Category: 51644-96-3

In 2017,Ozdemir, Zulal; Bildziukevich, Uladzimir; Saman, David; Havlicek, Libor; Rarova, Lucie; Navratilova, Lucie; Wimmer, Zdenek published 《Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid》.Steroids published the findings.Safety of tert-Butyl (5-aminopentyl)carbamate The information in the text is summarized as follows:

A series of amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid with the polyamine spermine and three other diamines, 1,2-diaminoethane, piperazine and cadaverine, were synthesized and their antimicrobial activity and cytotoxicity were investigated. Among the target compounds, several ones showed antimicrobial activity on Gram pos. and Gram neg. microorganisms. The most active compounds had (Streptococcus mutans CCM 7409, 3.125 μM), (Streptococcus mutans CCM 7409, 12.5 μM) and (Escherichia coli CCM 3954, 12.5 μM). In addition, four compounds displayed cytotoxicity on CEM (12.1 ± 2.1 μM, 7.6 ± 1.0 μM, 19.0 ± 0.4 μM and 5.9 ± 0.7 μM, resp.). Two addnl. compounds displayed medium cytotoxicity on CEM, (34.6 ± 5.2 μM) and (37.7 ± 5.9 μM). Two compounds displayed high toxicity also on normal fibroblasts. In addition to this study using tert-Butyl (5-aminopentyl)carbamate, there are many other studies that have used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Morris, David T. J.; Wales, Steven M.; Tilly, David P.; Farrar, Elliot H. E.; Grayson, Matthew N.; Ward, John W.; Clayden, Jonathan published an article in 2021. The article was titled 《A molecular communication channel consisting of a single reversible chain of hydrogen bonds in a conformationally flexible oligomer》, and you may find the article in Chem.Related Products of 51644-96-3 The information in the text is summarized as follows:

Communication of information through the global switching of conformation in synthetic mols. has hitherto entailed the inversion of chirality. Here, we report a class of oligomer through which information may be communicated through a global reversal of polarity. Ethylene-bridged oligoureas are constitutionally sym., conformationally flexible mols. organized by a single chain of hydrogen bonds running the full length of the oligomer. NMR reveals that this hydrogen-bonded chain may undergo a coherent reversal of directionality. The directional uniformity of the hydrogen-bond chain allows it to act as a channel for the spatial communication of information on a mol. scale. A binding site at the terminus of an oligomer detects local information about changes in pH or anion concentration and transmits that information-in the form of a directionality switch in the hydrogen-bond chain-to a remote polarity-sensitive fluorophore. This propagation of polarity-encoded information provides a new mechanism for mol. communication. The experimental process involved the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Related Products of 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Related Products of 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: tert-Butyl (5-aminopentyl)carbamateIn 2019 ,《Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction》 appeared in Organic Letters. The author of the article were Qiu, Xing; Sun, Ning; Kong, Ying; Li, Yan; Yang, Xiaobao; Jiang, Biao. The article conveys some information:

Using DIPEA as base in N-methyl-2-pyrrolidinone (NMP), lenalidomide underwent regioselective alkylation with bromoesters and Boc-protected bromoamines followed by deprotection to yield lenalidomide derivatives as a library of potential PROTAC reagents. One of the products was coupled to the known BET binding agent JQ1 to yield I; I degraded BET protein in cells and effectively inhibited cancer cell proliferation.tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Name: tert-Butyl (5-aminopentyl)carbamate) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Name: tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A water-soluble boronic acid sensor for caffeic acid based on double sites recognition》 was published in RSC Advances in 2020. These research results belong to Bian, Zhancun; Fang, Guiqian; Wang, Ran; Zhan, Dongxue; Yao, Qingqiang; Wu, Zhongyu. Name: tert-Butyl (5-aminopentyl)carbamate The article mentions the following:

Due to reversibly and covalently binding with Lewis bases and polyols, boronic acid compounds as fluorescent sensors have been widely reported to recognize carbohydrates, ions, hydrogen peroxide, and so on. However, boronic acid sensors for highly selective recognition of caffeic acid rather than catechol or catechol derivatives have not been reported yet. Herein a novel water-soluble sensor 5c with double recognition sites based on a boronic acid was reported. When 2.3 x 10-4 M of caffeic acid was added, the fluorescence intensity of sensor 5c decreased by 99.6% via inner filter effect (IFE) because its excitation spectrum well overlaps with the absorption spectrum of caffeic acid under neutral condition, while the fluorescence increased or did not change obviously after binding with other analytes including carbohydrates and other catechol derivatives In addition, the response time to caffeic acid is fast at room temperature, and a high binding constant (9245.7 ± 348.3 M-1) and low LOD (1.81 x 10-6 M) was calculated Moreover, determination of caffeic acid content in caffeic acid tablets was studied, and the recovery rate is sufficient. Therefore, sensor 5c can be used as a potential tool for detecting biol. significant caffeic acid in real samples. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Name: tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Name: tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Bruckner, Eric P.; Curk, Tine; Djordjevic, Luka; Wang, Ziwei; Yang, Yang; Qiu, Ruomeng; Dannenhoffer, Adam J.; Sai, Hiroaki; Kupferberg, Jacob; Palmer, Liam C.; Luijten, Erik; Stupp, Samuel I. published an article in ACS Nano. The title of the article was 《Hybrid Nanocrystals of Small Molecules and Chemically Disordered Polymers》.Synthetic Route of C10H22N2O2 The author mentioned the following in the article:

Organic crystals formed by small mols. can be highly functional but are often brittle or insoluble structures with limited possibilities for use or processing from a liquid phase. A possible solution is the nanoscale integration of polymers into organic crystals without sacrificing long-range order and therefore function. This enables the organic crystals to benefit from the advantageous mech. and chem. properties of the polymeric component. We report here on a strategy in which small mols. cocrystallize with side chains of chem. disordered polymers to create hybrid nanostructures containing a highly ordered lattice. Synchrotron X-ray scattering, absorption spectroscopy, and coarse-grained mol. dynamics simulations reveal that the polymer backbones form an “”exo-crystalline”” layer of disordered chains that wrap around the nanostructures, becoming a handle for interesting properties. The morphol. of this “”hybrid bonding polymer”” nanostructure is dictated by the competition between the polymers’ entropy and the enthalpy of the lattice allowing for control over the aspect ratio of the nanocrystal by changing the degree of polymer integration. We observed that nanostructures with an exo-crystalline layer of polymer exhibit enhanced fracture strength, self-healing capacity, and dispersion in water, which benefits their use as light-harvesting assemblies in photocatalysis. Guided by computation, future work could further explore these hybrid nanostructures as components for functional materials. The experimental process involved the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Synthetic Route of C10H22N2O2)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Synthetic Route of C10H22N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Koblan, Luke W.; Buckley, Dennis L.; Ott, Christopher J.; Fitzgerald, Mark E.; Ember, Stuart W. J.; Zhu, Jin-Yi; Liu, Shuai; Roberts, Justin M.; Remillard, David; Vittori, Sarah; Zhang, Wei; Schonbrunn, Ernst; Bradner, James E. published 《Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET》.ChemMedChem published the findings.Synthetic Route of C10H22N2O2 The information in the text is summarized as follows:

Evaluating the engagement of a small mol. ligand with a protein target in cells provides useful information for chem. probe optimization and pharmaceutical development. While several techniques exist that can be performed in a low-throughput manner, systematic evaluation of large compound libraries remains a challenge. In-cell engagement measurements are especially useful when evaluating compound classes suspected to target multiple cellular factors. In this study we used a bioluminescent resonant energy transfer assay to assess bromodomain engagement by a compound series containing bromodomain- and kinase-biasing polypharmacophores based on the known dual BRD4 bromodomain/PLK1 kinase inhibitor BI2536. With this assay, we discovered several novel agents with bromodomain-selective specificity profiles and cellular activity. Thus, this platform aids in distinguishing mols. whose cellular activity is difficult to assess due to polypharmacol. effects. The experimental process involved the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Synthetic Route of C10H22N2O2)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Synthetic Route of C10H22N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self-assembly Chemical Library》 was published in ChemMedChem in 2020. These research results belong to Catalano, Marco; Moroglu, Mustafa; Balbi, Petra; Mazzieri, Federica; Clayton, James; Andrews, Katrina H.; Bigatti, Martina; Scheuermann, Joerg; Conway, Stuart J.; Neri, Dario. Formula: C10H22N2O2 The article mentions the following:

DNA-encoded chem. libraries (DECLs) are collections of chem. moieties individually coupled to distinctive DNA barcodes. Compounds can be displayed either at the end of a single DNA strand (i. e., single-pharmacophore libraries) or at the extremities of two complementary DNA strands (i. e., dual-pharmacophore libraries). The authors describe the use of a dual-pharmacophore encoded self-assembly chem. (ESAC) library for the affinity maturation of a known 4,5-dihydrobenzodiazepinone ring (THBD) acetyl-lysine (KAc) mimic for the cyclic-AMP response element binding protein (CREB) binding protein (CREBBP or CBP) bromodomain. The new pair of fragments discovered from library selection showed a sub-micromolar affinity for the CREBBP bromodomain in fluorescence polarization and ELISA assays, and selectivity against BRD4(1). In addition to this study using tert-Butyl (5-aminopentyl)carbamate, there are many other studies that have used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Formula: C10H22N2O2) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Formula: C10H22N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2017,Bigatti, Martina; Dal Corso, Alberto; Vanetti, Sara; Cazzamalli, Samuele; Rieder, Ulrike; Scheuermann, Joerg; Neri, Dario; Sladojevich, Filippo published 《Impact of a Central Scaffold on the Binding Affinity of Fragment Pairs Isolated from DNA-Encoded Self-Assembling Chemical Libraries》.ChemMedChem published the findings.HPLC of Formula: 51644-96-3 The information in the text is summarized as follows:

The screening of encoded self-assembling chem. libraries allows the identification of fragment pairs that bind to adjacent pockets on target proteins of interest. For practical applications, it is necessary to link these ligand pairs into discrete organic mols., devoid of any nucleic acid component. Here the authors describe the discovery of a synergistic binding pair for acid alpha-1 glycoprotein and a chem. strategy for the identification of optimal linkers, connecting the two fragments. The procedure yielded a set of small organic ligands, the best of which exhibited a dissociation constant of 9.9 nM, as measured in solution by fluorescence polarization. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3HPLC of Formula: 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).HPLC of Formula: 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C(sp3)-H Activation》 was published in Organic Letters in 2020. These research results belong to Ilazi, Agron; Huang, Bin; de Almeida Campos, Valery; Gademann, Karl. Quality Control of tert-Butyl (5-aminopentyl)carbamate The article mentions the following:

The synthesis of pyrrolidono[3,4-d]pyridones of relevance to putative genotoxic colibactin structures featuring a doubly conjugated 1,6-Michael acceptor system was reported. Highly selective Pd-catalyzed C(sp3)-H activation reaction as a key step and further functionalized the pyridone core was reported. Evaluating the role of this structural unit of relevance to colibactin, we found that this structure displayed a high degree of stability toward both acidic conditions and nucleophiles. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Quality Control of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Quality Control of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2018,Cheng, Zhi-Qiang; Song, Jia-Li; Zhu, Kongkai; Zhang, Juan; Jiang, Cheng-Shi; Zhang, Hua published 《Total synthesis of pulmonarin B and design of brominated phenylacetic acid/tacrine hybrids: marine pharmacophore inspired discovery of new ChE and Aβ aggregation inhibitors》.Marine Drugs published the findings.Safety of tert-Butyl (5-aminopentyl)carbamate The information in the text is summarized as follows:

A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogs were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory activity, while the hybrid 12j proved to be the most potent dual inhibitor among the designed derivatives, being almost as active as tacrine. Mol. modeling studies together with kinetic anal. suggested that 12j interacted with both the catalytic active site and peripheral anionic site of AChE. Compounds 1 and 12j could also inhibit self-induced and AChE-induced Aβ aggregation. In addition, the cell-based assay against the human hepatoma cell line (HepG2) revealed that 1 and 12j did not show significant hepatotoxicity compared with tacrine and donepezil. Taken together, the present study confirmed that compound 1 was a potential anti-Alzheimer’s disease (AD) hit, and 12j could be highlighted as a multifunctional lead compound for anti-AD drug development. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics