Category: 51857-17-1

In 2022,Li, Yachao; Shen, Cheng; Liang, Xiaoyu; Deng, Kefurong; Zeng, Zenan; Xu, Xianghui published an article in Biomaterials Science. The title of the article was 《Dynamic-responsive virus-mimetic nanocapsules facilitate protein drug penetration and extracellular-specific unpacking for antitumor treatment》.Recommanded Product: 51857-17-1 The author mentioned the following in the article:

Protein-based drugs have been demonstrating great potential for the treatment of various diseases, but most of them encounter many difficulties in clin. trials or uses, such as instability, low bioavailability, and poor in vivo efficacy. In this work, we developed virus-mimetic nanocapsules (VMNs) for improving protein systemic delivery and pharmaceutical effects through bioinspired macromol. and supramol. engineering. These VMNs possessed hierarchical nanostructures including artificial capsids, encapsulated proteins, and synthetic envelopes. These dynamic-responsive VMNs can harbor protein drugs, resist protein adsorption, target solid tumors, penetrate into deep tissue, and site-specifically unpack protein drugs. Through surmounting the sequential physio-pathol. barriers, protein-loaded VMNs successfully maximized the in vitro and in vivo therapeutic efficacy of proteins, giving a promising strategy to address dilemmas on clin. TRAIL therapy. This study is expected to promote in vivo treatment outcomes and clin. transformation of protein drugs. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: 51857-17-1) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Recommanded Product: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formula: C11H24N2O2In 2020 ,《Impact of amino acids on the aqueous self-assembly of benzene trispeptides into supramolecular polymer bottle brushes》 was published in Polymer Chemistry. The article was written by Klein, Tobias; Ulrich, Hans F.; Gruschwitz, Franka V.; Kuchenbrod, Maren T.; Takahashi, Rintaro; Fujii, Shota; Hoeppener, Stephanie; Nischang, Ivo; Sakurai, Kazuo; Brendel, Johannes C.. The article contains the following contents:

In contrast to covalent polymer brushes, directional supramol. forces such as hydrogen bonds or π-π-interactions govern the formation of supramol. polymer bottle brushes (SPBs) in a self-assembly process starting from single polymer building units. In an attempt to broaden our understanding of these processes and the required supramol. forces, we here investigated the benzene trispeptide (BTP) motif to self-assemble polyethylene oxide (PEO) chains into SPBs in water. For this purpose, we synthesized a library of BTP-PEO conjugates, in which we varied the amino acid unit (alanine vs. leucine vs. phenylalanine), the hydrophobic spacer (C6 vs.C12), and the steric hindrance imposed by PEO (2 vs. 5 vs. 10 kg mol-1, one vs. three polymer chains). In particular, the type of amino acid was hypothesized to have a crucial influence on the final morphol. A detailed characterization of the resp. solutions revealed that for the C6 spacer and one PEO2k chain, only phenylalanine containing core units formed the desirable SPBs, while in the other cases only spherical micelles (leucine) or barely any aggregation (alanine) was observed In contrast, the more hydrophobic C12 spacer resulted in an exclusive formation of SPBs, whereas the choice of the amino acid moiety had a minor influence on the observed morphol. Increasing the steric hindrance finally resulted in a transition from cylindrical toward spherical micelles. The broad structural variety offered by the choice of amino acids not only allows for an excellent control of the solution morphologies but also the potential integration of functional units to the core. In the experiment, the researchers used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Formula: C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Formula: C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Integration of [12]aneN3 and Acenaphtho[1,2-b]quinoxaline as non-viral gene vectors with two-photon property for enhanced DNA/siRNA delivery and bioimagingã€?was written by Liu, Jin-Yu; Liu, Xu-Ying; Liu, Rui; Tang, Fang; Yang, Jing-Bo; Tang, Quan; Lu, Zhong-Lin; Qiao, Hai-Jun; He, Lan. Recommanded Product: N-Boc-1,6-Diaminohexane And the article was included in Bioorganic Chemistry in 2021. The article conveys some information:

Two-photon fluorescent Acenaphtho[1,2-b]quinoxaline (ANQ) and the hydrophilic di-(triazole-[12]aneN3) moieties were combined through an alkyl chain (ANQ-A-M) or a β-hairpin motif with two aromatic γ-amino acid residues (ANQ-H-M) to explore their capabilities for in vitro and in vivo gene delivery and tracing. ANQ-A-M and ANQ-H-M showed the same maximum absorption at 420 nm, and their fluorescent intensities around 650 nm were varied in different solvents and became poor in the protic solvents. Gel electrophoresis assays indicated that both compounds completely retarded the migration of pDNA at 20 μM in the presence of DOPE. However, the DNA condensation with ANQ-H-M was not reversible, and the particle size of the corresponding complexes were larger indicated from the SEM and DLS measurements. In vitro transfections indicated ANQ-A-M/DOPE achieved Luciferase and GFP expressions were to be 7.9- and 5.7-fold of those by Lipo2000 in A549 cells resp. However, ANQ-H-M showed very poor transfection efficiency in Luciferase expression. With the help of single/two-photon fluorescence imaging it clearly demonstrated that the successful transfection of ANQ-A-M was attributed to its cellular uptake, apparent lysosomal escape, and reversible release of DNA; and the poor transfection of ANQ-H-M was resulted from the aggregation of the DNA complexes which prevented them from the cellular uptake, and also the strong binding ability which is not easy to release DNA. ANQ-A-M/DOPE also exhibited robust gene silencing (83% knockdown of Luciferase) and GFP expression (2.47-fold higher) efficiency compared with Lipo2000 in A549 and zebrafish, resp. The work demonstrated that the linkage structure between fluorescent and di(triazole-[12]aneN3) played the important role for their gene delivery performance, and that ANQ-A-M represents a vector with the strong transfection efficiency in vitro and in vivo as well as the efficient real time bioimaging properties, which is potential for the development in biomedical research. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Recommanded Product: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 51857-17-1In 2022 ,《Synthesis of novel reactive disperse dyes comprising carbamate and cyanuric chloride groups for dyeing polyamide and cotton fabrics in supercritical carbon dioxideã€?appeared in Dyes and Pigments. The author of the article were Penthala, Raju; Oh, Hyeon; Park, Si Hyeong; Lee, In Yeol; Ko, Eun Hee; Son, Young-A.. The article conveys some information:

Two types of novel reactive disperse dyes comprising carbamates (CNU-6A, CNU-6B and CNU-6C) and cyanuric chloride (CNU-8A, CNU-8B and CNU-8C) reactive functional groups were designed and synthesized from the anthraquinone parent body. The structures of these synthesized reactive disperse dyes have been defined by IR, 1H NMR, 13C NMR, HRMS and UV-Vis spectroscopy. Further, the dyeing experiments were performed on polyamide and cotton fabrics in supercritical carbon dioxide conditions with the 0.5% (owf) of dye concentration, at 25 MPa (pressure), and 120°C (temperature) for 1 h. A significant improvement in the color strength and dye fixation efficiency has been observed for the carbamate reactive disperse dyes. This is due to the formation of a covalent bond between the carbamate functional group and the amine (-NH) and hydroxy (-OH) group of the fabrics. Besides, the dyed fabrics displayed favorable fastness (wash, crocking, light and sweat) properties indicating that the synthesized dyes meet the garment dyeing standards In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Product Details of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Raja, Sebastian; Hamouda, Ahmed E. I.; de Toledo, Marcelo A. S.; Hu, Chaolei; Bernardo, Marcela P.; Schalla, Carmen; Leite, Liliane S. F.; Buhl, Eva Miriam; Dreschers, Stephan; Pich, Andrij; Zenke, Martin; Mattoso, Luiz H. C.; Sechi, Antonio published their research in Biomacromolecules in 2021. The article was titled 《Functionalized Cellulose Nanocrystals for Cellular Labeling and Bioimagingã€?Formula: C11H24N2O2 The article contains the following contents:

Cellulose nanocrystals (CNCs) are unique and promising natural nanomaterials that can be extracted from native cellulose fibers by acid hydrolysis. In this study, we developed chem. modified CNC derivatives by covalent tethering of PEGylated biotin and perylenediimide (PDI)-based near-IR organic dye and evaluated their suitability for labeling and imaging of different cell lines including J774A.1 macrophages, NIH-3T3 fibroblasts, HeLa adenocarcinoma cells, and primary murine dendritic cells. PDI-labeled CNCs showed a superior photostability compared to similar com. available dyes under long periods of constant and high-intensity illumination. All CNC derivatives displayed excellent cytocompatibility toward all cell types and efficiently labeled cells in a dose-dependent manner. Moreover, CNCs were effectively internalized and localized in the cytoplasm around perinuclear areas. Thus, our findings demonstrate the suitability of these new CNC derivatives for labeling, imaging, and long-time tracking of a variety of cell lines and primary cells. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Formula: C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Formula: C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Bo; Zhang, Xinyue; Wen, Xinyi; Liu, Qi; Ma, Hua; Guo, Weihua; Tan, Mingqian; Jia, Lei; Yuan, Jingli published an article in 2021. The article was titled 《Development of a tumor-targetable heteropolymetallic lanthanide-complex-based magnetoluminescent probe for dual-modal time-gated luminescence/magnetic resonance imaging of cancer cells in vitro and in vivo》, and you may find the article in New Journal of Chemistry.Product Details of 51857-17-1 The information in the text is summarized as follows:

Probes combining luminescence and magnetic resonance (MR) imaging activities have attracted tremendous attention since they can offer both mol. and anatomical information to effectively improve the accuracy of detection. In this work, a β-diketone ligand (CDHH) was modified by covalent conjugation with an MRI contrast agent (DO3A-Gd) and a tumor-targetable biomacromol. transferrin (Tf). When Eu3+ ions were added into the mixture of two functionalized β-diketone ligands, they triggered a self-assembly to form a heteropolymetallic lanthanide complex that was conjugated to Tf. The as-prepared bioconjugate, i.e., Tf-Eu-Gd, exhibited intense long-lived luminescence (ϕ = 0.20, τ = 0.34 ms), remarkably high MR relaxivities (r1 = 9.18 mM-1 s-1 and r2 = 12.03 mM-1 s-1), as well as good water solubility, stability, and biocompatibility. Time-gated luminescence (TGL) imaging of live cells using Tf-Eu-Gd as a probe demonstrated that the probe can distinguish Tf-receptor-overexpressed cancerous cells, which enables the probe to be specifically accumulated in these cells. On the basis of magnetoluminescent properties of Tf-Eu-Gd, it was further used as a bimodal probe for both TGL and MR imaging of cancerous cells in tumor-bearing nude mice. The results indicated that Tf-Eu-Gd could significantly increase the T1-weighted MRI contrast value in the tumor region, and the TGL imaging of tumor tissue sections provided clear histol. validation of the MRI signals. The research outcomes revealed the feasibility of Tf-Eu-Gd for the tracing and precise detection of cancerous cells, which suggested its potential for serving to the clin. diagnosis, therapy, and medical research of tumor diseases. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Product Details of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Rita Neves, Ana; Vilas Boas, Catia; Goncalves, Catarina; Vasconcelos, Vitor; Pinto, Madalena; Silva, Elisabete R.; Sousa, Emilia; Almeida, Joana R.; Correia-da-Silva, Marta published an article in Bioorganic Chemistry. The title of the article was 《Gallic acid derivatives as inhibitors of mussel (Mytilus galloprovincialis) larval settlement: Lead optimization, biological evaluation and use in antifouling coatings》.Safety of N-Boc-1,6-Diaminohexane The author mentioned the following in the article:

The addition of biocides to marine coatings has been the most used solution to avoid marine biofouling, however they are persistent, bioaccumulative, and toxic (PBT) to marine ecosystems. The development of natural products or Nature-inspired synthetic compounds to replace these harmfull biocides has been pursued as one of the most promising antifouling (AF) alternatives. Following a bioprospection strategy, we have previously reported the AF activity of gallic acid persulfate (1) against the settlement of Mytilus galloprovincialis larvae (EC50 = 18 μM and LC50/EC50 = 27) without exhibiting ecotoxicity to Artemia salina. In this work, a lead optimization strategy was applied to compound gallic acid persulfate in order to improve potency while maintaining a low ecotoxicity profile. In this direction, twenty-seven compounds were synthesized, from which eighteen were obtained for the first time. An AF screening was performed against the settlement of mussel M. galloprovincialis larvae and 2-(3,4,5-trihydroxybenzamido)ethan-1-aminium bromide, was found to be more potent (EC50 = 3 μM and LC50/EC50 = 73) than compound 1 and the biocide Econea (EC50 = 4 μM). The potential impact on neurotransmission, and ecotoxicity against two non-target marine organisms was also evaluated. Marine polyurethane (PU)-based coatings containing compound 2-(3,4,5-Trihydroxybenzamido)ethan-1-aminium bromide were prepared and lower adherence of mussel larvae was observed compared to compound 2-(3,4,5-Trihydroxybenzamido)ethan-1-aminium bromide free PU-coatings. Studies concerning the leaching of compound 2-(3,4,5-Trihydroxybenzamido)ethan-1-aminium bromide from the prepared coating were also conducted, and < 10% of this compound was detected after 45 days of submersion in water. Overall, we have optimized the potency against the settlement of mussels of our initial lead compound, not compromising the toxicity and compatibility with PU-based coatings. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C11H24N2O2In 2020 ,《Peptoid-based siderophore mimics as dinuclear Fe3+ chelators》 was published in Dalton Transactions. The article was written by D’Amato, Assunta; Ghosh, Pritam; Costabile, Chiara; Della Sala, Giorgio; Izzo, Irene; Maayan, Galia; De Riccardis, Francesco. The article contains the following contents:

A practical synthesis of preorganized tripodal enterobactin/corynebactin-type ligands (consisting of a C3-sym. macrocyclic peptoid core, three catecholamide coordinating units, and C2, C4, and C6 spacers) is reported. The formation of complexes with Fe3+ was investigated by spectrophotometric (UV-Vis) and spectrometric (ESI, neg. ionization mode) methods and corroborated by theor. (DFT) calculations Preliminary studies revealed the intricate interplay between the conformational chirality of cyclic trimeric peptoids and metal coordination geometry of mononuclear species similar to that of natural catechol-based siderophores. Exptl. results demonstrated the unexpected formation of unique dinuclear Fe3+ complexes. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Electric Literature of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Electric Literature of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Perrone, Maria Grazia; Vitale, Paola; Miciaccia, Morena; Ferorelli, Savina; Centonze, Antonella; Solidoro, Roberta; Munzone, Cristina; Bonaccorso, Carmela; Fortuna, Cosimo Gianluca; Kleinmanns, Katrin; Bjoerge, Line; Scilimati, Antonio published an article in Pharmaceuticals. The title of the article was 《Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes》.Name: N-Boc-1,6-Diaminohexane The author mentioned the following in the article:

The identification and removal of all gross and microscopic tumor to render the patient disease free represents a huge challenge in ovarian cancer treatment. The presence of residual disease is an independent neg. prognostic factor. Herein, we describe the synthesis and the “”in vitro”” evaluation of compounds as cyclooxygenase (COX)-1 inhibitors, the COX-1 isoform being an ovarian cancer biomarker, each bearing fluorochromes with different fluorescence features. Two of these compounds N-[4-(9-dimethylimino-9H-benzo[a]phenoxazin-5-ylamino) butyl]-2-(3,4-bis(4-methoxyphenyl)isoxazol-5-yl)acetamide chloride (RR11) and 3-(6-(4-(2-(3,4-bis(4-methoxyphenyl)isoxazole-5-yl)acetamido)butyl)amino-6-oxohexyl)-2-[7-(1,3-dihydro-1,1-dimethyl-3-Et 2H-benz[e]indolin-2-yl-idene)-1,3,5-heptatrienyl]-1,1-dimethyl-3-(6-carboxilato-hexyl)-1H-benz[e]indolium chloride, 23 (MSA14) were found to be potent and selective inhibitors of cyclooxygenase (COX)-1 “”in vitro””, and thus were further investigated “”in vivo””. The IC50 values were 0.032 and 0.087 μM for RR11 and 23 (MSA 14), resp., whereas the COX-2 IC50 for RR11 is 2.4 μM while 23 (MSA14) did not inhibit COX-2 even at a 50 μM concentration Together, this represented selectivity index = 75 and 874, resp. Structure-based virtual screening (SBVS) performed with the Fingerprints for Ligands and Proteins (FLAP) software allowed both to differentiate highly active compounds from less active and inactive structures and to define their interactions inside the substrate-binding cavity of hCOX1. Fluorescent probes RR11 and 23 (MSA14), were used for preliminary near-IR (NIR) fluorescent imaging (FLI) in human ovarian cancer (OVCAR-3 and SKOV-3) xenograft models. Surprisingly, a tumor-specific signal was observed for both tested fluorescent probes, even though this signal is not linked to the presence of COX-1.N-Boc-1,6-Diaminohexane(cas: 51857-17-1Name: N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsName: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cokca, Ceren; Hack, Franz J.; Costabel, Daniel; Herwig, Kira; Huelsmann, Juliana; Then, Patrick; Heintzmann, Rainer; Fischer, Dagmar; Peneva, Kalina published an article in 2021. The article was titled 《PEGylation of Guanidinium and Indole Bearing Poly(methacrylamide)s – Biocompatible Terpolymers for pDNA Delivery》, and you may find the article in Macromolecular Bioscience.Quality Control of N-Boc-1,6-Diaminohexane The information in the text is summarized as follows:

This study describes the first example for shielding of a high performing terpolymer that consists of N-(2-hydroxypropyl)methacrylamide (HPMA), N-(3-guanidinopropyl)methacrylamide (GPMA), and N-(2-indolethyl)methacrylamide monomers (IEMA) by block copolymerization of a polyethylene glycol derivative – poly(nona(ethylene glycol)methyl ether methacrylate) (P(MEO9MA)) via reversible addition-fragmentation chain transfer (RAFT) polymerization The mol. weight of P(MEO9MA) is varied from 3 to 40 kg mol-1 while the comonomer content of HPMA, GPMA, and IEMA is kept comparable. The influence of P(MEO9MA) block with various mol. weights is investigated over cytotoxicity, plasmid DNA (pDNA) binding, and transfection efficiency of the resulting polyplexes. Overall, the increase in mol. weight of P(MEO9MA) block demonstrates excellent biocompatibility with higher cell viability in L-929 cells and an efficient binding to pDNA at N/P ratio of 2. The significant transfection efficiency in CHO-K1 cells at N/P ratio 20 is obtained for block copolymers with mol. weight of P(MEO9MA) up to 10 kg mol-1. Moreover, a fluorescently labeled analog of P(MEO9MA), bearing perylene monoimide methacrylamide (PMIM), is introduced as a comonomer in RAFT polymerization Polyplexes consisting of labeled block copolymer with 20 kg mol-1 of P(MEO9MA) and pDNA are incubated in Hela cells and investigated through structured illumination microscopy (SIM).N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Quality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics