Category: 4755-77-5

In 2019,Soft Matter included an article by Ma, Yao; Cametti, Massimo; Dzolic, Zoran; Jiang, Shimei. Computed Properties of C4H5ClO3. The article was titled 《Selective Cu(II) sensing by a versatile AIE cyanostilbene-based gel systemã€? The information in the text is summarized as follows:

Cyanostilbene-based derivatives were designed, synthesized and fully characterized. By screening their gelating abilities, we observed that the subtle difference in the position of the pyridine nitrogen greatly affected the resulting fluorescence and gelation properties. Notably, Cyanostilbene 1 was found to be a versatile ambidextrous gelator capable of forming organo-, hydro-, and Cu(II) specific metallogels. Furthermore, a rare organogel-to-metallogel transformation at room temperature was also observed upon exposure of the 1-DMSO/H2O gel to aqueous Cu(II). This process, accompanied by color and fluorescence changes, provides an effective strategy for the preparation of novel sensing soft materials. In the experiment, the researchers used many compounds, for example, Ethyl oxalyl monochloride(cas: 4755-77-5Computed Properties of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

�-(2-Ethoxy-2-oxoacetamido)benzoic acid�was published in IUCrData in 2020. These research results belong to Yu, MingChao; Wang, LinLin; Wang, LingYang; Wu, ZhiYong. HPLC of Formula: 4755-77-5 The article mentions the following:

The title compound, C11H11NO5, was synthesized by reacting Et chlorooxoacetate with 2-aminobenzoic acid and its structure was examined by x-ray crystallog. The compound has a nearly planar geometry except for the terminal Me group. The asym. unit contains one title compound adopting the expected transoid conformation. In the crystal, pairs of mols. are linked by O-H···O hydrogen bonds into inversion dimers. The results came from multiple reactions, including the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5HPLC of Formula: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Direct Synthesis of Vicinal Tricarbonyl Amides by Coupling of α-Oxo Acid Chlorides with Carbamoylsilanes》 was written by Han, Yuling; Li, Yuping; Han, Shenghua; Zhang, Pengpeng; Chen, Jianxin. Formula: C4H5ClO3This research focused onvicinal tricarbonyl amide preparation; oxo acid chloride carbamoylsilane cross coupling reaction. The article conveys some information:

A convenient synthetic method for vicinal tricarbonyl amides R(CO)3N(R1)(R2) (R = Me, Ph, OEt; R1 = Me, Bn, n-Pr; R2 = Me, CH2OCH3, 1-phenylethyl) by the cross-coupling reaction of α-oxo acid chlorides RC(O)C(O)Cl with carbamoylsilanes Si(CH3)3C(O)N(R1)(R2) is developed. The reaction tolerates a broad range of substituents on the amido nitrogen of carbamoylsilanes, and directly affords good yields of vicinal tricarbonyl amides under mild conditions without use of oxidants. The reaction of carbamoylsilanes with oxalyl chloride has also been explored, and is accompanied by decarbonylation to give vicinal tricarbonyl amides N(R1)(R2)(CO)3N(R1)(R2) (R1 = Me, R2 = Me, 1-phenylethyl). After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Introducing an α-Keto Ester Functional Group through Pt-Catalyzed Direct C-H Acylation with Ethyl Chlorooxoacetate》 was published in ACS Omega in 2020. These research results belong to Javed, Erman; Guthrie, Jacob D.; Neu, Justin; Chirayath, George S.; Huo, Shouquan. Category: esters-buliding-blocks The article mentions the following:

Platinum-catalyzed selective C-H acylation of 2-aryloxypyridines with Et chlorooxoacetate provided an efficient way of introducing an α-keto ester functional group. The reaction is oxidant-free, additive-free and more significantly free of any decarbonylative side reactions. The reaction tolerated a variety of substituents from strongly electron-donating to strongly electron-withdrawing groups. Double acylation was feasible for 2-phenoxypyridine and its derivatives with only one substituent at the para position. Although the reaction of 2-(2-methylphenoxy)pyridine with Et malonyl chloride did not produce the desired β-keto ester, the reaction with Et succinyl chloride proceeded smoothly to give the γ-keto ester. Et chlorooxoacetate was much more reactive than Et succinyl chloride in this Pt-catalyzed C-H acylation reaction. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C4H5ClO3In 2022 ,《Catalytic Enantioselective Construction of Chiral Benzo-Fused N-Heterocycles through Friedel-Crafts-Type Electrophilic Chlorination》 was published in CCS Chemistry. The article was written by Luo, Jie; Zhang, Yuanyuan; Zhong, Fuming; Zhao, Xiaodan. The article contains the following contents:

Chiral benzo-fused N-heterocycles are frequently found in natural and synthetic products. However, their synthesis usually suffers from different limitations such as difficulty in accessing appropriate starting materials and unsatisfactory stereoselectivities. In this work, an unprecedented chiral sulfide-catalyzed enantioselective Friedel-Crafts-type electrophilic chlorination is shown to construct various 3,4-functionalized tetrahydroquinolines with excellent enantio- and diastereoselectivities from readily available aniline derivatives Interestingly, employing N-allyl 1-naphthanilides as substrates, divergent reactions via chlorocarbocyclization and dearomatization occurred to afford two chiral polycyclic benzo-fused N-heterocycles. The system that authors developed extends the scope of asym. chlorination to general substrates without the need of a N-H group, and significantly promotes the synthesis of enantioenriched benzo-fused N-heterocycles. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.COA of Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cortes, Ivan; Cordisco, Estefania; Kaufman, Teodoro S.; Sortino, Maximiliano A.; Svetaz, Laura A.; Bracca, Andrea B. J. published their research in RSC Advances in 2021. The article was titled 《First total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against Candida albicans, a biofilm forming agent》.Safety of Ethyl oxalyl monochloride The article contains the following contents:

A straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone A was synthesized in 25.3% overall yield from the readily available pyrocatechol, whereas the second natural product was prepared in 39.7% global yield. A small library of chromones, including both natural products and some of their synthetic heterocyclic precursors, was evaluated against Candida albicans ATCC 10231, a biofilm forming agent. It was found that 8-methoxy-3-methyl-4-oxo-4H-chromene-2-carbaldehyde, a partially oxidized form of chromanone A, exhibited a min. inhibitory concentration of 7.8μg mL-1 and significantly inhibited the yeast’s virulence factors, including the adherence to buccal epithelial cells and the secretion of phospholipases, as well as the formation of germ tubes and the generation of the hyphal pseudomycelium. In addition, despite the heterocycle exhibiting non-significant inhibition of the formation of the Candida biofilm, it completely inhibited the growth of C. albicans in preformed biofilms at 62.5μg mL-1. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Safety of Ethyl oxalyl monochloride) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Safety of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Zhou, Kehan; Wang, Dongjie; Ju, Guodong; Deng, Zefeng; Huang, Pengcheng; Huang, Zhibin; Li, Bao; Zhao, Yingsheng published an article in Organic Letters. The title of the article was 《Ligand-Promoted Fluorinated Olefination of Isatins at the C5 Position via a Palladium Catalyst》.HPLC of Formula: 4755-77-5 The author mentioned the following in the article:

A palladium-catalyzed nondirected fluorinated olefination was developed. The oxalyl amide ligand greatly improved the yield of the reaction. A wide variety of isatin derivatives were well tolerated and yielded the corresponding (fluoroalkenyl)isatins I [R1 = H, 6-Me, 4-Cl, etc.; R2 = CF2CF2Br, CO2CH2CF3, C6F5, etc.; R3 = Me, Et, n-Pr, i-Pr; X = O, N(OMe), N(Ot-Bu)] in moderate to good yields. Various fluorinated olefins were also compatible. The application and synthesis of bioactive compounds such as a Metisazone derivative highlighted the synthetic value of this approach. After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5HPLC of Formula: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.HPLC of Formula: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《3D QSAR-based design and liquid phase combinatorial synthesis of 1,2-disubstituted benzimidazole-5-carboxylic acid and 3-substituted-5H-benzimidazo[1,2-d][1,4]benzodiazepin-6(7H)-one derivatives as anti-mycobacterial agents》 were Sitwala, Nikum D.; Vyas, Vivek K.; Gedia, Piyush; Patel, Kinjal; Bouzeyen, Rania; Kidwai, Saqib; Singh, Ramandeep; Ghate, Manjunath D.. And the article was published in MedChemComm in 2019. Reference of Ethyl oxalyl monochloride The author mentioned the following in the article:

A 3D QSAR study was performed for the design of novel substituted benzimidazole derivatives as anti-mycobacterial agents. The anti-tubercular activity of the designed compounds was predicted using the generated 3D QSAR models. The designed compounds which showed better activity were synthesized as I [R = pyridin-3-yl, 3,4-(MeO)2C6H3, 4-BrC6H4, etc.] and II [R1 = H, PhCO, 4-MeOC6H4SO2, etc.] using the liquid phase combinatorial approach using a soluble polymer assisted support (PEG5000). The compounds were characterized by 1H-NMR, 13C-NMR, FTIR and mass spectrometry. HPLC anal. was carried out to evaluate the purity of the compounds It was observed that the synthesized compounds inhibited the growth of intracellular M. tuberculosis H37Rv in a bactericidal manner. The most active compound, II [R1 = H] displayed an MIC value of 0.0975 μM against the Mtb H37Rv strain in liquid cultures. The lead compound was also able to inhibit the growth of intracellular mycobacteria in THP-1 macrophages. In the experiment, the researchers used Ethyl oxalyl monochloride(cas: 4755-77-5Reference of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Reference of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Methods for the Synthesis of Piperazine Derivatives Containing a Chiral Bi-2-naphthyl Moiety》 was published in Synthesis in 2020. These research results belong to Periasamy, Mariappan; Venkanna, Boda; Nagaraju, Miriyala; Mohan, Lakavathu. COA of Formula: C4H5ClO3 The article mentions the following:

Piperazine derivatives containing 1,1′-bi-2-naphthyl moiety were synthesized starting from 2,2′-dimethoxy-1,1′-bi-naphthalene via acylation using Et chlorooxoacetate and subsequent condensation with 1,2-diamines followed by reduction of the corresponding dihydro-2-piperazinone intermediate using the NaBH4/I2 reagent system. The corresponding chiral piperazine derivatives containing bi-2-naphthyl moiety was synthesized by asym. reduction of Et dimethoxy-bi-2-naphthyloxoacetate by chiral oxazoborolidine catalyst prepared in-situ using S-diphenylprolinol (S-DPP), B(OCH3)3 and H3B·THF. The resulting diols were mesylated and cyclized using 1,2-diamines to obtain the corresponding chiral piperazine derivatives The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.COA of Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Inorganic Chemistry included an article by Wi, Eun Hye; Ryu, Ji Yeon; Lee, Seul Gi; Farwa, Ume; Pait, Moumita; Lee, Sunwoo; Cho, Sung; Lee, Junseong. Application In Synthesis of Ethyl oxalyl monochloride. The article was titled 《Selective Self-Assembly of a Rectangular Ruthenium Supramolecule from an Unsymmetrical Bridging Unit》. The information in the text is summarized as follows:

Herein, the authors report the synthesis of an unsym. diruthenium bridging unit containing a multidentate oxamate ligand and the subsequent formation of a rectangular supramol. The reaction of oxamate 1, 2-((4-bromo-2,6-dimethylphenyl)amino)-2-oxo-HOAc, and [(p-cymene)RuCl2]2 affords a novel unsym. diruthenium acceptor clip 2, where two Ru metal centers are ligated with either [O,O] or [N,O]. The mol. clip 2 and bipyridine donor self-assemble to form two-dimensional rectangular supramol. 3. Self-assembly can produce seven possible isomers depending on the position of the substituted bromoaryl groups. However, 1H NMR spectroscopic study indicated only two different isomers in the reaction mixture A single isomer is isolated via crystallization, and x-ray crystallog. confirms that the product is a C1 sym. two-dimensional rectangular supramol., in which two bromoaryl groups are located in the farthest position from each other. Theor. calculations suggest that the self-assembly of supramol. 3 occurred via 1:1 adducts of the diruthenium mol. clip and bipyridine as an intermediate to predominantly form a single isomer. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Application In Synthesis of Ethyl oxalyl monochloride) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application In Synthesis of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics