Category: 4911-54-0

Reference of 4911-54-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4911-54-0 as follows.

43.7 g (0.2 mol) of 2-chloro-4-fluoro-5-nitrobenzaldehyde oxime was dissolved in 150 ml of N, N-dimethylformamide, the temperature was raised to 30 C, and 32 g ( 0.24 mol) of NCS to form a light yellow solution, and the reaction was held at 35 C for 1 hour. Lower to room temperature, add 300 ml of dichloromethane, then wash twice with 1N hydrochloric acid, twice with saturated brine, dry over anhydrous magnesium sulfate, suction filter, reduce the dichloromethane solution to 0-5 C, and add 42.6 g A mixed solution of 0.3 mol) of ethyl 4-methyl-4-pentenoate and 31 g (0.3 mol) of triethylamine was reacted while maintaining the temperature for 1 hour. The organic phase was washed with 1N hydrochloric acid and saturated brine in this order, and the organic phase was dried over anhydrous magnesium sulfate. After desolvation, column chromatography (ethyl acetate: petroleum ether = 1: 3) gave 41.9 g of a pale yellow solid.

According to the analysis of related databases, 4911-54-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shenyang Sinochem Pesticide Chemical Research And Development Co., Ltd.; Yang Jichun; Guan Aiying; Cui Dongliang; Wu Jiao; Yan Kecheng; Liu Changling; (13 pag.)CN110818699; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 4911-54-0,Some common heterocyclic compound, 4911-54-0, name is Ethyl 4-methylpent-4-enoate, molecular formula is C8H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a flame-dried flask that was purged under argon for 20 min was added LiAlH4 followed by 150 mL of anhydrous THF. The reaction mixture was cooled to 00C and a solution of compound 7 in THF (20 mL) was added slowly. The resulting solution was allowed to warm to room temperature and was stirred for 3 h until the starting material was completely consumed as indicated by TLC. The reaction was quenched by slow addition of the mixture to 300 mL of ice cold IM NaOH. The mixture was then allowed to stir for another hour and was filtered through Celite. A large amount of diethyl ether was used for rinsing. The filtrate was treated with water and extracted twice with diethyl ether. The combined organic phase was dried over Na2SO4 and evaporated in vacuo to give a residue which was purified via distillation at 20 mm Hg (bp 65-68 0C) to afford compound 8 as a yellow oil (9.5 g, 0.095 mol, 79%) (Mazzocchi et al. (1983) J. Org. Chem. 48, 2981-2989).1H NMR (500 MHz, CDCl3) delta 1.47 (br, IH), 1.69-1.74 (m, 5H), 2.1 (t, J = 7.5 Hz, 2H), 3.66 (t, J = 6.5 Hz, 2H), 4.71 (d, J = 0.8 Hz, IH), 4.73 (d, J = 0.8 Hz, IH), 4.73 (d, J = 0.4 Hz, IH); 13C NMR (125 MHz, CDCl3), delta 22.22, 30.41, 33.98, 62.64, 1 10.08, 145.40.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-methylpent-4-enoate, its application will become more common.

Reference:
Patent; PARHAMI, Farhad; KIM, Woo-Kyun; WO2008/82520; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 4911-54-0, name is Ethyl 4-methylpent-4-enoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Ethyl 4-methylpent-4-enoate

EXAMPLE 13 The reaction is carried out as described in Example 8 but using catalyst 4a (7.6 mg, 0.01%) in THF (5 ml) and KOMe (0.63 g, 9 mmol) in ethyl 4-methylpent-4-enoate 11 (12.9 g, 91 mmol) and THF (58 ml). Standard work-up gave a slightly yellow crude oil (5.6 g, 61%) which contained 4-methyl pent-4-en-1-ol 12 of 100% purity according to GC. The analytical data of 4-methylpent-4-en-1-ol 12 were identical with the ones obtained from commercial samples of this compound.

The synthetic route of Ethyl 4-methylpent-4-enoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Geisser, Roger Wilhelm; Goeke, Andreas; Schroeder, Fridtjof; US2015/152029; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 4911-54-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4911-54-0, name is Ethyl 4-methylpent-4-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The reaction is carried out as described in Example 8 but using catalyst 4a (7.6 mg, 0.01%) in THF (5 ml) and KOMe (0.63 g, 9 mmol) in ethyl 4-methylpent-4-enoate 11 (12.9 g, 91 mmol) and THF (58 ml). Standard work-up gave a slightly yellow crude oil (5.6 g, 61%) which contained 4-methylpent-4-en-l-ol 12 of 100% purity according to GC. The analytical data of 4-methylpent-4-en-l-ol 12 were identical with the ones obtained from commercial samples of this compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-methylpent-4-enoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GIVAUDAN SA; GEISSER, Roger Wilhelm; GOEKE, Andreas; SCHROEDER, Fridtjof; WO2013/171302; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics