Category: 51857-17-1

Zhang, Yonghong; Ma, Xia; Chau, Ho-Fai; Thor, Waygen; Jiang, Lijun; Zha, Shuai; Fok, Wan-Yiu; Mak, Ho-Nam; Zhang, Junhui; Cai, Jing; Ng, Chi-Fai; Li, Hongguang; Parker, David; Li, Li; Law, Ga-Lai; Wong, Ka-Leung published an article in 2021. The article was titled 《Lanthanide-Cyclen-Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging》, and you may find the article in ACS Applied Nano Materials.Recommanded Product: 51857-17-1 The information in the text is summarized as follows:

We have devised a mol.-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-IR (NIR) and magnetic resonance imaging (MRI) capabilities with defined lanthanide(III) ratio control. This cancer-selective lanthanide-based self-assembled nanocomposite (LnNPs) has been synthesized by conjugating lanthanide-cyclen complexes (cycLn) with a well-known drug-camptothecin (CPT) through a redox-sensitive disulfide bond (-ss-). By accurately controlling the ratio of Gd(III) and Yb(III) complexes, we prepared hybrid nanoparticles (Gd/YbNPs) with both NIR and MR imaging properties. The enhanced stability at ultralow critical aggregation concentrations (CACs), simultaneous optical and MR imaging, improved delivery/chemotherapeutic efficiency, and cancer cell selectivity of such nanomicellar theranostic prodrugs in vitro and in vivo have thus been achieved and validated. The work provides a blueprint combining a stimuli-activated NIR luminescence and real-time MR imaging into a safe and biocompatible nanoplatform for selective cancer treatment. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRecommanded Product: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of N-Boc-1,6-DiaminohexaneIn 2021 ,《Selective degradation-inducing probes for studying cereblon (CRBN) biology》 was published in RSC Medicinal Chemistry. The article was written by Powell, Chelsea E.; Du, Guangyan; Bushman, Jonathan W.; He, Zhixiang; Zhang, Tinghu; Fischer, Eric S.; Gray, Nathanael S.. The article contains the following contents:

Targeted protein degradation represents a rapidly growing area in drug discovery and development. Moreover, small mols. that induce the targeted degradation of a given protein also represent an important addition to the chem. probes toolbox as these compounds can achieve selective protein knockdown, thus providing an approach that is orthogonal to genetic knockdowns. In order to develop degradation-inducing chem. probes for studying cereblon (CRBN) biol., we generated six CRBN-CRBN (homo-PROTAC) degraders and six CRBN-VHL (hetero-PROTAC) degraders. From these compounds we identified two potent and selective CRBN degraders (ZXH-4-130 and ZXH-4-137), both of which are CRBN-VHL compounds We characterized these lead degraders by quant. proteomics in five cell lines (MM1.S, Kelly, SK-N-DZ, HEK293T, and MOLT-4) and observed high selectivity for CRBN in all cell lines. Furthermore, we directly compared our compounds to current lead CRBN degraders and demonstrated how these probes can be used as chem. knockdown reagents for studying CRBN-dependent processes. Overall, our work provides a roadmap for thorough degrader characterization by combination western and proteomic anal., as illustrated by the identification of ZXH-4-130 and ZXH-4-137 as CRBN-knockdown tool compounds suitable for cell-based studies. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Reference of N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Reference of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Shaowen; Sun, Yuan; Liu, Yulin; Li, Xinnan; Li, Xinuo; Zhong, Wenyi; Zhan, Feiyan; Zhu, Jingjie; Yao, Hong; Yang, Dong-Hua; Chen, Zhe-Sheng; Xu, Jinyi; Xu, Shengtao published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK)》.Computed Properties of C11H24N2O2 The article contains the following contents:

A series of novel anaplastic lymphoma kinase (ALK) degraders were designed and synthesized based on proteolysis-targeting chimera (PROTAC) technol. by linking two alectinib analogs (I and II) with pomalidomide through linkers of different lengths and types. The most promising degrader III possessed a high ALK-binding affinity and potent antiproliferative activity in the ALK-dependent cell lines and did not exhibit obvious cytotoxicity in ALK fusion-neg. cells. More importantly, the efficacy of compound III in a Karpas 299 xenograft mouse model was further evaluated based on its ALK-sustained degradation ability in vivo. The reduction in tumor weight in the compound III-treated group (10 mg/kg/day, I.V.) reached 75.82%, while alectinib reduced tumor weight by 63.82% at a dose of 20 mg/kg/day (P.O.). Taken together, our findings suggest that alectinib-based PROTACs associated with the degradation of ALK may have promising beneficial effects for treating ALK-driven malignancies. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Computed Properties of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Computed Properties of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and Applications of Cinchona Squaramide-Modified Poly(Glycidyl Methacrylate) Microspheres as Recyclable Polymer-Grafted Enantioselective Organocatalysts》 was written by Nagy, Sandor; Feher, Zsuzsanna; Karpati, Levente; Bagi, Peter; Kisszekelyi, Peter; Koczka, Bela; Huszthy, Peter; Pukanszky, Bela; Kupai, Jozsef. Name: N-Boc-1,6-Diaminohexane And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

This work presents the immobilization of cinchona squaramide organocatalysts on poly(glycidyl methacrylate) solid supports. Preparation of the well-defined monodisperse polymer microspheres was facilitated by comprehensive parameter optimization. By exploiting the reactive epoxy groups of the polymer support, three amino-functionalized cinchona derivatives I [R = Me, 2-aminoethyl; R1 = Me, 1-((4-(aminomethyl)phenyl)methyl)-1H-1,2,3-triazol-4-yl; R2 = 3,5-bis(trifluoromethyl)phenyl, 6-aminohexyl] were immobilized on this carrier. To explore the effect of the amino linker, these structurally varied precatalysts were synthesized by modifying the cinchona skeleton at different positions. The catalytic activities of the immobilized organocatalysts were tested in the Michael addition of pentane-2,4-dione and trans-β-nitrostyrene with excellent yields (up to 98%) and enantioselectivities (up to 96% ee). Finally, the catalysts were easily recovered five times by centrifugation without loss of activity. In the experiment, the researchers used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Name: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsName: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of N-Boc-1,6-DiaminohexaneIn 2020 ,《Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers》 appeared in Journal of Medicinal Chemistry. The author of the article were Cao, Chaoguo; Yang, Jie; Chen, Yong; Zhou, Peiting; Wang, Yingwei; Du, Wu; Zhao, Lifeng; Chen, Yuanwei. The article conveys some information:

The nuclear protein poly(ADP-ribose) polymerase-1 (PARP1) has a well-established role in the signaling and repair of DNA and is a validated therapeutic target for cancers and other human diseases. Here, we have designed, synthesized, and evaluated a series of small-mol. PARP1 degraders based on the proteolysis-targeting chimera (PROTAC) concept. Our efforts have led to the discovery of highly potent PARP1 degraders, as exemplified by compound 18 (SK-575). SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations SK-575 achieves durable tumor growth inhibition in mice when used as a single agent or in combination with cytotoxic agents, such as temozolomide and cisplatin. These data demonstrate that SK-575 is a highly potent and efficacious PARP1 degrader. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application In Synthesis of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsApplication In Synthesis of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Li, Steven A.; Cadelis, Melissa M.; Deed, Rebecca C.; Douafer, Hana; Bourguet-Kondracki, Marie-Lise; Michel Brunel, Jean; Copp, Brent R. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Valorisation of the diterpene podocarpic acid – Antibiotic and antibiotic enhancing activities of polyamine conjugates》.Reference of N-Boc-1,6-Diaminohexane The author mentioned the following in the article:

As part of our search for new antimicrobials and antibiotic adjuvants, a series of podocarpic acid-polyamine conjugates have been synthesized. The library of compounds made use of the phenolic and carboxylic acid moieties of the diterpene allowing attachment of polyamines (PA) of different lengths to afford a structurally-diverse set of analogs. Evaluation of the conjugates for intrinsic antimicrobial properties identified two derivatives of interest: a PA3-4-3 (spermine) amide-bonded variant 7a that was a non-cytotoxic, non-hemolytic potent growth inhibitor of Gram-pos. Staphylococcus aureus (MRSA) and 9d, a PA3-8-3 carbamate derivative that was a non-toxic selective antifungal towards Cryptococcus neoformans. Of the compound set, only one example exhibited activity towards Gram-neg. bacteria. However, in the presence of sub-therapeutic amounts of either doxycycline (4.5 μM) or erythromycin (2.7 μM) several analogs were observed to exhibit weak to modest antibiotic adjuvant properties against Pseudomonas aeruginosa and/or Escherichia coli. The observation of strong cytotoxicity and/or hemolytic properties for subsets of the library, in particular those analogs bearing Me ester or n-pentylamide functionality, highlighted the fine balance of structural requirements and lipophilicity for antimicrobial activity as opposed to mammalian cell toxicity. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Reference of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Reference of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 51857-17-1In 2021 ,《A PROTAC targets splicing factor 3B1》 appeared in Cell Chemical Biology. The author of the article were Gama-Brambila, Rodrigo A.; Chen, Jie; Zhou, Jun; Tascher, Georg; Muench, Christian; Cheng, Xinlai. The article conveys some information:

The proteolysis-targeting chimeras (PROTACs) are a new technol. to degrade target proteins. However, their clin. application is limited currently by lack of chem. binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs. We recently identified a 2-aminothiazole derivative (herein O4I2) as a promoter in the generation of human pluripotent stem cells. In this work, proteomic anal. on the biotinylated O4I2 revealed that O4I2 targeted SF3B1 and pos. regulated RNA splicing. Fusing thalidomide-the ligand of the cereblon ubiquitin ligase-to O4I2 led to a new PROTAC-O4I2, which selectively degraded SF3B1 and induced cellular apoptosis in a CRBN-dependent manner. In a Drosophila intestinal tumor model, PROTAC-O4I2 increased survival by interference with the maintenance and proliferation of stem cell. Thus, our finding demonstrates that SF3B1 is PROTACable by utilizing noninhibitory chems., which expands the list of PROTAC target proteins. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Product Details of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Fluorescent H2 Receptor Squaramide-Type Antagonists: Synthesis, Characterization, and Applications》 was written by Biselli, Sabrina; Alencastre, Ines; Tropmann, Katharina; Erdmann, Daniela; Chen, Mengya; Littmann, Timo; Maia, Andre F.; Gomez-Lazaro, Maria; Tanaka, Miho; Ozawa, Takeaki; Keller, Max; Lamghari, Meriem; Buschauer, Armin; Bernhardt, Guenther. Safety of N-Boc-1,6-Diaminohexane And the article was included in ACS Medicinal Chemistry Letters in 2020. The article conveys some information:

Fluorescence labeled ligands have been gaining importance as mol. tools, enabling receptor-ligand-binding studies by various fluorescence-based techniques. Aiming at red-emitting fluorescent ligands for the hH2R, a series of squaramides labeled with pyridinium or cyanine fluorophores (19-27) was synthesized and characterized. The highest hH2R affinities in radioligand competition binding assays were obtained in the case of pyridinium labeled antagonists 19-21 (pKi: 7.71-7.76) and cyanine labeled antagonists 23 and 25 (pKi: 7.67, 7.11). These fluorescent ligands proved to be useful tools for binding studies (saturation and competition binding as well as kinetic experiments), using confocal microscopy, flow cytometry, and high content imaging. Saturation binding experiments revealed pKd values comparable to the pKi values. The fluorescent probes 21, 23, and 25 could be used to localize H2 receptors in HEK cells and to determine the binding affinities of unlabeled compounds In the experiment, the researchers used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of N-Boc-1,6-DiaminohexaneIn 2021 ,《Label-free detection of target proteins using peptide molecular wires as conductive supports》 was published in Sensors and Actuators, B: Chemical. The article was written by Puiu, Mihaela; Zamfir, Lucian-Gabriel; Danila, George Madalin; Papi, Francesco; Nativi, Cristina; Mirceski, Valentin; Bala, Camelia. The article contains the following contents:

We report on the electrochem. of a peptide mol. wire as a conductive support for ligand immobilization in biosensing assays. The helical 9-mer peptide, tagged at Nterminus with Methylene Blue (MB) and thiol-functionalized at Cterminus was anchored on a gold surface via gold/thiol chem. The helical peptide acts as mol. wire, mediating the two-step electron transfer (ET) from MB to the gold surface. The forward and backward square wave voltametric (SWV) components recorded in the presence of peptide wire were used to estimate the kinetic parameters of the electrode reaction. The simulated data matched the exptl. ones for the two-step sequential surface mechanism (EE), with the rate constant of the first step ksur,1 = 20 s-1 and the cathodic ET coefficient α1 = 0.55. The kinetic parameters of the second step were ksur,2 > 1000 s-1, and α2 = 0.5. Small ligands for high-mol. weight targets can be grafted on the peptide wire between the MB tag and the surface through covalent bonding. The binding of the target to the peptide-anchored ligand hampers the ET transfer from MB to the electrode surface, causing a decrease of the peak current. These findings were used further to develop an electrochem. peptide-based biosensor with signaling-off interrogation. The biosensor was tested against two relevant targets for medical diagnosis: the anti-tumor-associated carbohydrate antigen (α-Tn) antibody and the growth hormone secretagogue receptor (GHS-R1a), after ligand grafting. Both targets were detected in the nanomolar range with an overall assay time of 10 min. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application In Synthesis of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Application In Synthesis of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scheiner, Matthias; Hoffmann, Matthias; He, Feng; Poeta, Eleonora; Chatonnet, Arnaud; Monti, Barbara; Maurice, Tangui; Decker, Michael published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer’s Disease Mouse Model》.Quality Control of N-Boc-1,6-Diaminohexane The article contains the following contents:

A series of multitarget-directed ligands (MTDLs) was designed by functionalizing a pseudo-irreversible butyrylcholinesterase (BChE) inhibitor. The obtained hybrids were investigated in vitro regarding their hBChE and hAChE inhibition, their enzyme kinetics, and their antioxidant physicochem. properties (DPPH, ORAC, metal chelating). In addition, in vitro assays were applied to investigate antioxidant effects using murine hippocampal HT22 cells and immunomodulatory effects on the murine microglial N9 cell line. The MTDLs retained their antioxidative properties compared to the parent antioxidant-moieties in vitro and the inhibition of hBChE was maintained in the submicromolar range. Representative compounds were tested in a pharmacol. Alzheimer’s disease (AD) mouse model and demonstrated very high efficacy at doses as low as 0.1 mg/kg. The most promising compound was also tested in BChE-/- mice and showed reduced efficacy. In vivo neuroprotection by BChE inhibition can be effectively enhanced by incorporation of structurally diverse antioxidant moieties. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Quality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics