Category: 517-23-7

Gao, Ya published the artcileDefluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base, Formula: C6H8O3, the publication is Advanced Synthesis & Catalysis (2022), 364(13), 2241-2247, database is CAplus.

Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols.

Advanced Synthesis & Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Patel, Harshkumar H. published the artcileFormation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers, Safety of 3-Acetyldihydrofuran-2(3H)-one, the publication is Journal of the American Chemical Society (2018), 140(18), 5895-5898, database is CAplus and MEDLINE.

This report details a palladium-catalyzed process to access highly functionalized, optically active allylic aryl ethers. A number of electron-deficient alkenyl triflates underwent enantioselective and site-selective coupling with acyclic aryl enol ethers in the presence of a chiral palladium catalyst. This transform provides chiral allylic ether products in high yields and excellent enantiomeric ratios, furnishing a unique disconnection to incorporate heteroatoms at a stereocenter. Finally, the applicability of the products to target synthesis was demonstrated through the formation of a chiral allylic alc. and the generation of a flavone-inspired product.

Journal of the American Chemical Society published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Safety of 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yuan, Qianjia published the artcileEnantioselective Synthesis of γ-Functionalized Cyclopentenones and β-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy, Quality Control of 517-23-7, the publication is Advanced Synthesis & Catalysis (2020), 362(2), 326-330, database is CAplus and MEDLINE.

In this report, the desymmetrization of cyclic enones under relay Heck conditions with an array of aryl boronic acids, alkenyl triflates and indole derivatives was described. This method granted facile access to diverse γ-functionalized cyclopentenones I [Ar = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, 4-oxocyclopent-2-en-1-yl, etc.] and δ-functionalized cycloheptenones II [R = Ph, 4-CF₃C₆H₄, C(Me):C(Me)CO₂Et, etc.]. Using this approach, a formal synthesis of (S)-baclofen was completed in high yield and excellent enantioselectivity.

Advanced Synthesis & Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C39H35N5O8, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yu, Bao published the artcileSilver(I) Oxide-/DBU-Promoted Synthesis of Dihydrofuran Units through Allenyl Silver Formation, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Chemistry – A European Journal (2020), 26(72), 17455-17461, database is CAplus and MEDLINE.

Herein, a formal [3+2] cyclization mediated by silver(I) oxide and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) was described. Through a broad variety of carbonyl compounds, this system can promote cyclization reactions with high yield (up to 85%) and diastereoselectivity (up to 95:5) for a straightforward access to complex and congested dihydrofuran derivatives in one step under mild conditions. Based on DFT studies, the proposed mechanism would involve an allenyl silver intermediate.

Chemistry – A European Journal published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C4Br2N2O4S, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Jiajun published the artcileTris(4-bromophenyl)aminium Hexachloroantimonate-Mediated Intermolecular C(sp²)-C(sp³) Free Radical Coupling of Vindoline with β-Ketoesters and Related Compounds, SDS of cas: 517-23-7, the publication is Journal of the American Chemical Society (2022), 144(1), 495-502, database is CAplus and MEDLINE.

A powerful tris(4-bromophenyl)aminium hexachloroantimonate (BAHA) mediated regioselective intermol. coupling reaction of vindoline with a wide range of substrates that include β-ketoesters, β-diketones, β-ketoaldehydes, β-ketonitriles, β-ketolactones, β-ketolactams, β-cyanoesters, and malononitriles is detailed. The BAHA-promoted intermol. sp³/sp² coupling, representing a special class of selective C-H functionalization reactions with direct carbon-carbon bond formation, proceeds with generation of a quaternary center bound to the aryl C15 center of vindoline capable of accommodating of the vinblastine C16′ Me ester and functionalized for subsequent divergent heterocycle introduction. A comprehensive examination of the reaction scope, optimization of subtle reaction parameters, and key insights into the reaction mechanism are described. Contrary to what might be prevailing expectations, studies suggest the plausible mechanism entails initial single-electron oxidation of the substrate enolate, not vindoline, and subsequent regiospecific addition of the resulting electrophilic radical to vindoline. As such and beyond the new arylation reaction with vindoline, the studies define a host of new, previously unrecognized, applications of BAHA and related triarylaminium radical cations that arises from their ability to generate stabilized electrophilic radicals from β-ketoesters and related substrates under nonreducing and metal-free conditions. Those exemplified herein include mediating stabilized enolate free radical arylation, dimerization, allylation, alkene addition, and α-oxidation reactions.

Journal of the American Chemical Society published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C12H17NS2, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ronsisvalle, Simone published the artcilePharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Future Medicinal Chemistry (2020), 12(22), 2001-2018, database is CAplus and MEDLINE.

Central and peripheral analgesia without adverse effects relies on the identification of μ-opioid agonists that are able to activate basal antinociceptive pathways. Recently developed μ-selective benzomorphan agonists that are not antagonized by naloxone do not activate G-proteins and β-arrestins. Which pathways do μ receptors activate How can each of them be selectively activated What role is played by allosteric binding sites. Mol. modeling studies characterize the amino acid residues involved in the interaction with various classes of endogenous and exogenous ligands and with agonists and antagonists. Critical binding differences between various classes of agonists with different pharmacol. profiles have been identified. MML series binding poses may be relevant in the search for an antinociception agent without side effects.

Future Medicinal Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Moulkrere, Bachar Rebat published the artcileEvaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties, Related Products of esters-buliding-blocks, the publication is Medicinal Chemistry Research (2018), 27(1), 308-320, database is CAplus.

Two series of heterocyclic compounds derived from 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (DHA) and 2-acetylbutyrolactone have been synthesized and characterized. The compounds were evaluated for their activities against Mycobacterium tuberculosis strain, and as inhibitors of InhA, a key enzyme involved in the type II fatty acid biosynthesis pathway of M. tuberculosis. Among the tested compounds, one DHA derivative, compound 2, showed promising activity against both mycobacteria and InhA. Docking studies were also carried out and give some new structure-activity trends compatible with current structural knowledge.

Medicinal Chemistry Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brear, Paul published the artcileNovel non-ATP competitive small molecules targeting the CK2 α/β interface, COA of Formula: C6H8O3, the publication is Bioorganic & Medicinal Chemistry (2018), 26(11), 3016-3020, database is CAplus and MEDLINE.

Increased CK2 levels are prevalent in many cancers. Combined with the critical role CK2 plays in many cell-signaling pathways, this makes it a prime target for down regulation to fight tumor growth. Herein, we report a fragment-based approach to inhibiting the interaction between CK2α and CK2β at the α-β interface of the holoenzyme. A fragment, CAM187, with an IC₅₀ of 44μM and a mol. weight of only 257gmol^-1 has been identified as the most promising compound Importantly, the lead fragment only bound at the interface and was not observed in the ATP binding site of the protein when co-crystallized with CK2α. The fragment-like mols. discovered in this study represent unique scaffolds to CK2 inhibition and leave room for further optimization.

Bioorganic & Medicinal Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Segura, Javier H. published the artcileBoreal tree species affect soil organic matter composition and saprotrophic mineralization rates, COA of Formula: C6H8O3, the publication is Plant and Soil (2019), 441(1-2), 173-190, database is CAplus.

To investigate how different tree species affect the composition of SOM and its mineralization in boreal forest ecosystems. We used pyrolysis GC-MS for mol.-level characterization of the SOM formed under five common boreal tree species at a replicated field experiment ∼50years after plantation. We incubated soil samples at 4, 9, 14 and 19°C and measured inherent CO₂ production and substrate-induced respiration. We then evaluated if the saprotrophic microbial activity and its temperature sensitivity was controlled by the SOM composition The mol. composition of the SOM emerged as key factor influencing SOM properties in plots with different tree species. Most of the variance in the SOM content was explained by the organo-chem. composition of the SOM. More importantly, the fraction of the microbial community able to utilize the native SOM was largely controlled by the SOM organo-chem. composition Temperature sensitivity of CO₂ production (Q₁₀) was not explained by SOM composition However, the microbial access to different SOM pools varied with temperature These results bridge the gap between the paradigms of short-term litter and long-term SOM decomposition showing that, on an intermediate timescale (∼50 years), boreal tree species affect SOM mol. composition and saprotrophic mineralization rates.

Plant and Soil published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C19H21N3O3S, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Jian published the artcileSupramolecular Polydimethylsiloxane Elastomer with Enhanced Mechanical Properties and Self-Healing Ability Engineered by Synergetic Dynamic Bonds, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is ACS Applied Polymer Materials (2021), 3(7), 3373-3382, database is CAplus.

Hydrophobic elastomers are required for use in industry and daily life because of their versatile properties. Developing a hydrophobic elastomer with self-healing abilities and excellent mech. performance has been very challenging because of the mutually exclusive nature of these properties. Herein, supramol. polydimethylsiloxane (PDMS) elastomers with excellent self-healing and mech. properties were designed through the synergetic combination of multistrength H-bonds and disulfide bonds. The hierarchical H-bonds formed with urethane, urea, and 2-ureido-4[1H]-pyrimidinone (UPy) moieties in the backbone of the supramol. polymer endow the resultant polymers with effective reversible crosslinking, whereas during stretching, the dynamic dissociation and reassociation of H-bonds enable polymers with high extensibility and enhanced toughness and recoverability. In addition, disulfide bond exchange under heat enables polymer network rearrangement, thus imbuing the supramol. elastomer with excellent self-healing ability. Based on the extraordinary properties of hydrophobic supramol. PDMS elastomers, some smart materials can be prepared, such as oil/water separation foams and hydrophobic hot-melt adhesives. Therefore, this concept of synergetic dynamic bonds will point out a direction for the development of sustainable, green, and functional materials of the next generation.

ACS Applied Polymer Materials published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics