Category: 50670-76-3

Kim, Dae Seok published the artcileSelf-Regulated Smectic Emulsion with Switchable Lasing Application, Category: esters-buliding-blocks, the publication is Small (2019), 15(49), 1903818, database is CAplus and MEDLINE.

A structurally reversible smectic liquid crystal (LC) emulsion made of semifluorinated rod-type mols. in silicone oil, which is controlled by simple heating and cooling, is presented. Without adding any kind of additives, such as surfactants, polymers or emulsifiers, and without using any special tools, such as microfluidics or gas bubbling, the LC mols. spontaneously form monodisperse spherical and myelin-like structures upon cooling from the isotropic temperature The LC emulsion can easily trap guest materials, providing a platform for repeatable and reliable switchable emulsification. For example, this interesting system enables the realization of an on-off lasing system by confining fluorescent dyes in the LC droplets.

Small published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Levoin, Nicolas published the artcileNovel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity, Quality Control of 50670-76-3, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5378-5383, database is CAplus and MEDLINE.

Pre-clin. investigation of some aryl-piperidinyl ether histamine H3 receptor antagonists revealed a strong hERG binding. To overcome this issue, we have developed a QSAR model specially dedicated to H3 receptor ligands. This model was designed to be directly applicable in medicinal chem. with no need of mol. modeling. The resulting recursive partitioning trees are robust (80-85% accuracy), but also simple and comprehensible. A novel promising lead I emerged from our work and the structure-activity relationships are presented.

Bioorganic & Medicinal Chemistry Letters published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Quality Control of 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Levoin, Nicolas published the artcileDetermination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists, Synthetic Route of 50670-76-3, the publication is Bioorganic & Medicinal Chemistry (2013), 21(15), 4526-4529, database is CAplus and MEDLINE.

Due to its involvement in major CNS functions, the histamine H3 receptor (H3R) is the subject of intensive medicinal chem. investigation, supported by the range of modern drug discovery tools, such as receptor modeling and ligand docking. Although the receptor models described to date share a majority of common traits, they display discrete alternatives in amino-acid conformation, rendering ligand binding modes quite different. Such variations impede structure-based drug design in the H3R field. In the present study, we used a combination of medicinal chem., receptor-guided and ligand-based methods to elucidate the binding mode of antagonists. The approaches converged towards a ligand orientation perpendicular to the membrane plane, bridging Glu206 of the transmembrane helix 5 to acidic amino acids of the extracellular loops. This consensus will help future structure-based drug design for H3R ligands.

Bioorganic & Medicinal Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Synthetic Route of 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Thesen, Manuel W. published the artcileInvestigation of spacer influences in phosphorescent-emitting nonconjugated PLED systems, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2010), 48(2), 389-402, database is CAplus.

An assay was introduced to clarify influences on electroluminescent behavior for RGB-colored phosphorescent terpolymers with N,N-Di-p-tolyl-aniline as hole-transporting unit, 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (tert-BuPBD) as electron-transporting unit, and different iridium complexes in RGB-colors as triplet emitting materials. All monomers were attached with spacer moieties to the “para” position of a polystyrene. Polymer light emitting diodes (PLEDs) were built to study the electro-optical behavior of these materials. The gist was a remarkable influence of hexyl-spacer units to the PLED performance. For all three colors only very restricted PLED performances were found. In comparison RGB-terpolymers were synthesized with directly attached charge transport materials to the polymer backbone. For this directly linked systems efficiencies were 28 cd A^-1 @ 6 V (green), 4.9 cd A^-1 @ 5 V (red) and 4.3 cd A^-1 @ 6 V (bluish). In summary we assume that an improved charge percolation pathways regarding to the higher content of semiconducting mols. and an improved charge transfer to the phosphorescent dopant in the case of the copolymers without spacers are responsible for the better device performance comparing the copolymers with hexyl spacers. The approach of the directly connected charge transport materials at the nonconjugated styrene polymer backbone should be favored for further investigations, therefore. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 389-402, 2010.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C9H9NO6S, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Demkowicz, Sebastian published the artcilePhosphate and Thiophosphate Biphenyl Analogs as Steroid Sulfatase Inhibitors, Category: esters-buliding-blocks, the publication is Drug Development Research (2015), 76(2), 94-104, database is CAplus and MEDLINE.

Preclin. Research In the present work, we report convenient methods for the synthesis and biol. evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity. The described synthesis is based on straightforward preparation of biphenyl-4-ol and 4′-hydroxy-biphenyl-4-carboxylic acid Et ester modified with various phosphate or thiophosphate moieties. The inhibitory effects of these compounds were tested on STS isolated from human placenta and led to two compounds of interest, 5a and 5d with IC₅₀ values of 28.0 and 22.1 μM, resp. and that had interesting new binding modes in the STS active site. Drug Dev Res, 2015. © 2015 Wiley Periodicals, Inc.

Drug Development Research published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lund, Birgitte W. published the artcileDesign, Synthesis, and Structure-Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2009), 52(6), 1540-1545, database is CAplus and MEDLINE.

We recently discovered the isoform selective RARβ2 ligand 4′-octyl-4-biphenylcarboxylic acid (3, AC-55649)(I). Although 3 is highly potent at RARβ2 and displays excellent selectivity, solubility issues make it unsuitable for drug development. Herein we describe the exploration of the SAR in a biphenyl and a phenylthiazole series of analogs of 3. This ultimately led to the design of 28 (II), a novel, orally available ligand with excellent isoform selectivity for the RARβ2.

Journal of Medicinal Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hoshino, Koji published the artcileIon-conductive liquid crystals: formation of stable smectic semi-bilayers by the introduction of perfluoroalkyl moieties, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Macromolecular Chemistry and Physics (2002), 203(10/11), 1547-1555, database is CAplus.

Two liquid-crystalline compounds having perfluoroalkyl-terminated mesogens at both ends of poly-(ethylene oxide) chains have been prepared These compounds show smectic A (S_A) and C phases over 100°C. The S_A-Iso (isotropic) transition temperatures are higher by about 70°C than those of the two corresponding alkyl-substituted compounds The incorporation of lithium triflate into the perfluoroalkyl-terminated mesogen-containing compounds widens the temperature ranges of the S_A phases for the resulting complexes. The complexes of these compounds containing 50 mol-% of lithium triflate exhibit columnar phases. The ionic conductivities of the homotropically aligned complexes based on fluoroalkyl-terminated compounds along the direction perpendicular to the mol. director of the S_A phases are higher than those of the corresponding compound containing alkyl groups. The increase of the ionic conductivities as well as the stabilization of the smectic phases for these perfluoroalkyl-terminated compounds may be due to the formation of more stabilized layered structures through the intermol. interactions among the perfluoroalkyl moieties.

Macromolecular Chemistry and Physics published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Application of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kang, Suk Hoon published the artcileEmbedding Nanofibers in a Polymer Matrix by Polymerization of Organogels Comprising Heterobifunctional Organogelators and Monomeric Solvents, Category: esters-buliding-blocks, the publication is Chemistry of Materials (2008), 20(17), 5532-5540, database is CAplus.

We demonstrate the embedding of nanofibers in a polymer matrix through the polymerization of an organogel. A series of organogelators based on a biphenyl ester having two different polymerizable groups, namely, acryl and diacetylene groups, are prepared The resulting heterobifunctional gelators show the ability to gelate various monomeric solvents. The photopolymerization of an organogel of a heterobifunctional gelator (1.5 or 10 wt %), formed in hexyl methacrylate (HMA), is carried out by UV irradiation in the presence of 2,2-dimethoxy-2-phenylacetophenone (photoinitiator, 4 wt %). The polymerization of HMA forms a polymer matrix, while the polymerization of the acryl and diacetylene groups of the gelator forms the nanofibers with a cross-linked structure. The copolymerization of a gelator and HMA at the interface will improve the adhesion between the nanofiber and the polymer matrix. The polymerized gels appear yellowish and exhibit strong fluorescence when irradiated with 365 nm UV light. This is due to the presence of polydiacetylene chains. The fluorescent polydiacetylene nanofibers embedded in the polymer matrix are visualized by using confocal laser scanning microscopy. The thermal and mech. properties of the nanofibers embedded in polyHMA are investigated using differential scanning calorimetry, dynamic mech. anal., and a universal testing machine. The polymerized gels show improved thermal and phys. properties in comparison to the matrix polymer (polyHMA).

Chemistry of Materials published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bachovchin, Daniel A. published the artcileSuperfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening, Quality Control of 50670-76-3, the publication is Proceedings of the National Academy of Sciences of the United States of America (2010), 107(49), 20941-20946, S20941/1-S20941/172, database is CAplus and MEDLINE.

Serine hydrolases (SHs) are-one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biol. understanding for most of the 110+ predicted mammalian metabolic SHs, in large part because of a dearth of assays to assess their biochem. activities and a lack of selective inhibitors to probe their function in living systems. We show here that the vast majority (>80%) of mammalian metabolic SHs can be labeled in proteomes by a single, active site-directed fluorophosphonate probe. We exploit this universal activity-based assay in a library-vs.-library format to screen 70+ SHs against 140+ structurally diverse carbamates. Lead inhibitors were discovered for ∼40% of the screened enzymes, including many poorly characterized SHs: Global profiles identified carbamate inhibitors that discriminate among highly sequence-related SHs and, conversely, enzymes that share inhibitor sensitivity profiles despite lacking sequence homol. These findings indicate that sequence relatedness is not a strong predictor of shared pharmaol. within the SH superfamily. Finally, we show that lead carbamate inhibitors can be optimized into pharmacol. probes that inactivate individual SHs with high specificity in vivo.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Quality Control of 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ahmed, Sabbir published the artcileDesign, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES), Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Journal of Steroid Biochemistry and Molecular Biology (2003), 82(4-5), 425-435, database is CAplus and MEDLINE.

We report the results of our study into a series of 4′-O-sulfamoyl-4-biphenyl based compounds as novel inhibitors of the enzyme estrone sulfatase (ES). From the results of the mol. modeling design process, it was suggested that these compounds would be able to mimic both the A and C rings of the steroid backbone, and thus possess inhibitory activity against ES. The results of the biochem. evaluation study show that these compounds are indeed good inhibitors, possessing greater inhibitory activity than COUMATE, but weaker inhibitory activity than EMATE or the tricyclic derivative of COUMATE, namely 667-COUMATE. Furthermore, the compounds are observed to be irreversible inhibitors.

Journal of Steroid Biochemistry and Molecular Biology published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics