Category: 517-23-7

On January 31, 2022, Kozma, Viktoria; Szollosi, Gyorgy published an article.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Conjugate addition of 1,3-dicarbonyl compounds to maleimides using bifunctional primary amine-(thio)phosphoramide organocatalysts. And the article contained the following:

Asym. Michael additions of 1,3-dicarbonyl compounds to N-substituted maleimides were carried out using primary amine-(thio)phosphoramide bifunctional chiral organocatalysts derived from optically pure C2-sym. 1,2-diamines. The addition of Et 2-fluoroacetoacetate using the 1,2-diphenylethane-1,2-diamine derived thiophosphoramide catalyst afforded various succinimides substituted with fluorine bearing quaternary carbon in high yields, good diastereomeric ratios and excellent enantiomeric excesses. Alicyclic β-ketoesters provided the diastereomerically pure Michael adducts in good yields and high enantioselectivities, whereas 2,4-pentanedione afforded products with slightly lower enantiomeric excesses. The bulkiness of the N-substituent of the maleimide ring influenced mostly the conversions. The thiophosphoramide catalyst was found also efficient in the addition of Et 2-fluoroacetoacetate to β-nitrostyrenes. Unprecedentedly, during this work the highly enantioselective addition of 1,3-dicarbonyl compounds to maleimides were catalyzed by a primary amine-hydrogen-bond donor groups containing bifunctional organocatalyst. These reactions occurred through enamine intermediate, as evidenced by electrospray-ionization mass spectrometry and NMR spectroscopy. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

The Article related to maleimide dicarbonyl compound stereoselective conjugate addition, primary amine thio phosphoramide organocatalyst, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 5, 2018, Chen, Kai; Zhang, Shuo-Qing; Brandenberg, Oliver F.; Hong, Xin; Arnold, Frances H. published an article.Related Products of 517-23-7 The title of the article was Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions. And the article contained the following:

We report a biocatalytic platform of engineered cytochrome P 450 enzymes to carry out carbene-transfer reactions using a lactone-based carbene precursor. By simply altering the heme-ligating residue, we obtained two enzymes that catalyze olefin cyclopropanation (Ser) or S-H bond insertion (Cys). Both enzymes exhibit high catalytic efficiency and stereoselectivity, thus enabling facile access to structurally diverse spiro[2.4]lactones and α-thio-γ-lactones. Computational studies revealed the mechanism of carbene S-H insertion and explain how the axial ligand controls reactivity and selectivity. This work expands the catalytic repertoire of hemeproteins and offers insights into how these enzymes can be tuned for new chem. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Related Products of 517-23-7

The Article related to heme ligation cytochrome p450 p411 carbene transfer reaction, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Related Products of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Niguez, Diego Ros; Khazaeli, Pegah; Alonso, Diego A.; Guillena, Gabriela published an article in 2018, the title of the article was Deep eutectic mixtures as reaction media for the enantioselective organocatalyzed α-amination of 1,3-dicarbonyl compounds.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one And the article contains the following content:

The enantioselective α-amination of 1,3-dicarbonyl compounds was performed using deep eutectic solvents (DES) as a reaction media and chiral 2-amino benzimidazole-derived compounds as a catalytic system to afford amino 1,3-dicarbonyl compounds, e.g., I. With this procedure, the use of toxic volatile organic compounds (VOCs) as reaction media was avoided. Furthermore, highly functionalized chiral mols., which were important intermediates for the natural product synthesis, were synthesized by an efficient and stereoselective protocol. Moreover, the reaction could be done on a preparative scale, with the recycling of the catalytic system being possible for at least five consecutive reaction runs. This procedure represented a cheap, simple, clean, and scalable method that meets most of the principles to be considered a green and sustainable process. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

The Article related to amino dicarbonyl compound green preparation enantioselective, dicarbonyl compound azodicarboxylate chiral amino benzimidazole catalyst amination sonication, Alicyclic Compounds: Cyclopentanes, Including Fulvenes and Fulvalenes and other aspects.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Begum, Zubeda; Sannabe, Haruka; Seki, Chigusa; Okuyama, Yuko; Kwon, Eunsang; Uwai, Koji; Tokiwa, Michio; Tokiwa, Suguru; Takeshita, Mitsuhiro; Nakano, Hiroto published an article in 2021, the title of the article was Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes.Electric Literature of 517-23-7 And the article contains the following content:

Simple primary β-amino alcs. acted as an efficient organocatalysts in the asym. Michael addition of β-keto esters with nitroalkenes which afforded highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Electric Literature of 517-23-7

The Article related to keto ester nitroalkene amino alc catalyst enantioselective diastereoselective michael, nitroalkanyl keto ester preparation, Alicyclic Compounds: Cyclopentanes, Including Fulvenes and Fulvalenes and other aspects.Electric Literature of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2022, Mudshinge, Sagar R.; Hammond, Gerald B.; Umemoto, Teruo published an article.Computed Properties of 517-23-7 The title of the article was Synthesis and applications of S-(trifluoromethyl)-2,8-bis(trifluoromethoxy)dibenzothiophenium triflate (Umemoto reagent IV). And the article contained the following:

A new, powerful, and easy-to-handle electrophilic trifluoromethylating agent, S-(trifluoromethyl)-2,8-bis(trifluoromethoxy)dibenzothiophenium triflate (Umemoto reagent IV), was developed. Due to the extraordinary electronic effect of trifluoromethoxy group, Umemoto reagent IV was easily synthesized by a one-pot method from readily available 3,3′-bis(trifluoromethoxy)biphenyl. It was shown that Umemoto reagent IV was more powerful than Umemoto reagent II and could trifluoromethylate many kinds of nucleophilic substrates more effectively. In addition, Umemoto reagent IV was successfully utilized for the preparation of trifluoromethyl nonaflate, a useful trifluoromethoxylating agent. The direct conversion of 2,8-bis(trifluoromethoxy)dibenzothiophene to Umemoto reagent IV with triflic anhydride was achieved, albeit in low yield. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Computed Properties of 517-23-7

The Article related to trifluoromethyl bis trifluoromethoxy dibenzothiophenium triflate preparation trifluoromethylation, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Computed Properties of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2022, La-ongthong, Kannika; Sawekteeratana, Natthapat; Klaysuk, Jasarin; Soorukram, Darunee; Leowanawat, Pawaret; Reutrakul, Vichai; Krobthong, Sucheewin; Wongtrakoongate, Patompon; Kuhakarn, Chutima published an article.Name: 3-Acetyldihydrofuran-2(3H)-one The title of the article was Cyclization of o-Alkynylisocyanobenzenes with 1,3-Dicarbonyl Compounds. And the article contained the following:

A facile and convenient reaction of o-alkynylisocyanobenzenes with various active-methylene compounds, including 1,3-diesters, 1,3-diketones,β-keto esters, and β-keto amides, under Bronsted basic conditions, had been developed. Di-Et malonate reacted smoothly with a collection of o-alkynylisocyanobenzenes to provide the corresponding 2-quinolin-2-yl malonates in excellent yields. Acetylacetone gave a mixture of quinolin-4-yl and quinolin-2-yl derivatives Acetoacetate esters and acetoacetyl amide derivative initially gave 2-quinolin-2-yl adducts that underwent partial deacetylation under the reaction conditions. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Name: 3-Acetyldihydrofuran-2(3H)-one

The Article related to quinoline preparation, alkynylisocyanobenzene dicarbonyl compound cyclization, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Name: 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2019, Zhang, Ruijie K.; Chen, Kai; Huang, Xiongyi; Wohlschlager, Lena; Renata, Hans; Arnold, Frances H. published an article.Quality Control of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp3 C-H functionalization. And the article contained the following:

Although abundant in organic mols., carbon-hydrogen (C-H) bonds are typically considered unreactive and unavailable for chem. manipulation. Recent advances in C-H functionalization technol. have begun to transform this logic, while emphasizing the importance of and challenges associated with selective alkylation at a sp3 carbon. Here we describe iron-based catalysts for the enantio-, regio- and chemoselective intermol. alkylation of sp3 C-H bonds through carbene C-H insertion. The catalysts, derived from a cytochrome P 450 enzyme in which the native cysteine axial ligand has been substituted for serine (cytochrome P411), are fully genetically encoded and produced in bacteria, where they can be tuned by directed evolution for activity and selectivity. That these proteins activate iron, the most abundant transition metal, to perform this chem. provides a desirable alternative to noble-metal catalysts, which have dominated the field of C-H functionalization. The laboratory-evolved enzymes functionalize diverse substrates containing benzylic, allylic or α-amino C-H bonds with high turnover and excellent selectivity. Furthermore, they have enabled the development of concise routes to several natural products. The use of the native iron-haem cofactor of these enzymes to mediate sp3 C-H alkylation suggests that diverse haem proteins could serve as potential catalysts for this abiol. transformation, and will facilitate the development of new enzymic C-H functionalization reactions for applications in chem. and synthetic biol. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one

The Article related to engineering cytochrome p411 heme iron substrate alkylation carbene insertion, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Eric; Mangunuru, Hari P. R.; Telang, Nakul S.; Kong, Caleb J.; Verghese, Jenson; Gilliland, Stanley E. III; Ahmad, Saeed; Dominey, Raymond N.; Gupton, B. Frank published an article in 2018, the title of the article was High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine.Synthetic Route of 517-23-7 And the article contains the following content:

Numerous synthetic methods for the continuous preparation of fine chems. and active pharmaceutical ingredients (API’s) have been reported in recent years resulting in a dramatic improvement in process efficiencies. Herein authors report a highly efficient continuous synthesis of the antimalarial drug hydroxychloroquine (HCQ). Key improvements in the new process include the elimination of protecting groups with an overall yield improvement of 52% over the current com. process. The continuous process employs a combination of packed bed reactors with continuous stirred tank reactors for the direct conversion of the starting materials to the product. This high-yielding, multigram-scale continuous synthesis provides an opportunity to achieve increase global access to hydroxychloroquine for treatment of malaria. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Synthetic Route of 517-23-7

The Article related to hydroxychloroquine antimalarial drug continuous flow preparation, api manufacturing, antimalarial, flow chemistry, hydrogenation, hydroiodic acid, hydroxychloroquine, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Synthetic Route of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2018, Durak, Halil; Genel, Yasar published an article.Quality Control of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Hydrothermal conversion of biomass (Xanthium strumarium) to energetic materials and comparison with other thermochemical methods. And the article contained the following:

In the present study, the biomass was converted into liquid and solid residues by using hydrothermal liquefaction method at 250, 300 and 350°C with (FeCl3, NaOH) and without catalyst. The resultant products were examined using GC-MS, FT-IR, 1H NMR, SEM, and elemental anal. methods. According to the performed analyses, the highest liquid product yield (total bio-oil) was found to be 38.08% at 300°C by using FeCl3 as catalyst. In the experiments carried out at 350°C, the highest HHV value was found to be 32.35 MJ kg-1 by using NaOH catalyst. The energy values of products obtained at the end of experiments were compared to the values obtained from pyrolysis and supercritical liquefaction method, and it was determined that the liquid products having higher level of energy value were achieved by using hydrothermal liquefaction method. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Quality Control of 3-Acetyldihydrofuran-2(3H)-one

The Article related to xanthium strumarium hydrothermal conversion process subcritical liquefaction, biofuels, biofuels (bio-oil), biomass, biomass pyrolysis fuel oils, charcoal role: spn (synthetic preparation), prep (preparation) (biochar), liquefaction, thermochemical liquefaction, xanthium strumarium and other aspects.Quality Control of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 16, 2021, Xie, Haopu; Liu, Xiangdong; Sheng, Dekun; Wu, Haohao; Zhou, Yan; Tian, Xinxin; Sun, Yinglu; Shi, Biru; Yang, Yuming published an article.Synthetic Route of 517-23-7 The title of the article was Novel titin-inspired high-performance polyurethanes with self-healing and recyclable capacities based on dual dynamic network. And the article contained the following:

It is still a huge challenge that integrating excellent mech. performance and high healing efficiency into self-healing materials at the same time, even if numerous dynamic bonds have been explored in preparing of self-healing materials in the last 20 years. Herein, we reported a novel titin-inspired strategy to prepare the polyurethanes via introducing dual dynamic network which contained the phys. crosslinking of quadruple hydrogen bonds formed by 5-(2-hydroxyethyl)-6-methyl-2-aminouracil (UPy) dimers and the covalent crosslinking of Diels-Alder (D-A) bonds. Specially, relying on the synergistic effect of the dual dynamic network, the resulting polyurethane F50U50-PU exhibited admirable mech. performance, such as a super-high strength of 51.9 MPa, a superb toughness of 166.7 MJ/m3 and a large elongation at break of 930%. Meanwhile, on account of the dynamic feature of quadruple hydrogen bonds and D-A bonds, the resulting polyurethane showed a high heat-induced healing efficiency of 91.2%. More importantly, the polyurethanes could be recycled by hot-pressing process to regain their initial mech. properties and integrity. And it was also used as substrate to construct self-healing conductive device, which displayed splendid self-healing of elec. conductivity after damage. It can be envisioned that the polyurethanes with both superior mech. performance and high healing efficiencies have great application prospect in multifarious fields. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Synthetic Route of 517-23-7

The Article related to polyurethane dual dynamic network self healing recyclable capacity, Plastics Manufacture and Processing: Physical Properties and Testing Methods and other aspects.Synthetic Route of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics