Category: 4897-84-1

Adding a certain compound to certain chemical reactions, such as: 4897-84-1, name is Methyl 4-bromobutanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4897-84-1, SDS of cas: 4897-84-1

To a solution of 3-bromophenol (3.44 g, 20.0 mmol) and methyl 4-bromobutanoate (4.32 g, 24.0 mmol) in DMF (20 mL) was added K2co3 (5.52 g, 40.0 mmol). The mixture was stirred at rt for 0.5 h and then heated with stirring at 90 oC for 1 h. After diluting with EtOAc (200 mL), the mixture was washed with water (3 x 50 mL), dried and concentrated. The crude product was purified by silica gel column chromatograph (petroleum/EtOAc = 10:1) to give methyl 4-(3- bromophenoxy)butanoate as a white liquid (5.2 g, yield: 96percent). ESI-MS (M+H) +: 273.1

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BIOGEN MA INC.; HOPKINS, Brian, T.; MA, Bin; PRINCE, Robin; MARX, Isaac; LYSSIKATOS, Joseph, P.; ZHENG, Fengmei; PETERSON, Matthew; PATIENCE, Daniel, B.; (205 pag.)WO2018/191577; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 4897-84-1, A common heterocyclic compound, 4897-84-1, name is Methyl 4-bromobutanoate, molecular formula is C5H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the methyl ester (XIV, 1.8 g, 0.15 mmol) in DMF (50 mL), is added 4-bromo-butyric acid methyl ester (1 g, 0.87 mmol) and Cs2CO3 (800 mg, 0.48 mmol). The reaction is stirred at 22° C. for 48 hours. 5 g SiO2 is added to the mixture and all solvents were evaporated in vacuo. The solid is purified by flash chromatography, eluting with MeOH/DCM (0-10percent) to provide 1.5 g (75percent), of a yellow solid. MS m/z 1357 (M +H2O).

The synthetic route of 4897-84-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bushell, Simon; LaMarche, Matthew J.; Leeds, Jennifer; Whitehead, Lewis; US2009/156628; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4897-84-1, name is Methyl 4-bromobutanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 4897-84-1

A mixture of vanillin (20.0 g, 131 mmol), methyl 4-bromobutanoate (17.5 mL, 139 mmol) and potassium carbonate (27.2 g, 197 mmol) in A V-dimethylformamide (100 mL) was stirred at room temperature for 18 h. The reaction mixture was diluted with water (500 mL) and the title compound (30.2 g, 91%) was obtained by filtration as a white solid. The product was carried through to the next step without any further purification. (1374) NMR (400 MHz, CDCI3) delta 9.84 (s, lH), 7-46-7-37 (m, 2H), 6.98 (d, J=8.2 Hz, lH), 4.16 (t, J=6.3 Hz, 2H), 3.91 (s, 3H), 3.69 (s, 3H), 2.56 (t, J=7.2 Hz, 2H), 2.20 (quin, J=6.7 Hz, 2H); FontWeight=”Bold” FontSize=”10″ C NMR (100 MHz, CDC13) delta 190.9, 173.4, 153-8, 149-9, 130-1, 126.8, 111.6, 109.2, 67.8, 56.0, 51.7, 30.3, 24.2; MS M/Z (EIMS) = 271.9 (M+Na)+, 253 (M+H)+; LCMS (Method A): tR = 6.48 min.

The synthetic route of 4897-84-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FEMTOGENIX LIMITED; JACKSON, Paul Joseph Mark; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; (243 pag.)WO2017/194960; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 4897-84-1, name is Methyl 4-bromobutanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4897-84-1, SDS of cas: 4897-84-1

To a solution of 3-bromophenol (3.44 g, 20.0 mmol) and methyl 4-bromobutanoate (4.32 g, 24.0 mmol) in DMF (20 mL) was added K2co3 (5.52 g, 40.0 mmol). The mixture was stirred at rt for 0.5 h and then heated with stirring at 90 oC for 1 h. After diluting with EtOAc (200 mL), the mixture was washed with water (3 x 50 mL), dried and concentrated. The crude product was purified by silica gel column chromatograph (petroleum/EtOAc = 10:1) to give methyl 4-(3- bromophenoxy)butanoate as a white liquid (5.2 g, yield: 96percent). ESI-MS (M+H) +: 273.1

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BIOGEN MA INC.; HOPKINS, Brian, T.; MA, Bin; PRINCE, Robin; MARX, Isaac; LYSSIKATOS, Joseph, P.; ZHENG, Fengmei; PETERSON, Matthew; PATIENCE, Daniel, B.; (205 pag.)WO2018/191577; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 4897-84-1, These common heterocyclic compound, 4897-84-1, name is Methyl 4-bromobutanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

STEP B: methyl 4- (nitrooxy) butanoateMethyl 4-bromobutanoate (6.0 g; 33 mmol) was dissolved in CH3CN (120 mL) and silver nitrate (14.0 g, 82.6 mmol) was added. The reaction was heated at 80¡ãC in the dark for 4 hours. Solvent was evaporated and the crude was dissolved in EtOAc (80 mL) .Precipitate was filtered off and organic phase was washed with water (2 x 100 mL) and brine (1 x 100 mL) , dried over Na2SC>4 and concentrated affording the title compound as an oil. (5.0 g, 93percent)1H-NMR (CDCI3) : 4.54 (2H,t J=6.31); 3.73 (3H,s); 2.48 (2H,tJ=7.15) ; 2.08 (2H,m)

Statistics shows that Methyl 4-bromobutanoate is playing an increasingly important role. we look forward to future research findings about 4897-84-1.

Reference:
Patent; NICOX S.A.; ALMIRANTE, Nicoletta; NICOTRA, Alessia; BORGHI, Valentina; ONGINI, Ennio; WO2011/92065; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

4897-84-1, Name is Methyl 4-bromobutanoate, molecular formula is C5H9BrO2, belongs to esters-buliding-blocks compound, is a common compound. In a patnet, author is Suzuki, Kensuke, once mentioned the new application about 4897-84-1, Formula: C5H9BrO2.

(o-Phenylenediamino)borylstannanes: Efficient Reagents for Borylation of Various Alkyl Radical Precursors

(o-Phenylenediamino)borylstannanes were newly synthesized to achieve radical boryl substitutions of a variety of alkyl radical precursors. Dehalogenative, deaminative, decharcogenative, and decarboxylative borylations proceeded in the presence of a radical initiator to give the corresponding organic boron compounds. Radical clock experiments and computational studies have provided insights into the mechanism of the homolytic substitution (S(H)2) of the borylstannanes with alkyl radical intermediates. DFT calculation disclosed that the phenylenediamino structure lowered the LUMO level including the vacant p-orbital on the boron atom to enhance the reactivity to alkyl radicals in S(H)2. Moreover, C(sp(3))-H borylation of THF was accomplished using the triplet state of xanthone.

If you’re interested in learning more about 4897-84-1. The above is the message from the blog manager. Formula: C5H9BrO2.

Chemistry is an experimental science, HPLC of Formula: C5H9BrO2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4897-84-1, Name is Methyl 4-bromobutanoate, molecular formula is C5H9BrO2, belongs to esters-buliding-blocks compound. In a document, author is Kamenova, Katya.

Mixed micellar system for codelivery of doxorubicin and caffeic acid phenethyl ester: design and enhanced antitumor activity

Multifunctional nanocarriers of two or more anticancer drugs with different pharmacological mechanisms are being developed for combination therapy, which aims at achieving synergistic effects in cancer treatment and overcoming the increasingly common problem of drug resistance. This contribution reports the fabrication of functional nanosized micellar carriers of doxorubicin (DOX) and caffeic acid phenethyl ester (CAPE) via coassembly of two well-defined amphiphilic ABA triblock copolymers comprising identical hydrophobic poly(epsilon-caprolactone) (PCL) blocks and different hydrophilic segments – poly(ethylene oxide) (PEO) or poly(acrylic acid) (PAA). CAPE was embedded into the PCL core via hydrophobic interactions, while DOX was loaded within a mixed PAA/PEO corona layer through complexation. The main physico-chemical properties of blank and dual drug-loaded micelles were investigated using dynamic and electrophoretic light scattering and transmission electron microscopy. Loading of CAPE and DOX increased the size and size distribution of carriers to some extent. However, the mixed micellar system was characterized by good colloidal stability and sustained release of the two drugs. The cytotoxic effect of DOX/CAPE-loaded mixed micelles in drug-resistant lymphoma cells expressing the multidrug resistance (MDR1) gene (L5178Y MDR1) was assessed.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4897-84-1, in my other articles. HPLC of Formula: C5H9BrO2.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Name: Methyl 4-bromobutanoate4897-84-1, Name is Methyl 4-bromobutanoate, SMILES is O=C(OC)CCCBr, belongs to esters-buliding-blocks compound. In a article, author is Unger, Cornelia C., introduce new discover of the category.

Oxygen-Rich Bis(trinitroethyl esters): Suitable Oxidizers as Potential Ammonium Perchlorate Replacements

In the area of solid rocket propellants, research efforts are ongoing to find suitable oxidizers as ammonium perchlorate (AP) replacements. On the one hand, AP’s performance data are excellent; on the other hand, AP and its combustion products lead to health and environmental issues. Herein, the nitraminodiacetic acid bis(2,2,2-trinitroethyl ester) (NABTNE) is presented as a green AP alternative and is compared to the bis(trinitroethyl ester) of malonic acid (MaBTNE). Simple syntheses based on economic starting materials furnished both compounds, with NABTNE having a positive oxygen balance (according to CO), a density of 1.84 g cm(-3) (@T = -118 degrees C), and a decomposition point of 180 degrees C. The density of MaBTNE (delta = 1.81 g cm(-3) @T = -147 degrees C) and the thermal stability (T-dec = 157 degrees C) are also advantageous. NABTNE as a moderately sensitive and the most promising derivative was shown to be of good stability toward long-term storage. Moreover, mixtures for a potential application in solid rocket formulations were calculated using EXPLOS (V 6.03).

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 4897-84-1. Name: Methyl 4-bromobutanoate.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4897-84-1, Name is Methyl 4-bromobutanoate, molecular formula is C5H9BrO2, belongs to esters-buliding-blocks compound, is a common compound. In a patnet, author is Wessig, Pablo, once mentioned the new application about 4897-84-1, Product Details of 4897-84-1.

Sulfur Tuning of [1,3]-Dioxolo[4.5-f]benzodioxole (DBD) Fluorescent Dyes

The replacement of oxygen by sulfur atoms of [1,3]-dioxolo[4.5-f]benzodioxole (DBD) fluorescent dyes is an efficient way to adjust the photophysical properties (sulfur tuning). While previously developed S-4-DBD dyes exhibit considerably red-shifted absorption and emission wavelength, the heavy atom effect of four sulfur atoms cause low fluorescence quantum yields and short fluorescence lifetimes. Herein, we demonstrate that the replacement of less than four sulfur atoms (S-1-DBD, 1,2-S-2-DBD, and 1,4-S-2-DBD dyes) permits a fine-tuning of the photophysical properties. In some cases, a similar influence on the wavelength without the detrimental effect on the quantum yields and lifetimes is observed. Furthermore, the synthetic accessibility of S-1- and S-2-DBD dyes is improved, compared with S-4-DBD dyes. For coupling with biomolecules a series of reactive derivatives of the new dyes were developed (azides, OSu esters, alkynes, maleimides).

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4897-84-1. The above is the message from the blog manager. Product Details of 4897-84-1.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.4897-84-1, Name is Methyl 4-bromobutanoate, SMILES is O=C(OC)CCCBr, belongs to esters-buliding-blocks compound. In a document, author is Zhang, Guang-Xiang, introduce the new discover, Product Details of 4897-84-1.

Discovery and Engineering of a Novel Baeyer-Villiger Monooxygenase with High Normal Regioselectivity

Baeyer-Villiger monooxygenases (BVMOs) are remarkable biocatalysts for the Baeyer-Villiger oxidation of ketones to generate esters or lactones. The regioselectivity of BVMOs is essential for determining the ratio of the two regioisomeric products (normal and abnormal) when catalyzing asymmetric ketone substrates. Starting from a known normal-preferring BVMO sequence from Pseudomonas putida KT2440 (PpBVMO), a novel BVMO from Gordonia sihwensis (GsBVMO) with higher normal regioselectivity (up to 97/3) was identified. Furthermore, protein engineering increased the specificity constant (k(cat)/K-M) 8.9-fold to 484 s(-1) mM(-1) for 10-ketostearic acid derived from oleic acid. Consequently, by using the variant GsBVMO(C308L) as an efficient biocatalyst, 10-ketostearic acid was efficiently transformed into 9-(nonanoyloxy)nonanoic acid, with a space-time yield of 60.5 g L-1 d(-1). This study showed that the mutant with higher regioselectivity and catalytic efficiency could be applied to prepare medium-chain omega-hydroxy fatty acids through biotransformation of long-chain aliphatic keto acids derived from renewable plant oils.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 4897-84-1. Product Details of 4897-84-1.