Category: 4949-44-4

Fantinel, Mariane; Valiati, Nayara; Moro, Pedro A. M.; Sa, Marcus M. published their research in Tetrahedron in 2021. The article was titled 《Amino-modified Merrifield resins as recyclable catalysts for the safe and sustainable preparation of functionalized α-diazo carbonyl compounds》.Quality Control of Ethyl 3-oxopentanoate The article contains the following contents:

Amino-functionalized polystyrene polymers derived from Merrifield resins were prepared and characterized. These basic materials were successfully employed as heterogeneous catalysts in the diazo transfer reaction to 1,3-dicarbonyl compounds R1C(O)CH2C(O)R2 [R1 = R2 = Me, Ph, MeO; R1 = Me, R2 = Ph; R1 = Me, Et, ClCH2, Ph, etc., R2 = EtO; R1R2 = (CH2)3, OCMe2O, etc.] furnishing the corresponding diazo compounds R1C(O)C(:N2)C(O)R2 in good to excellent yields and in relatively short reaction times. In addition, the work-up and purification protocols are simple and do not generate large amounts of waste, which are important features in sustainable catalysis and environmentally benign processes. The feasibility of the recovery and reuse of the amino-modified catalysts were also verified, since they can be employed up to five times without appreciable loss of catalytic activity. This straightforward procedure can be readily scaled up to gram scale, enabling the wide application of this method. The synthetic potential was demonstrated through the two-step preparation of 2-amino-N-dodecylacetamide (ANDA), a small mol. of com. relevance. After reading the article, we found that the author used Ethyl 3-oxopentanoate(cas: 4949-44-4Quality Control of Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Quality Control of Ethyl 3-oxopentanoate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Ethyl 3-oxopentanoateIn 2020 ,《Semi-Industrial Fluorination of β-Keto Esters with SF4 : Safety vs Efficacy》 was published in Synlett. The article was written by Trofymchuk, Serhii A.; Kliukovskyi, Denys V.; Semenov, Sergey V.; Khairulin, Andrii R.; Shevchenko, Valerii O.; Bugera, Maksym Y.; Tarasenko, Karen V.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.. The article contains the following contents:

The possibility of deoxofluorination of β-keto esters using SF4 was investigated. The scope and limitation of the reaction were determined The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chem., were synthesized on multigram scale. The safety of SF4 use was discussed. The described method does not improve upon the safety of using SF4, but practical recommendations for working with the reagent were proposed. Despite the hazards of using toxic SF4, a significant increase of efficacy in the synthesis of medicinal-chem.-relevant building blocks, based on the reaction, in comparison with earlier described approaches was shown. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxopentanoate(cas: 4949-44-4Quality Control of Ethyl 3-oxopentanoate)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Quality Control of Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Shao, You-Dong; Dong, Meng-Meng; Wang, You-An; Cheng, Pei-Ming; Wang, Tao; Cheng, Dao-Juan. HPLC of Formula: 4949-44-4. The article was titled 《Organocatalytic Atroposelective Friedlander Quinoline Heteroannulation》. The information in the text is summarized as follows:

An atroposelective Friedlaender heteroannulation reaction of 2-aminoaryl ketones with α-methylene carbonyl derivatives was developed for the first time with chiral phosphoric acid as an efficient organocatalyst. The desired enantioenriched axially chiral polysubstituted 4-arylquinoline architectures were prepared with good to high yields and enantioselectivities (up to 94% yield and up to 97% ee). Furthermore, the products can be readily derivatized to afford an array of new quinoline-containing heteroatropisomers, which hold great potential in asym. catalysis and drug discovery. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.HPLC of Formula: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Ruthenium(II)-Catalyzed Ortho-C-H Alkylation of Naphthylamines with Diazo Compounds for Synthesis of 2,2-Disubstituted π-Extended 3-Oxindoles in Water》 was written by Wang, Xiaogang; Zhang, Jin; He, Yuan; Chen, Di; Wang, Chao; Yang, Fangzhou; Wang, Weitao; Ma, Yangmin; Szostak, Michal. Recommanded Product: 4949-44-4 And the article was included in Organic Letters in 2020. The article conveys some information:

Ruthenium(II)-catalyzed ortho-C-H alkylation of naphthylamines with diazo compounds for the synthesis of 2,2-disubstituted π-extended 3-oxindoles has been developed. The method represents the first example of C-H alkylation via carbenoid insertion in water as a sustainable solvent. The procedure includes an inexpensive ruthenium catalyst as well as aqueous media and results in the release of benign N2. The π-extended 3-oxindole products exhibit favorable antitumor properties and remarkable fluorescent properties in aqueous solution for fluorescent imaging. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Recommanded Product: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4949-44-4In 2021 ,《Acetoacetyl-CoA reductase PhaB as an excellent anti-Prelog biocatalyst for the synthesis of chiral β-hydroxyl ester and the molecular basis of its catalytic performance》 was published in Molecular Catalysis. The article was written by Wang, Ting; Yang, Ke; Tian, Qing; Han, Ruiting; Zhang, Xuanshuo; Li, Aipeng; Zhang, Lianbing. The article contains the following contents:

Acetoacetyl-CoA reductase PhaB turned out to be capable of catalyzing the anti-Prelog asym. reduction of various β-ketoesters (1a-12a) and aromatic ketones (13a-29a). Particularly, PhaB showed high specific activity and excellent stereoselectivity (93.0%-99.8% eep) toward β-ketoesters. The specific activity of PhaB toward Et 4-chloroacetoacetate 11a was up to 1302.2 mU/mg. The mol. basis anal. showed the rotatable single bonds in β-ketoesters endow them with a high degree of structural flexibility and adaptability. Thus, β-ketoesters could quickly adjust their conformation and further form a productive conformation in the narrow substrate-binding pocket of the enzyme. In contrast, PhaB exhibited low specific activity and stereoselectivity toward the majority of aromatic ketones. The large steric hindrance and rigid structure resulted from aromatic rings made the aromatic ketones impossible to adjust their conformation as conveniently as β-ketoesters. Furthermore, it was found the halogen bond was the major driven force of the high specific activity of PhaB toward chlorinated β-ketoesters (10a and 11a), while the distribution of enzyme-substrate interactions was an important factor determining the enzyme activity besides the steric hindrance. Moreover, the geometric configuration of the substrate and the enzyme substrate-binding pocket played critical roles in determining the substrate binding mode and the enzyme stereoselectivity.Ethyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.HPLC of Formula: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Zheng, Fuqiang; Zhou, Jianhui; Fang, Feifei; Li, Jiyuan; Wang, Jing; Zheng, Miao; Liu, Hong; Xu, Yungen; Zhou, Yu published an article in Organic Letters. The title of the article was 《Rh(III)-Catalyzed C-H Activation and [4+1+1] Sequential Cyclization Cascade to Give Highly Fused Indano[1,2-b]azirines》.Synthetic Route of C7H12O3 The author mentioned the following in the article:

A Rh(III)-catalyzed C-H activation of α-keto oximes and a cyclization cascade with diazo compounds were developed to construct the highly fused indano[1,2-b]azirine frameworks in good yields with a broad range of substrates under mild reaction conditions. More intriguingly, a [4+1+1] sequential annulation cascade was demonstrated for the first time in this reaction and opened a new reaction mode for α-keto oximes. These fused indano[1,2-b]azirine derivatives could also be further transformed into intriguing privileged drug scaffolds. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Hao; Zhu, Xiao-Qing; Wang, Wenjie; Chen, Yu; Hu, Zhu; Zhang, Yu; Hu, De-Xuan; Yu, Le-Mao; Agama, Keli; Pommier, Yves; An, Lin-Kun published an article in 2021. The article was titled 《The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors》, and you may find the article in Bioorganic Chemistry.Synthetic Route of C7H12O3 The information in the text is summarized as follows:

In this work, the development of the furoquinolinedione I [W = X = Y = Z = CH, N; R = absent, H, Me, Cl, etc.; R1 = H, Me, (Me)2N, etc.; R2 = H, Et, EtO(O)C, 2-nitrophenyl; R3 = OHC, HOH2C, morpholin-4-ylmethyl, etc.] and isoxazoloquinolinedione II [W = X = Y = Z = CH, N; R4 = ethoxycarbonyl, 2-chlorophenoxymethyl, 3,4-dimethoxyphenyl, etc.] TDP2 inhibitors, further structure-activity relationship (SAR) was studied. A series of furoquinolinedione derivatives I and isoxazoloquinolinedione derivatives II were synthesized and tested for enzyme inhibitions. Enzyme-based assays indicated that isoxazoloquinolinedione derivatives II selectively showed high TDP2 inhibitory activity at sub-micromolar range, as well as furoquinolinedione derivatives I at low micromolar range. The most potent II [W = N, X = H, Y = H, Z = H, R4 = 3,4-dimethoxyphenyl] showed TDP2 inhibitory activity with IC50 of 0.46 ± 0.15μM. This work will facilitate future efforts for the discovery of isoxazoloquinolinediones II TDP2 selective inhibitors. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Copper-Catalyzed sp3-Carbon Radical/Halogen Radical Cross Coupling: Selective Halogenation of 1,3-Dicarbonyl Compounds》 was written by Lv, Shuai-Shuai; Yan, Xu-Ping; Li, Cheng-Kun; Zhou, Shao-Fang; Shoberu, Adedamola; Zou, Jian-Ping. Computed Properties of C7H12O3 And the article was included in ChemistrySelect in 2020. The article conveys some information:

A new copper-catalyzed sp3-carbon radical/halogen radical cross-coupling strategy for the formation of C(sp3)-X bond is described. This provides a general method for synthesis of α-halogenated-1,3-dicarbonyl compounds RC(O)CH(Br)C(O)R1 (R = Ph, Me, 1-naphthyl, etc.; R1 = Ph, Me, ethoxy, etc.) and α,α-dihalogenated-1,3-dicarbonyl compounds RC(O)C(X)2C(O)R1 (X = Br, Cl) using sodium halides as halogen source under mild conditions. In addition to this study using Ethyl 3-oxopentanoate, there are many other studies that have used Ethyl 3-oxopentanoate(cas: 4949-44-4Computed Properties of C7H12O3) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Computed Properties of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Design and synthesis of new energy restriction mimetic agents: Potent anti-tumor activities of hybrid motifs of aminothiazoles and coumarins》 was published in Scientific Reports in 2020. These research results belong to Hersi, Fatema; Omar, Hany A.; Al-Qawasmeh, Raed A.; Ahmad, Zainab; Jaber, Areej M.; Zaher, Dana M.; Al-Tel, Taleb H.. Recommanded Product: Ethyl 3-oxopentanoate The article mentions the following:

The incidence of obesity-related diseases like diabetes, cardiovascular diseases, and different types of cancers shed light on the importance of dietary control as preventive and treatment measures. However, long-term dietary control is challenging to achieve in most individuals. The use of energy restriction mimetic agents (ERMAs) as an alternative approach to affect the energy machinery of cancer cells has emerged as a promising approach for cancer therapy. ERMAs limit the high need for energy in rapidly growing tumor cells, with their survival rate strongly dependent on the robust availability of energy. In this context, initial phenotypic screening of an inhouse pilot compound library identified a new class of aminothiazole anchored on coumarin scaffold as potent anticancer lead drug candidates with potential activity as ERMA. The identified chemotypes were able to inhibit glucose uptake and increase ROS content in cancer cells. Compounds 9b, 9c, 9i, 11b, and 11c were highly active against colorectal cancer cell lines, HCT116 and HT-29, with half-maximal inhibitory concertation (IC50) range from 0.25 to 0.38μM. Further biol. evaluations of 9b and 9f using Western blotting, caspase activity, glucose uptake, ROS production, and NADPH/NADP levels revealed the ability of these lead drug candidates to induce cancer cell death via, at least in part, energy restriction. Moreover, the assessment of 9b and 9f synergistic activity with cisplatin showed promising outcomes. The current work highlights the significant potential of the lead compounds, 9b, and 9f as potential anticancer agents via targeting the cellular energy machinery in cancer cells. In addition to this study using Ethyl 3-oxopentanoate, there are many other studies that have used Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: Ethyl 3-oxopentanoate) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 3-oxopentanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Grams, Estevao Silveira; Silva Ramos, Alessandro; Neves Muniz, Mauro; Rambo, Raoni S.; Alberton Perello, Marcia; Sperotto, Nathalia; Calle Gonzalez, Laura; Duarte, Lovaine Silva; Galina, Luiza; Silva Dadda, Adilio; Arrache Goncalves, Guilherme; Valim Bizarro, Cristiano; Basso, Luiz Augusto; Machado, Pablo published an article in Molecules. The title of the article was 《Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolinesã€?SDS of cas: 4949-44-4 The author mentioned the following in the article:

A series of 27 N-(4-(benzyloxy)benzyl)-4-aminoquinolines were synthesized and evaluated for their ability to inhibit the M. tuberculosis H37Rv strain. Two of these compounds exhibited minimal inhibitory concentrations (MICs) similar to the first-line drug isoniazid. In addition, these hit compounds were selective for the bacillus with no significant change in viability of Vero and HepG2 cells. Finally, chem. stability, permeability and metabolic stability were also evaluated. The obtained data showed that the mol. hits can be optimized aiming at the development of drug candidates for tuberculosis treatment. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4SDS of cas: 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.SDS of cas: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics