Category: 51760-21-5

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51760-21-5 as follows. COA of Formula: C10H9BrO4

StepA: Pd0 couplingTo a solution of dimethyl 5-bromo-isophthalate (5.75 g, 21.1 mmol) in THF (50 ml) was added 2- cyanophenylzinc bromide (50.5 ml, 25.3 mmol) followed by tetrakis(triphenylphosphine)palladium (0) (0.122 g, 0.105 mmol). The solution was stirred overnight at 50 C. The next day the solution was cooled, filtered, and concentrated in vacuo. Purification by flash chromatography on silica gel (25% EtOAc in Hexanes) afforded 3.8g. lH NMR (400 MHz, CDCI3) delta 8.41 (d, J = 1.6 Hz, 1H), 7.85-7.80

According to the analysis of related databases, 51760-21-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2006/55434; (2006); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 51760-21-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51760-21-5, name is Dimethyl 5-bromoisophthalate, This compound has unique chemical properties. The synthetic route is as follows.

A (2 g, 11 mmol), B (2 g, 7.4 mmol), CsF (3 g, 15 mmol) and Pd(PPh3)4 (0.2 g, 0.17 mmol) was added to a 250 mE flask. The flask was connected to Schlenk line. 200 mE 1 ,2-Dimethoxyethane was degassed and added through a canula. The flask was equipped with a water condenser and refluxed under the nitrogen for 48 hours. The solution was dried on rotary evaporator. 100 mE H20 was added and then extract with CHC13. The organic phase was evaporated to dryness and purified with chloroform through a short silica gel colunm to yield a light yellow powder 1.56 g. (Yield:62%). ?H NMR (CDC13): oe=3.97 (s, 9H), 7.90 (d, 2H), 8.06 (d, 2H), 8.44 (d, 2H) 8.49 (t, 1H).

The chemical industry reduces the impact on the environment during synthesis Dimethyl 5-bromoisophthalate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Zhou, Hong-Cai; Feng, Dawei; Wang, Kecheng; US2015/152123; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

51760-21-5, A common compound: 51760-21-5, name is Dimethyl 5-bromoisophthalate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

PREPARATION 47 3-bromo-5-(methoxycarbonyl)benzoic acid To a solution of dimethyl 5-bromoisophthalate (2.80 g, 10.25mmols) in methanol (18.5 mL) was added a solution of potassium hydroxide (0.29 g, 5.13mmols) in 3.7 mL of water. The mixture was stirred overnight under reflux. The mixture was partitioned between water and ethyl ether. The aqueous phase was extracted twice with ether. The aqueous was then acidified to acid pH with 5N HCl and was extracted three times with ethyl ether. The combined organics were washed with brine and dried over sodium sulphate. Purification by chromatography (hexane 100% to ethyl acetate 100%) gave 0.700 g (2.70 mmol, 26%) of the title compound. HPLC/MS (10 min) retention time 5.79 min LRMS: m/z 259 (M-1)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 5-bromoisophthalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Almirall, S.A.; EP2394998; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics