Category: 4707-47-5

Mun, Seul-Ki;Kang, Kyung-Yun;Jang, Ho-Yeol;Hwang, Yun-Ho;Hong, Seong-Gyeol;Kim, Su-Jin;Cho, Hyun-Wook;Chang, Dong-Jo;Hur, Jae-Seoun;Yee, Sung-Tae published 《Atraric acid exhibits anti-inflammatory effect in lipopolysaccharide-stimulated RAW264.7 cells and mouse models》 in 2020. The article was appeared in 《International Journal of Molecular Sciences》. They have made some progress in their research.HPLC of Formula: 4707-47-5 The article mentions the following:

Lichens, composite organisms resulting from the symbiotic association between the fungi and algae, produce a variety of secondary metabolites that exhibit pharmacol. activities. This study aimed to investigate the anti-inflammatory activities of the secondary metabolite atraric acid produced by Heterodermia hypoleuca. The results confirmed that atraric acid could regulate induced pro-inflammatory cytokine, nitric oxide, prostaglandin E2, induced nitric oxide synthase and cyclooxygenase-2 enzyme expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Meanwhile, atraric acid downregulated the expression of phosphorylated IκB, extracellular signal-regulated kinases (ERK) and nuclear factor kappa B (NFκB) signaling pathway to exhibit anti-inflammatory effects in LPS-stimulated RAW264.7 cells. Based on these results, the anti-inflammatory effect of atraric acid during LPS-induced endotoxin shock in a mouse model was confirmed. In the atraric acid treated-group, cytokine production was decreased in the peritoneum and serum, and each organ damaged by LPS-stimulation was recovered. These results indicate that atraric acid has an anti-inflammatory effect, which may be the underlying mol. mechanism involved in the inactivation of the ERK/NFκB signaling pathway, demonstrating its potential therapeutic value for treating inflammatory diseases. The experimental procedure involved many compounds, such as Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.HPLC of Formula: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

SDS of cas: 4707-47-5In 2017, Ismed, Friardi;Lohezic-Le Devehat, Francoise;Rouaud, Isabelle;Ferron, Solenn;Bakhtiar, Amri;Boustie, Joel published 《NMR reassignment of stictic acid isolated from a Sumatran lichen Stereocaulon montagneanum (Stereocaulaceae) with superoxide anion scavenging activities》. 《Zeitschrift fuer Naturforschung, C: Journal of Biosciences》published the findings. The article contains the following contents:

The phytochem. study of Stereocaulon montagneanum harvested in Sumatra (Indonesia) led to the isolation of 11 known compounds including two metabolites not previously described in the genus Stereocaulon, peristictic acid (8) and menegazziaic acid (10). The complete ¹H and ¹³C NMR spectral assignments of stictic acid derivatives are reported with some revisions. Five depsidones belonging to the stictic acid chemosyndrome were superoxide anion scavengers as potent as ascorbic acid and with no toxicity on two human cell lines.Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) were involved in the experimental procedure.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.SDS of cas: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Van Nguyen, Kieu;Duong, Thuc-Huy;Nguyen, Kim Phi Phung;Sangvichien, Ek;Wonganan, Piyanuch;Chavasiri, Warinthorn published 《Chemical constituents of the lichen Usnea baileyi (Stirt.) Zahlbr》. The research results were published in《Tetrahedron Letters》 in 2018.Computed Properties of C10H12O4 The article conveys some information:

An investigation of the chem. constituents of the lichen U. baileyi (Stirt.) Zahlbr led to the isolation of a new dimeric xanthone, bailexanthone (1), and a novel depsidone, bailesidone (2), along with 25 known metabolites (3-27). Their structures were established by means of extensive spectroscopic anal. and comparison with data reported in the literatures. Compound 1 was derived from a secalonic acid scaffold with C-8/8′ reduction and compound 2 represents the 1st example of menegazziaic acid derivative with an unprecedented B-ring moiety. Compounds 1 and 2 were evaluated for their cytotoxic activities against A549 (human lung carcinoma) and HT29 (human colorectal adenocarcinoma) cell lines. The compounds showed weak or no activity against the 2 cell lines. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Computed Properties of C10H12O4

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gandhi, Arumugam Dhanesh;Miraclin, Prasanna A.;Abilash, Doraiah;Sathiyaraj, Sivaji;Velmurugan, Rajendran;Zhang, Yang;Soontarapa, Khantong;Sen, Priyankar;Sridharan, T. B. published 《Nanosilver reinforced Parmelia sulcata extract efficiently induces apoptosis and inhibits proliferative signalling in MCF-7 cells》. The research results were published in《Environmental Research》 in 2021.Safety of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article conveys some information:

The Lichen, Parmelia sulcata synthesizes various secondary metabolites, in which phenolic based compounds received much attention due to their importance in biomedical application. Especially the phenolic compound was effective against the cancer treatment. An effective administration of such plant natural product can represent a significant conventional management of cancer in terms of chemoprevention. The nanomedicines are group of agents that selectively interfere the cancer cells which leads to reduction of side effect thereby reducing the doses. Silver nanoparticles is a promising antitumor agent, however, the conventional production of silver nanoparticles have many drawbacks which led to increase in need of eco-friendly biol. production methods. In this study, we made an attempt to synthesize a nano silver (Ps-AgNPs) from phenolic extract of lichen Parmelia sulcata extract The Ps-AgNps was applied for anticancer activity using MCF-7 cells and the effect was characterised by western blotting method. The FTIR, XRD, UV and TEM results confirms the presence of silver nanoparticles in phenolic extract of lichen Parmelia sulcata. The cytotoxicity assay shows that the Ps-AgNPs is toxic against cancer cells (MCF-7) but not to normal cells (NIH3T3), which confirm the selective induction of cell death (apoptosis) against cancer cells. The Western blot anal. also clearly indicates the down regulation of inflammatory genes (TNF-alpha and IL-6) and cell cycle genes (PCNA and Cyclin-D1) thus promoting intrinsic apoptotic pathway. The results suggest that Ps-AgNPs can effectively kill cancer cells and can be used as an alternative therapeutic agent for cancer treatment. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Safety of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4707-47-5In 2021, Kalra, Rishu;Conlan, Xavier A.;Areche, Carlos;Dilawari, Rahul;Goel, Mayurika published 《Metabolite profiling of the indian food spice lichen, Pseudevernia furfuracea combined with optimisedextraction methodology to obtain bioactive phenolic compounds》. 《Frontiers in Pharmacology》published the findings. The article contains the following contents:

Pseudevernia furfuracea (L.) Zopf (Parmeliaceae) is a well-known epiphytic lichen commonly used in Indian spice mixtures and food preparations such as curries. This study is an attempt to find the best extraction methodol. with respect to extractive yield, total polyphenolic content (TPC), total flavonoid content and antioxidant activities of lichen P. furfuracea. Two phenolic compounds, atraric acid and olivetoric acid were isolated and quantified in their resp. extracts with the aid of reverse phase high performance liquid chromatog. (RP-HPLC). The highest concentration of both the compounds, atraric acid (4.89 mg/g DW) and olivetoric acid (11.46 mg/g DW) were found in 70% methanol extract A direct correlation was also observed between the concentrations of these compounds with the free radical scavenging potential of the extracts which might contribute towards the antioxidant potential of the extract Moreover, SEM and HPLC anal. which was used to study the effect of pre-processing on extraction process highlighted the capacity of a mixer grinder technique for improved separation of surface localized metabolites and enrichment of the fraction. An investigation of the chem. profile of the bioactive extract 70% methanol extract using UHPLC-DAD-MS lead to tentative identification of forty nine compounds This extract was also assessed towards HEK 293 T cell line for cytotoxicity anal. Concentration range of 0.156 to 100 μg/mL of PF70M extract exhibited no significant cell death as compared to control. Further, the active extract showed protective effect against hydroxyl radical′s destructive effects on DNA when assessed using DNA nicking assay. Based upon this, it can be concluded that optimization of extraction solvent, sample pre-processing and extraction techniques can be useful in extraction of specific antioxidant metabolites. The experimental procedure involved many compounds, such as Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.HPLC of Formula: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Youn, Ui Joung;So, Jae Eun;Kim, Ji Hee;Han, Se Jong;Park, Hyun;Kim, Il Chan;Yim, Jung Han published 《Chemical constituents from the Antarctic lichen, Stereocaulon caespitosum》 in 2018. The article was appeared in 《Biochemical Systematics and Ecology》. They have made some progress in their research.Name: Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:

A phytochem. study of the methanol extract of the Antarctic lichen Stereocaulon caespitosum Redgr. led to the isolation of a tridepside (1), two depsides (2 and 3), a montagnetol derivative (4), and four mono-phenolic compounds (5-8). The structures of these compounds were confirmed by 1D- and 2D-NMR (NMR) experiments, as well as by comparison with published values. This is the first phytochem. study of S. caespitosum. In particular, compounds 1, 3, 4, and 8 have been isolated for the first time from the genus Stereocaulon and the family Stereocaulaceae. The chemotaxonomic significance of the isolated compounds is discussed. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Name: Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thadhani, Vinitha M.;Mesaik, M. Ahmed;Asif, Muhammad;Karunaratne, Veranja;Choudhary, Iqbal M. published 《Immunomodulatory activities of some common lichen metabolites》. The research results were published in《International Journal of Pharmacy and Pharmaceutical Sciences》 in 2015.Computed Properties of C10H12O4 The article conveys some information:

Objective: To evaluate the immunomodulatory activities of some of the common lichen compounds by using chemiluminescence based cellular assays. Methods:Number of secondary lichen metabolites, representing a breadth of lichen substances, was investigated for their effects on the respiratory burst of human whole blood phagocytes, isolated human polymorphonuclear leukocytes (PMNs) and murine macrophages using luminol or lucigenin-based chemiluminescence probes. Results: This study identify a clear suppressive effect of some lichen metabolites on phagocytosis response upon activation with serum opsonized zymosan by several lichen substances. Amongst the compounds tested, orsellinic acid, Me orsellinate, Me haematomate, lecanoric acid and lobaric acid, showed a potent immunomodulatory activity as compared to the standards The lobaric acid suppressed both the myloperoxidase dependent and myloperoxidase independent, Reactive Oxygen Species (ROS) production in the oxidative burst of polymorphonuclear neutrophils (PMN) at the lowest concentration tested (3.1 μg/mL). Whereas, lecanoric acid, suppressed only the myloperoxidase dependent ROS production with IC50< 3.1 μg/mL when compared to the standard sodium diethyldithiocarbamate trihydrate (SDT) (IC50 = 1.3 ± 0.2 μg/mL). Orsellinic acid, Me orsellinate and Me haematomate showed a selective myloperoxidase independent pathway with IC50 values; < 3.1μg/mL; 6.1 ± 1.0 μg/mL; 3.3 ± 0.1 μg/mL, resp., being lower as compared to standard SDT (IC50= 8.2 ± 1.9 μg/mL). Conclusion: Based on the results obtained it is appropriate to conclude that lichen are not only a good source of antioxidants, but also potent immunomodulators, and thus deserve to be investigated further.Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) were involved in the experimental procedure.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Computed Properties of C10H12O4

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deng, Yifan;Yang, Chia-Ping H.;Smith, Amos B. III published 《Enantioselective Total Synthesis of (+)-Peniciketals A and B: Two Architecturally Complex Spiroketals》 in 2021. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Application In Synthesis of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:

The enantioselective total syntheses of (+)-peniciketals A and B (I and II, resp.), two members of a family of architecturally complex spiroketals, have been achieved. Key synthetic transformations comprise Type I Anion Relay Chem. (ARC) to construct the benzannulated [6,6]-spiroketal skeleton, a Negishi cross-coupling/olefin cross-metathesis reaction sequence to generate the trans-enone structure, and a late-stage large fragment union exploiting our recently developed photoisomerization/cyclization tactic. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Application In Synthesis of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4707-47-5In 2018, Seklic, Dragana S.;Obradovic, Ana D.;Stankovic, Milan S.;Zivanovic, Marko N.;Mitrovic, Tatjana Lj.;Stamenkovic, Slavisa M.;Markovic, Snezana D. published 《Proapoptotic and antimigratory effects of Pseudevernia furfuracea and Platismatia glauca on colon cancer cell lines original scientific paper》. 《Food Technology and Biotechnology》published the findings. The article contains the following contents:

The aim of this study is to investigate cytotoxic, proapoptotic, antimigratory and pro-antioxidant effects of methanol, acetone and Et acetate extracts of lichens Pseudevernia furfuracea and Platismatia glauca on colorectal cancer (HCT-116 and SW-480) cell lines. We compared the cytotoxic effects on colorectal cancer cells with the effects obtained from normal human fibroblast (MRC-5) cell line. Tetrazolium (MTT) test evaluated the cytotoxic effects, Transwell assay evaluated cell migration, acridine orange/ethidium bromide (AO/EB) fluorescent method followed the apoptosis, while prooxidant/antioxidant effects were determined spectrophotometrically through concentration of redox parameters. The tested extracts showed considerable cytotoxic effect on cancer cells with no observable cytotoxic effect on normal cells. Et acetate and acetone extract of P. furfuracea induced the highest cytotoxicity (IC50 = (21.2 ± 1.3) μg/mL on HCT-116, and IC50 = (51.3 ± 0.8) μg/mL on SW-480 cells, resp., after 72 h), with noteworthy apoptotic and prooxidant effects, and antimigratory potential of methanol extract P. glauca extracts induced cytotoxic effects on HCT-116 cells after 72 h (IC50<40μg/mL), while only methanol and acetone extracts had cytotoxic effects on SW-480 cells after 24 h, with proapoptotic/necrotic activity, as a consequence of induced oxidative stress. In conclusion, lichen extracts changed to a great extent cell viability and migratory potential of colorectal cancer cell lines. HCT-116 cells were more sensitive to treatments, P. furfuracea had better proapoptotic and antimigratory effects, and both investigated lichen species might be a source of substances with anticancer activity.Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) were involved in the experimental procedure.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.HPLC of Formula: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kekuda, T. R. Prashith;Lavanya, D.;Rao, Pooja published 《Lichens as promising resources of enzyme inhibitors: a review》 in 2019. The article was appeared in 《Journal of Drug Delivery and Therapeutics》. They have made some progress in their research.Reference of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:

A review. Inhibition of some enzymes seems to be one of the therapeutic strategies for the management of certain diseases or conditions such as diabetes, Alzheimer’s disease, cancer and obesity. In this review, an updated information on the enzyme inhibitory activity of lichen extracts and lichen compounds by an intensive literature survey is presented. Crude solvent extracts and isolated compounds from lichens were shown to be effective in causing inhibition of several enzymes such as amylase, lipase, lipoxygenase, aromatase, cyclooxygenase, trypsin, β-glucoronidase, prolyl endopeptidase, monoamine oxidase, urease, tyrosinase, xanthine oxidase, Thioredoxin reductase, glucosidase, topoisomerase, pancreatic elastase, phosphodiesterase, telomerase and acetylcholinesterase. Lichen metabolites such as usnic acid and its derivatives, lobaric acid, physodic acid, ramalin, protolichestrinic acid, salazinic acid, atranorin, evernic acid, zeorin, diffractic acid, psoromic acid, Me β-orcinolcarboxylate, methylorsellinate, and anziaic acid were shown to be inhibitors of some enzymes. In conclusion, lichens can be employed as promising therapeutic agents in terms of their potential to inhibit the activity of certain enzymes that are involved in some diseases or disorders. In vitro culturing of lichen symbionts in optimized media can be carried out to isolate enzyme inhibitors in larger scale and to develop effective therapeutic agents. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Reference of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics