Category: 46193-76-4

Electric Literature of 46193-76-4,Some common heterocyclic compound, 46193-76-4, name is Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, molecular formula is C9H9NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step (1) Preparation of thiophene pyrrole:Lipidothiophene pyrrole (1.95 g, 10 mmol)And potassium hydroxide (1 g, 18 mmol)Mixed in ethylene glycol (19.5 mL)Under inert gas protection and dark conditions, heated to 150 reaction 3h,After cooling to room temperature, add a large amount of distilled water to dilute,Extract with chloroform several times,Organic phase with water,Saturated sodium chloride solution,After drying, the solvent was removed by rotary evaporation,Quickly purified by silica gel column,Dichloromethane as eluent,Point before collecting components, dried to give thiophene pyrrole,Yield 85%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, its application will become more common.

Reference:
Patent; Henan Normal University; Chang Yi; Niu Mengyuan; Liu Mengyang; (11 pag.)CN106905351; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 46193-76-4, name is Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate

Ethyl-6-nitro-4H-thieno[3,2-b]pyrrole-5-carboxyIate (95). Pulverized Cu(NO3)2′ hydrate (953 mg, 4.10 mmol) dissolved in acetic anhydride (8.2 niL) was added dropwise to a solution of carboxylate 96 dissolved in acetic anhydride (10 mL) at 0 0C. The addition was completed in 1.5 h and the mixture was then stirred at r.t. for 2 h. After filtration the organic layer was poured over ice and extracted with diethyl ether (3×30 mL). The combined organic layers were washed with saturated aqueous sodium carbonate solution and dried over MgSO4. After the removal of organic solvent, the residue was purified by column chromatography (EtOAc/Hexane: 1/6) to give the desired nitration product 94 (148 mg, 12 %) as a light yellow solid along with another nitration product 95 (300 mg, 25%).

The synthetic route of 46193-76-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; THOMAS, Craig J.; AULD, Douglas S.; INGLESE, James; SKOUMBOURDIS, Amanda P.; JIANG, Jian-Kang; BOXER, Matthew; WO2010/42867; (2010); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

46193-76-4, name is Ethyl 4H-thieno[3,2-b]pyrrole-5-carboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 46193-76-4

To a solution of 4H-thiophene [3,2-b] pyrrole-5-carboxylic acid ethyl ester (4.24 g, 21.7 mmol) in DMF (20 mL) at room temperature was added K2CO3 (7.82 g, 56.6 mmol),Then iodomethane (2.52 g, 17.8 mmol) was added dropwise.The mixture was stirred at room temperature for 2 h.The reaction was quenched with water and extracted with EtOAc (3 ¡Á).The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.The residue was purified by silica gel chromatography,Elution with 0-10% EtOAc in hexanes gave the title compound (3.96 g, 18.9 mmol, 87% yield).

The synthetic route of 46193-76-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Jiakesitu Drug Discovery Co., Ltd.; Beijing Jiakesi Drug Discovery Co., Ltd.; Fang Haiquan; Li Haijun; Yang Guiqun; Wang Yanping; Wu Lingjun; Li Qinglong; Du Yuelei; Zhang Lei; Hu Shaojing; (65 pag.)CN110407854; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics