Category: 51857-17-1

Liu, Yue; Ma, Congcong; Leonen, Calvin J. A.; Chatterjee, Champak; Novakova, Gabriela; Marek, Ales; Turecek, Frantisek published an article in 2021. The article was titled 《Tackling a Curious Case: Generation of Charge-Tagged Guanosine Radicals by Gas-Phase Electron Transfer and Their Characterization by UV-vis Photo-dissociation Action Spectroscopy and Theory》, and you may find the article in Journal of the American Society for Mass Spectrometry.Synthetic Route of C11H24N2O2 The information in the text is summarized as follows:

We report the generation of gas-phase ribo-guanosine radicals that were tagged at ribose with a fixed-charge 6-(trimethylammonium)hexane-1-aminocarbonyl group. The radical generation relied on electron transfer from fluoranthene anion to noncovalent dibenzo-crown-ether dication complexes which formed nucleoside cation radicals upon one-electron reduction and crown-ether ligand loss. Rate constant measurements revealed an inverse isotope effect on the loss of either hydrogen or deuterium with rate constants kH = 0.25-0.26 s-1 and kD = 0.39-0.54 s-1. We used time-dependent d. functional theory calculations, including thermal vibronic effects, to predict the absorption spectra of several radical isomers. The calculated spectra of low-energy N-7-H guanine-radical tautomers closely matched the action spectra. Transition-state-theory calculations of the rate constants for the loss of H-7 and guanine agreed with the exptl. rate constants for a narrow range of ion effective temperatures Our calculations suggest that the observed inverse isotope effect does not arise from the isotope-dependent differences in the transition-state energies. Instead, it may be caused by the dynamics of post-transition-state complexes preceding the product separation In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Synthetic Route of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsSynthetic Route of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Introducing aldehyde functionality to proteins using ligand-directed affinity labeling》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Song, Yinan; Xiong, Feng; Peng, Jianzhao; Fung, Yi Man Eva; Huang, Yiran; Li, Xiaoyu. Quality Control of N-Boc-1,6-Diaminohexane The article mentions the following:

Aldehyde is a versatile chem. handle for protein modification. Although many methods have been developed to label proteins with aldehyde, target-specific methods amenable to endogenous proteins are limited. Here, the authors report a simple affinity probe strategy to introduce aldehydes to native proteins. Notably, the probe contains a latent aldehyde functionality that is only exposed upon target binding, thereby enabling a one-pot labeling procedure. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Quality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 51857-17-1In 2020 ,《A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarization》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Li, Zhihong; Zhen, Shuai; Su, Kaijun; Tumber, Anthony; Yu, Quanwei; Dong, Ying; McDonough, Michael; Schofield, Christopher J.; Zhang, Xiaojin. The article conveys some information:

Inhibition of the dioxygen sensing hypoxia-inducible factor prolyl hydroxylases has potential therapeutic benefit for treatment of diseases, including anemia. We describe the discovery of a small-mol. probe useful for monitoring binding to human prolyl hydroxylase domain 2 (PHD2) via fluorescence polarization. The assay is suitable for high-throughput screening of PHD inhibitors with both weak and strong affinities, as shown by work with clin. used inhibitors and naturally occurring PHD inhibitors. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Application of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《An endoplasmic reticulum-targeting fluorescent probe for imaging OH in living cells》 was written by Zhao, Yanyan; Li, Hongyu; Chai, Ziyin; Shi, Wen; Li, Xiaohua; Ma, Huimin. Safety of N-Boc-1,6-Diaminohexane And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The hydroxyl radical (OH) in the endoplasmic reticulum has not been studied thoroughly due to the lack of proper methods. Here, an endoplasmic reticulum-targeting fluorescent probe for detecting OH is reported. With this probe, the action of OH in the endoplasmic reticulum has been imaged in living cells. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 51857-17-1In 2020 ,《Constructing conjugate vaccine against Salmonella Typhimurium using lipid-A free lipopolysaccharide》 was published in Journal of Biomedical Science (London, United Kingdom). The article was written by Chiu, Tzu-Wei; Peng, Chi-Jiun; Chen, Ming-Cheng; Hsu, Mei-Hua; Liang, Yi-Hua; Chiu, Cheng-Hsun; Fang, Jim-Min; Lee, Yuan Chuan. The article contains the following contents:

Salmonella enterica serotype Typhimurium is a nontyphoidal and common foodborne pathogen that causes serious threat to humans. There is no licensed vaccine to prevent the nontyphoid bacterial infection caused by S. Typhimurium. To develop conjugate vaccines, the bacterial lipid-A free lipopolysaccharide (LFPS) is prepared as the immunogen and used to synthesize the LFPS-linker-protein conjugates 6a-9b. The designed bifunctional linkers 1-5 comprising either an o-phenylenediamine or amine moiety are specifically attached to the exposed 3-deoxy-D-manno-octulosonic acid (Kdo), an α-ketoacid saccharide of LFPS, via condensation reaction or decarboxylative amidation. In addition to bovine serum albumin and ovalbumin, the S. Typhimurium flagellin (FliC) is also used as a self-adjuvanting protein carrier. The synthesized conjugate vaccines are characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and fast performance liquid chromatog. (FPLC), and their contents of polysaccharides and protein are determined by phenol-sulfuric acid assay and bicinchoninic acid assay, resp. ELISA (ELISA) shows that immunization of mouse with the LFPS-linker-protein vaccines at a dosage of 2.5 μg is sufficient to elicit serum IgG (IgG) specific to S. Typhimurium lipopolysaccharide (LPS). The straight-chain amide linkers in conjugates 7a-9b do not interfere with the desired immune response. Vaccines 7a and 7b derived from either unfractionated LFPS or the high-mass portion show equal efficacy in induction of IgG antibodies. The challenge experiments are performed by oral gavage of S. Typhimurium pathogen, and vaccine 7c having FliC as the self-adjuvanting protein carrier exhibits a high vaccine efficacy of 74% with 80% mice survival rate at day 28 post the pathogen challenge. This study demonstrates that lipid-A free lipopolysaccharide prepared from Gram-neg. bacteria is an appropriate immunogen, in which the exposed Kdo is connected to bifunctional linkers to form conjugate vaccines. The decarboxylative amidation of Kdo is a novel and useful method to construct a relatively robust and low immunogenic straight-chain amide linkage. The vaccine efficacy is enhanced by using bacterial flagellin as the self-adjuvanting carrier protein. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Product Details of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Unraveling Decisive Structural Parameters for the Self-Assembly of Supramolecular Polymer Bottlebrushes Based on Benzene Trisureas》 was written by Gruschwitz, Franka V.; Fu, Mao-Chun; Klein, Tobias; Takahashi, Rintaro; Higashihara, Tomoya; Hoeppener, Stephanie; Nischang, Ivo; Sakurai, Kazuo; Brendel, Johannes C.. Safety of N-Boc-1,6-DiaminohexaneThis research focused onunraveling decisive self supramol polymer bottlebrushe benzene trisureas. The article conveys some information:

By introducing strong directed hydrogen bonds to an amphiphilic polymer, we demonstrate that phase transitions from spherical to cylindrical morphologies in aqueous solutions can significantly be shifted to favor the assembly of supramol. polymer bottlebrushes. In water, a forced self-assembly of polymers into cylindrical structures remains a challenge as the often required hydrophobic shielding induces forces, which tend to minimize the surface area. The herein presented novel benzene trisureas can overcome these limitations due to strong hydrogen bonds and alter the morphol. to cylinders despite an unfavorable packing parameter, which dominated the previously reported trisamide analogs. The systematic variation of composition and architecture revealed that a transition to spherical morphologies still occurs, but the phase-transition boundaries appear to be shifted to tolerate larger hydrophilic polymer chains. The strength of the directing interactions appears to be decisive for the shift, though we addnl. observed that any restrictions of lateral aggregation can diminish the effect of the directing hydrogen bonds. Overall, the straightforward synthesis and versatile design render the presented systems an interesting blueprint for the development of more advanced supramol. polymer bottlebrushes and multifunctional nanostructures. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Safety of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《The in-vitro biocompatibility of ureido-pyrimidinone compounds and polymer degradation products》 was written by Besseling, Paul J.; Mes, Tristan; Bosman, Anton W.; Peeters, Joris W.; Janssen, Henk M.; Bakker, Maarten H.; Fledderus, Joost O.; Teraa, Martin; Verhaar, Marianne C.; Gremmels, Hendrik; Dankers, Patricia Y. W.. Reference of N-Boc-1,6-DiaminohexaneThis research focused onureido pyrimidinone compound polymer degradation product biocompatibility. The article conveys some information:

Supramol. biomaterials based on ureido-pyrimidinone (UPy) moieties are versatile polymer materials as their function can be tailored to the application. These UPy-materials can be designed into polymer coatings, self-healing polymers, hydrogels and elastomers. The biocompatibility of UPy-based materials and their degradation products is a long-term success requirement for many regenerative medicine and biomedical applications. Earlier research has shown that UPy-based materials and polymers display no immediate toxic effects, but in-depth in-vitro studies on potential UPy-polymer degradation products have not been executed. Owing to their resemblance to naturally occurring purines and pyrimidines, UPy-compounds and their degradation products could potentially initiate an immune response or be mutagenic. Accordingly, 11 selected UPy-compounds were synthesized, and their effect on cell viability, wound healing, and their immunogenicity and potential mutagenic potential, were studied. We showed that low mol. weight degradation products of UPy-based biomaterials do not affect cell viability, nor do these interfere with several aspects of endothelial function including proliferation, angiogenic sprouting and cellular migration even in levels exceeding plausibly attainable concentrations Furthermore, the compounds are neither immunogenic nor mutagenic, showing that UPy-biomaterials exhibit good biocompatibility in vitro, and could in principle be used in humans. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Reference of N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Reference of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lan; Zhang, Yuhuan; Han, Ying; Zhang, Qi; Wen, Zhenfu; Li, Hongjuan; Sun, Shiguo; Chen, Xin; Xu, Yongqian published an article in 2021. The article was titled 《Nanoscale photosensitizer with tumor-selective turn-on fluorescence and activatable photodynamic therapy treatment for COX-2 overexpressed cancer cells》, and you may find the article in Journal of Materials Chemistry B: Materials for Biology and Medicine.SDS of cas: 51857-17-1 The information in the text is summarized as follows:

Effective targeting and in situ imaging-guided treatment are particularly important for accurate clin. photodynamic therapy (PDT) of malignant tumors. Herein, we propose a single mol., named IMC-DAH-SQ, which possesses dual-targeting components, including structure-inherent targeting (SIT) and cyclooxygenase-2 (COX-2) targeting units, and controllable turn-on near IR (NIR) fluorescence. Due to its amphiphilicity, IMC-DAH-SQ assembles into a nanoprobe with low background fluorescence. After incubation with tumor cells, the SIT and COX-2 recognition characteristics of IMC-DAH-SQ endow it with preferential tumor-targeting activity. The strong binding with overexpressed COX-2 can collapse the nanoprobe to monomers after accumulation in tumor cells, leading to turn-on NIR fluorescence that is completely different from normal cells. Addnl., benefiting from the single mol. model tactic, the nanoprobe has the advantages of simple synthesis without ever considering the loading rate and separation between the photosensitizer and targeting unit. Other favorite features, including superior biocompatibility, weak dark toxicity, and mitochondria enrichment capability, are implemented. All these traits not only afford nanoprobe precision tumor cell targeting capability but also provide promising imaging-guided antitumor therapy. We believe that the single mol. protocol will establish a novel strategy for simultaneous diagnosis and anticancer medicine treatment utilizing versatile but small compounds In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1SDS of cas: 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsSDS of cas: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics