Category: 4707-47-5

Quality Control of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate《Chemical constituents from stem bark of Pterostyrax psilophyllus》 was published in 2015. The authors were Zhang, Ya-mei;Zhang, Pu-zhao, and the article was included in《Zhongguo Shiyan Fangjixue Zazhi》. The author mentioned the following in the article:

Objective: To study the chem. constituents in the stem bark of Pterostyrax psilophyllus. Method: The chem. constituents were separated and purified by chromatog. methods combined with spectroscopic analyses. Result: Twelve compounds were isolated from the stem bark of P. psilophyllus and identified as following: methyl-2,4-dihydroxy-3,6-dimethylbenzoate (1), lupeol (2), prunetin (3), genistein (4), 2-hydroxy-4-methoxy-3,6-dimethyl benzoic acid (5), genistein-4′-O-β-glucoside (6), amyrin (7), catechin (8), epicatechin (9), vanillic acid (10), β-sitosterol (11), daucosterol (12). Conclusion: All twelve compounds were isolated from the plants of P. psilophyllus for the first time. The experimental procedure involved many compounds, such as Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Quality Control of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peixoto, Philippe A.;Boulange, Agathe;Ball, Malcolm;Naudin, Bertrand;Alle, Thibault;Cosette, Pascal;Karuso, Peter;Franck, Xavier published 《Design and Synthesis of Epicocconone Analogues with Improved Fluorescence Properties》. The research results were published in《Journal of the American Chemical Society》 in 2014.Recommanded Product: 4707-47-5 The article conveys some information:

Epicocconone is a natural latent fluorophore that is widely used in biotechnol. because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited its wider use, and in the absence of a total synthesis, this limitation was a long-standing problem. Here the authors report a general strategy for the synthesis of epicocconone analogs that relies on a 2-iodoxybenzoic acid-mediated dearomatization and on the replacement of the triene tail of the natural product by an aromatic ring. This design element is general and the synthesis is straightforward, providing ready access to libraries of polyfunctional fluorophores with long Stokes shifts based on the epicocconone core. The structural modifications resulted in analogs with increased photostability and quantum yields compared with the natural product. Staining proteomic gels with these new analogs showed significant lowering of the detection limit and a 30% increase in the number of low-abundance proteins detected. These epiccoconone analogs will substantially improve the discovery rate of biomarker needles in the proteomic haystack. And Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) was used in the research process.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Recommanded Product: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Today I want to share an article with you. The article is 《Synthesis of barbacic acid》,you can find this article in 《Journal of Asian Natural Products Research》. The following contents are mentioned:

A new approach for the synthesis of the active barbatic acid has been achieved in eight steps with 22.3% total yield by using com. available Me atratate as starting material. This synthesis provides access to multi-gram quantities of barbatic acid with good purity for reference supplies and further anal. and toxicol. investigations. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Safety of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Njateng, Guy Sedar Singor;Du, Zhizhi;Gatsing, Donatien;Donfack, Arno Rusel Nanfack;Talla, Michel Feussi;Wabo, Hippolyte Kamdem;Tane, Pierre;Mouokeu, Raymond Simplice;Luo, Xiaodong;Kuiate, Jules-Roger published 《Antifungal properties of a new terpernoid saponin and other compounds from the stem bark of Polyscias fulva Hiern (Araliaceae)》. The research results were published in《BMC Complementary and Alternative Medicine》 in 2015.Safety of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article conveys some information:

Background: In our previous studies, it was evident that the dichloromethane-methanol (1:1 volume/volume) stem barks extract of Polyscias fulva and fractions (Et acetate, n-butanol and residue) demonstrated interesting antidermatophytic activities. So, as a continuity of that, this work aimed at identifying active principles with antifungal properties from P. fulva that could be used as markers for possible standardization of this plant as phytomedicine. Methods: The Et acetate, n-butanol and residual fractions of the dichloromethane-methanol (1:1 volume/volume) stem bark extract of Polyscias fulva were further fractionated by column chromatog. and the structures of isolated compounds elucidated based on their spectroscopic data in comparison with existing literature information. Antifungal activity was assayed by broth microdilution techniques on yeasts and dermatophytes spores. Results: The fractionation of the crude dichloromethane-methanol (1:1 volume/volume) stem bark extract of Polyscias fulva led to the isolation of 10 known compounds (1 to 10) and one new saponin (11: 3-O-[α-L-rhamnopyranosyl (1-2)-α-L-arabinopyranosyl]-28-O-[α-L-4-O-acetyl-rhamnopyranosyl (1-4)-β-D-glucopyranosyl-(1-6)-β-D-glucopyranosyl]-hederagenin). Among these compounds, 3-O-α-L- arabinopyranosyl-hederagenin and 3-O-[α-L-rhamnopyranosyl (1-2)-α-L-arabinopyranosyl]-hederagenin were the most active on the tested fungi with MIC values ranging from 0.78 to 100 μg/mL against both yeasts and dermatophytes. Conclusion: The results of this work constitute a step forward in the possible development of an antidermatophytic phytomedicine from Polyscias fulva stem bark, the isolated compounds being possible markers for the standardisation. And Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) was used in the research process.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Safety of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reddy, R. Gajendra;Veeraval, Lenin;Maitra, Swati;Chollet-Krugler, Marylene;Tomasi, Sophie;Devehat, Francoise Lohezic-Le;Boustie, Joel;Chakravarty, Sumana published 《Lichen-derived compounds show potential for central nervous system therapeutics》 in 2016. The article was appeared in 《Phytomedicine》. They have made some progress in their research.Reference of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:

Natural products from lichens are widely investigated for their biol. properties, yet their potential as central nervous system (CNS) therapeutic agents is less explored. The present study investigated the neuroactive properties of selected lichen compounds (atranorin, perlatolic acid, physodic acid and usnic acid), for their neurotrophic, neurogenic and acetylcholine esterase (AChE) activities. Neurotrophic activity (neurite outgrowth) was determined using murine neuroblastoma Neuro2A cells. A MTT assay was performed to assess the cytotoxicity of compounds at optimum neurotrophic activity. Neuro2A cells treated with neurotrophic lichen compounds were used for RT-PCR to evaluate the induction of genes that code for the neurotrophic markers BDNF and NGF. Immunoblotting was used to assess acetyl H3 and H4 levels, the epigenetic markers associated with neurotrophic and/or neurogenic activity. The neurogenic property of the compounds was determined using murine hippocampal primary cultures. AChE inhibition activity was performed using a modified Ellman’s esterase method. Lichen compounds atranorin, perlatolic acid, physodic acid and (+)-usnic acid showed neurotrophic activity in a preliminary cell-based screening based on Neuro2A neurite outgrowth. Except for usnic acid, no cytotoxic effects were observed for the two depsides (atranorin and perlatolic acid) and the alkyl depsidone (physodic acid). Perlatolic acid appears to be promising, as it also exhibited AChE inhibition activity and potent proneurogenic activity. The neurotrophic lichen compounds (atranorin, perlatolic acid, physodic acid) modulated the gene expression of BDNF and NGF. In addition, perlatolic acid showed increased protein levels of acetyl H3 and H4 in Neuro2A cells. These lichen depsides and depsidones showed neuroactive properties in vitro (Neuro2A cells) and ex vivo (primary neural stem or progenitor cells), suggesting their potential to treat CNS disorders. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Oettl, Sarah K.;Hubert, Jane;Nuzillard, Jean-Marc;Stuppner, Hermann;Renault, Jean-Hugues;Rollinger, Judith M. published 《Dereplication of depsides from the lichen Pseudevernia furfuracea by centrifugal partition chromatography combined to ¹³C nuclear magnetic resonance pattern recognition》 in 2014. The article was appeared in 《Analytica Chimica Acta》. They have made some progress in their research.Computed Properties of C10H12O4 The article mentions the following:

Lichens produce a diversity of secondary metabolites, among them depsides comprised of two or more hydroxybenzoic acid units linked by ester, ether, or C-C-bonds. During classic solid support-based purification processes, depsides are often hydrolyzed and in many cases time, consuming procedures result only in the isolation of decomposition products. In an attempt to avoid extensive purification steps while maintaining metabolite structure integrity, we propose an alternative method to identify the major depsides of a lichen crude extract (Pseudevernia furfuracea var. ceratea (Ach.) D.Hawksw., Parmeliaceae) directly within mixturesExploiting the acidic character of depsides and differences in polarity, the extract was fractionated by centrifugal partition chromatog. in the pH-zone refining mode resulting in twelve simplified mixtures of depsides. After ¹³C NMR anal. of the produced fractions, the major mol. structures were directly identified within the fraction series by using a recently developed pattern recognition method, which combines spectral data alignment and hierarchical clustering anal. The obtained clusters of ¹³C chem. shifts were assigned to their corresponding mol. structures with the help of an inhouse ¹³C NMR chem. shift database, resulting in six unambiguously identified compounds, namely Me β-orcinolcarboxylate (1), atranorin (2), 5-chloroatranorin (3), olivetol carboxylic acid (4), olivetoric acid (5), and olivetonide (6). And Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) was used in the research process.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Computed Properties of C10H12O4

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics