Some scientific research about 5202-89-1

According to the analysis of related databases, 5202-89-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5202-89-1, name is Methyl 2-amino-5-chlorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H8ClNO2

Methyl 2-amino-5-chlorobenzoate (compound A) (4.0 g) was dissolved in anhydrous methylene chloride (80.0 ml). Subsequently, pyridine (2.8 ml) and 3-(chloromethyl)benzoyl chloride (compound B) (5.0 g) were added to the solution at room temperature, and the mixture was stirred at that temperature for 2 hr. After the completion of the reaction, distilled water was added thereto, and the mixture was subjected to separatory extraction with chloroform. The organic layer was washed with a saturated aqueous sodium chloride solution and saturated brine, was dried over sodium sulfate, and was then concentrated to give methyl 5-chloro-2-[3-(chloromethyl)benzoyl]aminobenzoate as a useful intermediate (3.32 g, yield 100%).

According to the analysis of related databases, 5202-89-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1614676; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simple exploration of 5202-89-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-chlorobenzoate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 5202-89-1, name is Methyl 2-amino-5-chlorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5202-89-1, Application In Synthesis of Methyl 2-amino-5-chlorobenzoate

Water was added (5 ml) to a stirred suspension of 2-amino-5-chloro methyl benzoate (0.33 g, 1.77 mmol) in concentrated hydrochloric acid (1.1 ml) at [0C.] A solution of sodium nitrite (0.12 g, 1.77 [MMOL)] in water (1 [ML)] was added dropwise and the solution stirred until complete dissolution. The diazonium salt was brought to Ph. 6.0. with saturated sodium bicarbonate. In a separate flask, a solution of [CUS04.] 5H20 (0.53 g, 2.12 [MMOL)] in water (2 [ML)] was added dropwise to a stirred solution of potassium cyanide (0.53 g, 8.13 [MMOL)] in water (2 [ML)] at [0C.] Toluene (3 [ML)] was added and the resultant brown mixture stirred and heated to [60C.] The previously prepared diazonium solution was added to the Cu [(I)] CN at [60C] over a period of 30 mins. The reaction mixture was heated to [70C] for an additional 1 hour, then cooled to room temperature. The brown mixture was diluted with ethyl acetate (70 [MI),] filtered through a pad of [CELITE,] washed with ethyl acetate (3 x 20 ml), the combined organics washed with brine (50 [ML),] dried over magnesium sulfate, filtered and the solvent removed by evaporation under reduced pressure to give a dark orange solid. The solid was dissolved in minimum [DICHLOROMETHANE] was purified by flash chromatography on silica gel eluting with a solvent gradient of heptane: ethyl acetate (3: 1) to give the title compound (0.23 g, 65 %) as an off-white solid. H-NMR (400 MHz, [CDCI3)] : [9] = 4.0 (s, 3H), 7.62 (dd, [1H),] 7.72 (dd, [1H),] 8.12 (d, 1H). LRMS (Electrospray) : m/z [M + [H] + 218.] Microanalysis : Found: C, 55.16 ; H, 3.09 ; N, 7. 08. [C9H6N02CI] requires C, 55.26 ; H, 3.09 ; N, 7.16%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-chlorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/14357; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics