Category: 4949-44-4

The author of 《Design, synthesis and antimycobacterial activity of less lipophilic Q203 derivatives containing alkaline fused ring moieties》 were Wang, Apeng; Wang, Hongjian; Geng, Yunhe; Fu, Lei; Gu, Jian; Wang, Bin; Lv, Kai; Liu, Mingliang; Tao, Zeyu; Ma, Chao; Lu, Yu. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Category: esters-buliding-blocks The author mentioned the following in the article:

We report herein the design and synthesis of a series of less lipophilic Q203 derivatives containing an alk. fused ring moiety. Most of them show considerable potency against MTB H37Rv strain (MIC < 0.25 μM). Nine compounds (13, 15, 19, 21, 23, 25, 29, 35, 36) have the same excellent activity against both drug-sensitive and -resistant strains (MIC < 0.035 μM) as Q203 and PBTZ169. Especially, compound 29 also displays acceptable safety, greater absorption in plasma and aqueous solubility than Q203, suggesting its promising potential to be lead compound for future antitubercular drug discovery. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Yi-Kang; Xu, Si-Yu; Zhang, Shu-Sheng; Fu, Jian-Guo; Lin, Guo-Qiang; Feng, Chen-Guo published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Palladium-Catalyzed Tandem γ-Arylation/Aromatization of Cyclohex-2-En-1-One Derivatives: A Route to 3,4-Dihydroanthracen-1(2H)-Ones》.Formula: C7H12O3 The article contains the following contents:

An intramol. palladium-catalyzed tandem γ-arylation/aromatization reaction of cyclohex-2-en-1-one derivatives was developed. This work provides a simple and efficient approach for the construction of substituted 3,4-dihydroanthracen-1(2H)-ones in good yields with a broad substrate scope. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-oxopentanoate(cas: 4949-44-4Formula: C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Ran; Dou, You; Zhang, Yinli; Qu, Lingbo; Sun, Yuanqiang; Li, Zhaohui published an article in 2021. The article was titled 《A facile and highly efficient fluorescent turn-on switch strategy based on diketone isomerization and its application in peroxynitrite fluorescent imaging》, and you may find the article in Sensors and Actuators, B: Chemical.COA of Formula: C7H12O3 The information in the text is summarized as follows:

A fluorescence turn-on switch induced by functional group conversion offers great potential in fluorescent probes and bioimaging due to its high specificity and efficiency. Exploring novel fluorescence turn-on switches and their singling mechanism are of great significance. In this manuscript, a novel fluorescent turn-on switch strategy induced by diketone isomerization was reported. It was found that when the diketone group of the synthesized coumarin derivative was converted into its monoketone or carboxylic acid derivatives, it could be illuminated. With this fluorescence turn-on strategy, the obtained probe could be used as a trigger for peroxynitrite (ONOO-). The imaging and monitoring of ONOO- in RAW 264.7 cells endogenously induced by acetaminophen and heat shock were successfully achieved. This diketone isomerization strategy will promote the design and construction of a series of novel redox probes. In the experiment, the researchers used Ethyl 3-oxopentanoate(cas: 4949-44-4COA of Formula: C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.COA of Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and Antimicrobial Activity of Burkholderia-Related 4-Hydroxy-3-methyl-2-alkenylquinolines (HMAQs) and Their N-Oxide Counterparts》 was published in Journal of Natural Products in 2020. These research results belong to Piochon, Marianne; Coulon, Pauline M. L.; Caulet, Armand; Groleau, Marie-Christine; Deziel, Eric; Gauthier, Charles. Recommanded Product: Ethyl 3-oxopentanoate The article mentions the following:

The synthesis of a series of six 4-hydroxy-3-methyl-2-alkenylquinolines (HMAQs)/4-hydroxy-3-methyl-2-alkenylquinoline N-oxides (HMAQNOs) featuring a trans-Δ2 double bond at the C2-alkyl chain was reported. The quinolone scaffold was obtained via the Conrad-Limpach approach, while the (E)-2-alkenyl chain was inserted through Suzuki-Miyaura cross-coupling under microwave radiation without noticeable isomerization according to the optimized conditions. Subsequent oxidation of enolate-protected HMAQs cleanly led to the formation of HMAQNOs following cleavage of the Et carbonate group. Synthetic HMAQs/HMAQNOs were evaluated in vitro for their antimicrobial activity against different Gram-neg. and Gram-pos. bacteria as well as against molds and yeasts. The biol. results support and extend the potential of HMAQs/HMAQNOs as antimicrobials, especially against Gram-pos. bacteria. The involvement of HMAQs in the autoregulation of the Hmq system in Burkholderia ambifaria was confirmed. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fares, Mohamed; Canfield, Peter; Alsherbiny, Muhammad A.; Lewis, William; Willis, Anthony C.; Guang Li, Chun; Neyts, Johan; Jochmans, Dirk; Gale, Philip A.; Keller, Paul A. published an article in 2022. The article was titled 《Synthesis, X-ray crystallographic analysis, DFT studies and biological evaluation of triazolopyrimidines and 2-anilinopyrimidines》, and you may find the article in Journal of Molecular Structure.Recommanded Product: 4949-44-4 The information in the text is summarized as follows:

Inspired by the reported antiviral activity of pyrimidines and triazolopyrimidines, two series of 2-anilinopyrimidines I (R1 = H, 3-F, 3-Cl-4-CF3 etc.) and 1-aryl-[1,2,4]triazolo[4,3-a]pyrimidines II (R2 = COMe, CO2Et; Ar = 3-FC6H4, 3-CH3COC6H4, 3-iPrOPh, etc.) were designed and synthesized as potential antiviral agents. The pharmacokinetic properties and calculation of drug likeness scores (DLS) of I and II suggested good traditional drug-like properties and led to the synthesis of derivatives II which were evaluated for their anti-viral activity with the most potent derivatives subjected to cytotoxicity screening. Compounds II (R2 = COMe; Ar = 3-FC6H4) II (R2 = COMe; Ar = 3-CH3COC6H4), II (R2 = COMe; Ar = 3-iPrOPh), II (R2 = CO2Et; Ar = 3-iPrOPh) and II (R2 = COMe; Ar = 4-BrPh) showed moderate to strong antiviral activity with EC50 values 38 – 186μM. Compound I (DLS = 0.29) showed the best anti-CHIKV activity (EC50 = 38μM) and lowest cytotoxicity (CC50 > 300μg/mL) against breast cancer cell lines, MCF-7 and MD-AMB-231 and normal cell line EA.hy926. Simplification of [1,2,4]triazolo[4,3-a]pyrimidine ring, led to series I (DLS = 0.03 – 0.77). Derivatives I showed fair anti-CHIKV activity (EC50 > 200μM), while I (R1 = 3-Cl-4-CF3) emerged as the most active antiviral agent, however the most cytotoxic. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

SDS of cas: 4949-44-4In 2021 ,《Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones》 appeared in Chemistry – A European Journal. The author of the article were Wang, Rong-Hui; Li, Ya-Ling; He, Hong-Jiao; Xiao, You-Cai; Chen, Fen-Er. The article conveys some information:

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins was developed. In the presence of morpholine-containing chiral amino alc. ligand, the corresponding chiral cyclic tertiary alcs. were produced in good to excellent yields (up to 97%) and enantioselectivities (up to 95% ee). The notable feature of this protocol included its mild reaction conditions, Lewis acid additives free and broad functional group tolerance. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4SDS of cas: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.SDS of cas: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: Ethyl 3-oxopentanoateIn 2019 ,《Design, synthesis, insecticidal, and acaricidal activities of novel pyrimidinamine derivatives containing a biphenyl ether》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Li, Lizhong; Zhou, Chunge; Liu, Minhua; Zhang, Ping; Zhang, Ning; Li, Jianming; Li, Tao; Liu, Xingping; Cheng, Shufen; Li, Qianhe; Liu, Aiping. The article conveys some information:

A series of original pyrimidinamine derivatives containing a biphenyl ether moiety I (R = H, Me; R1 = Me, Et, i-Pr; R2 = R3 = H, Me; R4 = H, Me, Cl, etc.) were designed and synthesized. Their insecticidal activities against lepidopteran and hemiptera insects and acaricidal activities were tested. The results of bioassay demonstrated that I (R = Me; R1 = Et; R2 = R3 = H; R4 = t-Bu) showed the best activity (LC50 = 2.08 mg/L) against Tetranychus urticae, which is comparable with the pos. control, spirotetramat (LC50 = 2.27 mg/L), and I (R = Me; R1 = Et; R2 = R3 = H; R4 = Me) showed better activity (LC50 = 0.52 mg/L) against Aphis fabae than the pos. control, imidacloprid (LC50 = 1.02 mg/L), and relatively good activity (LC50 = 2.49 mg/L) against T. urticae. Their structure-activity relationships indicated that both an Et group on the 4-position of the pyrimidine ring and alkyl chain as a para-substituent group of the benzene ring showed good biol. activity. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-oxopentanoate(cas: 4949-44-4Name: Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Name: Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2022 ,《A Novel Trisubstituted Tetrahydropyran as a Possible Pheromone Component for the South American Cerambycid Beetle Macropophora accentifer》 was published in Journal of Chemical Ecology. The article was written by Silva, Weliton D.; Zou, Yunfan; Hanks, Lawrence M.; Bento, Jose Mauricio S.; Millar, Jocelyn G.. The article contains the following contents:

A novel trisubstituted tetrahydropyran was isolated and identified from the sex-specific volatiles produced by males of the cerambycid beetle Macropophora accentifer (Olivier), a serious pest of citrus and other fruit crops in South America. The compound was the major component in the headspace volatiles and it was synthesized in racemic form. However, in field trials, the racemate was only weakly attractive to beetles of both sexes, suggesting that attraction might be inhibited by the presence of the “”unnatural”” enantiomer in the racemate. Alternatively, the male-produced volatiles contained a number of minor and trace components, including a compound tentatively identified as a homolog of the major component, as well as a number of unsaturated 8-carbon alcs. and aldehydes. Further work is required to conclusively identify and synthesize these minor components, to determine whether one or more of them are crucial components of the active pheromone blend for this species. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic & Biomolecular Chemistry included an article by Huang, Junmin; Hu, Xinwei; Chen, Fengjuan; Gui, Jiao; Zeng, Wei. COA of Formula: C7H12O3. The article was titled 《Rhodium(I)-catalyzed vinylation/[2+1] carbocyclization of 1,6-enynes with α-diazocarbonyl compounds》. The information in the text is summarized as follows:

A sequential Rh(I)-catalyzed vinylation/[2+1]carbocyclization between enynes and diazo compounds has been developed. This transformation features a wide range of enynes and acceptor/acceptor diazo compounds, providing easy access to versatile vinyl-substituted azabicyclo[3.1.0]hexanes having a broad tolerance to functional groups. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4COA of Formula: C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.COA of Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Zhang, Xin-Ke; Miao, Xiao-Yu; Zhou, Yu; Wang, Yu-Mei; Song, Ying-Chun; Liu, Hang; Xiong, Yi-Lu; Li, Ling-Yu; Wu, An-Xin; Zhu, Yan-Ping published an article in Organic & Biomolecular Chemistry. The title of the article was 《Iodine-catalyzed oxidative annulation: facile synthesis of pyrazolooxepinopyrazolones via methyl azaarene sp3 C-H functionalization》.Recommanded Product: 4949-44-4 The author mentioned the following in the article:

An iodine-catalyzed Me azaarene sp3 C-H functionalization has been developed for the synthesis of a seven-membered O-heterocyclic architecture containing three different heterocyclic aromatic hydrocarbons. This method can be applied to a wide range of substituted Me azaarenes and diverse 2,4-dihydro-3H-pyrazol-3-ones, and brings about the efficient preparation of 2,9-dihydrooxepino[2,3-c:6,5-c’]dipyrazol-3(7H)-ones in high yields with the merits of low catalyst loading, good functional group tolerance and metal-free conditions.Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics