Category: 51857-17-1

《PET probe with Aggregation Induced Emission characteristics for the specific turn-on of aromataseã€?was written by Wu, Renbo; Liu, Song; Liu, Yajing; Sun, Yuli; Xiao, Hao; Huang, Yong; Yang, Zequn; Wu, Zehui. Application of 51857-17-1 And the article was included in Talanta in 2020. The article conveys some information:

Aromatase is an attractive target for the diagnosis and treatment of breast cancer. To combine the anti-photobleaching properties of Aggregation Induced Emission (AIE) with the high sensitivity and whole-body imaging characteristics of positron emission tomog. (PET), the authors designed a bifunctional complexing agent with AIE characteristics by modifying the structure of tetraphenylethene, which is linked with triazole derivatives capable of complexing with naTGA3+/68Ga3+ to obtain [natGa/68Ga] 2 for targeting the aromatase. [natGa] 2 has typical AIE characteristics, which can form uniform nanomicelles above the critical micelle concentration, and illuminate estrogen receptor (+) MCF-7 cells. [natGa] 2 itself is almost nonemissive in PBS buffer solution, but it turns on its fluorescence upon interaction with human aromatase, with a detection limit of 0.15μg/mL [68Ga] 2 is easy to prepare and has high stability. Compared to the estrogen receptor that is neg. expressed by MDA-MB-231 cells, MCF-7 cells pos. expressing estrogen have a higher uptake of [naTGA] 2. The distribution of aromatase in a tumor can be co-localized by using [68Ga] 2. These results can be used to effectively assess estrogen receptor status and aromatase levels at the cellular level. The authors anticipate that this research could provide a new strategy for the fabrication of PET probes with AIE characteristics, providing useful probes for PET- FL (Fluorescence imaging) bimodal imaging. In the experiment, the researchers used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsApplication of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer》 was written by Amedei, Amedeo; Asadzadeh, Fatemeh; Papi, Francesco; Vannucchi, Maria Giuliana; Ferrucci, Veronica; Bermejo, Iris A.; Fragai, Marco; De Almeida, Carolina Vieira; Cerofolini, Linda; Giuntini, Stefano; Bombaci, Mauro; Pesce, Elisa; Niccolai, Elena; Natali, Francesca; Guarini, Eleonora; Gabel, Frank; Traini, Chiara; Catarinicchia, Stefano; Ricci, Federica; Orzalesi, Lorenzo; Berti, Francesco; Corzana, Francisco; Zollo, Massimo; Grifantini, Renata; Nativi, Cristina. Related Products of 51857-17-1 And the article was included in iScience in 2020. The article conveys some information:

The Tn antigen is a well-known tumor-associated carbohydrate determinant, often incorporated in glycopeptides to develop cancer vaccines. Herein, four copies of a conformationally constrained mimetic of the antigen TnThr (GalNAc-Thr) were conjugated to the adjuvant CRM197, a protein licensed for human use. The resulting vaccine candidate, mime[4]CRM elicited a robust immune response in a triple-neg. breast cancer mouse model, correlated with high frequency of CD4+ T cells and low frequency of M2-type macrophages, which reduces tumor progression and lung metastasis growth. Mime[4]CRM-mediated activation of human dendritic cells is reported, and the proliferation of mime[4]CRM-specific T cells, in cancer tissue and peripheral blood of patients with breast cancer, is demonstrated. The locked conformation of the TnThr mimetic and a proper presentation on the surface of CRM197 may explain the binding of the conjugate to the anti-Tn antibody Tn218 and its efficacy to fight cancer cells in mice. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Related Products of 51857-17-1) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRelated Products of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Verona, Marco; Rubagotti, Sara; Croci, Stefania; Sarpaki, Sophia; Borgna, Francesca; Tosato, Marianna; Vettorato, Elisa; Marzaro, Giovanni; Mastrotto, Francesca; Asti, Mattia published an article in 2021. The article was titled 《Preliminary study of a 1,5-benzodiazepine-derivative labelled with indium-111 for CCK-2 receptor targeting》, and you may find the article in Molecules.Recommanded Product: 51857-17-1 The information in the text is summarized as follows:

A nastorazepide-based ligand functionalized with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator (IP-001) was synthesized and labeled with indium-111. The radiolabeling process yielded >95% with a molar activity of 10 MBq/nmol and a radiochem. purity of >98%. Stability studies showed a remarkable resistance to degradation (>93%) within 120 h of incubation in human blood. The in-vitro uptake of [111In]In-IP-001 was assessed for up to 24 h on a high CCK-2R-expressing tumor cell line (A549) showing maximal accumulation after 4 h of incubation. Biodistribution and single photon emission tomog. (SPECT)/CT imaging were evaluated on BALB/c nude mice bearing A549 xenograft tumors. Implanted tumors were clearly visualized after only 4 h post injection (2.36 ± 0.26% ID/cc), although a high amount of radiotracer was also found in the liver, kidneys, and spleen (8.25 ± 2.21%, 6.99 ± 0.97%, and 3.88 ± 0.36% ID/cc, resp.). Clearance was slow by both hepatobiliary and renal excretion. Tumor retention persisted for up to 24 h, with the tumor to organs ratio increasing over-time and ending with a tumor uptake (1.52 ± 0.71% ID/cc) comparable to liver and kidneys. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRecommanded Product: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Modular Design of Stimuli-Responsive Supramolecular Nanocarriers Based on Pro-Guest Strategy》 was published in ChemNanoMat in 2020. These research results belong to Mao, Weipeng; Yang, Xuan; Ma, Da. Quality Control of N-Boc-1,6-Diaminohexane The article mentions the following:

High affinity host-guest interactions were used to assemble supramol. nanocarriers, and controlled release cargo based on a “”pro-guest”” strategy. Supramol. nanocarriers were prepared by modular design, which were responsive to photo-irradiation or reducing agents. Model cargo nile red was stably encapsulated by nanocarriers in water, and released when photo-irradiation or reducing agent was applied. Cargo release rate was tunable by using different pro-guests for photo-responsive nanocarriers. A mechanistic study was carried out to confirm a cascade process of stimuli-responsive pro-guest degradation and competitive displacement. Supramol. nanocarriers were able to deliver model cargo to the cell cytoplasm. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Quality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wannian; Zhang, Ming-Yuan; Wang, Kai; Sun, Ruixia; Zhao, Shanlin; Zhang, Zhiqiang; He, Yu-Peng; Yu, Fang published their research in RSC Advances in 2021. The article was titled 《Geometry transformation of ionic surfactants and adsorption behavior on water/n-decane-interface: calculation by molecular dynamics simulation and DFT study》.HPLC of Formula: 51857-17-1 The article contains the following contents:

Understanding the effect of surfactant structure on their ability to modify interfacial properties is of great scientific and industrial interest. In this work, we have synthesized four amide based ionic surfactants under acidic or basic conditions, including CTHA·HCl, CTEA·HCl, CTHA-Na+ and CTEA-Na+. Experiments have proved that the anionic surfactant with polyethylene oxide groups (CTEA-Na+) had the lowest surface tension on the water/n-decane interface. Mol. dynamics simulations have been applied to investigate the structural effect on the adsorption behavior of four different surfactants. The surface tension, interface thickness, interface formation energy, d. profiles, order parameters, radial distribution function on the water/n-decane interfaces were calculated and compared. During the equilibrium states, we found that the interface configuration of two cationic surfactants are almost linear while the two anionic surfactants are changed to bending shapes due to the different positions of the hydrophilic head groups. Further DFT study and wavefunction anal. of surfactants have shown that CTEA-Na+ can form stronger vdW interactions with n-decane mols. due to a more neutral electrostatic potential distribution. Meanwhile, the introduction of polyethylene oxide groups has offered more H-bonding sites and resulted in more concentrated H-bonding interactions with water mols. The difference of weak interactions may contribute to the conformational change and finally affect the interface properties of these ionic surfactants.N-Boc-1,6-Diaminohexane(cas: 51857-17-1HPLC of Formula: 51857-17-1) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.HPLC of Formula: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xinyi; Chen, Junfeng; Alghoraibi, Nawal M.; Henckel, Danielle A.; Zhang, Ruixian; Nwabara, Uzoma O.; Madsen, Kenneth E.; Kenis, Paul J. A.; Zimmerman, Steven C.; Gewirth, Andrew A. published an article in 2021. The article was titled 《Electrochemical CO2-to-ethylene conversion on polyamine-incorporated Cu electrodes》, and you may find the article in Nature Catalysis.Recommanded Product: 51857-17-1 The information in the text is summarized as follows:

Electrochem. conversion of CO2 into value-added chems. holds promise to enable the transition to carbon neutrality. Enhancing selectivity for a specific hydrocarbon product is challenging, however, due to numerous possible reaction pathways of CO2 electroreduction Here we present a Cu-polyamine hybrid catalyst, developed through co-electroplating, that significantly increases the selectivity for ethylene production The Faradaic efficiency for ethylene production is 87% ± 3% at -0.47 V vs. reversible hydrogen electrode, with full-cell energetic efficiency reaching 50% ± 2%. Raman measurements indicate that the polyamine entrained on the Cu electrode results in higher surface pH, higher CO content and higher stabilization of intermediates compared with entrainment of additives containing little or no amine functionality. More broadly, this work shows that polymer incorporation can alter surface reactivity and lead to enhanced product selectivity at high current densities. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRecommanded Product: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of N-Boc-1,6-DiaminohexaneIn 2020 ,《One-pot thiol-amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation》 was published in Chemical Science. The article was written by Wall, Archie; Wills, Alfie G.; Forte, Nafsika; Bahou, Calise; Bonin, Lisa; Nicholls, Karl; Ma, Michelle T.; Chudasama, Vijay; Baker, James R.. The article contains the following contents:

Maleimide chem. is widely used in the site-selective modification of proteins. However, hydrolysis of the resultant thiosuccinimides is required to provide robust stability to the bioconjugates. Herein, we present an alternative approach that affords simultaneous stabilization and dual functionalisation in a one pot fashion. By consecutive conjugation of a thiol and an amine to dibromomaleimides, we show that aminothiomaleimides can be generated extremely efficiently. Furthermore, the amine serves to deactivate the electrophilicity of the maleimide, precluding further reactivity and hence generating stable conjugates. We have applied this conjugation strategy to peptides and proteins to generate stabilized trifunctional conjugates. We propose that this stabilization-dual modification strategy could have widespread use in the generation of diverse conjugates. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Quality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Targeted degradation of CD147 proteins in melanoma》 was published in Bioorganic Chemistry in 2020. These research results belong to Zhou, Zhe; Long, Jing; Wang, Yuan; Li, Ya Yun; Zhang, Xu; Tang, Ling; Chang, Qi; Chen, Zhuo; Hu, Gao Yun; Hu, Shuo; Li, Qian Bin; Peng, Cong; Chen, Xiang. Formula: C11H24N2O2 The article mentions the following:

CD147 is a transmembrane glycoprotein and a member of Ig superfamily, is strongly expressed in melanoma cells. CD147 has a pivotal role in tumor development. Therefore, it is a potential drug target for melanoma. In this article, we report the discovery of the first CD147 protein proteolysis targeting chimeras (PROTACs) derived from the natural product pseudolaric acid B (PAB). The representative compound 6a (I) effectively induced degradation of CD147 and inhibited melanoma cells in vitro and in vivo. 6A could be used as the novel type of anticancer agent or as a part of the mol. biol. research toolkit used in the gain-of-function study of the dynamic roles of CD147 in cancer networks. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Formula: C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Formula: C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,White, Dawanna S.; Mongeluzi, Daniel; Curry, Alyson M.; Donu, Dickson; Cen, Yana published an article in RSC Advances. The title of the article was 《Facile synthesis of photoactivatable adenosine analogs》.Recommanded Product: N-Boc-1,6-Diaminohexane The author mentioned the following in the article:

Adenosine and its derivatives are important building blocks of the biol. system. They serve as the universal energy currency, amplify intracellular signals for various signal transduction pathways, and can also be used as the co-substrates for enzymic transformations. The synthesis and regulation of adenosine and its analogs rely on the adenosine binding proteins (ABPs). Dysregulated ABP activity contributes to numerous diseases such as cancer, metabolic disorders, and neurodegenerative diseases. Presently, there is intense interest in targeting ABPs for therapeutic purposes. A large fraction of the human ABP family remains poorly characterized. The need for innovative chem. probes to investigate ABP function in the native biol. matrix is apparent. In this study, an adenosine analog, probe 1, with a photoaffinity group and biotin tag was synthesized using concise synthetic strategies. This probe was able to label and capture individual recombinant ABPs with good target selectivity. Probe 1 was also evaluated for its ability to label spiked ABP in complex cell lysates. This chem. probe, together with the labeling and enrichment assay, is of great value to interrogate the biol. functions of ABPs and to elucidate their diversity under different physiol. conditions. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRecommanded Product: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors》 was published in Scientific Reports in 2020. These research results belong to Ramzy, Lydia; Metwally, Abdelkader A.; Nasr, Maha; Awad, Gehanne A. S.. Application of 51857-17-1 The article mentions the following:

The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanopptn. technique using Eudragit S100 as polymeric shell. Conjugation of anisamide as a targeting ligand for sigma receptors overexpressed by colon cancer cells to Eudragit S100 was carried out via carbodiimide coupling reaction, and was confirmed by thin layer chromatog. and 1H-NMR. TQ nanocapsules were characterized for particle size, surface morphol., zeta potential, entrapment efficiency % (EE%), in vitro drug release and phys. stability. A cytotoxicity study on three colon cancer cell lines (HT-29, HCT-116, Caco-2) was performed. Results revealed that the polymeric nanocapsules were successfully prepared, and the in vitro characterization showed a suitable size, zeta potential, EE% and phys. stability. TQ exhibited a delayed release pattern from the nanocapsules in vitro. Anisamide-targeted TQ nanocapsules showed higher cytotoxicity against HT-29 cells overexpressing sigma receptors compared to their non-targeted counterparts and free TQ after incubation for 48 h, hence delineating anisamide as a promising ligand for active colon cancer targeting. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Application of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics