Category: 53518-15-3

Electric Literature of 53518-15-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53518-15-3, name is 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

7-Amino-4-trifluoromethylcoumarin 3.71 g (16.2 mmol) was dissolved in dichloromethane (20 mL). After slow addition of the distilled pyridine (20 mL) and p-toluenesulfonyl chloride (6.80 g, 35.7 mmol), the mixture was then stirred for 4 h at room temperature. Then ethyl acetate 150 mL was added, followed by wash of citric acid solution for three times and brine once. The resulting solution was dried with sodium sulfate and evaporated, washed with a small portion of cooled dichloromethane and dried in vacuo to give the compound 2 as white solid. Yield: 5.64 g (91%). Mp 193-194 C. 1H NMR (CDCl3, 400 MHz): delta 7.81 (d, J=8.0 Hz, 2H), 7.57 (d, J=8.8 Hz, 1H), 7.30 (d, J=8.0 Hz, 2H), 7.21 (d, J=2.4 Hz, 1H), 7.08 (dd, J1=2.0 Hz, J2=2.0 Hz, 1H), 6.67 (s, 1H), 2.40 (s, 3H). EI-MS: m/z, calcd 383.34, found 383.02.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Jun; Zhang, Chun-Fang; Ming, Ze-Zhong; Hao, Ge-Fei; Yang, Wen-Chao; Yang, Guang-Fu; Tetrahedron; vol. 69; 23; (2013); p. 4743 – 4748;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 53518-15-3, name is 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53518-15-3, SDS of cas: 53518-15-3

A vial was charged with S6 (20 mg, 0.027 mmol), 7-amino-4-(trifluoromethyl)coumarin (19 mg, 0.08 1 mmol, 3 eq.), HATU (31 mg, 0.081 mmol, 3 eq.), Et3N (76 1iL, 0.543 mmol, 20 eq.) and DIvIF (500 jiL). Contents were stirred at room temperature and ambient atmosphere for 24 h, after which the solvent was concentrated to dryness, and the crude product was purified via reverse phase HPLC (10-95% MeCN/H20, linear gradient, with constant 0.1% v/v TFA additive; 23 mm run, 42 mL/min flow, detection at 550 nm) to afford S7 (8 mg, 31%). LRMS (ESI) calcd for C46H40F3N30I2S2 [Mj 948.0, found 948.1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HOWARD HUGHES MEDICAL INSTITUTE; LAVIS, Luke; JRADI, Fadi, M.; (109 pag.)WO2018/182811; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 53518-15-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53518-15-3, name is 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 159 8-Hydroxy-N-[4-(trifluoromethyl)coumarin-7-yl]-7-quinolinecarboxamide monohydrochloride (V-11) (Refer to Chart V): According to GP II, starting from anhydride U-1 (200 mg), pyridinium chloride (42 mg), 7-amino-4-(trifluoromethyl)coumarin (85 mg) and CHCl3 (8 mL), amide V-11 is obtained as a yellow powder (25 mg). Physical characteristics are as follows: 1H-NMR (d6-DMSO, 300 MHz) delta 8.94, 8.65, 8.11, 8.05, 7.83, 7.71, 7.66, 7.38, 6.91. 13C-NMR (d6-DMSO, 75 MHz) delta 166.40, 159.13, 155.28, 146.35, 143.73, 140.72, 131.77, 128.52, 125.91, 124.11, 117.29, 116.40, 114.67, 114.57, 108.91, 107.41. MS (EI) m/z 400 (M+), 172, 116, 89.

The chemical industry reduces the impact on the environment during synthesis 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Pharmacia & Upjohn Company; US6211376; (2001); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 53518-15-3, A common heterocyclic compound, 53518-15-3, name is 7-Amino-4-(trifluoromethyl)-2H-chromen-2-one, molecular formula is C10H6F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 7-aminocoumarin (500 mg, 12-16) and DMAP (10-20 mg) was dissolved in minimum amount of THF. To this acetic anhydride was added and the resultant mixture was stirred at room temperature for 24 h. On completion of the reaction 50 mL ice cold water was added. The crude off-white solid was then filtered, washed with water and dried. The crude solid so obtained was crystallized with ethanol to give 7-N-acetylaminocoumarin derivatives.

The synthetic route of 53518-15-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kathuria, Abha; Priya, Nivedita; Chand, Karam; Singh, Prabhjot; Gupta, Anjali; Jalal, Sarah; Gupta, Shilpi; Raj, Hanumantharao G.; Sharma, Sunil K.; Bioorganic and Medicinal Chemistry; vol. 20; 4; (2012); p. 1624 – 1638;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics