Category: 4949-44-4

Kawaii, Satoru; Matsuoka, Yu; Noguchi, Hideki; Sato, Takanori; Yoshizawa, Yuko published an article in 2022. The article was titled 《Relationship between the structure of alkylpsoralens and their antiproliferative activity in HL60 cells》, and you may find the article in Anticancer Research.Application of 4949-44-4 The information in the text is summarized as follows:

A series of alkylpsoralens I were synthesized, and their antiproliferative activity was evaluated in leukemic HL60 cells. Alkylpsoralens I were systematically synthesized from the combination of several chloroketones and 7-hydroxycoumarin derivatives Among the compounds synthesized, 4,4′,8-trimethylpsoralen demonstrated the most potent activity (IC50 = 6.6μM). The correlation between the alkylation pattern and antiproliferative activity showed the importance of the C4-Me and C8-Me moieties in the psoralen nucleus as well as the importance of lipophilicity for their antiproliferative activity.Ethyl 3-oxopentanoate(cas: 4949-44-4Application of 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 4949-44-4In 2021 ,《Convenient one-step synthesis of quinoline-3,4-dicarboxylate derivatives》 appeared in Synthetic Communications. The author of the article were Ge, Youjin; Yu, Niefang. The article conveys some information:

Herein a practical and convenient procedure for the one-step synthesis of quinoline-3,4-dicarboxylate derivatives from isatins and β-keto esters in alcs. catalyzed by sulfuric acid was described. This novel protocol offers the advantages of high conversion rates, short reaction times, and easy handling. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Product Details of 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of Ethyl 3-oxopentanoateIn 2020 ,《Promoter regulated selective annulation preparation of polysubstituted quinolines via bond cleavage from styrylanilines and beta ketoesters》 was published in Organic Chemistry Frontiers. The article was written by Xu, Hui; Yu, Fei; Huang, Ronglu; Weng, Mingyue; Chen, Hong; Zhang, Ze. The article contains the following contents:

A powerful construction of 2-alkylquinolines and quinoline-2-carboxylates was been successfully accomplished employing I2 and Mn(OAc)3, resp., to promote the annulation of 2-styrylanilines and β-keto esters accompanied by selective C-C bond cleavage. Following this promoter-regulated strategy, various 2-alkylquinolines and quinoline-2-carboxylates were chemoselectively synthesized from easily available 2-styrylanilines and β-keto esters. The reaction mechanism was also tentatively investigated. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Safety of Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Safety of Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Guo, Peng; Yuan, Guo-Cai; Xu, Liu-Hui; Ye, Ke-Yin published an article in Organic Chemistry Frontiers. The title of the article was 《Cobalt-catalyzed modular assembly toward multi-functionalized furan derivatives》.Recommanded Product: Ethyl 3-oxopentanoate The author mentioned the following in the article:

A cobalt-catalyzed modular [3+2] assembling of unsaturated hydrocarbons and β-dicarbonyls was reported. This protocol featured mild reaction conditions and a broad substrate scope, providing facile entries toward diverse multi-functionalized dihydrofurans such as I [R = H, Me, Ph, etc.; R1 = Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Me, Et; R3 = OMe, OEt, Ot-Bu; R4 = H, Ph; R2R3 = (CH2)3] and furans II [Ar = ph, 1-naphthyl, 2-thienyl, etc.; R5 = H, Me, CO2Et, TMS; R6 = OMe, OEt; R7 = Me; R6R7 = (CH2)2, (CH2)3, (CH2)4, CH2CH(Me)CH2, CH2C(Me2)CH2]. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Physically mixed catalytic system of amino and sulfo-functional porous organic polymers as efficiently synergistic co-catalysts for one-pot cascade reactions》 was written by Sun, Zunming; Liu, Fuyao; Yang, Xinyue; Huang, Xianpei; Zhang, Mengmeng; Bian, Guomin; Qi, Yonglin; Yang, Xinlin; Zhang, Wangqing. Quality Control of Ethyl 3-oxopentanoateThis research focused onvinylsulfonate vinylbenzylamine polymer phys mixture recyclable catalyst; cyclohexenone arylidenecyanoacetate arylidenemalononitrile preparation; polymer mixture recyclable catalyst deacetalization Knoevenagel rearrangement reaction; dimethoxymethylbenzene tandem deacetalization Knoevenagel reaction recyclable polymer mixture catalyst; pyrancarboxylate rearrangement recyclable polymer mixture catalyst. The article conveys some information:

In this article, acid/base bi-functional polymeric materials were prepared using phys. mixed porous poly(divinylbenzene-co-4-vinylbenzenesulfonic acid) (P(DVB-VBS)) with sulfonic acid groups and poly(divinylbenzene-co-4-vinylbenzyl amine) (P(DVB-VBA)) with amino groups, which were synthesized by solvothermal polymerization of crosslinker DVB with either Ph 4-vinylbenzenesulfonate (PVBS) or 4-vinylbenzyl amine hydrochloride (VBAH) functional monomers together with subsequent hydrolyzation or alk. treatment. The bi-functional polymeric materials were utilized as a synergistic catalytic system for one-pot cascade reactions including deacetalization-Henry condensation reaction, deacetalization-Knoevenagel condensation reaction and the transformation of 3,4-dihydropyran derivatives to α-ester cyclohexenone compounds The crosslinked polymeric frameworks effectively isolated sulfonic acid and primary amine groups to ensure their roles as both acid and base catalyst simultaneously in a one-pot system. The hierarchical porosity of a phys. mixed acid/base co-catalyst system provided the possibility for the multi-step transformation of more complex substrates. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Quality Control of Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Quality Control of Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xueguo; Wang, Peigen; Zhu, Liangwei; Chen, Baohua published an article in 2021. The article was titled 《Rhodium(III)-catalyzed chemodivergent annulations between phenyloxazoles and diazos via C-H activation》, and you may find the article in Chinese Chemical Letters.Electric Literature of C7H12O3 The information in the text is summarized as follows:

Acid-controlled, chemodivergent and redox-neutral annulations for the synthesis of isocoumarins I (R = t-Bu, 4-bromophenyl, cyclohexyl, thiophen-2-yl, etc.; R1 = Me, Et, Ph; R2 = Me, Et, t-Bu) and isoquinolinones II (R3 = t-Bu, heptyl, furan-2-yl, etc.) have been realized via Rh(III)-catalyzed C-H activation. Diazo compounds R1C(O)C(=N2)C(O)OR2 act as a carbene precursor, and coupling occurs in one-pot process, where adipic acid and trimethylacetic acid promote chemodivergent cyclizations. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Electric Literature of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Electric Literature of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Krishna; Singh, Bhuvnesh; Hore, Soumyadip; Singh, Ravi P. published their research in New Journal of Chemistry in 2021. The article was titled 《Catalytic enantioselective synthesis of chiral 4-hydroxy 4′-substituted pyrazolones by the vinylogous aldol reaction of pyrazole-4,5-diones with 3-alkylidene-2-oxindoles》.Related Products of 4949-44-4 The article contains the following contents:

A bifunctional quinine-derived benzamide catalyzed direct enantioselective vinylogous aldol reaction between 3-alkylidene-2-oxindoles and pyrazole-4,5-diones was developed. This challenging protocol was achieved via the H-bonding dual activation mode of the catalyst. Highly functional rich pyrazolone moieties had an oxindole core was obtained with an excellent E/Z (>19 : 1), and high yields along with moderate enantioselectivity. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-oxopentanoate(cas: 4949-44-4Related Products of 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Related Products of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reihani, Neda; Kiyani, Hamzeh published their research in Current Organic Chemistry in 2021. The article was titled 《Three-component Synthesis of 4-Arylidene-3-alkylisoxazol-5(4H)-ones in the Presence of Potassium 2,5-dioxoimidazolidin-1-ide》.Category: esters-buliding-blocks The article contains the following contents:

An efficient synthesis of 4-arylidene-3-alkylisoxazole-5(4H)-ones I (R = Me, Et, propyl; Ar = 4-dimethylaminophenyl, 2-thienyl, 3-indolyl, etc.) has been implemented via the three-component cyclocondensation of aryl(heteroaryl)aldehydes ArCHO with hydroxylamine hydrochloride and β-ketoesters RC(O)CH2C(O)OCH2CH3. The potassium 2,5-dioxoimidazolidin-1-ide II has been introduced as the new organocatalyst to facilitate this heterocyclization. In the current process, three starting materials, including substituted benzaldehydes/heterocyclic aromatic aldehydes ArCHO, hydroxylamine hydrochloride, and Et acetoacetate/propyl acetoacetate/butyryl acetoacetate have been successfully used to synthesize the number of substituted isoxazole- 5(4H)-ones I in good to high yields in ethylene glycol as a green reaction medium at 80°C. The low catalyst loading is also a main advantage over some reported catalysts. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nasseri, Mohammad Ali; Rezazadeh, Zinat; Kazemnejadi, Milad; Allahresani, Ali published their research in Catalysis Letters in 2021. The article was titled 《Cu-Mn Bimetallic Complex Immobilized on Magnetic NPs as an Efficient Catalyst for Domino One-Pot Preparation of Benzimidazole and Biginelli Reactions from Alcohols》.Computed Properties of C7H12O3 The article contains the following contents:

An efficient magnetically recyclable bimetallic catalyst by anchoring copper and manganese complexes on the Fe3O4 NPs was prepared and named as Fe3O4@Cu-Mn. It was founded as a powerful catalyst for the domino one-pot oxidative benzimidazole and Biginelli reactions from benzyl alcs. as a green protocol in the presence of air, under solvent-free and mild conditions. Fe3O4@Cu-Mn NPs were well characterized by FT-IR, XRD, FE-SEM, TEM, VSM, TGA, EDX, DLS, and ICP analyses. The optimum range of parameters such as time, temperature, amount of catalyst, and solvent were investigated for the domino one-pot benzimidazole and Biginelli reactions to find the optimum reaction conditions. The catalyst was compatible with a variety of benzyl alcs., which provides favorable products with good to high yields for all of derivatives Hot filtration and Hg poisoning tests from the nanocatalyst revealed the stability, low metal leaching and heterogeneous nature of the catalyst. To prove the synergistic and cooperative effect of the catalytic system, the various homologs of the catalyst were prepared and then applied to a model reaction sep. Finally, the catalyst could be filtered from the reaction mixture simply, and reused for five consecutive cycles with a min. loss in catalytic activity and performance. Graphic Abstract: A new magnetically recyclable Cu/Mn bimetallic catalyst has been developed for domino one-pot oxidation-condensation of benzimidazole and Biginelli reactions from alcs. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Computed Properties of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Computed Properties of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4949-44-4In 2020 ,《Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation》 appeared in RSC Medicinal Chemistry. The author of the article were Poirier, Marion; Pujol-Gimenez, Jonai; Manatschal, Cristina; Buhlmann, Sven; Embaby, Ahmed; Javor, Sacha; Hediger, Matthias A.; Reymond, Jean-Louis. The article conveys some information:

Solute carrier proteins (SLCs) control fluxes of ions and mols. across biol. membranes and represent an emerging class of drug targets. SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis. Here we report a micromolar (IC50 = 1.1 μM) pyrazolyl-pyrimidone inhibitor of radiolabeled iron uptake in hDMT1 overexpressing HEK293 cells acting by a non-competitive mechanism, which however does not affect the electrophysiol. properties of the transporter. Isothermal titration calorimetry, competition with calcein, induced precipitation of radioactive iron and cross inhibition of the unrelated iron transporter SLC39A8 (hZIP8) indicate that inhibition is mediated by metal chelation. Mapping the chem. space of thousands of pyrazolo-pyrimidones and similar 2,2′-diazabiaryls in ChEMBL suggests that their reported activities might partly reflect metal chelation. Such metal chelating groups are not listed in pan-assay interference compounds (PAINS) but should be checked when addressing SLCs. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.HPLC of Formula: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics