Continuously updated synthesis method about Methyl 4-chlorophenylacetate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-chlorophenylacetate, other downstream synthetic routes, hurry up and to see.

Application of 52449-43-1, The chemical industry reduces the impact on the environment during synthesis 52449-43-1, name is Methyl 4-chlorophenylacetate, I believe this compound will play a more active role in future production and life.

Example 1 Preparation of Methyl 2-bromo-(4-Chlorophenyl)acetate 116 g (0.585 mol) of 1,3-dibromo-5,5-dimethylhyntantoin [sic] and 1 g of AIBN were added portionwise to the solution of 215.3 g (1.17 mol) of methyl 4-chlorophenylacetate in 500 ml of tetrachloromethane, and the mixture was refluxed for 24 hours. This was followed by washing with water and 1 N sodium hydroxide solution, the aqueous phases were extracted with methylene chloride, and the organic phases were dried and concentrated. This gave 260 g of the title compound. 1H NMR [delta, (CDCl3)]: 3.8 (s, 3H); 5.3 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-chlorophenylacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Grammenos, Wassilios; Sauter, Hubert; Cullmann, Oliver; Gewehr, Markus; Muller, Bernd; Blasco, Jordi Tormo i; Gotz, Norbert; Volk, Thorsten; Lorenz, Gisela; Ammermann, Eberhard; Stierl, Reinhard; Strathman, Siegfried; US2003/191190; (2003); A1;,
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Extended knowledge of 52449-43-1

These common heterocyclic compound, 52449-43-1, name is Methyl 4-chlorophenylacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H9ClO2

These common heterocyclic compound, 52449-43-1, name is Methyl 4-chlorophenylacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H9ClO2

(S)-2-(4-chlorophenylV3-(isoDropylaminoVl-r4-((RV5-methyl-6.7-dihvdro-5H- cvclopentard1pyrimidin-4-yl)piperazin- 1 -vDpropan- 1 -one dihydrochloride; [00303] Step 1: Methyl 2-(4-chlorophenyl)acetate (36.7 g, 199 mmol) and paraformaldehyde (6.27 g, 209 mmol) were dissolved/suspended in DMSO (400 itiL) and treated with NaOMe (537 mg, 9.94 mmol). The mixture was allowed to stir at room temperature for 2 hours to completion by TLC analysis of the crude. The reaction was poured into ice-cold water (700 mL; white emulsion) and neutralized with the addition of IM HCl solution. The aqueous portion was extracted with ethyl acetate (3 X), and the organics were combined. The organic portion was washed with water twice, once with brine, separated, dried over MgSO4, filtered, and concentrated in vacuo to afford the crude product as a yellow oil. The residue was loaded onto a large fritted filtered with silica gel and eluted with 9:1 hexanes:ethyl acetate until the starting material/olefin were collected. The plug was then eluted with 1:1 hexanes:ethyl acetate until the pure desired product was eluted completely. The concentrated pure fractions yielded methyl 2-(4- chlorophenyl)-3-hydroxypropanoate as a colorless oil (39.4 g, 92%).

The synthetic route of Methyl 4-chlorophenylacetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; MITCHELL, Ian S.; BLAKE, James F.; XU, Rui; KALLAN, Nicholas C.; XIAO, Dengming; SPENCER, Keith Lee; BENCSIK, Josef R.; LIANG, Jun; SAFINA, Brian; LI, Jun; CHABOT, Christine; WO2008/6032; (2008); A1;,
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Application of 52449-43-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52449-43-1, name is Methyl 4-chlorophenylacetate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52449-43-1, name is Methyl 4-chlorophenylacetate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

a) At 35 C. a solution of 4-chlorophenylacetic acid methyl ester (52 g) in THF (170 ml) was carefully added over a period of 70 min to a suspension of NaH (15.6 g) in dry THF (550 ml). Stirring was continued for 40 min without heating and the temperature dropped to 290C. The evolution of gas had stopped before dimethylcarbonate (94.8 ml) was added dropwise while the temperature of the mixture was maintained at 25-28 C. After the evolution of gas had ceased, the mixture was diluted with THF (200 ml) and stirring was continued for 72 h at rt. The mixture was carefully acidified with aq. HCl before bulk of the THF was removed in vacuo. The residue was dissolved in diethyl ether (1200 ml), washed three times with 1 N aq. HCl and once with brine, dried over MgSO4 and evaporated. The residue formed was collected, washed with diethyl ether and dried to give 2-(4-chloro-phenyl)-malonic acid dimethyl ester (42 g) as white crystals.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Weller, Thomas; Bolli, Martin; Boss, Christoph; Clozel, Martine; Fischli, Walter; US2004/102464; (2004); A1;,
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Discovery of Methyl 4-chlorophenylacetate

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52449-43-1, name is Methyl 4-chlorophenylacetate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 52449-43-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52449-43-1, name is Methyl 4-chlorophenylacetate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 52449-43-1

Step 1: Methyl 2-(4-chlorophenyl)acetate (36.7 g, 199 mmol) and paraformaldehyde (6.27 g, 209 mmol) were dissolved/suspended in DMSO (400 mL) and treated with NaOMe (537 mg, 9.94 mmol). The mixture was allowed to stir at room temperature for 2 hours, at which time the reaction was complete as determined by TLC analysis of the crude. The reaction was poured into ice-cold water (700 mL; emulsion) and neutralized with the addition of IM HCl solution. The aqueous layer was extracted with ethyl acetate (3 X), and the organics were combined. The organic layer was washed with water (2 X), brine (1 X), separated, dried over MgSO4, filtered, and concentrated in vacuo to afford the crude product as an oil. The residue was loaded onto a large fritted filtered with silica gel and eluted with 9:1 hexanes:ethyl acetate and then with 1:1 hexane:ethyl acetate to give methyl 2-(4-chlorophenyl)-3-hydroxypropanoate as an oil (39.4 g, 92%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52449-43-1.

Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; WO2009/89459; (2009); A1;,
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Some tips on 52449-43-1

Adding a certain compound to certain chemical reactions, such as: 52449-43-1, name is Methyl 4-chlorophenylacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52449-43-1, Product Details of 52449-43-1

Adding a certain compound to certain chemical reactions, such as: 52449-43-1, name is Methyl 4-chlorophenylacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52449-43-1, Product Details of 52449-43-1

[00244] Methyl 2-(4-chlorophenyl)acetate (36.7 g, 199 mmol) and paraformaldehyde(6.27 g, 209 mmol) were dissolved/suspended in DMSO (400 mL) and treated with NaOMe (537 mg, 9.94 mmol). The mixture was allowed to stir at room temperature for 2 hours to completion by thin layer chromatography (“TLC”) analysis of the crude. The reaction was poured into ice-cold water (700 mL; white emulsion) and neutralized with the addition of IM HCl solution. The aqueous layer was extracted with ethyl acetate (3 X), and the organics were combined. The organic layer was washed with water (2 X), brine (1 X), separated, dried over MgSO4, filtered, and concentrated in vacuo to afford the crude product as an oil. The residue was loaded onto a large fritted filtered with silica gel and eluted with 9:1 hexanes: ethyl acetate until the starting material/olefm were collected. The plug was then eluted with 1 :1 hexanes: ethyl acetate until the pure desired product was eluted completely. The concentrated pure fractions yielded methyl 2-(4-chlorophenyl)-3-hydroxypropanoate as an oil (39.4 g, 92%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-chlorophenylacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; WO2009/89359; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New learning discoveries about 52449-43-1

The chemical industry reduces the impact on the environment during synthesis Methyl 4-chlorophenylacetate. I believe this compound will play a more active role in future production and life.

Electric Literature of 52449-43-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52449-43-1, name is Methyl 4-chlorophenylacetate, This compound has unique chemical properties. The synthetic route is as follows.

Referential Example 2 Methyl (4-chlorophenyl)bromoacetate To a solution of 102 g (0.55 mole) of methyl (4-chlorophenyl)acetate in 100 ml of carbon tetrachloride was added 97.9 g (0.55 mole) of N-bromosuccinimide. The resulting mixture was refluxed and irradiated with a 500 W bromo lamp for 5 hours. It was then cooled, filtered, and the filtrate was evaporated to dryness to give 150 g (103% yield) of methyl (4-chlorophenyl)bromoacetate. NMR (CDCl3) delta ppm; 3.79 (3H, s), 5,31 (1H, s), 7.3-7.7 (4H, s)

The chemical industry reduces the impact on the environment during synthesis Methyl 4-chlorophenylacetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SUMITOMO PHARMACEUTICALS COMPANY, LIMITED; SUMITOMO CHEMICAL COMPANY, LIMITED; EP256687; (1991); B1;,
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Share a compound : 52449-43-1

According to the analysis of related databases, 52449-43-1, the application of this compound in the production field has become more and more popular.

Related Products of 52449-43-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52449-43-1 as follows.

Example 50AMethyl (4-chlorophenyl)(cyclopentyl)acetate; A suspension of 3.65 g (32.5 mmol) of potassium tert-butoxide in 65 ml of abs. DMF was cooled to 0 C., and a solution of 5.0 g (27.08 mmol) of methyl 4-chlorophenylacetate in about 2 ml of abs. DMF was added dropwise. The mixture was stirred at 0 C. for 30 min, and 4.84 g (32.5 mmol) of cyclopentyl bromide were then slowly added dropwise. The reaction mixture was stirred at 0 C. for 1 h and then added to water and extracted with ethyl acetate. The organic phase was dried over sodium sulphate and concentrated under reduced pressure, and the residue was dried under high vacuum. The crude product was purified by chromatography on silica gel (mobile phase cyclohexane/ethyl acetate 100:1). This gave 6.28 g of the target compound (91.8% of theory).GC-MS (Method 1): Rt=6.07 min; m/z=193 (M-C2H3O2)+.1H-NMR (400 MHz, DMSO-d6): delta [ppm]=0.96-1.04 (m, 1H), 1.08-1.37 (m, 2H), 1.37-1.48 (m, 1H), 1.49-1.70 (m, 3H), 1.79 (dtd, 1H), 2.33-2.50 (m, 1H), 3.42 (d, 1H), 3.58 (s, 3H), 7.29-7.46 (m, 4H).

According to the analysis of related databases, 52449-43-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; US2012/172448; (2012); A1;,
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