Category: 5340-78-3

Nazir, Nausheen published the artcileChemical composition, in vitro antioxidant, anticholinesterase, and antidiabetic potential of essential oil of Elaeagnus umbellata Thunb, Computed Properties of 5340-78-3, the publication is BMC Complementary Medicine and Therapies (2021), 21(1), 73, database is CAplus and MEDLINE.

Elaeagnus umbellata Thunb. (autumn olive) is a high valued medicinal plant. It belongs to Elaeagnaceae family and is widely distributed in Himalayan regions of Pakistan. In the present study essential oil were extracted from the fruit of this plant and their antioxidant, anticholinesterase and antidiabetic potentials were also evaluated. Essential oils were extracted from the fruit of E. umbellata using hydro-distillation method and were characterized by GC-MS. The extracted oil were tested for its antioxidant, anticholinesterase, and antidiabetic potentials using standard protocols. About 68 compounds were identified by GC-MS. The extracted oil exhibited a fairly high free radical scavenging activities against DPPH and ABTS radicals with IC50 values of 70 and 105 μg/mL resp. (for ascorbic acid, used as standard, the IC50 values were 32 and 29 μg/mL, resp. against the mentioned radicals). The essential oil also exhibited anticholinesterase activities with IC50 values of 48 and 90 μg/mL resp. against AChE and BChE (for galantamine used as standard, the IC50 values were 25 and 30 μg/mL resp.). The essential oil also exhibited antidiabetic potential with IC50 values of 120 and 110 μg/mL resp. against α-glucosidase and α-amylase (IC50 values for standard acarbose = 28 and 30 μg/mL resp.). Conclusion: Essential oil extracted from the fruits of E. umbellata exhibited reasonable antioxidant, anticholinesterase, and antidiabetic potentials that could be used as alternative medicine in treating diabetes and neurodegenerative disorders. However, further studies are needed to isolate responsible compounds and evaluate the observed potential in animal models.

BMC Complementary Medicine and Therapies published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Computed Properties of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Langer, Peter published the artcileNew and efficient synthesis of pyrrolo[3,2-b]pyrrole-2,5-diones by double-anion-capture reactions of ester carbanions with bis(imidoyl)chlorides of oxalic acid, Application of Ethyltert-butylacetate, the publication is Journal of Organic Chemistry (2000), 65(3), 729-734, database is CAplus.

A variety of pyrrolo[3,2-b]pyrrole-2,5-diones were efficiently prepared by a new domino-reaction of ester carbanions with oxalic acid bis(imidoyl)chlorides. This reaction proceeded by condensation of 2 equiv of the ester with the bis(imidoyl)chloride and subsequent intramol. attack of the nitrogen atoms of the bis-enamine intermediate onto the ester groups. The products, which can be regarded as dilactams of pentalene, represent useful synthetic pigments due to their optical features, their stability, and low solubility The UV-visible properties of the pyrrolo[3,2-b]pyrrole-2,5-diones could be efficiently controlled by the substituents attached to the heterocyclic core. The scope and the limitations of the new cyclization reaction were investigated.

Journal of Organic Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Guitang published the artcileVolatile components of white Hypsizygus marmoreus detected by electronic nose and HS-SPME-GC-MS: Influence of four drying methods, Computed Properties of 5340-78-3, the publication is International Journal of Food Properties (2017), 20(12), 2901-2910, database is CAplus.

Four drying methods, viz hot air drying (HD), vacuum drying (VD), microwave-vacuum drying (MVD), and vacuum freeze-drying (FD), were used to dry white Hypsizygus marmoreus (WHM). The volatile and taste components of the dried WHM were comparatively analyzed by electronic nose technol. (E-nose) and head-space solid-phase microextraction combined with gas chromatog.-mass spectrometry (HS-SPME-GS-MS). Principal component anal. (PCA) showed that E-nose could distinguish fresh WHM and four dried products clearly. Dominant volatile components in fresh WHM were found to be 1-octen-3-ol, 3-octanone, and (E)-2-nonenal. However, it was found that the drying methods caused damage to the 8-carbon compounds (C8), especially to 8-carbon alc. greatly. For instance, HD produced more ester materials, MVD yielded more aldehyde compounds, FD brought more hydrocarbon products, and VD produced more ketone substances.

International Journal of Food Properties published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Computed Properties of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lee, Koo published the artcileReaction of diethyl phosphorochloridite with enolates: a general method for synthesis of β-keto phosphonates and α-phosphono esters through carbon-phosphorus bond formation, Application In Synthesis of 5340-78-3, the publication is Journal of Organic Chemistry (1991), 56(19), 5556-60, database is CAplus.

The reaction of ketone enolates, e.g., from cyclopentanone and LDA, with di-Et phosphorochloridite, followed by air oxidation of the immediate reaction products, has proven to be a general and convenient method for preparation of β-keto phosphonates, e.g., I. Fourteen β-keto phosphonates were prepared by this method, in an average yield greater than 60%. This procedure also appears to be applicable to the preparation of both α-phosphono aldehydes and α-phosphono esters. Although special precautions may be necessary to avoid aldol condensation during formation of aldehydes enolates, in two cases the resulting enolates reacted readily with di-Et chlorophosphite. Finally, a set of five Et esters was converted to α-phosphono esters by this method. Yields of the α-phosphono esters are influenced by steric hindrance at the enolate carbon, but the average yield for this series was ca. 70%. Because this synthetic method relies upon an electrophilic phosphorus reagent for formation of the C-P bond, it is complementary to the traditional Arbuzov synthesis.

Journal of Organic Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Whitmore, Frank C. published the artcileAction of primary Grignard reagents on tert-butylacetyl chloride. II, Computed Properties of 5340-78-3, the publication is Journal of the American Chemical Society (1938), 2790-2, database is CAplus.

Addition of EtMgBr to tert-BuCH₂COCl gives tert-BuCH₂CO₂Et(I), 77% of neopentylethylcarbinyl tert-butylacetate, 51% of Et neopentyl ketone and some tert-BuCH₂CO₂H (II). PrMgBr gives I, II, 36.7% of Pr neopentyl ketone, 20% of neopentylpropylcarbinyl tert-butylacetate and dodecenes. BuMgBr gives I, 34% of Bu neopentyl ketone, 23% of neopentylbutylcarbinyl tert-butylacetate and some tetradecenes. AmMgBr gives I, II, 29% of Am neopentyl ketone, 21% of neopentylamylcarbinyl tert-butylacetate. In no experiment was neopentyl carbinol or its tert-butylacetate found. The above yields are nearly the same as those obtained by adding the acid chloride to an excess of the Grignard reagent. Neopentyl chloride (0.8 mol.), through the Mg derivative, gives with HCHO 0.47 mol. of neopentylcarbinol, b₇₃₉ 140-6°; this with tert-BuCH₂COCl gives 57% of neopentylcarbinyl tert-butylacetate, b₂₆ 104°. tert-BuCH₂CO₂H and EtOH with concentrated H₂SO₄ gives 77% of Et tert-butylacetate, b₇₄₀ 102°.

Journal of the American Chemical Society published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C10H10O3, Computed Properties of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ahmad, Sajjad published the artcileChemical composition, antioxidant and anticholinesterase potentials of essential oil of Rumex hastatus D. Don collected from the North West of Pakistan, Application In Synthesis of 5340-78-3, the publication is BMC Complementary and Alternative Medicine (2016), 29/1-29/11, database is CAplus and MEDLINE.

Background: Ethnomedicinally Rumex hastatus D. Don has been used since long for various ailments especially in neurol. disorders. The reported data and the importance of Rumex genus demonstrate the vital medicinal value of R. hastatus. Methods: In the current investigational study, isolation of essential oil and its antioxidant and anticholinesterase assays were performed. The essential oil of R. hastatus was analyzed by GC-MS for the first time. The essential oil was evaluated for anticholinesterase and antioxidant assays. The anticholinesterase assay was conducted at various concentrations (62.5 to 1000 μg/mL) against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Similarly, the antioxidant potential was determined using DPPH and ABTS free radicals. Results: The GC-MS anal. of essential oil showed 123 components. The result recorded for the anticholinesterase assays demonstrated a marked potential against AChE and BChE with IC50 values of 32.54 and 97.38 μg/mL resp. which were comparable with the pos. control i.e., galanthamine (AChE, IC50 = 4.73 μg/mL and BChE, IC50 = 11.09 μg/ ml). The antioxidant assays against DPPH and ABTS free radicals also exhibited significant scavenging potential with IC50 values of 3.71 and 6.29 μg/mL resp., while for ascorbic acid the IC50 value was <0.1 μg/mL against both free radicals. Conclusions: Based on the current investigational studies, it may be concluded that R. hastatus is an effective source of essential oil’s components having anticholinesterase and antioxidant potentials, which after subjecting to drug development may lead to novel drug candidates against neurodegenerative disorders.

BMC Complementary and Alternative Medicine published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

DeTar, DeLos F. published the artcileCalculations of steric hindrance in ester hydrolysis based on estimation of van der Waals strain energies of alkanes, Application In Synthesis of 5340-78-3, the publication is Journal of the American Chemical Society (1976), 98(15), 4567-71, database is CAplus.

The Taft Es parameters were calculated from the difference, ΔΔH,. In the ΔHf° of the neoalkane and the isoalkane where RCMe3 (R = alkyl) was the neoalkane. ΔHf°, estimated by mol. mechanics, gave the relation Es = 4.419 + 0.552.DELTA..DELTA.H with a standard deviation of 0.4 for a total range of 4Es units; the correlation coefficient was 0.94 for the hydrolysis of twenty-four RCO2Et(R = alkyl). Empirically estimated ΔHf° gave poor results.

Journal of the American Chemical Society published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

DeTar, DeLos F. published the artcileTheoretical calculation of steric effects in ester hydrolysis, Related Products of esters-buliding-blocks, the publication is Journal of the American Chemical Society (1976), 98(25), 7903-8, database is CAplus.

Steric effects in aliphatic reaction series are represented quant. by Es values which are derived empirically. Es = -log krel = log k/k0 where k is the rate constant for acid-catalyzed hydrolysis of an aliphatic ester RCO2Et and k0 is the corresponding rate constant for AcOEt. Log krel = 0.340-0.789ΔSE where ΔSE = steric energy of RC(OH)3-steric energy of RCO2H. Steric energies are calculated by mol. mechanics using minor modifications of the Schleyer (1973) hydrocarbon force field; ΔSE values closely parallel ΔΔHf0 values. The standard deviation of Es is 0.24 and the correlation coefficient is -0.98 for 25 esters spanning a range of 4000 in relative rates. Rates are also calculated for another group of 20 esters for which only qual. information is available, and these extend the range of predicted relative rates to about 800,000. The success of these theor. calculations support the hypothesis that Es values do in fact measure steric effects for alkyl groups and that polar and steric effects are separable.

Journal of the American Chemical Society published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chretien, Jacques R. published the artcileGas chromatography of homologous esters. XXX. Unexpected predominancy of polar effects over steric effects in crowded aliphatic esters: a gas-liquid chromatographic appraisal of specific interactions, Application of Ethyltert-butylacetate, the publication is Journal of Chromatography (1985), 324(2), 355-62, database is CAplus.

The chromatog. behavior of sixteen hindered α,α-disubstituted or α,α,α-trisubstituted aliphatic Et or Me esters containing C_4-9 acyl groups is presented. Kovats index increments, on height stationary phases of increasing polarity and the contributions of the Me groups, obtained by progressive substitution are discussed. The polar and steric effects are separated by use of IR and an extended Taft scale (-E‘_s) ranging over 8 powers of 10 for the considered acyl groups. Predominancy of polar effects over steric effects is demonstrated for the congested α,α,α-trisubstituted esters containing C_7-9 acyl groups.

Journal of Chromatography published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Spielman, M. A. published the artcileMesitylmagnesium bromide as a reagent in the acetoacetic ester condensation, SDS of cas: 5340-78-3, the publication is Journal of the American Chemical Society (1937), 2009-10, database is CAplus.

Et isovalerate (I), Et tert-butylacetate (II) and Et isobutyrate (III), 3 esters which do not undergo the acetoacetic ester type of condensation with EtONa, do so with mesitylmagnesium bromide (IV). Since the resulting β-keto esters give no color with FeCl₃, their failure to be formed in the presence of EtONa is attributed to their inability to enolize as do ordinary β-keto esters. I (24 g.) in 2 volumes Et₂O and 0.189 mole of IV in 170 cc. Et₂O give 10 g. (51%) of Et α-isovalerylisovalerate, b₃₂ 128-33°; if the ester is added to the IV, the yield is substantially the same, but the product is more difficult to purify; iso-PrMgBr gave 1.2% yields. II (27 g.) and 0.194 mole of IV give 32% of Et α,γ-di-tert-butylacetoacetate, b₃₂ 138-40°, n_D²⁵ 1.4389; hydrolysis at 200° with 8% KOH in 50% EtOH yields dineopentyl ketone, b₇₄₀ 185°, n_D²⁵ 1.4210; semicarbazone, m. 178-9°. III gives 26.5% of Et tetramethylacetoacetate, b₃₃, 105-9°. Et stearate gives 27% of Et α-stearylstearate, m. 48-9°.

Journal of the American Chemical Society published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C6H12N2O, SDS of cas: 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics