Category: 517-23-7

Xu, Yan-Li; Qin, Zhou-Zhou; Wang, Yu-Xia; Zhao, Peng-Fei; Li, Hong-Feng; Du, Zhi-Hong; Da, Chao-Shan published an article in 2021, the title of the article was Highly enantioselective one-pot sequential synthesis of valerolactones and pyrazolones bearing all-carbon quaternary stereocentres.COA of Formula: C6H8O3 And the article contains the following content:

Highly enantiopure and bioactive δ-valerolactones I (R = Me, Ph, 1-naphthyl, 2-chlorophenyl, etc.; R1 = Ph, 1-naphthyl, 2-methylphenyl, etc.; n = 0, 1), and pyrazolones II, bearing α-all-carbon quaternary stereocentres, were successfully and sequentially prepared via a one-pot procedure starting from readily available, inexpensive materials, catalyzed by a new chiral squaramide III under mild reaction conditions. An organocatalytic Michael reaction afforded the valerolactones I, while a one-pot Michael-hydrazinolysis-imidization cascade yielded the pyrazolones II. This procedure is economically efficient and environmentally benign. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).COA of Formula: C6H8O3

The Article related to acyl alkyl valerolactone preparation enantioselective, vinyl ketone acyl valerolactone conjugate michael addition squaramide catalyst, dialkyl aryl pyrazolone preparation enantioselective green chem, vinylketone valerolactone michael hydrazinolysis imidization tandem one pot squaramide and other aspects.COA of Formula: C6H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 5, 2021, Hayrapetyan, Davit; Stepanova, Valeriya published an article.Formula: C6H8O3 The title of the article was Facile Synthesis of Spirocyclic Lactams via [3+2] and [3+3] Aza-Annulation Reactions. And the article contained the following:

Spirocyclic pyrrolidones and piperidones such as I and II were synthesized starting from readily available α-ketolactones and α-ketolactams employing [3+2]- and [3+3]-aza-annulation reactions. Tandem reactions of enamino lactams and lactones with maleic and itaconic anhydride yielded alkylidenespirolactams in good yields; further reduction of the exocyclic C=C double bond of the enamino moiety proceeded with excellent diastereoselectivity. Overall, one C-C and two C-N bonds, as well as three new stereocenters were created in a diastereoselective manner resulting in a fast upbuild of mol. complexity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Formula: C6H8O3

The Article related to pyrrolidinone piperidinone spirolactam diastereoselective preparation, tandem michael addition cyclization maleic itaconic anhydride aminoalkylidene lactam, stereoselective cyclization maleic itaconic anhydride aminoalkylidene lactam, reduction stereoselective alkylidene spirolactam and other aspects.Formula: C6H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 5, 2018, Wang, Mengdan; Kong, Lingkai; Wang, Ye; Song, Bo; Sun, Yue; Tang, Rong; Li, Yanzhong published an article.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Sequential C-C σ-Bond Cleavage/(sp2) C-O Bond Formation via C-H Functionalization toward Pyranoindolones Fused with Medium-Sized Rings. And the article contained the following:

An atom-economical procedure for the synthesis of pyranoindolones fused with 7- or 8-membered rings has been developed. This process is realized through the sequential Cs2CO3-promoted C-C σ-bond cleavage of cyclic ketoesters and a ZnI2-mediated selective C-H/O-H coupling reaction. Two of the C-C σ-bonds are cleaved and one of the sp2 C-H bonds is functionalized during the reaction process. Easily accessible starting materials and broad substrate scope make this protocol attractive in synthetic organic chem. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

The Article related to carbon bond cleavage, bond formation carbon oxygen, pyranoindolone fused sized ring preparation, indolyl alkynyl ketone cyclization oxocycloalkane carboxylate, indolecarbonyl phenylcyclooctadiene carboxylate preparation crystal mol structure, oxohexahydrocyclooctapyranoindole carboxylate preparation crystal mol structure and other aspects.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2018, Tran, Van T.; Gurak, John A. Jr; Yang, Kin S.; Engle, Keary M. published an article.Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one The title of the article was Activation of diverse carbon-heteroatom and carbon-carbon bonds via palladium(II)-catalyzed β-X elimination. And the article contained the following:

γ-Substituted N-(8-quinolinyl) alkanecarboxamides and cycloalkanecarboxamides such as I underwent regioselective substitution reactions with nucleophiles such as 1-methyl- and 1,2-dimethylindoles in the presence of Pd(OAc)2 and 1-adamantanecarboxylic acid (1-AdCO2H) to yield substitution products such as II (R = H, Me). The substitutions occurred using elimination reactions of the β-palladated carboxamides as a key step; a β-palladation product was isolated and its structure determined by X-ray crystallog. The substitution reactions occurred at alkyl C(sp3)-oxygen, nitrogen, carbon, fluorine and sulfur bonds with high regioselectivity. The method was used for substitution reactions of γ-substituted amino acids such as the 8-aminoquinolinyl amide of L-methionine and its sulfoxide to give functionalized amino acids in 60-98% ee. Unstrained 8-aminoquinolinyl heterocyclylalkanecarboxamides underwent regioselective γ-substitution reactions with ring opening if a heteroatom was in the γ-position; if the heteroatom was in an appropriate position, lactonization and lactamization reactions also occurred with loss of the aminoquinoline moieties. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one

The Article related to quinolinyl carboxamide regioselective substitution ring opening, amino acid aminoquinoline amide gamma substituted regioselective stereoselective preparation, palladium catalyst regioselective directed substitution quinolinyl alkanecarboxamide, aminoquinoline amino acid amide regioselective gamma substitution and other aspects.Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 2018, Akcha, Selma; Gomez-Ruiz, Santiago; Kellou-Tairi, Safia; Lezama, Luis; Perez, Frank Blanco; Benali-Baitich, Ouassini published an article.Safety of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Synthesis, characterization, solution equilibria, DFT study, DNA binding affinity and cytotoxic properties of a cobalt(II) complex with a 5-pyrazolone ligand. And the article contained the following:

The authors’ work describes the synthesis, the complexation and the characterization of a cobalt(II) complex with a 5-pyrazolone ligand carrying a thioamide group on N1 position. The study of the complexation in solution allowed the determination of the stability constants of the complex and the distribution of the species involving Co(II) over the whole pH-range. The solid cobalt(II) complex has then been synthesized and fully characterized by IR, electronic, EPR and mass spectrometries, in addition to magnetic and voltammetric measurements. The data clearly indicated an octahedral high spin Co(II) complex with two mononeg. mols. of the N,S-ligand, and two water mols., likely in a cis position because of the high anisotropy. DFT calculations performed on both the ligand and the complex structures allowed the authors to study the spectral features, and to propose the most fitting structures to the exptl. data. The interaction of the 5-pyrazolone ligand and its cobalt(II) complex with fish-sperm DNA has been studied by electronic spectrometry and cyclovoltammetry. Intercalation has been identified as a binding mode and the strength of the binding assessed. In order to explore eventual cytotoxic and/or cytostatic properties of the authors’ compounds, the ligand and the cobalt complex have been tested on PC-3 (human prostate carcinoma) and HT-29 (human colon carcinoma) using sulforhodamine B (SRB) assay. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Safety of 3-Acetyldihydrofuran-2(3H)-one

The Article related to cobalt carbothioamidepyrazolone aqua complex preparation formation constant, magnetic property optimized mol structure cobalt carbothioamidepyrazolone aqua complex, electrochem dna binding cobalt carbothioamidepyrazolone aqua complex, antitumor activity cobalt carbothioamidepyrazolone aqua complex and other aspects.Safety of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Qianjia; Prater, Matthew B.; Sigman, Matthew S. published an article in 2020, the title of the article was Enantioselective Synthesis of γ-Functionalized Cyclopentenones and β-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy.Name: 3-Acetyldihydrofuran-2(3H)-one And the article contains the following content:

In this report, the desymmetrization of cyclic enones under relay Heck conditions with an array of aryl boronic acids, alkenyl triflates and indole derivatives was described. This method granted facile access to diverse γ-functionalized cyclopentenones I [Ar = Ph, 2-naphthyl, benzo[d][1,3]dioxol-5-yl, 4-oxocyclopent-2-en-1-yl, etc.] and δ-functionalized cycloheptenones II [R = Ph, 4-CF3C6H4, C(Me):C(Me)CO2Et, etc.]. Using this approach, a formal synthesis of (S)-baclofen was completed in high yield and excellent enantioselectivity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Name: 3-Acetyldihydrofuran-2(3H)-one

The Article related to gamma functionalized cyclopentenone enantioselective preparation, cyclopentenone aryl boronic acid alkenyl triflate palladium relay heck, delta functionalized cycloheptenone enantioselective preparation, cycloheptenone aryl boronic acid alkenyl triflate palladium relay heck, asymmetric catalysis, c–c coupling, heck reaction, palladium and other aspects.Name: 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 17, 2021, Zhu, Yasheng; Wang, Hongliang; Wang, Gang; Wang, Zehua; Liu, Zhaopeng; Liu, Lei published an article.Safety of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Enantioselective Construction of Single and Vicinal All-Carbon Quaternary Stereocenters through Ion Pair Catalyzed 1,6-Conjugate Addition. And the article contained the following:

An asym. 1,6-conjugate addition to presynthesized δ-aryl-δ-cyano disubstituted para-quinone methides I (R = H, 3-Me, 3-bromo; Ar = Ph, 4-methylphenyl, 2-naphthyl, etc.) through bifunctional phosphonium-amide promoted ion pair catalysis for acyclic all-carbon quaternary stereocenter construction has been described. Both acyclic and cyclic 1,3-dicarbonyls CH2(C(O)OR1)2 (R1 = Ph, 2-methylphenyl, benzyl, etc.)/II (R2 = Me, Et, Bu, allyl) participate in asym. alkylation reaction, furnishing a wide array of diarylmethanes bearing a single acyclic or vicinal cyclic and acyclic quaternary carbon stereocenters III/IV in high efficiency with excellent stereoselectivity. Computational studies elucidate the origin of enantioselectivity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Safety of 3-Acetyldihydrofuran-2(3H)-one

The Article related to cyano hydroxyphenyl aryl methyl propane dicarboxylic ester preparation enantioselective, quinonemethide acyclic dicarbonyl compound conjugate addition phosphonium amide catalyst, cyanohydroxyphenyl aryl methyl oxocyclopentane carboxylic ester preparation enantioselective, cyclic dicarbonyl compound quinonemethide conjugate addition phosphonium amide catalyst and other aspects.Safety of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thiyagarajan, Subramanian; Krishnakumar, Varadhan; Gunanathan, Chidambaram published an article in 2020, the title of the article was KOtBu-Catalyzed Michael Addition Reactions Under Mild and Solvent-Free Conditions.Quality Control of 3-Acetyldihydrofuran-2(3H)-one And the article contains the following content:

Herein, a mild and environmentally friendly strategy of readily available KOtBu-catalyzed Michael addition reactions was demonstrated. This simple inorganic base efficiently catalyzed the Michael addition of underexplored acrylonitriles, esters and amides with oxa-, aza-, and thia-heteroatom nucleophiles to afford Michael addition products. This catalytic process proceeded under solvent-free conditions and at room temperature Notably, this protocol offered an easy operational procedure, broad substrate scope with excellent selectivity, reaction scalability and excellent TON (>9900). Preliminary mechanistic studies revealed that the reaction followed an ionic mechanism. Formal synthesis of promazine was demonstrated using this catalytic protocol. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one

The Article related to nitrile alkyl green preparation, acrylonitrile heteroatom nucleophile michael base catalyst, ester alkyl green preparation, acrylic ester heteroatom nucleophile michael base catalyst, amide alkyl green preparation, acrylamide heteroatom nucleophile michael base catalyst, michael addition, base catalysis, green synthesis, nitriles, sustainable chemistry and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics