Category: 4949-44-4

《Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5》 was written by Ortiz Zacarias, Natalia V.; van Veldhoven, Jacobus P. D.; den Hollander, Lisa S.; Dogan, Burak; Openy, Joseph; Hsiao, Ya-Yun; Lenselink, Eelke B.; Heitman, Laura H.; IJzerman, Adriaan P.. Related Products of 4949-44-4This research focused ontriazolopyrimidinone preparation chemokine receptor antagonist. The article conveys some information:

In this study, synthesis and the biol. activity of a series of triazolopyrimidinones I (R1 = Ph, 2-MeOC6H4, 3-ClC6H4, 3,4-Cl2C6H3, etc.; R2 = H, Me, H2N; R3 = Me, Et, i-Pr, cyclopropyl, Ph, etc.) as intracellular antagonists for CC chemokine receptors 2 and 5 (CCR2 and CCR5) are reported. Radioligand binding assays first showed that these compounds bind to the intracellular site of CCR2, and in combination with functional assays on CCR5, structure-affinity/activity relationships in both receptors were explored. Although most compounds were CCR2-selective, the compounds I (R1 = 2,3-Cl2C6H3, 3-Br-4-ClC6H3; R2 = H2N; R3 = i-Pr) inhibited β-arrestin recruitment in CCR5 with high potency. Moreover, these compounds displayed an insurmountable mechanism of inhibition in both receptors, which holds promise for improved efficacy in inflammatory diseases.Ethyl 3-oxopentanoate(cas: 4949-44-4Related Products of 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Related Products of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cariello Silva, Guilherme; de Souza, Gabriela F. P.; Salles, Airton G. Jr published an article in 2022. The article was titled 《Catalytic redox-neutral C-H functionalisation with TEMPO in water to access aminomethyl-substituted pyrroles》, and you may find the article in Organic & Biomolecular Chemistry.Computed Properties of C7H12O3 The information in the text is summarized as follows:

Synthesis of aminomethyl-substituted pyrroles I [R1 = H, 4-Me, 4-Cl, etc.; R2 = H, Me; R3 = R4 = Me, Et] via TEMPO-catalyzed redox-neutral C-H functionalization in water was reported. Starting from cheap and com. chem. feedstocks (ketoesters and anilines), this approach delivered targeted products I in good yields and represented an endeavour to address redox economy in radical transformations. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Computed Properties of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Computed Properties of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Mirjalili, Bi Bi Fatemeh; Bamoniri, Abdolhamid; Fazeli-Attar, Seyede Azita published an article in Research on Chemical Intermediates. The title of the article was 《Nano-BFn/cellulose: a bio-based nano-catalyst for synthesis of bio-active 7-hydroxycoumarins》.Category: esters-buliding-blocks The author mentioned the following in the article:

Nano-BFn/cellulose as a modified bio-based nano-catalyst was synthesized from nanocellulose and boron triflouride via very simple steps. This novel nano-catalyst exhibited many advantages in the synthesis of 7-hydroxycoumarins, e.g., I such as good reaction time, high yield, and easy work-up method with reusability and environment friendly of nano-catalyst. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2022 ,《Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction》 appeared in European Journal of Medicinal Chemistry. The author of the article were Le Biannic, Raphael; Magnez, Romain; Klupsch, Frederique; Leleu-Chavain, Natascha; Thiroux, Bryan; Tardy, Morgane; El Bouazzati, Hassiba; Dezitter, Xavier; Renault, Nicolas; Vergoten, Gerard; Bailly, Christian; Quesnel, Bruno; Thuru, Xavier; Millet, Regis. The article conveys some information:

The microwave-assisted synthesis and the characterization of an innovative series of synthetic compounds I (R1 = pyridin-2-yl, pyrimidin-2-yl, Ph, etc.; R2 = Ph, Me, adamantan-1-yl, t-Bu, etc.) endowed with nanomolar activity against programmed death ligand 1 (PD-L1) were described. The properties of the compounds were characterized using several biophys. techniques including microscale thermophoresis (MST) and fluorescence resonance energy transfer (FRET) measurements. A few small mols. demonstrated a high affinity for human PD-L1, potently disrupted the PD-L1:PD-1 interaction and inhibited Src homol. region 2 domain-containing phosphatase (SHP2) recruitment to programmed death receptor 1 (PD-1). More than 30 mols. from the pyrazolone family have been synthesized and 5 highly potent quot PD-L1 silencing compounds” have been identified, based on in vitro measurements. Structure-activity relationships have been defined and ADME properties were evaluated. The phenyl-pyrazolone unit offers novel perspectives to design PD-L1-targeting agents, potentially useful to combat cancer and other pathologies implicating the PD-1/PD-L1 checkpoint. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Mirjalili, Bi Bi Fatemeh; Bamoniri, Abdolhamid; Fazeli-Attar, Seyede Azita published an article in Research on Chemical Intermediates. The title of the article was 《Nano-BFn/cellulose: a bio-based nano-catalyst for synthesis of bio-active 7-hydroxycoumarins》.Category: esters-buliding-blocks The author mentioned the following in the article:

Nano-BFn/cellulose as a modified bio-based nano-catalyst was synthesized from nanocellulose and boron triflouride via very simple steps. This novel nano-catalyst exhibited many advantages in the synthesis of 7-hydroxycoumarins, e.g., I such as good reaction time, high yield, and easy work-up method with reusability and environment friendly of nano-catalyst. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2022 ,《Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction》 appeared in European Journal of Medicinal Chemistry. The author of the article were Le Biannic, Raphael; Magnez, Romain; Klupsch, Frederique; Leleu-Chavain, Natascha; Thiroux, Bryan; Tardy, Morgane; El Bouazzati, Hassiba; Dezitter, Xavier; Renault, Nicolas; Vergoten, Gerard; Bailly, Christian; Quesnel, Bruno; Thuru, Xavier; Millet, Regis. The article conveys some information:

The microwave-assisted synthesis and the characterization of an innovative series of synthetic compounds I (R1 = pyridin-2-yl, pyrimidin-2-yl, Ph, etc.; R2 = Ph, Me, adamantan-1-yl, t-Bu, etc.) endowed with nanomolar activity against programmed death ligand 1 (PD-L1) were described. The properties of the compounds were characterized using several biophys. techniques including microscale thermophoresis (MST) and fluorescence resonance energy transfer (FRET) measurements. A few small mols. demonstrated a high affinity for human PD-L1, potently disrupted the PD-L1:PD-1 interaction and inhibited Src homol. region 2 domain-containing phosphatase (SHP2) recruitment to programmed death receptor 1 (PD-1). More than 30 mols. from the pyrazolone family have been synthesized and 5 highly potent quot PD-L1 silencing compounds” have been identified, based on in vitro measurements. Structure-activity relationships have been defined and ADME properties were evaluated. The phenyl-pyrazolone unit offers novel perspectives to design PD-L1-targeting agents, potentially useful to combat cancer and other pathologies implicating the PD-1/PD-L1 checkpoint. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of Ethyl 3-oxopentanoateIn 2019 ,《Investigation of biaryl heterocycles as inhibitors of Wee1 kinase》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Mastracchio, Anthony; Lai, Chunqiu; Torrent, Maricel; Bromberg, Kenneth; Buchanan, Fritz G.; Ferguson, Debra; Bontcheva, Velitchka; Johnson, Eric F.; Lasko, Loren; Maag, David; Soni, Nirupama; Shoemaker, Alexander R.; Penning, Thomas D.. The article conveys some information:

In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure-activity exploration of substituents at C-8 or N-8 which were used for tuning compound properties and to improve compound profiles. The lead mol. I demonstrated a desirable pharmacokinetic profile and potentiated the anti-proliferative activity of irinotecan in vivo when dosed orally in the human breast MX-1 xenograft model. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Safety of Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Safety of Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A competitive and highly selective 7-, 6- and 5-annulation with 1,3-migration through C-H and N-H – alkyne coupling》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Ajarul, Sk; Kayet, Anirban; Pati, Tanmay K.; Maiti, Dilip K.. HPLC of Formula: 4949-44-4 The article mentions the following:

A highly competitive and selective C-C and N-C cross-coupled 7-, 6- and 5-annulation was described utilizing 2-ethynylanilides to afford functionalized 1H-benzo[b]azepin-2(5H)-ones I [R1 = Me, Et, Ph, 4-O2NC6H4; R2 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R3 = H, 7-Me, 7-Cl, 8-Cl], 2-quinolinones II [R4 = Me, Et, Ph, etc.; R5 = H, Ph, 4-O2NC6H4, etc.; R6 = H, 6-Me, 7-Cl, etc.] and 3-acylindoles III [R7 = Me, Et, Ph, 4-MeC6H4; R8 = Ph, 4-MeOC6H4, 4-BrC6H4; R9 = H, Me, Cl, Br] resp., with high yields and operational simplicity. Zinc chloride was found to be the smart catalyst for 7- and 5-annulation with 1,3-migration through C-H and N-H functionalization, resp., whereas mol. iodine performed the C-H functionalized 6-annulation with a non-conventional 1,3 H-shift. The mechanism was investigated by intermediate trapping, control and labeling experimentsEthyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.HPLC of Formula: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis, crystal structure and ADME prediction studies of novel imidazopyrimidines as antibacterial and cytotoxic agents》 was written by Abdel-Mohsen, Heba T.; Abood, Amira; Flanagan, Keith J.; Meindl, Alina; Senge, Mathias O.; El Diwani, Hoda I.. Name: Ethyl 3-oxopentanoate And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2020. The article conveys some information:

In the present study, a novel series of polyfunctionalized imidazopyrimidines I [R1 = H, 4-OMe, 2,5-di-OMe, 3,4,5-tri-OMe; R2 = H, 3,4-di-Cl, 2-OMe, etc.; R3 = H, CN] were efficiently constructed by a domino reaction between 2-imino-6-substituted-2,3-dihydropyrimidin-4(1H)-ones II [ R3 = H, CN; R4 = Me, Ph, 2,5-di-OMeC6H4, etc.] and 2-bromoacetophenones under mild basic conditions. The synthesized series were screened for their antibacterial activity against S. aureus and B. subtilis as Gram-pos. (+) bacteria, as well as against Gram-neg. (-) bacteria E. coli, K. pneumoniae, P. aeruginosa and S. typhi. Most of the synthesized derivatives of imidazopyrimidines I showed remarkable selectivity against Gram(-) bacteria over the Gram(+) ones. Compounds I [R1 = H; R2 = 4-Cl, 3,4-di-Cl, 2-OMe; R3 = CN] displayed potent and broad-spectrum antibacterial activity against all tested strains. Compounds I [R1 = H; R2 = 3,4-di-Cl, 2-OMe; R3 = CN] displayed promising inhibitory activity on GryB ATPase from E. coli with IC50 = 1.14 and 0.73μM, resp. Simultaneously, some of the synthesized imidazopyrimidines were screened for their antiproliferative activity against 60 cancer cell lines at a concentration of 10μM. Compound I [R1 = Ph; R2 = 4-F; R3 = H] showed potent activity against most of the tested cell lines, with a mean growth inhibition of 37%. The ADME (absorption, distribution, metabolism, and excretion) prediction study demonstrated that the synthesized hits had, in addition to their promising chemotherapeutic activity, acceptable pharmacokinetic properties, and a drug-likeness nature to be further developed. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-oxopentanoate(cas: 4949-44-4Name: Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Name: Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tharra, Prabhakara R.; Mikhaylov, Andrey A.; Svejkar, Jiri; Gysin, Marina; Hobbie, Sven N.; Svenda, Jakub published an article in 2022. The article was titled 《Short Synthesis of (+)-Actinobolin: Simple Entry to Complex Small-Molecule Inhibitors of Protein Synthesis》, and you may find the article in Angewandte Chemie, International Edition.Application of 4949-44-4 The information in the text is summarized as follows:

We report a concise synthesis of the naturally occurring protein synthesis inhibitor (+)-actinobolin. The densely functionalized and stereochem. complex mol. structure of (+)-actinobolin was assembled from (-)-quinic acid, L-threonine, and L-alanine as the principal components. Our route is based around a convergent strategy that features conjugate addition of an α-amino radical in the key fragment-coupling step. The dramatically simplified synthesis of (+)-actinobolin proceeding in 9 steps with 18% overall yield has practical implications for analog preparation, as demonstrated herein.Ethyl 3-oxopentanoate(cas: 4949-44-4Application of 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics