acid preparation cannabinoid receptor modulator, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 5, 1995, Oshida, Junichi; Kawabata, Hiroshi; Kato, Yoshinori; Kokubo, Masayuki; Ueshima, Yasuhide; Sato, Osami; Fujii, Katsuhiko published a patent.Product Details of 53838-27-0 The title of the patent was Preparation of amino acid moiety-containing benzoxazines as elastase inhibitors. And the patent contained the following:

The title compounds I [R1 = H, alkyl; X = Y1A1, Y2(A2)mA3; when X is Y1A1 : R2, R3 = H, (carboxy)alkyl, or NR2R3 = ring; when X is Y2(A2)mA3 : R2 = alkyl, R3 = H; Y1 = amino-protecting group; Y2 = H, sulfonyl; A1, A2 = amino acid residue, etc.; A3 = lysine residue, etc.; m = 0 or 1] are prepared 7-(N-benzyloxycarbonyl-L-phenylalanyl)amino-5-methyl-2-(1-carboxyethyl)amino-4H-3,1-benzoxazin-4-one (preparation given) in vitro showed IC50 values of 5.1 x 10-8 M and 1.5 x 10-6 M against elastase and chymotrypsin, resp. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Product Details of 53838-27-0

The Article related to amino acid benzoxazine preparation elastase inhibitor, elastase inhibitor amino acid benzoxazine preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 28, 2006, Xu, Le-Cun; Vlahov, Iontcho Radoslavov; Leamon, Christopher Paul; Santhapuram, Hari Krishna; Li, Chunhong published a patent.SDS of cas: 53838-27-0 The title of the patent was Synthesis and purification of pteroic acid and conjugates thereof. And the patent contained the following:

Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof were also described. Thus, folate-fluorescein conjugate I via a synthetic sequence starting from FITC N10-trifluoroacetyl-protected pteroic acid, glutamate α-tert-butyl-γ-Me diester and ethylene diamine. I was tested for its effect on the growth of solid tumors. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0

The Article related to pteroic acid conjugate preparation immunostimulant, antitumor activity folate fluorescein conjugate preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.SDS of cas: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 25, 2011, Xu, Le-Cun; Vlahov, Iontcho Radoslavov; Leamon, Christopher Paul; Santhapuram, Hari Krishna; Li, Chunhong published a patent.Computed Properties of 53838-27-0 The title of the patent was Synthesis and purification of pteroic acid and conjugates thereof. And the patent contained the following:

Methods for purifying pteroic acid, analogs of pteroic acid, and derivatives of pteroic acid are described. Methods for synthesizing and purifying conjugates of vitamins, including FITC conjugates of folic acid, folic acid analogs, and derivatives of folic acid and folic acid analogs are also described. Purified forms of pteroic acid, derivatives and analogs of pteroic acid, and conjugates thereof are also described. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Computed Properties of 53838-27-0

The Article related to pteroic acid conjugate preparation immunostimulant, antitumor activity folate fluorescein conjugate preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Computed Properties of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rosowsky, Andre; Freisheim, James H.; Bader, Henry; Forsch, Ronald A.; Susten, Sandra A.; Cucchi, Carol A.; Frei, Emil III published an article in 1985, the title of the article was Methotrexate analogs. 25. Chemical and biological studies on the γ-tert-butyl esters of methotrexate and aminopterin.Synthetic Route of 53838-27-0 And the article contains the following content:

γ-tert-Bu aminopterin (I; R = R1 = H, R2 = CMe3) (II) was prepared, and new routes to the known γ-tert-Bu methotrexate (I; R = Me, R1 = H, R2 = CMe3) (III) were developed. Thus, pteridine IV (R3 = OH) was brominated by Br2/PPh3 to give IV (R3 = Br), which was treated in situ with p-H2NC6H4CO2H to give pteroic acid V (R = H), which was formylated to give V (R = CHO). The latter was condensed with H-Glu(OCMe3)-OMe.HCl by ClCO2CH2CHMe2 in DMF containing Et3N to give I (R = CHO, R1 = Me, R2 = CMe3), which was hydrolyzed and then deformylated to give II. II was also prepared by treating IV.HBr (R3 = Br) with p-RNHC6H4CO-Glu(OCMe3)-OR1 (VI, R = R1 = H) in AcNMe2 containing Me2CHNEt2. III was prepared by brominating IV (R3 = OH), treating the resulting IV (R3 = Br) with VI (R = R1 = Me), and hydrolyzing the resulting I (R = R1 Me, R2 = CMe3). The inhibitory effects of II on the activity of dihydrofolate reductase (DHFR) from L1210 murine leukemia cells, the growth of 4210 cells and CEM human leukemic lymphoblasts in suspension culture, and the growth of human squamous cell carcinoma of the head and neck in monolayer culture were compared with the effects of III and the parent acids aminopterin (I, R-R2 = H) and methotrexate (I, R = Me, R1 = R2 = H). The activity of II was close to that of III in the DHFR inhibition assay, but II was more potent than III against cells in culture and against L1210 leukemia in mice. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Synthetic Route of 53838-27-0

The Article related to tertiary butyl ester aminopterin methotrexate, dihydrofolate reductase inhibitor aminopterin ester, leukemia inhibitor aminopterin methotrexate ester, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Synthetic Route of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 1990, Poncet, Joel; Jouin, Patrick; Castro, Bertrand; Nicolas, Louisette; Boutar, Mohamed; Gaudemer, Alain published an article.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the article was Tetramic acid chemistry. Part 1. Reinvestigation of racemization during the synthesis of tetramic acids via Dieckmann cyclization. And the article contained the following:

Epimerization during the synthesis of tetramic acids by Dieckmann cyclization of chiral N-acyl-α-amino esters was investigated. In the case of the isoleucine derivative, the extent of epimerization was directly evaluated by 1H-NMR anal. of the 3-acylated tetramic acids I (R = Me) and its (5R)-isomer and I (R = OMe). A chem. correlation was carried out in the case of the 5-benzyl derivative II. The moderate overall yield and the partial epimerization at position C-5 limit the usefulness of this approach for tetramic acid preparation The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to dieckmann acylamino ester racemization, tetramate racemization, Biomolecules and Their Synthetic Analogs: General and other aspects.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 21, 2015, Vlahov, Iontcho R.; Leamon, Christopher P.; Low, Philip S.; Parham, Garth L.; Chen, Qingshou published a patent.Application of 53838-27-0 The title of the patent was Compounds for positron emission tomography. And the patent contained the following:

Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomog. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors; L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application of 53838-27-0

The Article related to pet contrast agent conjugate, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Application of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weber, Ulrich; Andre, Michael published an article in 1975, the title of the article was Synthesis of a [Glu5,Ala12,Ala18,Ala21] sheep insulin A chain by fragment condensation on a polymer support.Formula: C10H19NO4 And the article contains the following content:

[Glu5,Ala12,Ala18,-Ala21]sheep insulin-A-chain (I) was prepared in 9% yield by condensation of Boc-Glu(OCMe3)-Ala-Tyr(CH2Ph)-Cys(CHMe2)-N2H3, Boc-Cys(CHMe2)-Ala-Leu-Tyr-Gln-Leu, Boc-Cys(CHMe2)-Ala-Gly-Val, Boc-Cys(CHMe2)-OH, and Boc-Gly-Ile-Val-Glu(OCMe3)-Glu(OCMe3)-OH (Boc = Me3CO2C), which were prepared in 60-98% yields on an alanine polymer. The failure sequence peptides were separated by ion exchange chromatog. on DEAD-Sephadex and by chromatog. on Biogel P 4. Combination of I with natural B-chain gave insulin activities comparable to that obtained with natural A-chain. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Formula: C10H19NO4

The Article related to insulin a analog sheep, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.Formula: C10H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 17, 1974, Wuensch, Erich; Wendlberger, Gerhard; Jaeger, Ernst; Scharf, Regine; Deimer, Karl H.; Stocker, Hans published a patent.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Norleucine-13-motiline. And the patent contained the following:

Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Glu-Arg-Nle-Glu-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln (I) was prepared by successive coupling and deblocking of Arg(HBr)-Asn-Lys(CO2CMe3)-Gly-Gln-OCMe3.HBr, PhCH2O2C-Glu(OCMe3)-Glu(OCMe3)-Lys-(CO2CMe3)-Glu(OCMe3)-OH, PhCH2O2C-Arg[δ,ω – (CO2CH2Ph)2]Nle-OH, PhCH2O2C-Glu(OCMe3)-Leu-Gln-OH, Thr(CMe3)-Tyr(CMe3)-Gly-OH, and Me3CO2C-Phe-Val-Pro-Ile-Phe-OH, which were prepared by standard coupling methods. I, after purification on ion exchange resin, had 90% of the activity of naturally occurring motilin. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to motilin norleucine analog, stomach motilin norleucine analog, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics