Reference of 457097-93-7, A common heterocyclic compound, 457097-93-7, name is Methyl 4-amino-3-(trifluoromethoxy)benzoate, molecular formula is C9H8F3NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 500 mL round-bottom t1ask was added methyl4-amino-3-(trifluoromethoxy)5 benzoate (7.1 g, 30.19 mmoL 1.0 equiv.), AcOH (100 mL), and NaSCN (12.1 g, 149.25mmol, 5.0 equiv .), followed by the dropwise addition of a solution of bromine (9.6 g, 60.07mrnol, 2.0 equiv.) in AcOH (50 rnL) at 0 C over 1 hr. The mixture vvas stirred at 0 C for 2h, and then at 40 C overnight The reaction mixture vas cooled to 0 C, and a second batchofNaSCN (12.2 g, 150.49 mmol, 5.0 equiv.) was added, followed by the dropwise addition10 of a solution of bromine (9.6 g, 60.07 mmol, 2 0 equiv.) in AcOFf (50 mL) over l hr. Again,the reaction mixture was stirred at 0 C tor 2 h, and then at 40 C for 3 days. The resultingmixture was diluted Vith 200 mL of water and the pH value of the aqueous solution wasadjusted to 9 with sodium hydroxide. The resulting solids were collected by filtration,·washed ·with ·water (20 mL x 2), and dried in an oven at 60 C for 6 h to provide of rnethyl 2-15 amino-4-(trifluoromethoxy)-1 ,3-benzothiazole-6-carboxy late A-4b (54 g, 61 %) as a brornsolid.
The synthetic route of 457097-93-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
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