Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5159-59-1, name is Methyl 6-amino-2-naphthoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C12H11NO2
To a solution of methyl 6-amino-2-naphthoate (1.2 g, 6.0 mmol, 1.0 eq) and 4-(trifluoromethyl)cyclohexanone (2.0 g, 12.0 mmol, 2.0 eq) in DCM (20 mL) were added NaBH(OAc)3 (2.6 mg, 12.0 mmol, 2.0 eq) and HO Ac (360 mg, 6.0 mmol, 1.0 eq). The mixture was stirred at rt for 16 h and washed with sat. aq. NaHC03 (30 mL). The aqueous layer was extracted with EtOAc (30 mLx2). The combined organic layers were combined and concentrated. The residue was washed with MeOH to give the title compound as a yellow solid (700 mg, yield: 30%) with cis isomer only. 1H NMR (400 MHz, CDC13) delta 8.42 (s, 1H), 7.93 (dd, /= 1.6 Hz, 9.2 Hz, 1H), 7.72 (d, /= 9.2 Hz, 1H), 7.59 (d, /= 8.0 Hz, 1H), 6.92 (d, / = 8.0 Hz, 1H), 6.78 (s, 1H), 3.94 (s, 3H), 3.83 (s, 1H), 2.22-2.05 (m, 3H), 1.85-1.60 (m, 6H); ESI-MS (M+H) +: 352.2.
According to the analysis of related databases, 5159-59-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOGEN IDEC MA INC.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam; MA, Bin; MI, Sha; SHAO, Zhaohui; SUN, Lihong; TAVERAS, Arthur; WANG, Deping; XIN, Zhili; ZHANG, Lei; WO2014/18887; (2014); A1;,
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