Category: 4755-77-5

Application In Synthesis of Ethyl oxalyl monochlorideIn 2020 ,《Efficient separation of thorium from rare earth using oxamic acid in hydrochloric acid medium》 appeared in Separation and Purification Technology. The author of the article were Bie, Chao; Gao, Yun; Su, Jia; Dong, Yamin; Guo, Xiangguang; Sun, Xiaoqi. The article conveys some information:

Thorium (Th) is a promising element that can be converted to fissile uranium for nuclear energy. A large amount of slag containing Th need to be effectively treated and stacked in rare earth (RE) industry. It is of importance to develop some novel processes for separating Th from REs using solvent extraction The amide group was considered to have good selectivity for Th separation from REs. In order to solve the problem of RE entrainment during Th separation together with primary amine (N1923, (CnH2n+1)2CHNH2 n = 9-11) does not extract Th in hydrochloric acid system, three oxamic acid type extractants have been designed and synthesized in this paper. Among the extractants, the separation performance of 2-(dibenzylamino)-2-oxoacetic acid (DBOA) was indicated to be the best. As for the effective separation, the electron affinity of Th was larger, it was more preferred to coordinate with the extractant. The hydrogen ions released by the extractant could inhibit the extraction of REs rather than Th. Accordingly, Th could be separated from REs. Saponification process of oxamic acid extractant could be omitted in this separation process. By extracting Th using a lower concentration of oxamic acid selectively, not only the loss of RE could be reduced, but also a higher purity of Th could be obtained. Using a simplified fractional extraction experiment, the purity of RE in aqueous phase was increased to be 99.92% or higher, and the purity of obtained Th after stripping from loaded organic phase was increased to be 99.5%. After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5Application In Synthesis of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Application In Synthesis of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate》 were Reinke, Ashley A.; Li, Shih-Hon; Warnock, Mark; Shaydakov, Maxim E.; Guntaka, Naga Sandhya; Su, Enming J.; Diaz, Jose A.; Emal, Cory D.; Lawrence, Daniel A.. And the article was published in Journal of Biological Chemistry in 2019. Safety of Ethyl oxalyl monochloride The author mentioned the following in the article:

Plasminogen activator inhibitor type-1 (PAI-1) is a serine protease inhibitor (serpin) implicated in numerous pathol. processes, including coronary heart disease, arterial and venous thrombosis, and chronic fibrotic diseases. These associations have made PAI-1 an attractive pharmaceutical target. However, the complexity of the serpin inhibitory mechanism, the inherent metastability of serpins, and the high-affinity association of PAI-1 with vitronectin in vivo have made it difficult to identify pharmacol. effective small-mol. inhibitors. Moreover, the majority of current small-mol. PAI-1 inhibitors are poor pharmaceutical candidates. To this end and to find leads that can be efficiently applied to in vivo settings, we developed a dual-reporter high-throughput screen (HTS) that reduced the rate of nonspecific and promiscuous hits and identified leads that inhibit human PAI-1 in the high-protein environments present in vivo. Using this system, we screened >152,000 pure compounds and 27,000 natural product extracts (NPEs), reducing the apparent hit rate by almost 10-fold compared with previous screening approaches. Furthermore, screening in a high-protein environment permitted the identification of compounds that retained activity in both ex vivo plasma and in vivo. Following lead identification, subsequent medicinal chem. and structure-activity relationship (SAR) studies identified a lead clin. candidate, MDI-2268, having excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in a murine model of venous thrombosis. This rigorous HTS approach eliminates promiscuous candidate leads, significantly accelerates the process of identifying PAI-1 inhibitors that can be rapidly deployed in vivo, and has enabled identification of a potent lead compound The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Safety of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Safety of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Direct C-H Carbamoylation of Nitrogen-Containing Heterocycles》 were Jouffroy, Matthieu; Kong, Jongrock. And the article was published in Chemistry – A European Journal in 2019. Category: esters-buliding-blocks The author mentioned the following in the article:

Using bench stable and com. available alkyl oxamate and oxamic acid derivatives in combination with photoredox catalysis, a direct carbamoylation of heterocycles yielding amide functionalized pharmacophores in a single step was reported. The reaction conditions reported are compatible with structurally complex heterocyclic substrates of pharmaceutical interest. Notably, derivatives containing functional groups incompatible with standard amidation reactions, such as carboxylic acids and unprotected amines, were found to be amenable to this reaction paradigm. In the experiment, the researchers used Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and characterization of vinazene end capped dipyrrolo[2,3-b:2′,3′-e]pyrazine-2,6(1H,5H)-dione small molecules as non-fullerene acceptors for bulk heterojunction organic solar cells》 was published in Materials Chemistry and Physics in 2020. These research results belong to Sivakumar, Gangala; Bernardo, Douglas Rosa; Marchezi, Paulo Ernesto; Nogueira, Ana Flavia. Recommanded Product: Ethyl oxalyl monochloride The article mentions the following:

Two dipyrrolo[2,3-b:2′,3′-e]pyrazine-2,6(1H,5H)-dione (PzDP)-based small mols. DPDV and DPEV with PzDP as the core building block and 4,5-dicyano-2-vinylimdazole (vinazene) as end-cap units were synthesized by Heck coupling reaction. The photophys., electrochem. properties of DPDV and DPEV were investigated and applied as non-fullerene acceptors (NFAs) for solution-processed bulk heterojunction (BHJ) organic solar cells (OSCs). Theor. evaluated optical and electrochem. properties were well matched with exptl. values. Solution processed BHJOSCs employing poly[(4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b’]dithiophene-2,6-diyl)-alt-(3-fluoro-2-[(2-ethylhexy)carbonyl]thieno[3,4-b]thiophene-4,6-diyl)] (PTB7) as the donor polymer and DPDV/DPEV as NFAs exhibited short-circuit c.d. (JSC) of 2.23/2.44 mA cm-2, open-circuit voltage (VOC) of 0.54/0.55 V, fill factor (FF) of 36.97/38.62 and power conversion efficiency (PCE) of 0.45/0.52%, resp. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure》 were Kalinin, Stanislav; Valtari, Annika; Ruponen, Marika; Toropainen, Elisa; Kovalenko, Alexander; Nocentini, Alessio; Gureev, Maxim; Dar’in, Dmitry; Urtti, Arto; Supuran, Claudiu T.; Krasavin, Mikhail. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Recommanded Product: 4755-77-5 The author mentioned the following in the article:

Four inhibitors of human carbonic anhydrase II (hCA II) were designed based on the previously reported subnanomolar 1,3-oxazole-based sulfonamide inhibitors of the enzyme to incorporate primary and secondary amine functionality in the carboxamide side chain. The new hydrophilic compounds were found to inhibit the target isoform in sub-nanomolar to low nanomolar range with a good degree of selectivity to several other hCA isoforms. The hydrophilic character of these compounds is advantageous for intraocular residence time but not for corneal permeability which generally requires that a drug be sufficiently lipophilic. Two of the four compounds investigated, however, were found to exert comparable efficacy as 1% eye drops in PBS to that of the clin. used 2% dorzolamide (Trusopt) eye drops. This indicated that the absorption of the compounds may occur via alternative route across conjunctiva and sclera. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C4H5ClO3In 2019 ,《Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Hou, Yunlei; Zhu, Liangyu; Li, Zhiwei; Shen, Qi; Xu, Qiaoling; Li, Wei; Liu, Yajing; Gong, Ping. The article conveys some information:

To develop novel therapeutic agents with anticancer activities, two series of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivatives were designed and synthesized. All compounds were tested for anti-proliferative activities against five cancer cell lines. The structure-activity relationships (SARs) studies were conducted through the variation in two regions, the moiety of A ring and the terminal aniline B on pteridinone core. 1-Methyl-1,2,4-triazole derivative I with 2,6-dimethylpiperazine showed the most potent antiproliferative activity against A549, PC-3, HCT116, MCF-7 and MDA-MB-231 cell lines with IC50 values of 0.16 μM, 0.30 μM, 0.51 μM, 0.30 μM, and 0.70 μM, resp. Combined with the results of the mol. docking and enzymic studies, the PLK1 was very likely to be one of the drug targets of compound I. Furthermore, to clarify the anticancer mechanism of compound I, further explorations in the bioactivity were conducted. The results showed that compound I obviously inhibited proliferation of A549 cell lines, induced a great decrease in mitochondrial membrane potential leading to apoptosis of cancer cells, suppressed the migration of tumor cells, and arrested G1 phase of A549 cells. After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5Electric Literature of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Electric Literature of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of Ethyl oxalyl monochlorideIn 2022 ,《Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis》 was published in Journal of Medicinal Chemistry. The article was written by Mohamed, Abdelrahman; Salah, Mohamed; Tahoun, Mariam; Hawner, Manuel; Abdelsamie, Ahmed S.; Frotscher, Martin. The article contains the following contents:

A novel approach for the dual inhibition of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1(17β HSD1) by a single drug was explored, starting from inhouse 17β HSD1 inhibitors via masking their phenolic OH group with a sulfamate ester. The sulfamates were intentionally designed as drugs for the inhibition of STS and, at the same time, prodrugs for 17β-HSD1 inhibition (“”drug-prodrug approach””). The most promising sulfamates 13, 16, 18-20, 22-24, 36, and 37 showed nanomolar IC50 values for STS inhibition in a cellular assay and their corresponding phenols displayed potent 17β-HSD1 inhibition in cell-free and cellular assays, high selectivity over 17β-HSD2, reasonable metabolic stability, and low estrogen receptor α affinity. A close relationship was found between the liberation of the phenolic compound by sulfamate hydrolysis and 17β-HSD1 inactivation. These results showed that the envisaged drug-prodrug concept was successfully implemented. The novel compounds constitute a promising class of therapeutics for the treatment of endometriosis and other estrogen-dependent diseases. The results came from multiple reactions, including the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Safety of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Safety of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Liu, Dan; Luo, Ling; Wang, Zhengxing; Ma, Xiaoyun; Gan, Xiuhai published an article in International Journal of Molecular Sciences. The title of the article was 《Design, Synthesis and Antifungal/Nematicidal Activity of Novel 1,2,4-Oxadiazole Derivatives Containing Amide Fragments》.Recommanded Product: Ethyl oxalyl monochloride The author mentioned the following in the article:

A series of novel 1,2,4-oxadiazole derivatives containing amide fragments I (R = C6H5, 4-CH3C6H4, 4-ClC6H4, etc.; R1 = 2-pyridyl, 2,4-Cl2C6H3, 2,4-F2C6H3 etc; n = 0, 1, 2) were designed and synthesized. Addnl., the bioassays revealed that the compound I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) demonstrated excellent antifungal activity against Sclerotinia sclerotiorum (S. sclerotiorum) in vitro, and the EC50 value of that was 2.9μg/mL, which is comparable with commonly used fungicides thifluzamide and fluopyram. Meanwhile, I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) demonstrated excellent curative and protective activity against S. sclerotiorum-infected cole in vivo. The SEM results showed that the hyphae of S. sclerotiorum treated with I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) became abnormally collapsed and shriveled, thereby inhibiting the growth of the hyphae. Furthermore, I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) exhibited favorable inhibition against the succinate dehydrogenase (SDH) of the S. sclerotiorum (IC50 = 12.5μg/mL), and the combination mode and binding ability between compound I (R = thienyl; R1 = 2,4-F2C6H3; n = 1) and SDH were confirmed by mol. docking. In addition, compound (R = 4-ClC6H4; R1 = 2,4-F2C6H3; n = 1) showed excellent nematicidal activity against Meloidogyne incognita at 200μg/mL, the corrected mortality rate was 93.2%, which is higher than that of tioxazafen. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Petti, Alessia; Fagnan, Corentin; van Melis, Carlo G. W.; Tanbouza, Nour; Garcia, Anthony D.; Mastrodonato, Andrea; Leech, Matthew C.; Goodall, Iain C. A.; Dobbs, Adrian P.; Ollevier, Thierry; Lam, Kevin published their research in Organic Process Research & Development in 2021. The article was titled 《Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates》.Quality Control of Ethyl oxalyl monochloride The article contains the following contents:

A new electrochem. supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. Simple, practical, and phosgene-free route includes the generation of an isocyanate intermediate in-situ via anodic decarboxylation of an oxamic acid in the presence of an organic base, followed by the one-pot addition of suitable nucleophiles to afford the corresponding ureas, carbamates, and thiocarbamates. This procedure was applicable to different amines, alcs., and thiols. Furthermore, when single-pass continuous electrochem. flow conditions were used and this reaction were run in a carbon graphite Cgr/Cgr flow cell, urea compounds was obtained in high yields within a residence time of 6 min, unlocking access to substrates that were inaccessible under batch conditions while being easily scalable. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Quality Control of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Synthesis and Properties of Ethyl [(Adamantan-1-yl)alkylene(phenylene)amino]oxoacetates and N1,N2-Bis[(adamantan-1-yl)alkylene(phenylene)]oxamides》 were D’yachenko, V. S.; Burmistrov, V. V.; Butov, G. M.. And the article was published in Russian Journal of Organic Chemistry in 2019. Electric Literature of C4H5ClO3 The author mentioned the following in the article:

Et [(adamantan-1-yl)alkylene(phenylene)amino]oxoacetates I (X = CH2, CHCH3, benzen-1,4-diyl) and Et ([2-(adamantan-2-yl)pentyl]amino)oxoacetate and N1,N2-bis[(adamantan-1-yl)-alkylene(phenylene)]oxamides II (R = CH2, (CH2)2, benzen-1,4-diyl) were prepared in yields of 72-87 and 18-60%, resp., by the reaction of amines of the adamantane series (adamantan-1-yl)methylamine, 4-(adamantan-1-yl)phenylamine, 2-(adamantan-2-yl)pentylamine, etc. with Et chlorooxoacetate/oxalyl chloride in methylene chloride in mild conditions. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Electric Literature of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Electric Literature of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics