Category: 4949-44-4

HPLC of Formula: 4949-44-4In 2020 ,《Mechanochemically Activated Asymmetric Organocatalytic Domino Mannich Reaction-Fluorination》 appeared in ACS Sustainable Chemistry & Engineering. The author of the article were Kristofikova, Dominika; Meciarova, Maria; Rakovsky, Erik; Sebesta, Radovan. The article conveys some information:

Mechanochem. activation effectively mediated asym. organocatalytic domino Mannich addition followed by diastereoselective fluorination. The Mannich reactions of pyrazolone and to a lesser extent of isoxazolones were effective under solvent-free ball-milling conditions. This reaction in combination with chiral squaramide catalyst provided corresponding products in high yields and enantiomeric purities up to 99:1 e.r. and as a single diastereomer. DFT calculations revealed reasons for high diastereoselectivity. Mechanochem. activation shortens reaction time and increase mass intensity of the stereoselective organocatalytic Mannich reaction-fluorination that afford chiral heterocyclic compoundsEthyl 3-oxopentanoate(cas: 4949-44-4HPLC of Formula: 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.HPLC of Formula: 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wande; Wei, Shiqiang; Wang, Wenyao; Qu, Jingping; Wang, Baomin published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements》.Product Details of 4949-44-4 The article contains the following contents:

An organocatalytic asym. process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives I (R1 = Bn, Me, 1-naphthylmethyl, etc.; R2 = Et, Ph, 2-thienyl, etc.; R3 = H, Br; Ar = Ph, 2-bromophenyl, 2-thienyl, etc.) bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20 : 1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-oxopentanoate(cas: 4949-44-4Product Details of 4949-44-4)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of C7H12O3In 2021 ,《Synthesis and pharmacological evaluation of novel benzimidazole derivatives as antiulcer and H+ K+ ATPase inhibitor》 appeared in Journal of Advances in Medical and Pharmaceutical Sciences. The author of the article were Khan, Farhan R.; Farooqui, Mohd. Saleemuddin. The article conveys some information:

A series of new 2-[(substituted-pyrimidin-4-yl) sulfinyl]-1H-benzimidazoles I [R1 = H, Me, nitro; R2 = Me, Et, propyl] were synthesized by the condensation of O-phenylenediamine, KOH and CS2 resulting potassium 1-H-benzimidazole 2-thiolate further treated with glacial acetic acid gives 1H-benzimidazole 2- thiol (2-mercaptobenzimidazole). 4-Chloro 2 Me, 6-Alkylpyrimidine- 4-ol prepared by ethanimidamide and alkyl acetoacetate gives 2-Me, 6-Alkylpyrimidine-4-ol by chlorination using thionyl chloride 4-Chloro 2 Me, 6-Alkylpyrimidine- 4-ol was obtained. Further reacted with sodium oxide followed by m-chloroperbenzoic finally gives 2-[(substituted-pyrimidin-4-yl) sulfinyl]- 1H-benzimidazole. Structural characterization of these synthesized compounds I was confirmed by FT-IR, 1HNMR, and Mass spectral data. Later synthesized derivatives evaluated for their antiulcer and H+ K+ ATPase inhibitory activity by aspirin induced method and assays of H+/K+-ATPase activity resp. Compound I [R1 = H; R2 = methyl] (74.03%), I [R1 = methyl; R2 = propyl] (72.87%) and I [R1 = nitro; R2 = propyl] (75.15%) shows highly significant antiulcer activity compared to standard drug and compound I [R1 = H; R2 = propyl] (88.88%), I [R1 = R2 = methyl] (91.03%), I [R1 = methyl; R2 = propyl] (86.48%) and I [R1 = nitro; R2 = methyl] (84.21%) shows highly significant antisecretory activity when compare to standard drug. These research work provoked further to work for development of different derivatives of 2-(pyrimidinyl-sulfinyl) benzimidazole I which have lesser side effect and better action than few of marketed drugs. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Polyacrylonitrile fiber with strongly acidic electrostatic microenvironment: Highly efficient and recyclable heterogeneous catalyst for the synthesis of heterocyclic compounds》 were Xiao, Jian; Xu, Gang; Wang, Lu; Li, Pengyu; Zhang, Wenqin; Ma, Ning; Tao, Minli. And the article was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2019. Synthetic Route of C7H12O3 The author mentioned the following in the article:

Four categories of sulfonic acid functionalized fiber catalysts with different surface microenvironments were synthesized by covalent grafting using polyacrylonitrile fiber (PANF) as the support. After the effect of acid structure on catalytic activity was investigated by Friedlander reaction, PANEOSF was chosen for the synthesis of quinolines and coumarin derivatives with high yields and extensive substrate scope (51 examples) in ethanol or water. The effect of electrostatic microenvironment and solvent was discussed and a “”release-catch-release-catch”” catalytic pattern was proposed accordingly. PANEOSF can be easily recycled for 20 times without any decrease of catalytic activity. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An, Xiaoying; Gao, Lei; Wang, Mingliang; Wu, Haitao; Wang, Lanzhi published an article in 2021. The article was titled 《One-pot synthesis of 1,5-benzodiazepine-2,3-dicarboxylates via three-component domino reactions in the presence of γ-Fe2O3@SiO2/Ce(OTf)3》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).Product Details of 4949-44-4 The information in the text is summarized as follows:

Novel, efficient and environmentally friendly approaches was developed for the synthesis of 1,5-benzodiazepine-2,3-dicarboxylates I [R1 = H, Me, Cl, Br; R2 = Me, Et, Ph; R3 = Me, Et, Pr] and II by one-pot three-component domino reactions in the presence of a catalytic amount of γ-Fe2O3@SiO2/Ce(OTf)3 in EtOH at ambient temperature A total of synthesized 2,5-dihydro-1H-1,5-benzodiazepine-2,3-dicarboxylates I and 2-methyl-2,3-dihydro-1H-1,5-benzodiazepine-2,3-dicarboxylates II with enamine or imine structure of the heterocycle, resp., were obtained in good yields by reacting substituted 1,2-phenylenediamine, β-carbonyl esters and Et glyoxylate or Et pyruvate. One-pot reactions were successfully realized to form one new cycle and four new bonds (one C-C, two C-N, one C=C or two C-C, one C-N, one C=N). The salient features of this reaction included short reaction time, mild reaction conditions, moderate to excellent yields, recyclability of the catalyst, and wide substrate scope.Ethyl 3-oxopentanoate(cas: 4949-44-4Product Details of 4949-44-4) was used in this study.

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 4949-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics