Category: 51644-96-3

In 2017,D’Errico, Stefano; Borbone, Nicola; Piccialli, Vincenzo; Di Gennaro, Elena; Zotti, Andrea; Budillon, Alfredo; Vitagliano, Carlo; Piccialli, Ilaria; Oliviero, Giorgia published 《Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold》.European Journal of Organic Chemistry published the findings.Quality Control of tert-Butyl (5-aminopentyl)carbamate The information in the text is summarized as follows:

Herein the authors report on the synthesis and evaluation of the preliminary antitumor properties of a small collection of Pt(II) complexes in which a cisplatin-like unit is tethered to 7-deazaadenosine through linear alkyl chains (from two to six C atoms) installed at the purine C6 position. The complexation was performed by exploiting the reactivity of the bidentate amino ligands (R)- and (S)-2,3-diaminopropanoic acids (DAPA) attached to the end of the alkyl chain spacer. By varying the length of the alkyl chain and the chirality of the DAPA moiety the authors obtained 10 novel nucleoside-Pt complexes, the anticancer properties of which were evaluated against the A549 and Cal27 human cancer cell lines. In the experiment, the researchers used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Quality Control of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Quality Control of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer》 were Huang, Meng-Ruo; Hsu, Yuan-Ling; Lin, Tzu-Chen; Cheng, Ting-Jen; Li, Ling-Wei; Tseng, Yu-Wei; Chou, Yu-shu; Liu, Jyung-Hurng; Pan, Szu-Hua; Fang, Jim-Min; Wong, Chi-Huey. And the article was published in European Journal of Medicinal Chemistry in 2019. Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate The author mentioned the following in the article:

An 8-oxopurine-6-carboxamide compound, 2-(4-ethoxyphenyl)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide [869069-21-6], (1a) was previously identified as an inhibitor of non-small cell lung cancer (NSCLC). In this study, more than 30 purine-6-carboxamide derivatives with variations at the C2, N7, C8, and N9 positions were synthesized to investigate the structure-activity relationship as a basis for the construction of an advanced pharmacophore model. This model suggests that purine-6-hydroxamate and purine-6-amidoxime analogs could form more hydrogen bonds with a target protein to enhance the inhibitory activities against H1975 cells. Among the series of analogs, the hydroxamate, 2-(4-ethoxyphenyl)-9-(2-methoxyphenyl)-8-oxopurine-6(N-hydroxy)carboxamide [2124217-41-8] (17) and amidoxime, (Z)-2-(4-ethoxyphenyl)-N0-hydroxy-9-(2-methoxyphenyl)8-oxo-8,9-dihydro-7H-purine-6-carboximidamide (19a), exhibited excellent potency against H1975 cells (IC50 < 1.5 μM) and other lung cancer cells with either wild-type or mutated epidermal growth factor receptor (EGFR). Mouse experiments indicated that (17) and (19a) were efficient anticancer agents with no appreciable toxicity. The mechanisms of action for the induction of cell apoptosis were determined to involve microtubule fragmentation and p53-mediated signaling pathways. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: 51644-96-3In 2017 ,《Solvent-free mechanochemical deprotection of N-Boc group》 was published in International Journal of Organic Chemistry. The article was written by Djud, Mateja; Margetic, Davor. The article contains the following contents:

Boc protection group could be readily removed in a very mild mechanochem. conditions. In a short reaction time, ball milling of Boc-protected amines with p-toluenesulfonic acid in solvent-free conditions affords corresponding amine p-TsOH salts. In addition to this study using tert-Butyl (5-aminopentyl)carbamate, there are many other studies that have used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Recommanded Product: 51644-96-3) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Recommanded Product: 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of tert-Butyl (5-aminopentyl)carbamateIn 2020 ,《Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Fulton, Mark G.; Loch, Matthew T.; Rodriguez, Alice L.; Lin, Xin; Javitch, Jonathan A.; Conn, P. Jeffrey; Niswender, Colleen M.; Lindsley, Craig W.. The article conveys some information:

This Letter details our ongoing efforts to develop selective pos. allosteric modulators (PAMs) of the mGlu2/4 heterodimeric receptor that exists in the CNS and may represent a novel drug target to modulate the glutamatergic system. As multiple hit-to-lead campaigns from HTS hits failed to produce selective small mol. mGlu2/4 heterodimer PAMs, we were inspired by the work of Portoghese to synthesize and evaluate a set of nine bivalent tethered ligands (possessing an mGlu2 PAM at one terminus and an mGlu4 PAM at the other). Utilizing G protein-Inwardly Rectifying Potassium (GIRK) channel functional assays, we found that the tethered ligands displayed PAM activity in a cell line co-expressing both mGlu2 and mGlu4 but also in cells expressing mGlu2 or mGlu4 alone. In a CODA-RET assay, one of the tethered ligands potentiated mGlu2/4 heterodimers; however, another compound displayed 75-fold preference for the mGlu2/2 homodimer over heterodimeric mGlu2/4 or homomeric mGlu4/4. This work highlights the development of mGlu receptor PAMs with homodimer/heterodimer preference and expands the potential for PAMs as tethered ligands beyond the more classical antagonists and NAMs. In the experimental materials used by the author, we found tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness》 was written by Sundaram, Aparna; Chen, Chun; Isik Reed, Nilgun; Liu, Sean; Ki Yeon, Seul; McIntosh, Joel; Tang, You-Zhi; Yang, Hyunjun; Adler, Marc; Beresis, Richard; Seiple, Ian B.; Sheppard, Dean; DeGrado, William F.; Jo, Hyunil. Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Inhibition of integrin α5β1 emerges as a novel therapeutic option to block transmission of contractile forces during asthma attack. We designed and synthesized novel inhibitors of integrin α5β1 by backbone replacement of known αvβ1 integrin inhibitors. These integrin α5β1 inhibitors also retain the nanomolar potency against αvβ1 integrin, which shows promise for developing dual integrin α5β1/αvβ1 inhibitor. Introduction of hydrophobic adamantane group significantly boosted the potency as well as selectivity over integrin αvβ3. We also demonstrated one of the inhibitors (11)(I) reduced airway hyperresponsiveness in ex vivo mouse tracheal ring assay. Results from this study will help guide further development of integrin α5β1 inhibitors as potential novel asthma therapeutics.tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Journal of Agricultural and Food Chemistry included an article by Hellwig, Michael; Auerbach, Christian; Mueller, Nicole; Samuel, Pauline; Kammann, Sophie; Beer, Falco; Gunzer, Florian; Henle, Thomas. HPLC of Formula: 51644-96-3. The article was titled 《Metabolization of the Advanced Glycation End Product N-ε-Carboxymethyllysine (CML) by Different Probiotic E. coli Strains》. The information in the text is summarized as follows:

N-ε-Carboxymethyllysine (CML) is formed during glycation reactions (synonym, Maillard reaction). CML is degraded by the human colonic microbiota, but nothing is known about the formation of particular metabolites. In the present study, 6 probiotic Escherichia coli strains were incubated with CML in the presence or absence of oxygen in either minimal or nutrient-rich medium. CML was degraded by all strains only in the presence of oxygen. HPLC-MS/MS was applied for identification of metabolites of CML. For the 1st time, 3 bacterial metabolites of CML were identified, namely N-carboxymethylcadaverine (CM-CAD), N-carboxymethylaminopentanoic acid (CM-APA), and the N-carboxymethyl-Δ1-piperideinium ion. During 48 h of incubation of CML with 5 different E. coli strains in minimal medium in the presence of oxygen, 37-66% of CML was degraded, while CM-CAD (1.5-8.4% of the initial CML dose) and CM-APA (0.04-0.11% of the initial CML dose) were formed linearly. Formation of the metabolites is enhanced when dipeptide-bound CML is applied, indicating that transport phenomena may play an important role in the handling of the compound by microorganisms. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3HPLC of Formula: 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).HPLC of Formula: 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Federico, Stephanie; Margiotta, Enrico; Moro, Stefano; Kozma, Eszter; Gao, Zhan-Guo; Jacobson, Kenneth A.; Spalluto, Giampiero. Recommanded Product: tert-Butyl (5-aminopentyl)carbamate The article mentions the following:

Compounds able to simultaneously bind a biol. target and be conjugated to a second specific moiety are attractive tools for the development of multi-purpose ligands useful as multi-target ligands, receptor probes or drug delivery systems, with both therapeutic and diagnostic applications. The human A3 adenosine receptor is a G protein-coupled receptor involved in many physio-pathol. conditions, e.g. cancer and inflammation, thus representing a promising research target. In this work, two series of conjugable hA3AR antagonists, based on the pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine nucleus, were developed. The introduction of an aromatic ring at the 5 position of the scaffold, before (phenylacetamido moiety) or after (1,2,3-triazole obtained by click chem.) the conjugation is aimed to increase affinity and selectivity towards the hA3AR receptor. As expected, conjugable compounds showed good affinity towards the hA3AR. In order to prove their potential in the development of hA3AR ligands for different purposes, compounds were also functionalized with fluorescent probes. Unfortunately, conjugation decreased affinity and selectivity for the target as compared to the hA2AAR. Computational studies identified specific non-conserved residues of the extracellular loops which constitute a structural barrier able to discriminate between ligands, giving insights into the rational development of new highly selective ligands. After reading the article, we found that the author used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Recommanded Product: tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Recommanded Product: tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Cucurbit[7]uril Enables Multi-Stimuli-Responsive Release from the Self-Assembled Hydrophobic Phase of a Metal Organic Polyhedron》 was written by Samanta, Soumen K.; Quigley, Jeffrey; Vinciguerra, Brittany; Briken, Volker; Isaacs, Lyle. Reference of tert-Butyl (5-aminopentyl)carbamateThis research focused ontumor antitumor doxorubicin cucurbituril drug carrier. The article conveys some information:

Mixed self-assembly of ligands 1, 2, 1,6-hexanediamine (HDA), and Pd(NO3)2 afforded Fujita-type metal organic polyhedron MOP1 (diameter ≈ 8.2 nm), which is covalently functionalized with an average of 18 cucurbit[7]uril (CB[7]) units, as evidenced by 1H NMR, diffusion-ordered spectroscopy NMR, and transmission electron microscopy measurements. By virtue of the host-guest properties of CB[7], the inner cavity of MOP can be rendered hydrophobic by using octadecyl HDA (3) as guest during the self-assembly process. The hydrophobic cavity was successfully utilized to trap the hydrophobic dye Nile Red (NR) and the anticancer drug doxorubicin (DOX). The stimuli-responsive release of encapsulated NR or DOX occurs (1) upon addition of a competitive binder (e.g., adamantane ammonium (ADA)) for CB[7], (2) by a dual pH-chem. stimulus involving the protonation state change of adamantane carboxylate at pH 5.8, and (3) by a dual pH-photochem. stimulus involving photoisomerization of trans-6 to cis-6 at pH 5.8. NR is released from NR@MOP2 within HeLa cancer cells. This body of work suggests that the covalent attachment of cucurbit[n]uril to metal organic polyhedra constitutes a promising vehicle for the development of both diagnostic and therapeutic nanoparticles. In the experimental materials used by the author, we found tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Reference of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Reference of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schneider, Hendrik; Englert, Simon; Palacios, Arturo Macarron; Romero, Jorge Alberto Lerma; Ali, Ataurehman; Avrutina, Olga; Kolmar, Harald published an article in 2021. The article was titled 《Synthetic integrin-targeting dextran-Fc hybrids efficiently inhibit tumor proliferation in vitro》, and you may find the article in Frontiers in Chemistry (Lausanne, Switzerland).Related Products of 51644-96-3 The information in the text is summarized as follows:

Herein, we present the design, synthesis, and biol. evaluation of novel integrin-targeting mol. hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endosomal-cleavable cytotoxic agent monomethyl auristatin E (MMAE) and dextran as multimerization site were covalently connected by two bioorthogonal enzyme-mediated reactions site-specifically. Decoration of dextran with cyclic RGD peptides, introduced by copper “”click”” reaction, resulted in the final constructs with the potential to kill integrin-overexpressing tumor cells. We found that these modifications had little impact on the stability of the Fc scaffold and the RGD-bearing construct showed good binding properties of αvβ3- expressing U87MG cells. Furthermore, the construct showed a remarkable antiproliferative activity. These results demonstrate the general capability of our design to provoke receptor-mediated endocytosis upon binding to the cellular surface, followed by endosomal cleavage of the linkage between Fc-dextran and MMAE and its subsequent release. Our approach opens new avenues to transcribe small mol. binders into tailor-made multimeric mol. hybrids with antitumor potential.tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Related Products of 51644-96-3) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Related Products of 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Substrate scope for trimethyllysine hydroxylase catalysis》 was written by Al Temimi, Abbas H. K.; Pieters, Bas J. G. E.; Reddy, Y. Vijayendar; White, Paul B.; Mecinovic, Jasmin. Safety of tert-Butyl (5-aminopentyl)carbamateThis research focused ontrimethyllysine hydroxylase recognition substrate amino acid analog hydroxylation. The article conveys some information:

Trimethyllysine hydroxylase (TMLH) is a non-haem Fe(II) and 2-oxoglutarate dependent oxygenase that catalyzes the C-3 hydroxylation of an unactivated C-H bond in L-trimethyllysine in the first step of carnitine biosynthesis. The examination of trimethyllysine analogs as substrates for human TMLH reveals that the enzyme does hydroxylate substrates other than natural L-trimethyllysine. The experimental process involved the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics