Patinote, Cindy’s team published research in European Journal of Medicinal Chemistry in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsReference of N-Boc-1,6-Diaminohexane

Patinote, Cindy; Deleuze-Masquefa, Carine; Kaddour, Kamel Hadj; Vincent, Laure-Anais; Larive, Romain; Zghaib, Zahraa; Guichou, Jean-Francois; Assaf, Mona Diab; Cuq, Pierre; Bonnet, Pierre-Antoine published an article in 2021. The article was titled 《Imidazo[1,2-a]quinoxalines for melanoma treatment with original mechanism of action》, and you may find the article in European Journal of Medicinal Chemistry.Reference of N-Boc-1,6-Diaminohexane The information in the text is summarized as follows:

The malignant transformation of melanocytes causes several thousand deaths each year, making melanoma an important public health concern. Melanoma is the most aggressive skin cancer, which incidence has regularly increased over the past decades. We described here the preparation of new compounds based on the 1-(3,4-dihydroxyphenyl)imidazo[1,2-a]quinoxaline structure. Different positions of the quinoxaline moiety were screened to introduce novel substituents in order to study their influence on the biol. activity. Several alkylamino or alkyloxy groups were also considered to replace the methylamine of our first generation of Imiqualines. Imidazo[1,2-a]pyrazine derivatives were also designed as potential minimal structure. The investigation on A375 melanoma cells displayed interesting in vitro low nanomolar cytotoxic activity. Among them, 9d (EAPB02303) is particularly remarkable since it is 20 times more potent than vemurafenib, the reference clin. therapy used on BRAF mutant melanoma. Contrary to the first generation, EAPB02303 does not inhibit tubulin polymerization, as confirmed by an in vitro assay and a mol. modelisation study. The mechanism of action for EAPB02303 highlighted by a transcriptomic anal. is clearly different from a panel of 12 well-known anticancer drugs. In vivo EAPB02303 treatment reduced tumor size and weight of the A375 human melanoma xenografts in a dose-dependent manner, correlated with a low mitotic index but not with necrosis. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Reference of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsReference of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manickam, Manoj’s team published research in Bioorganic & Medicinal Chemistry Letters in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Synthetic Route of C11H24N2O2

Manickam, Manoj; Boggu, Pulla Reddy; Pillaiyar, Thanigaimalai; Nam, Yeo Jin; Abdullah, Md.; Lee, Seung Jin; Kang, Jong Seong; Jung, Sang-Hun published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《Design, synthesis and anticancer activity of 2-amidomethoxy-1,4-naphthoquinones and its conjugates with Biotin/polyamine》.Synthetic Route of C11H24N2O2 The article contains the following contents:

In continuation with the previous work, a series of 5-hydroxy-2-amidomethoxy-1,4-naphthoquinones were prepared to establish the structure-activity relationship studies toward anticancer activity (IC50 in μM) against three cell lines; colo205 (colon adenocarcinoma), T47D (breast ductal carcinoma) and K562 (chronic myelogenous leukemia). Among the synthesized compounds, naphthoquinone amines, I (0.8; 0.6; 0.8), II (0.8; 0.6; 0.5) and the amine precursor, III (1.3; 0.3; 1.0) displayed potent anticancer activities. A tumor targeting drug delivery system was achieved by synthesizing the conjugate IV (1.4; 0.5; 1.1) of naphthoquinone-amine I and Biotin which also proved its potency. Finally, to introduce polyamine conjugate, spermidine was attached with 2-amidomethoxy-1,4-naphthoquinone. The naphthoquinone-spermidine conjugate V (1.2; 1.7; 1.7) also retained the activity. Thus, potent naphthoquinone amines were explored and Biotin/polyamine conjugate was developed as tumor targeting drug delivery system. In the part of experimental materials, we found many familiar compounds, such as N-Boc-1,6-Diaminohexane(cas: 51857-17-1Synthetic Route of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Synthetic Route of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gockel, Lukas M.’s team published research in Archiv der Pharmazie (Weinheim, Germany) in 2022 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Computed Properties of C11H24N2O2

In 2022,Gockel, Lukas M.; Pfeifer, Vladlena; Baltes, Fabian; Bachmaier, Rafael D.; Wagner, Karl G.; Bendas, Gerd; Guetschow, Michael; Sosic, Izidor; Steinebach, Christian published an article in Archiv der Pharmazie (Weinheim, Germany). The title of the article was 《Design, synthesis and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models》.Computed Properties of C11H24N2O2 The author mentioned the following in the article:

Three subgroups of enzalutamide-based PROTACs was presented in which only the exit vector was modified. By recruiting cereblon, the potent degradation of AR in lung cancer cells was demonstrated. Furthermore, the initial evaluation enabled the design of an optimized PROTAC with a rigid linker that degraded AR with a DC50 value in the nanomolar range. These results provide novel AR-directed PROTACs and a clear rationale for further investigating AR involvement in lung cancer models. After reading the article, we found that the author used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Computed Properties of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Computed Properties of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jovanovic, Dragana’s team published research in Journal of the Serbian Chemical Society in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Name: N-Boc-1,6-Diaminohexane

Jovanovic, Dragana; Stanojkovic, Jovana; Halilovic, Dzeneta; Kolasinac, Rejhana; Kop, Tatjana J.; Bjelakovic, Mira S.; Milic, Dragana R. published their research in Journal of the Serbian Chemical Society in 2021. The article was titled 《Fulleropyrrolidines with orthogonally flexible substituents – synthesis and electrochemical properties》.Name: N-Boc-1,6-Diaminohexane The article contains the following contents:

A large series of disubstituted fulleropyrrolidines I [R1 = (CH2)6, (CH2)10, (CH2)3O(CH2)2O(CH2)2O(CH2)3; R2 = H, C9H19, 4-O2NC6H4, etc.] was synthesized and analyzed by cyclic voltammetry. The three main groups of target compounds differ by a flexible N-chain, while their further diversity was achieved by introduction of various rigid, aryl substituents at pyrrolidine carbon. Some dialkyl analogs were also designed for comparison, a standard [3 + 2]-cycloaddition of in situ generated azomethine ylides to C60 afforded a variety of disubstituted fulleropyrrolidines. Furthermore, a set of dumbbell-shaped di(fulleropyrrolidine) derivatives containing rigid fumaryl or isophthaloyl diamide platform II [R1 = (CH2)6; R2 = H, C9H19] and III [R1 = (CH2)6, (CH2)3O(CH2)2O(CH2)2O(CH2)3; R2 = H, Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4] was prepared with aim of investigating a long-range effect of second fulleropyrrolidine moiety on their electrochem. properties. All compounds were fully characterized by comparative anal. of spectral data, while examination of electrochem. properties was performed on representative samples, distinguished by main structural subunits. All compounds expressed quite similar electron-accepting ability, lower than C60, but higher in comparison to structurally similar N-methylfulleropyrrolidine. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Name: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Name: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ao’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsCategory: esters-buliding-blocks

Li, Ao; Li, Lingxuan; Liu, Xing; Chen, Dongxia; Fan, Yifan; Lin, Hongyu; Gao, Jinhao published an article in 2021. The article was titled 《Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Category: esters-buliding-blocks The information in the text is summarized as follows:

Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled 19F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI. After reading the article, we found that the author used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Category: esters-buliding-blocks)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsCategory: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jovanovic, Dragana’s team published research in Journal of the Serbian Chemical Society in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Name: N-Boc-1,6-Diaminohexane

Jovanovic, Dragana; Stanojkovic, Jovana; Halilovic, Dzeneta; Kolasinac, Rejhana; Kop, Tatjana J.; Bjelakovic, Mira S.; Milic, Dragana R. published their research in Journal of the Serbian Chemical Society in 2021. The article was titled 《Fulleropyrrolidines with orthogonally flexible substituents – synthesis and electrochemical properties》.Name: N-Boc-1,6-Diaminohexane The article contains the following contents:

A large series of disubstituted fulleropyrrolidines I [R1 = (CH2)6, (CH2)10, (CH2)3O(CH2)2O(CH2)2O(CH2)3; R2 = H, C9H19, 4-O2NC6H4, etc.] was synthesized and analyzed by cyclic voltammetry. The three main groups of target compounds differ by a flexible N-chain, while their further diversity was achieved by introduction of various rigid, aryl substituents at pyrrolidine carbon. Some dialkyl analogs were also designed for comparison, a standard [3 + 2]-cycloaddition of in situ generated azomethine ylides to C60 afforded a variety of disubstituted fulleropyrrolidines. Furthermore, a set of dumbbell-shaped di(fulleropyrrolidine) derivatives containing rigid fumaryl or isophthaloyl diamide platform II [R1 = (CH2)6; R2 = H, C9H19] and III [R1 = (CH2)6, (CH2)3O(CH2)2O(CH2)2O(CH2)3; R2 = H, Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4] was prepared with aim of investigating a long-range effect of second fulleropyrrolidine moiety on their electrochem. properties. All compounds were fully characterized by comparative anal. of spectral data, while examination of electrochem. properties was performed on representative samples, distinguished by main structural subunits. All compounds expressed quite similar electron-accepting ability, lower than C60, but higher in comparison to structurally similar N-methylfulleropyrrolidine. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Name: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Name: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ao’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsCategory: esters-buliding-blocks

Li, Ao; Li, Lingxuan; Liu, Xing; Chen, Dongxia; Fan, Yifan; Lin, Hongyu; Gao, Jinhao published an article in 2021. The article was titled 《Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Category: esters-buliding-blocks The information in the text is summarized as follows:

Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled 19F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI. After reading the article, we found that the author used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Category: esters-buliding-blocks)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsCategory: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Yuxiang’s team published research in Macromolecules (Washington, DC, United States) in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Category: esters-buliding-blocks

Category: esters-buliding-blocksIn 2021 ,《Controlled Ring-Opening Polymerization of Macrocyclic Monomers Based on the Quinone Methide Elimination Cascade Reaction》 was published in Macromolecules (Washington, DC, United States). The article was written by He, Yuxiang; Wu, Ying; Zhang, Minghui; Zhang, Yuanxing; Ding, Hao; Zhang, Ke. The article contains the following contents:

A controlled ring-opening polymerization (ROP) of macrocyclic monomers was developed based on the nucleophilic ring-opening mechanism for the first time. This novel ROP was designed to prepare backbone functional and sequence-defined polymers with controlled mol. weights and narrow dispersities (D < 1.1) by polymerizing the macrocycles with a quinone methide elimination-based self-immolative spacer as the ""ring-opening trigger"". This ROP was initiated by an efficient nucleophilic substitution of activated carbonate with a primary amine to ring open the macrocyclic monomers. The following spontaneous 1,6-elimination-decarboxylation cascade reaction disassembled the self-immolative spacer to regenerate the primary amine end group for subsequent polymer chain propagation. The versatility of this novel ROP was demonstrated by the formation of well-defined water-soluble, backbone-degradable, and sequence-defined polyurethanes and their block copolymers. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Category: esters-buliding-blocks)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ousaka, Naoki’s team published research in Macromolecules (Washington, DC, United States) in 2021 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsQuality Control of N-Boc-1,6-Diaminohexane

Ousaka, Naoki; Endo, Takeshi published an article in 2021. The article was titled 《One-Pot Nonisocyanate Synthesis of Sequence-Controlled Poly(hydroxy urethane)s from a Bis(six-membered cyclic carbonate) and Two Different Diamines》, and you may find the article in Macromolecules (Washington, DC, United States).Quality Control of N-Boc-1,6-Diaminohexane The information in the text is summarized as follows:

Sequence-controlled synthetic polymers have received increasing interest because of their great potential to develop next-generation functional materials. Here, we report a facile synthesis of a sym. spiro bis(six-membered cyclic carbonate), 2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-dione (1), its reactivity, and a one-pot, nonisocyanate synthesis of sequence-controlled poly(hydroxy urethane)s (PHUs) from 1 with two different sym. diamines. The second-order rate constant for the ring-opening addition reaction of one of the two cyclic carbonates of 1 with 1-hexylamine is two orders of magnitude larger than that of the remaining one of the resulting intermediate due to a remarkable difference between their ring strain energies. This difference in the reactivity enables the selective formation of a diurethane-linked bis(six-membered cyclic carbonate) from the reaction of 1 with a diamine (0.5 equiv). The subsequent addition of a different diamine (0.5 equiv) to the same pot affords sequence-controlled PHUs with an ABAC sequence. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsQuality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Gang’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 51857-17-1

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Computed Properties of C11H24N2O2

Computed Properties of C11H24N2O2In 2020 ,《Protein degradation through covalent inhibitor-based PROTACs》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Xue, Gang; Chen, Jiahui; Liu, Lihong; Zhou, Danli; Zuo, Yingying; Fu, Tiancheng; Pan, Zhengying. The article conveys some information:

Tremendous advancements in proteolysis targeting chimera (PROTAC) technol. have been made in recent years. However, whether a covalent inhibitor-based PROTAC can be developed remains controversial. Here, we successfully developed chimeric degraders based on covalent inhibitors to degrade BTK and BLK kinases, demonstrating that covalent inhibitor-based PROTACs are viable and useful tools. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Computed Properties of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Computed Properties of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics