Synthetic Route of 51175-79-2,Some common heterocyclic compound, 51175-79-2, name is Methyl 1-bromocyclobutanecarboxylate, molecular formula is C6H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 46; Preparation of intermediate l-(4-chloro-2-formyl-phenoxy)-cyc Io butanecarboxylic acid methyl ester; M.W. 268.70 C13H13C1O4A mixture of 5-chloro-2-hydroxy-benzaldehyde (10 g, 64 mmol), 1-bromo- cyclobutanecarboxylic acid methyl ester (15 g, 77 mmol), K2CO3 (13 g, 94 mmol) in DMF (100 mL) was heated at 140 0C for 1.5 h. Then the mixture was partitioned between ethyl acetate and water, the organic layer was washed with water 4 times, dried over anhydrous Na2SO4, concentrated to give crude product as dark oil (18 g ).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 1-bromocyclobutanecarboxylate, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; HAN, Xingchun; YANG, Song; ZHANG, Zhuming; WO2010/121995; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics