Category: 517-23-7

Maczka, Wanda; Winska, Katarzyna; Grabarczyk, Malgorzata; Zarowska, Barbara published an article in 2018, the title of the article was Biotransformation of α-acetylbutyrolactone in Rhodotorula strains.Quality Control of 3-Acetyldihydrofuran-2(3H)-one And the article contains the following content:

Due to its structural similarity, the α-1-hydroxyethyl-γ-butyrolactone obtained by reduction of (±)-α-acetyl-γ-butyrolactone may have a similar function in the body to γ-butyrolactone (GBL). In the work presented, biotransformation of α-acetyl-γ-butyrolactone by three Rhodotorula strains was performed obtaining enantiomerically enriched alc. The process was carried out in growing and resting cultures. We studied how both media composition and organic solvent volume affected stereoselectivity and effectiveness of biotransformation. After 2 h, the enantiomerically pure (3R, 1 S)-α-1-hydroxyethyl-γ-butyrolactone was obtained using the R. marina AM77 strain in YPG (Yeast extract-Peptone-Glucose) medium enriched with 5% glycerol. To our best knowledge there is no previous information in the literature about the (±)-α-acetyl-γ-butyrolactone biotransformation performed in medium with addition of organic and deep eutectic solvents. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one

The Article related to rhodotorula biotransformation alpha acetyl gamma butyrolactone, des, biotransformation, glycerol, lactone, yeast, Microbial, Algal, and Fungal Biochemistry: Metabolism and Microbial Nutrition and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ali, Ahmed R.; El-Bendary, Eman R.; Ghaly, Mariam A.; Shehata, Ihsan A. published an article in 2018, the title of the article was Synthesis, in vitro anticancer evaluation, and in silico studies of new thiazolo[3,2-a]pyrimidin-5-one derivatives.COA of Formula: C6H8O3 And the article contains the following content:

Synthesis of thiazolo[3,2-a]pyrimidin-5-ones derivatives I [R = H, Me, Cl] and II [R1 = Me, NH2; X = NH, O] were developed and evaluated against antitumor activity. The target compounds I and II showed observed activity against Renal UO-31 cancer cell line with cell growth promotion 52.72%-64.52%. Assessment of toxicities, drug likeness and drug score profiles were reported. Some of the synthesized compounds showed good docking scores with potential anticancer targets. In vitro anticancer evaluation, together with in silico studies, revealed that compounds I [R = Me, Cl] and II [R = R1 = Me; X = O] were the most active members in this study. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).COA of Formula: C6H8O3

The Article related to thiazolopyrimidinone preparation antitumor human docking, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C6H8O3

Referemce:
Ester – Wikipedia,
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On September 17, 2021, Jiang, Meifen; Liu, Minjie; Yu, Chao; Cheng, Dang; Chen, Fener published an article.Computed Properties of 517-23-7 The title of the article was Fully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1. And the article contained the following:

A fully continuous flow synthesis of 3-chloro-4-oxopentyl acetate, an important intermediate for vitamin B1, was developed. This continuous flow manufacturing included two chem. transformations and an inline extraction step without intermediate purification and solvent exchange. In this work, the traditional synthetic route for batch operation was efficiently simplified via a series of separated screening tests in flows under various conditions. The authors found that the chlorination reaction can be carried out in only 30 s at room temperature by flow. The decarboxylation/acylation step was also simplified by using a cross-mixer, so that acetic anhydride was no longer required in the acylation reaction. A computational fluid dynamics simulation was carried out to study the improved micromixing of liquid-liquid two-phase streams. Finally, 3-chloro-4-oxopentyl acetate was obtained in a 90% isolated yield with a product purity of 96% and a total residence time of approx. 32 min. This fully continuous process was operated smoothly for 12 h, and approx. 19.1 g of the desired product was generated with a production rate of 1.79 g h-1. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Computed Properties of 517-23-7

The Article related to chlorooxopentyl acetate preparation vitamin b1 intermediate continuous flow, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Computed Properties of 517-23-7

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gupta, Poonam published an article in 2021, the title of the article was Synthesis of related substances of antipsychotic drug Risperidone.SDS of cas: 517-23-7 And the article contains the following content:

European pharmacopeia related substances I [ R1 = H, CH3; R2 = (5-fluoro-1,2-benzoxazol-3-yl), (4-fluoro-2-hydroxy-benzoyl) etc] (impurities) was obtained during the synthesis of Risperidone. Described the detection, origin, synthesis, characterization and control of the related substances, which was improved the com. process. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).SDS of cas: 517-23-7

The Article related to methyl piperidyl ethyl tetrahydropyridopyrimidinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 517-23-7

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 14, 2021, Rong, Jinchuang; Zhong, Jiang; Yan, Wanlong; Liu, Maochen; Zhang, Yalei; Qiao, Yongluo; Fu, Changqing; Gao, Fei; Shen, Liang; He, Haifeng published an article.Product Details of 517-23-7 The title of the article was Study on waterborne self-healing polyurethane with dual dynamic units of quadruple hydrogen bonding and disulfide bonds. And the article contained the following:

The novel self-healable waterborne polyurethanes (WPU) with the synergistic reversible units of aliphatic disulfide bonds and quadruple hydrogen bonding have been successfully prepared The ureidopyrimidone (UPy) functional motifs were introduced into polymer backbones of polyurethane, where also placed the reversible disulfide bonds. The quadruple hydrogen bonds of UPy groups endowed the material a strong phys. crosslinking network, which provided a superior Young’s moduli. The features of dual dynamic structure could also produce a relatively low active energy of 36.1 kJ/mol, resulting in a good self-repairing efficiency of 94% under a mild condition. Furthermore, the influence of self-healing time and different repairing temperature on the healed performance was also systematically investigated. In order to describe the self-healing progress of multiple dynamic units, a phys. model was used to study the evolution of self-repairing efficiency with variable healing time, indicating that quadruple H-bonding and disulfide bonds predominantly supported time dependent reconstruction of phys. crosslinking network to recover the original mech. property. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Product Details of 517-23-7

The Article related to waterborne self healing polyurethane, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Product Details of 517-23-7

Referemce:
Ester – Wikipedia,
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On December 5, 2020, Yang, Ziyue; Sun, Dongcheng published an article.Recommanded Product: 517-23-7 The title of the article was Self-healing supramolecular waterborne polyurethane dispersions with quadruple hydrogen bonds in main chain. And the article contained the following:

A facile method for preparing supramol. waterborne polyurethane (WPU) based on quadruple hydrogen bonds (4H-WPU) is reported. Herein, 4H-WPU with quadruple hydrogen bonds in main chain were synthesized by poly (1,4-butylene-neopentylene adipate glycol) as soft segment, 2-ureido-4[1H]-pyrimidinone (UPy) functionalized monomer, isophorone diisocyanate, 2,2-Bis(hydroxymethyl)propionic acid (hydrophilic monomer), isophoronediamine, triethylamine (neutralizer), and monoethanolamine (blocking agent) as hard segment. The mol. weight of 4H-WPU was controlled around 18,000 consistently. The properties of 4H-WPU with different content of hydrophilic group, hard segment, and UPy units were characterized and the results could provide the reference for preparing supramol. WPU with high mech. and self-healing performance while maintaining dispersion stability. The tensile strength of 4H-WPU was 10 times of the blank sample. The healing time of scratched 4H-WPU film was inversely proportional to the content of UPy-functionalized monomer and the shortest healing time is 2.5 h at 80°C. Mech. performance of healed films can be restored to more than 90%. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Recommanded Product: 517-23-7

The Article related to polyurethane preparation self healing morphol mech property, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2019, Segura, Javier H.; Nilsson, Mats B.; Sparrman, Tobias; Serk, Henrik; Schleucher, Jurgen; Tolu, Julie; Oequist, Mats G. published an article.Quality Control of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Boreal tree species affect soil organic matter composition and saprotrophic mineralization rates. And the article contained the following:

To investigate how different tree species affect the composition of SOM and its mineralization in boreal forest ecosystems. We used pyrolysis GC-MS for mol.-level characterization of the SOM formed under five common boreal tree species at a replicated field experiment �0years after plantation. We incubated soil samples at 4, 9, 14 and 19°C and measured inherent CO2 production and substrate-induced respiration. We then evaluated if the saprotrophic microbial activity and its temperature sensitivity was controlled by the SOM composition The mol. composition of the SOM emerged as key factor influencing SOM properties in plots with different tree species. Most of the variance in the SOM content was explained by the organo-chem. composition of the SOM. More importantly, the fraction of the microbial community able to utilize the native SOM was largely controlled by the SOM organo-chem. composition Temperature sensitivity of CO2 production (Q10) was not explained by SOM composition However, the microbial access to different SOM pools varied with temperature These results bridge the gap between the paradigms of short-term litter and long-term SOM decomposition showing that, on an intermediate timescale (�0 years), boreal tree species affect SOM mol. composition and saprotrophic mineralization rates. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one

The Article related to boreal tree species soil organic matter saprotrophic mineralization, Fertilizers, Soils, and Plant Nutrition: Soil Composition, Fertility, and Physicochemistry and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 8, 2022, Zhang, Jinhong; Sekyere, Daniel T.; Niwamanya, Noah; Huang, Yansheng; Barigye, Andrew; Tian, Yuanyu published an article.Quality Control of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Study on the Staged and Direct Fast Pyrolysis Behavior of Waste Pine Sawdust Using High Heating Rate TG-FTIR and Py-GC/MS. And the article contained the following:

To understand the fast pyrolysis kinetics and product evolution of waste pine sawdust, high heating rate thermogravimetry-Fourier transform IR (TG-FTIR) was used to obtain the kinetic parameters and the chem. groups formed during the pyrolysis process, while pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS) was used to investigate the detailed compositions of products under the staged (seven stages from 300 to 600°C) and direct fast pyrolysis process. Spectral bands were identified for acids, alcs., aldehydes, aromatics, esters, ethers, hydrocarbons, ketones, phenols, and sugars. Research found that the apparent activation energy for fast pyrolysis is much higher than that of slow pyrolysis. The evolution of CO2 is the major deoxygenation route. Cracking mainly occurred at the 450°C stage with phenols, ketones, aldehydes, and sugars as the main products. The product distributions for different stages are significantly different; the selectivity of aldehydes decreased, while phenols showed an upward trend with an increase in pyrolysis temperature Ketones and sugars reached their peak values at 450°C. The changes in the mol. composition of each stage helped to understand the pyrolysis process. Compared with the staged pyrolysis, the direct pyrolysis process had higher selectivity of acids, aldehydes, esters, and sugars and lower selectivity of phenols, ketones, and alcs. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one

The Article related to staged pyrolysis behavior waste pine sawdust heating, Cellulose, Lignin, Paper, and Other Wood Products: Wood and Other Cellulosic Materials and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 4, 2019, Shershnev, Ivan; Dar’in, Dmitry; Chuprun, Sergey; Kantin, Grigory; Bakulina, Olga; Krasavin, Mikhail published an article.Safety of 3-Acetyldihydrofuran-2(3H)-one The title of the article was The use of α-diazo-γ-butyrolactone in the Buchner-Curtius-Schlotterbeck reaction of cyclic ketones: A facile entry into spirocyclic scaffolds. And the article contained the following:

The first example of the Buchner-Curtius-Schlotterbeck reaction of cyclic ketones with a stabilized cyclic diazo compound partner is described. The approach towards spirocyclic scaffolds has been exemplified with readily available α-diazo-γ-butyrolactone. The reaction proved to be viable with BF3·OEt2 as the preferred catalyst and displayed substantial sensitivity to the size of the cyclic ketone. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Safety of 3-Acetyldihydrofuran-2(3H)-one

The Article related to spirocyclic ketolactone preparation lewis acid catalyst, cyclic ketone diazo butyrolactone buchner curtius schlotterbeck reaction, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Safety of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Goma’a, Hebat-Allah M.; Ghaly, Mariam A.; Abou-zeid, Laila A.; Badria, Farid A.; Shehata, Ihsan A.; El-Kerdawy, Mohamed M. published an article in 2019, the title of the article was Synthesis, Biological Evaluation and In Silico Studies of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Antiherpetic Agents.Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one And the article contains the following content:

Two isosteric series of 1,2,4-triazole and 1,3,4-thiadiazole derivatives were synthesized and evaluated for their antiviral activity against herpes simplex virus type 1, HSV-1, using acyclovir (ACV) as a reference drug. In addition, mol. docking into the active site of HSV-1 thymidine kinase was performed to interpret the data obtained from biol. testing, and all compounds were subjected to an in-silico screening of their physicochem. properties to estimate their drug-likeness and safety. The results revealed that triazolopyrimidine derivative I was able to reduce the viral plaques by 50% at a dose of 80 μM, but interestingly, retained high selectivity compared to ACV (>200 μM vs. 80 μM). The best effective and safe compound in this study, triazolopyrimidine derivative I, was further tested for its combined effects with ACV on the anti-HSV-1 activity in the plaque reduction assay. This compound proved to improve the selectivity of ACV and reduce its ED that produced 100% inhibition of viral plaques. The compound I was suggested to be a promising candidate for further development as an antiherpetic agent. Mol. docking into the active site of HSV-1 thymidine kinase emphasized the superior interaction of the compound I. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one

The Article related to triazole thiadiazole preparation antiherpetic activity docking cytotoxicity, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics