Category: 4891-38-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4891-38-7, name is Methyl Phenylpropiolate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C10H8O2

General procedure: (ESI) calcd for C20H16F3N4O2 [M+H]+ 401.12253, found 401.12283. Methyl 4-methoxy-2-phenylpyrazolo[1,5-a]pyridine-3-carboxylate (11): typical procedure To a solution of ethyl o-mesitylsulfonylacetohydroxamic acid (78.5 g, 0.275 mol) in 1,4-dioxane (69 mL) was added a 70% aqueous solution of hydrogen perchlorate (28.5 mL, 0.330 mol), and the mixture was stirred at 0C for 0.5 h. After the addition of ice-water, the precipitate was collected. The cake was dissolved in dichloromethane (229 mL) and dried over Na2SO4. To the mixture was added a solution of 3-methoxypyridine (25.0 g, 0.229 mol) in dichloromethane (229 mL). After stirring at room temperature for 1 h, the mixture was concentrated in vacuo. To a solution of the resulting material in 10% DMF-THF (253 mL) was added potassium carbonate (63.0 g, 0.458 mol) and methyl 3-phenylpropiolate (18.0 g, 0.115 mol) at room temperature. After the addition of DMF (217 mL), the mixture was stirred at room temperature for 20 h. Water was added, and then the mixture was extracted with ethyl acetate. The combined organic layer was washed with water and brine, and then dried over sodium sulfate and concentrated in vacuo. The crude material was purified by flash column chromatography on silica gel (hexane:AcOEt = 4:1) to give methyl 4-methoxy-2-phenylpyrazolo[1,5-a]pyridine-3-carboxylate 11 as a yellow solid (11.7 g, 36%, two steps).

According to the analysis of related databases, 4891-38-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Umei, Kentaro; Nishigaya, Yosuke; Kondo, Atsushi; Tatani, Kazuya; Tanaka, Nobuyuki; Kohno, Yasushi; Seto, Shigeki; Bioorganic and Medicinal Chemistry; vol. 25; 9; (2017); p. 2635 – 2642;,
Ester – Wikipedia,
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4891-38-7, name is Methyl Phenylpropiolate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: esters-buliding-blocks

1.0 mmol (123.1 mg) of m-methoxyaniline and 1.0 mmol (160.2 mg) of methyl phenylpropiolate and1.2 mmol (122.4 mg) of phenylacetylene and0.005 mmol (1.8 mmol) of Cu (OTf)2catalystmg), HOTf 0.01mmol(1.5mg), a nitrile solvent has 2mL, deg.] C for 8h at 100 oil bath, cooled to room temperature, water was added 5mL, extracted with ethyl acetate threetimes, the organic layers were combined, concentrated under reduced pressure, the product after Purification by column chromatography, silica gel 300-400 mesh, eluantmixtureof ethyl acetate andpetroleum ether, the volume ratio of 1: 5, to obtain a white solid product 296.4mg, 95% yield, purity 99.9%

The synthetic route of 4891-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanyang Normal College; Zhang Xu; Xu Xuefeng; (13 pag.)CN106380463; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 4891-38-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4891-38-7, name is Methyl Phenylpropiolate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A 25 mL Schlenk tube equipped with a magnetic stirringbar was charged with I2 (12.7 mg, 0.05 mmol), substituted thiol1 (0.5 mmol) and alkyne 2 (0.75 mmol). The tube was evacuatedtwice and backfilled with nitrogen, and DTBP (2.5 mmol)was added into the tube under nitrogen atmosphere. The tubewas sealed with a balloon and the mixture was stirred undernitrogen atmosphere at 110 C for 18 h. Upon completion of thereaction, the resulting solution was cooled to r.t., and thesolvent was removed with the aid of a rotary evaporator. Theresidue was purified by column chromatography on silica gel(PE-EtOAc) to give 3.

The synthetic route of Methyl Phenylpropiolate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yan, Kelu; Yang, Daoshan; Zhang, Mengqi; Wei, Wei; Liu, Yao; Tian, Laijin; Wang, Hua; Synlett; vol. 26; 13; (2015); p. 1890 – 1894;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 4891-38-7, name is Methyl Phenylpropiolate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4891-38-7, COA of Formula: C10H8O2

General procedure: To the mixture of terminal alkyne (1mmol), water (2.0 equiv), and acetic acid (2 mL), silver tetrafluoroborate (5 mol%) was added. The mixture was stirred at 110C for 10 h. Water (10 mL) was added and the solution was extracted with ethyl acetate (3¡Á8 mL), the combined extract was dried with anhydrous MgSO4. The solvent was removed and the crude product was separated by column chromatography to give the pure sample.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl Phenylpropiolate, and friends who are interested can also refer to it.

Reference:
Article; Chen, Zheng-Wang; Ye, Dong-Nai; Qian, Yi-Ping; Ye, Min; Liu, Liang-Xian; Tetrahedron; vol. 69; 30; (2013); p. 6116 – 6120;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 4891-38-7, name is Methyl Phenylpropiolate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4891-38-7, category: esters-buliding-blocks

The reaction was carried out in a 10 ml Schlenk reaction tube. The reaction tube was evacuated and replaced with argon three times. 5 mol % (6.1 mg) of [Cp*RuCl2]2 (relative to substrate 1b) and 2 ml of solvent 1,2- were added. Dichloroethane, stirring 2min;Then 0.2 mmol (48.6 mg) of aziridine 1b and 1.0 mmol (160.2 mg) of methyl phenylpropiolate 2a are added and the reaction is heatedStir for 20 hours at 80C.After the reaction is completed, the solvent is removed by a rotary evaporator, and the solid is dissolved in dichloromethane and subjected to silica gel column chromatography using petroleum ether:The column was washed with an eluent of ethyl acetate = 10:1 – 5:1 (by volume) to give 46.8 mg of a white solid polysubstituted pyrrole compound 3b in an isolated yield of 58%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl Phenylpropiolate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dalian Institute of Chemical Physics; Wan Boshun; Li Tengfei; Wu Fan; (17 pag.)CN107522645; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4891-38-7, name is Methyl Phenylpropiolate, A new synthetic method of this compound is introduced below., Safety of Methyl Phenylpropiolate

General procedure: A reaction kettle (30 mL) was charged with aniline (1.0 mmol), and alkyne ester (1.0 mmol). The mixture was stirred at room temperature for 10 minutes, then added terminal alkyne (1.2 mmol, 1.2 eq), AgOTf (5 mol%, 12.9 mg), HOTf (10 mol%, 15 mg), MeOH (2 mL) in the mixture. The mixture was stirred at 120 oC for 24 hours, the mixture was quenched by sat. aq. NaHCO3, and diluted with 20 mL of dichloromethane and washed with 10 mL of H2O. The aqueous layer was extracted twice with dichloromethane (10 mL) and the combined organic phase was dried over Na2SO4. After evaporation of the solvents, the residue was purified by silica gel chromatography (hexane/AcOEt = 5:1) to afford quinoline derivatives. All other compounds are synthesized in a similar manner, with the yields listed in the main text calculated from the isolated, pure products.

The synthetic route of 4891-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Yunlan; Zhang, Qiurui; Xu, Xuefeng; Zhang, Xu; Yang, Yurong; Yi, Wei; Tetrahedron Letters; vol. 60; 14; (2019); p. 965 – 970;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics