Category: 4755-77-5

In 2019,Crystal Growth & Design included an article by Kalinke, Lucas H. G.; Cangussu, Danielle; Lloret, Francesc; Bruno, Rosaria; Armentano, Donatella; Pardo, Emilio; Ferrando-Soria, Jesus. Formula: C4H5ClO3. The article was titled 《A Metalloligand Approach for the Self-Assembly of a Magnetic Two-Dimensional Grid-of-Grids》. The information in the text is summarized as follows:

The efficient organization of discrete functional mols. into extended frameworks, while retaining their phys. properties, is a mandatory requisite to move toward applications. Here the authors describe the validity of the metalloligand design strategy as a versatile and powerful approach to build up a two-dimensional (2D) magnetic metal-organic framework (MOF) composed of preformed discrete antiferromagnetically coupled [3 × 3] CuII9 incomplete grids. In the 1st stage, a novel oxamato-based nonanuclear copper(II) complex was self-assembled from the reaction of a polytopic organic ligand, with well-defined coordination pockets, with CuII ions. Then, the nonanuclear complex was used as metalloligand toward calcium(II) cations to afford a CaII-CuII 2-dimensional MOF [Ca3(H2O)12[Cu9(dabtzox)6μ2(H2O)4μ3(H2O)2]].20H2O (1) with a grid-like topol. and the magnetic properties of the preformed nonanuclear grids. In the experimental materials used by the author, we found Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Formula: C4H5ClO3

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Pan, Langheng; Zhan, Tao; Oh, Jiyeon; Zhang, Yue; Tang, Haoran; Yang, Mingqun; Li, Mengmeng; Yang, Changduk; Liu, Xi; Cai, Ping; Duan, Chunhui; Huang, Fei; Cao, Yong published their research in Chemistry – A European Journal in 2021. The article was titled 《N-Type Quinoidal Polymers Based on Dipyrrolopyrazinedione for Application in All-Polymer Solar Cells》.Recommanded Product: 4755-77-5 The article contains the following contents:

Conjugated mols. and polymers with intrinsic quinoidal structure are promising n-type organic semiconductors, which have been reported for application in field-effect transistors and thermoelec. devices. In principle, the mol. and electronic characteristics of quinoidal polymers can also enable their application in organic solar cells. Herein, two quinoidal polymers, named PzDP-T and PzDP-ffT, based on dipyrrolopyrazinedione were synthesized and used as electron acceptors in all-polymer solar cells (all-PSCs). Both PzDP-T and PzDP-ffT showed suitable energy levels and wide light absorption range that extended to the near-IR region. When combined with the polymer donor PBDB-T, the resulting all-PSCs based on PzDP-T and PzDP-ffT exhibited a power conversion efficiency (PCE) of 1.33 and 2.37 %, resp. This is the first report on the application of intrinsic quinoidal conjugated polymers in all-PSCs. The photovoltaic performance of the all-PSCs was revealed to be mainly limited by the relatively poor and imbalanced charge transport, considerable charge recombination. Detailed investigations on the structure-performance relationship suggested that synergistic optimization of light absorption, energy levels, and charge transport properties is needed to achieve more successful application of intrinsic quinoidal conjugated polymers in all-PSCs. In the experiment, the researchers used Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexes》 was published in Bioorganic Chemistry in 2020. These research results belong to Kavukcu, Serdar Batikan; Sahin, Onur; Seda Vatansever, Hafize; Kurt, Feyzan Ozdal; Korkmaz, Mehmet; Kendirci, Remziye; Pelit, Levent; Turkmen, Hayati. Safety of Ethyl oxalyl monochloride The article mentions the following:

A series of mono and bimetallic ruthenium(II) arene complexes bearing diamine (Ru1-6) were prepared and fully characterized by 1H, 13C, 19F, and 31P NMR spectroscopy and elemental anal. The crystal structure of the bimetallic complex (Ru5) was determined by X-ray crystallog. Monometallic analogs (Ru1-3) were synthesized to investigate the contributions of ruthenium and the other organic groups (arene, ethylenediamine, butyl) to the activity. The electrochem. behaviors of mono and bimetallic complexes were obtained from the relationship between cyclic voltammetry (CV) and the biol. activities of the compounds The cytotoxic activities of the complexes (Ru1-6) were tested against wide-scale cancer cell lines, namely HeLa, MDA-MB-231, DU-145, LNCaP, Hep-G2, Saos-2, PC-3, and MCF-7, and normal cell lines 3T3-L1 and Vero. Diamine Ru(II) arene complexes have unique biol. characteristics and they are promising models for new anticancer drug development. MTT anal. reveals that each synthesized Ru complex showed cytotoxic activity towards the different cancer cells. In particular, three Ru complexes (Ru3, Ru5 and Ru6) showed less toxic effects on the cancer cells than the others. These novel Ru complexes affected both cancer and normal cell lines. As they had a toxic effect on the cells, the dosage applied should be tested before being used for in vivo applications. Cytotoxicity tests have shown that the bimetallic complex Ru6 was effective on all cancer cells. The effect of bimetallic enhancement on cancer cell lines, the systematic variation of the intermetallic distance and the ligand donor properties of the mono and bimetallic complexes were explored based on the cytotoxic activity. The interaction with FS-DNA and the stability/aquation of the complexes (Ru3 and Ru6) were investigated with 1H NMR spectroscopy. The binding modes between the complexes (Ru3 and Ru6) and DNA were investigated via UV-Vis spectroscopy. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Safety of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Safety of Ethyl oxalyl monochloride

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Synthesis of a chiral rod-like metal-organic framework from a preformed amino acid-based hexanuclear wheel》 were Grancha, T.; Ferrando-Soria, J.; Armentano, D.; Pardo, E.. And the article was published in Journal of Coordination Chemistry in 2019. SDS of cas: 4755-77-5 The author mentioned the following in the article:

The authors report the two-step synthesis of a chiral rod-like metal-organic framework (MOF). The chem. approach consists on the use of a previously prepared oxamato-based homochiral hexanuclear wheel, the ligand being a derivative of the natural amino acid L-alanine, (Me4N)6{CuII6[(S)-alama]6}·10H2O (1) [where (S)-alama = (S)-N-(Et oxoacetate)alanine]. The anionic hexacopper(II) wheels, stabilized by the presence of templating tetramethylammonium countercations, disassemble in the presence of cationic square-planar [Ni(cyclam)]2+ complexes to yield, after a supramol. reorganization process that involves axial coordination of the [Ni(cyclam)]2+ cations through the free carbonyl groups of the copper(II) moieties, a neutral chiral rod-like, three-dimensional (3D) MOF [Ni(cyclam)][Cu(S)-alama]2·16H2O (2). The resulting MOF constitutes one of the few examples where such a high-nuclearity metal complex was used as precursor for the construction of rod-like MOFs. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5SDS of cas: 4755-77-5) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors》 was written by Patel, Manoj; Naidu, B. Narasimhulu; Dicker, Ira; Higley, Helen; Lin, Zeyu; Terry, Brian; Protack, Tricia; Krystal, Mark; Jenkins, Susan; Parker, Dawn; Panja, Chiradeep; Rampulla, Richard; Mathur, Arvind; Meanwell, Nicholas A.; Walker, Michael A.. Formula: C4H5ClO3This research focused ontricyclic pyrimidinone carboxamide preparation antiviral activity; Bridged tricyclic pyrimidinone; HIV; HIV Integrase; Integrase inhibitor; Strand transfer inhibitor. The article conveys some information:

The design, synthesis and structure-activity relationships associated with a series of bridged tricyclic pyrimidinone carboxamides I (R = (dimethylcarbamoyl)carbonyl, (dimethylcarbamoyl)methyl, [cyclopropyl(methyl)carbamoyl]carbonyl, etc.; R1 = H, 2-F, 3-CF3, 2-C(O)NHCH3, etc.) as potent inhibitors of HIV-1 integrase strand transfer are described. Structural modifications to these mols. were made in order to examine the effect on potency towards wild-type and clin.-relevant resistant viruses. The [3.2.2]-bridged tricyclic system I was identified as an advantageous chemotype, with representatives exhibiting excellent antiviral activity against both wild-type viruses and the G140S/Q148H resistant virus that arises in response to therapy with raltegravir and elvitegravir. After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Defining the mechanism of action of S1QELs, specific suppressors of superoxide production in the quinone-reaction site in mitochondrial complex I》 were Banba, Atsushi; Tsuji, Atsuhito; Kimura, Hironori; Murai, Masatoshi; Miyoshi, Hideto. And the article was published in Journal of Biological Chemistry in 2019. SDS of cas: 4755-77-5 The author mentioned the following in the article:

Site-specific suppressors of superoxide production (named S1QELs) in the quinone-reaction site in mitochondrial respiratory complex I during reverse electron transfer have been previously reported; however, their mechanism of action remains elusive. Using bovine heart submitochondrial particles, we herein investigated the effects of S1QELs on complex I functions. We found that the inhibitory effects of S1QELs on complex I are distinctly different from those of other known quinone-site inhibitors. For example, the inhibitory potencies of S1QELs significantly varied depending on the direction of electron transfer (forward or reverse). S1QELs marginally suppressed the specific chem. modification of Asp160 in the 49-kDa subunit, located deep in the quinone-binding pocket, by the tosyl chem. reagent AL1. S1QELs also failed to suppress the binding of a photoreactive quinazoline-type inhibitor ([125I]AzQ) to the 49-kDa subunit. Moreover, a photoaffinity labeling experiment with photoreactive S1QEL derivatives indicated that they bind to a segment in the ND1 subunit that is not considered to make up the binding pocket for quinone or inhibitors. These results indicate that unlike known quinone-site inhibitors, S1QELs do not occupy the quinone- or inhibitor-binding pocket; rather, they may indirectly modulate the quinone-redox reactions by inducing structural changes of the pocket through binding to ND1. We conclude that this indirect effect may be a prerequisite for S1QELs’ direction-dependent modulation of electron transfer. This, in turn, may be responsible for the suppression of superoxide production during reverse electron transfer without significantly interfering with forward electron transfer. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5SDS of cas: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.SDS of cas: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C4H5ClO3In 2019 ,《Design, synthesis and biological activities of new pyrazole derivatives possessing both coxib and combretastatins pharmacophores》 appeared in Chemistry & Biodiversity. The author of the article were Thi, Thuy Hang Nguyen; Thi, Yen Tran; Nguyen, Le Anh; Vo, Ngoc Binh; Ngo, Quoc Anh. The article conveys some information:

In our efforts to discover novel multi-target agents having better antitumor activities than celecoxib, 21 new aryl-substituted pyrazole derivatives possessing cis-diphenylethylene scaffold were mostly synthesized by a one-pot approach to Et 1,4,5-triaryl-1H-pyrazole-3-carboxylates via an improved Claisen condensation – Knorr reaction sequence. The cytotoxic effects of these compounds against three human cancer cell lines HT-29, Hep-G2, MCF-7 as well as their inhibition of NO production were studied. Results showed that incorporation of the important pharmacophoric groups of two original mols. celecoxib and combretastatin A-4 in a single mol. plays an important role in determining a better biol. activities of the new coxib-hybrided compounds In the experimental materials used by the author, we found Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.COA of Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of Ethyl oxalyl monochlorideIn 2022 ,《[3+2] Cycloaddition of Nitrile Imines with 3-Benzylidene Succinimides: A Facile Access to Functionalized Spiropyrazolines》 was published in Asian Journal of Organic Chemistry. The article was written by Yuan, Cheng; Ning, Xiaojun; Gao, Tao; Zeng, Zhigang; Lee, Kevin; Xing, Yalan; Sun, Shaofa; Wang, Gangqiang. The article contains the following contents:

A wide range of substituted spiro-pyrazoline derivatives I [R1 = heptyl, 4-methoxyphenyl, naphthalen-2-yl, etc.; R2 = cyclopropyl, 4-fluorophenyl, furan-2-yl, thiophen-2-yl, etc.; R3 = Ph, 3-methylphenyl, 4-cyanophenyl, etc.] containing the pyrrolidinone core have been prepared by alkalic treatment of 3-benzylidene succinimides II and nitrile imines. All reactions proceeded under mild conditions and the products I were isolated by column chromatog. in good yields with high diastereoselectivity. Furthermore, this method featured several advantages such as good functional group tolerance and simple scalability. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Reference of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Reference of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A Bis-Polydentate Oxamate-Based Achiral Ligand That Can Stabilize a Macrocyclic Mixed Valence Compound or Induce a 1D Helical Chain》 was written by Li, Ang; Li, Yanling; Chamoreau, Lise-Marie; Desmarets, Christophe; Lisnard, Laurent; Journaux, Yves. Category: esters-buliding-blocks And the article was included in European Journal of Inorganic Chemistry in 2020. The article conveys some information:

The reaction of the N-(2-hydroxyphenyl)oxamate ligand (ohpma) has been investigated with cobalt(II) and copper(II) ions. It has led to two coordination compounds, (TMA)3[{CoIII(ohpma)2CoII(MeOH)2}3]·10H2O·5MeOH (1) and (HNEt3)[Cu(ohpma)] (2). Both compounds have been characterized by single-crystal x-ray diffraction and magnetometry. The x-ray diffraction studies have revealed atypical structures that are not commonly observed in oxamate coordination chem. with a macrocyclic arrangement for the mixed-valence cobalt-based complex 1, and a helical chiral chain for compound 2. In the latter, the bis-polydentate nature of the (ohpma)3- ligand with distinct tridentate and bidentate coordination sites creates a chirogenic center on the copper ion. The investigation of the magnetic properties shows for complex 1 a single-mol. magnet behavior detectable under static field, while antiferromagnetic interactions dominate the behavior of 2. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Peng, Wei-Yu; Lan, Jian; Zhu, Zheng-Mei; Si, Li-Ping; Zhang, Hao; Zhan, Shu-Zhong; Liu, Hai-Yang published an article in Inorganic Chemistry Communications. The title of the article was 《Synthesis of metal (Ga, Co and Fe) 5,15-bis(pentafluorophenyl)-10-ethoxycarbonylcorrole and their electrocatalytic hydrogen evolution activity》.Computed Properties of C4H5ClO3 The author mentioned the following in the article:

5,15-Bis(pentafluorophenyl)-10-ethoxycarbonylcorrole and their metal complexes (metal = Ga, Co, Fe) had been synthesized and characterized (new complexes). These metal complexes had been used as electrocatalysts for hydrogen evolution reaction (HER) in organic acid and aqueous medium, in which the gallium corrole was firstly used for HER. The results showed that the redox potential of central metal atom for metal-centered metal (eg. Co and Fe) corroles plays a significant role in adjusting catalytic HER activity. Gallium corrole is a ligand-centered HER catalyst, the electronic structure of corrole ligand may play a key role in controlling the electrocatalytic activity. In the experiment, the researchers used many compounds, for example, Ethyl oxalyl monochloride(cas: 4755-77-5Computed Properties of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics